Detailed information for compound 503751

Basic information

Technical information
  • TDR Targets ID: 503751
  • Name: [[(4-chlorophenyl)methylamino]-[cyclohexyl(pr opan-2-yl)amino]methylidene]-dimethylazanium
  • MW: 336.923 | Formula: C19H31ClN3+
  • H donors: 1 H acceptors: 0 LogP: 4.38 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(N(C(=[N+](C)C)NCc1ccc(cc1)Cl)C1CCCCC1)C
  • InChi: 1S/C19H30ClN3/c1-15(2)23(18-8-6-5-7-9-18)19(22(3)4)21-14-16-10-12-17(20)13-11-16/h10-13,15,18H,5-9,14H2,1-4H3/p+1
  • InChiKey: XJJYCCQIXOJVOA-UHFFFAOYSA-O  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [[(4-chlorophenyl)methylamino]-[cyclohexyl(isopropyl)amino]methylene]-dimethyl-ammonium
  • [[(4-chlorophenyl)methylamino]-[cyclohexyl(isopropyl)amino]methylene]-dimethylammonium
  • [[(4-chlorophenyl)methylamino]-[cyclohexyl(propan-2-yl)amino]methylidene]-dimethyl-azanium
  • [[(4-chlorobenzyl)amino]-[cyclohexyl(isopropyl)amino]methylene]-dimethyl-ammonium
  • [[(4-chlorophenyl)methylamino]-(cyclohexyl-propan-2-ylamino)methylidene]-dimethylazanium
  • [[(4-chlorophenyl)methylamino]-(cyclohexyl-isopropyl-amino)methylene]-dimethyl-ammonium
  • [[(4-chlorophenyl)methylamino]-(cyclohexyl-isopropylamino)methylene]-dimethylammonium
  • [[(4-chlorobenzyl)amino]-(cyclohexyl-isopropyl-amino)methylene]-dimethyl-ammonium
  • [[(4-chlorophenyl)methylamino]-(cyclohexyl-propan-2-yl-amino)methylidene]-dimethyl-azanium

