Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | glucosidase, putative | 0.0037 | 0.0156 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0037 | 0.0156 | 0.0443 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0156 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.0156 | 0.5 |
Echinococcus multilocularis | geminin | 0.0175 | 0.185 | 0.1721 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0169 | 0.1767 | 0.5213 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.185 | 0.9925 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.0156 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0156 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0169 | 0.1767 | 0.5004 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1595 | 0.4705 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0156 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0037 | 0.0156 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.185 | 0.9925 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0312 | 0.3531 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.1863 | 0.1734 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1863 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.339 | 0.96 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1595 | 0.4705 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.339 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0155 | 0.1595 | 0.1461 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0037 | 0.0156 | 0.0461 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0156 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0155 | 0.1595 | 0.4517 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0037 | 0.0156 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0156 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1863 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.339 | 0.96 |
Schistosoma mansoni | alpha-glucosidase | 0.0145 | 0.1479 | 0.775 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0156 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0155 | 0.1595 | 0.1461 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0156 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.1563 | 0.1429 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0169 | 0.1767 | 0.1636 |
Schistosoma mansoni | alpha-glucosidase | 0.0145 | 0.1479 | 0.775 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.3373 | 0.995 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0156 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0155 | 0.1595 | 0.8494 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0037 | 0.0156 | 0.5 |
Onchocerca volvulus | 0.0098 | 0.0894 | 0.5 | |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.1563 | 0.8306 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0156 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0169 | 0.1767 | 0.1636 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.1563 | 0.8244 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0169 | 0.1767 | 0.951 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0156 | 0.5 |
Echinococcus granulosus | geminin | 0.0175 | 0.185 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.34 | Inhibition of thyroid hormone receptor alpha (unknown origin) | ChEMBL. | 17467994 |
IC50 (binding) | = 6.72 | Inhibition of thyroid hormone receptor beta (unknown origin) | ChEMBL. | 17467994 |
Log IC50 (binding) | = 6.34 | Inhibition of thyroid hormone receptor alpha (unknown origin) | ChEMBL. | 17467994 |
Log IC50 (binding) | = 6.72 | Inhibition of thyroid hormone receptor beta (unknown origin) | ChEMBL. | 17467994 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.