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.1011 0.6345
Loa Loa (eye worm) hypothetical protein 0.0025 0.0204 0.1313
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0623 0.0559
Loa Loa (eye worm) hypothetical protein 0.005 0.1011 0.6504
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0068 0.1089
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.1011 0.095
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0204 0.3277
Loa Loa (eye worm) hypothetical protein 0.0027 0.025 0.1605
Schistosoma mansoni nuclear receptor 0.0024 0.0158 0.0091
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0158 0.0091
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0204 0.2455
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.025 0.0183
Loa Loa (eye worm) hypothetical protein 0.0038 0.0623 0.4008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.1011 0.095
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.1017
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.1017
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0204 0.3277
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0623 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0204 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0281 0.8385 0.8374
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0068 1
Onchocerca volvulus 0.0038 0.0623 0.545
Schistosoma mansoni nuclear receptor 0.0024 0.0158 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.1011 0.6504
Loa Loa (eye worm) hypothetical protein 0.0038 0.0623 0.4008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.1017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.1011 0.1134
Onchocerca volvulus Bile acid receptor homolog 0.005 0.1011 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1555 0.1497
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.1017
Loa Loa (eye worm) hypothetical protein 0.0027 0.025 0.1605
Mycobacterium ulcerans lipase LipD 0.0038 0.0623 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0158 0.0607
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.1011 0.1134
Echinococcus multilocularis FTZ F1 alpha 0.005 0.1011 0.095
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0623 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.1011 0.095
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.1011 1
Loa Loa (eye worm) hypothetical protein 0.005 0.1011 0.6504
Loa Loa (eye worm) RNA binding protein 0.0067 0.1555 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.1011 0.095
Brugia malayi hypothetical protein 0.0024 0.0158 0.0607
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.1017
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.1017
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0158 0.0091
Schistosoma mansoni hypothetical protein 0.018 0.517 0.5137
Brugia malayi conserved hypotetical protein 0.0024 0.0158 0.0607
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0068 0.5
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0623 0.0861
Brugia malayi hypothetical protein 0.0027 0.025 0.1222
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.025 0.1222
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0204 0.0282
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.1555 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.1011 0.1134
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.1011 0.6345
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0623 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.1011 0.6345
Mycobacterium tuberculosis Conserved protein 0.0038 0.0623 0.0861
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.1011 1
Schistosoma mansoni hypothetical protein 0.0036 0.0557 0.0493
Brugia malayi nuclear hormone receptor 0.005 0.1011 0.6345
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0204 0.3277
Brugia malayi RNA binding protein 0.0067 0.1555 1
Loa Loa (eye worm) beta-lactamase 0.0038 0.0623 0.4008
Brugia malayi nuclear receptor RXR 0.0024 0.0158 0.0607
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.1011 0.6345
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.1011 0.1134
Schistosoma mansoni thyroid hormone receptor 0.0331 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0204 0.2455
Mycobacterium tuberculosis Conserved protein 0.0038 0.0623 0.0861
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.1017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0204 0.1313
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.1555 1
Brugia malayi beta-lactamase family protein 0.0038 0.0623 0.3735
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0158 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0623 1
Schistosoma mansoni zinc finger protein 0.0024 0.0158 0.0091
Mycobacterium ulcerans hypothetical protein 0.0038 0.0623 1
Brugia malayi tailless protein 0.0024 0.0158 0.0607
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0158 0.0607
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.1017
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0158 0.0109
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.025 0.0218
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0158 0.1017
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0158 0.0109
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.1011 0.095
Loa Loa (eye worm) hypothetical protein 0.0025 0.0204 0.1313
Loa Loa (eye worm) hypothetical protein 0.0053 0.1095 0.7043
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.1011 0.095
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0158 0.0607
Loa Loa (eye worm) hypothetical protein 0.0027 0.025 0.1605
Brugia malayi Steroid receptor seven-up type 2 0.005 0.1011 0.6345
Mycobacterium tuberculosis Conserved protein 0.0038 0.0623 0.0861
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1555 0.1497
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0158 0.0109
Brugia malayi nuclear receptor NHR-88 0.0024 0.0158 0.0607
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.1017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0623 0.3735
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0158 0.0091
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.1011 0.095
Loa Loa (eye worm) steroid hormone receptor 0.005 0.1011 0.6504
Brugia malayi hypothetical protein 0.0027 0.025 0.1222
Schistosoma mansoni coup transcription factor 0.005 0.1011 0.095
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.1011 0.095
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1555 0.1497
Schistosoma mansoni hypothetical protein 0.018 0.517 0.5137
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0623 0.0861
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1555 0.1497
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0158 0.0607
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0623 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0158 0.0091
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0068 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0623 0.4008
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.1011 0.095
Schistosoma mansoni thyroid hormone receptor 0.0331 1 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0204 0.3277
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0623 1
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0158 0.0091
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0623 0.0861
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.1011 0.1134
Mycobacterium ulcerans beta-lactamase 0.0038 0.0623 1
Schistosoma mansoni hypothetical protein 0.0281 0.8385 0.8374
Loa Loa (eye worm) hypothetical protein 0.005 0.1011 0.6504
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0158 0.0091
Brugia malayi hypothetical protein 0.0024 0.0158 0.0607
Brugia malayi beta-lactamase family protein 0.0038 0.0623 0.3735
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0623 0.0559
Loa Loa (eye worm) hypothetical protein 0.0038 0.0623 0.4008
Brugia malayi ecdysone receptor 0.0024 0.0158 0.0607
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0158 0.0109
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0557 0.3293
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.1011 0.1134
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0623 0.0861
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0 0.5
Brugia malayi TAR-binding protein 0.0067 0.1555 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.025 0.1605
Brugia malayi ecdysteroid receptor 0.005 0.1011 0.6345
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.1011 0.6345
Toxoplasma gondii ABC1 family protein 0.0038 0.0623 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.1011 0.6504
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0623 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.1011 0.6345
Brugia malayi beta-lactamase 0.0038 0.0623 0.3735
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.1011 0.095
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0158 0.1017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.1011 0.6504
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0623 1
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.1011 0.6345
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.1011 0.6504
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0623 1
Onchocerca volvulus 0.0025 0.0204 0.054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.1011 0.1134
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.1095 0.6908
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0204 1
Onchocerca volvulus 0.0038 0.0623 0.545
Loa Loa (eye worm) DR-78 0.0024 0.0158 0.1017
Brugia malayi nuclear receptor NHR-88 0.005 0.1011 0.6345
Echinococcus granulosus FTZ F1 alpha 0.005 0.1011 0.1134
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.025 0.1222
Loa Loa (eye worm) hypothetical protein 0.0027 0.025 0.1605
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1555 0.1497
Brugia malayi nuclear hormone receptor 0.0024 0.0158 0.0607
Loa Loa (eye worm) hypothetical protein 0.005 0.1011 0.6504
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0204 0.0917
Trichomonas vaginalis esterase, putative 0.0038 0.0623 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0623 0.4008
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0068 0.5
Loa Loa (eye worm) hypothetical protein 0.005 0.1011 0.6504
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.1011 0.095
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0204 0.3277
Brugia malayi nuclear receptor NHR-67 0.0024 0.0158 0.0607
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.1011 0.6504
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.025 0.0183
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0158 0.0607
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.1017
Brugia malayi nuclear receptor RXR 0.0027 0.025 0.1222
Echinococcus granulosus geminin 0.018 0.517 0.6134
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0204 0.0282
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.1017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.025 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.1011 0.6345
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.1011 0.095
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0281 0.8385 1
Mycobacterium leprae Probable lipase LipE 0.0038 0.0623 1
Loa Loa (eye worm) TAR-binding protein 0.0067 0.1555 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0204 0.0917
Loa Loa (eye worm) hypothetical protein 0.005 0.1011 0.6504
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.1011 0.6345
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0158 0.0091
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.1011 0.6345
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.1011 0.6504
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0068 0.0094
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0623 0.0559
Brugia malayi steroid hormone receptor 0.005 0.1011 0.6345
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.1011 0.6345
Echinococcus multilocularis geminin 0.018 0.517 0.5137
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.1011 0.1134
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.1095 0.7043
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.1011 0.6345
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0204 0.0917
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0623 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0158 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.1011 0.6504
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0623 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.1011 0.095
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.1095 0.6908
Onchocerca volvulus 0.005 0.1011 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.1011 0.095
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0204 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0623 0.4008
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0204 0.3277
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.1011 0.6345
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0158 0.0091
Leishmania major hypothetical protein, conserved 0.0038 0.0623 1
Echinococcus multilocularis tar DNA binding protein 0.0067 0.1555 0.1497
Loa Loa (eye worm) hypothetical protein 0.0036 0.0557 0.3586
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0204 0.3277
Schistosoma mansoni nuclear hormone receptor 0.005 0.1011 0.095
Loa Loa (eye worm) hypothetical protein 0.0038 0.0623 0.4008
Echinococcus granulosus tar DNA binding protein 0.0067 0.1555 0.1788
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0158 0.0607
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0623 0.0861
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0623 0.0668
Loa Loa (eye worm) hypothetical protein 0.005 0.1011 0.6504
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0623 0.0861
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.1011 0.6345
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0623 0.0861
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0158 0.0109
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0158 0.1017
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.1017
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.1011 0.6345
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.1011 0.095
Onchocerca volvulus 0.0038 0.0623 0.545
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0068 0.1089
Loa Loa (eye worm) hypothetical protein 0.005 0.1011 0.6504
Mycobacterium ulcerans hypothetical protein 0.0025 0.0204 0.3277
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0204 0.2455
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0158 0.0091
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0623 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0158 0.0091
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.7233 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.1017
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.1011 0.095
Loa Loa (eye worm) hypothetical protein 0.0027 0.025 0.1605
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0068 0.0436

Activities

Activity type Activity value Assay description Source Reference
Ki (ADMET) = 1.7017 Inhibition of CYP2C9 ChEMBL. 18211009
Log Ki (ADMET) = 1.7017 Inhibition of CYP2C9 ChEMBL. 18211009

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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