TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 408.232 | Formula: C19H15Cl2NO5
H donors: 3 H acceptors: 4 LogP: 4.85 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cc2[nH]c(cc(=O)c2c(c1Oc1ccc(c(c1)C(C)C)O)Cl)C(=O)O
InChi: 1S/C19H15Cl2NO5/c1-8(2)10-5-9(3-4-14(10)23)27-18-11(20)6-12-16(17(18)21)15(24)7-13(22-12)19(25)26/h3-8,23H,1-2H3,(H,22,24)(H,25,26)
InChiKey: REFNRSMJTOAWKU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	thyroid hormone receptor, beta	Starlite/ChEMBL	References
Homo sapiens	thyroid hormone receptor, alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_156853	All targets in OG5_156853
Schistosoma japonicum	ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Loa Loa (eye worm)	nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Brugia malayi	Nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Brugia malayi	Nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus multilocularis	thyroid hormone receptor alpha	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	expressed protein	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Brugia malayi	Nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	photoreceptor-specific nuclear receptor	thyroid hormone receptor, alpha	451 aa	372 aa	25.3 %
Brugia malayi	photoreceptor-specific nuclear receptor	thyroid hormone receptor, beta	461 aa	414 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0437	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0312	0.9068	0.9891
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0063	0.0437	0.0828
Onchocerca volvulus		0.0063	0.0437	1
Onchocerca volvulus		0.0063	0.0437	1
Schistosoma mansoni	opsin-like receptor	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0063	0.0437	0.0828
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0437	0.0828
Echinococcus granulosus	neuropeptides capa receptor	0.0063	0.0437	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus multilocularis	g protein coupled receptor	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Brugia malayi	RE15519p	0.0063	0.0437	0.0437
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0063	0.0437	0.0828
Echinococcus granulosus	sex peptide receptor	0.0063	0.0437	0.1243
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0437	0.0828
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0437	0.0828
Brugia malayi	hypothetical protein	0.0063	0.0437	0.0437
Brugia malayi	sulfakinin receptor protein	0.0063	0.0437	0.0437
Echinococcus granulosus	neuropeptide s receptor	0.0063	0.0437	0.1243
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0063	0.0437	0.0828
Onchocerca volvulus		0.0063	0.0437	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0063	0.0437	1
Onchocerca volvulus		0.0063	0.0437	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0437	0.1243
Loa Loa (eye worm)	melatonin receptor type 1A	0.0063	0.0437	0.0477
Schistosoma mansoni	growth hormone secretagogue receptor	0.0063	0.0437	0.0828
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0063	0.0437	0.0828
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0063	0.0437	0.0477
Brugia malayi	Serotonin receptor	0.0063	0.0437	0.0437
Schistosoma mansoni	neuropeptide f receptor 76f	0.0063	0.0437	0.0828
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0063	0.0437	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Schistosoma mansoni	thyroid hormone receptor	0.0203	0.528	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Onchocerca volvulus		0.0063	0.0437	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0063	0.0437	0.0828
Echinococcus granulosus	tm gpcr rhodopsin	0.0063	0.0437	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0063	0.0437	0.0437
Onchocerca volvulus		0.0063	0.0437	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0437	0.0828
Schistosoma mansoni	amine GPCR	0.0063	0.0437	0.0828
Schistosoma mansoni	neuropeptide receptor	0.0063	0.0437	0.0828
Schistosoma mansoni	hypothetical protein	0.0063	0.0437	0.0828
Echinococcus multilocularis	allatostatin A receptor	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0437	0.1243
Echinococcus granulosus	neuropeptide Y receptor	0.0063	0.0437	0.1243
Echinococcus granulosus	G protein coupled receptor 139	0.0063	0.0437	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Schistosoma mansoni	amine GPCR	0.0063	0.0437	0.0828
Brugia malayi	G protein-coupled receptor F59B2.13	0.0063	0.0437	0.0437
Echinococcus multilocularis	neuropeptide receptor	0.0063	0.0437	0.0828
Schistosoma mansoni	hypothetical protein	0.0152	0.3515	0.6658
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0063	0.0437	0.1243
Schistosoma mansoni	hypothetical protein	0.0063	0.0437	0.0828
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0437	0.0828
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Brugia malayi	hypothetical protein	0.0063	0.0437	0.0437
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0063	0.0437	0.0828
Brugia malayi	G-protein coupled receptor	0.0063	0.0437	0.0437
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0063	0.0437	0.0437
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0063	0.0437	0.0477
Echinococcus granulosus	g-protein coupled receptor	0.0063	0.0437	0.1243
Echinococcus granulosus	g protein coupled receptor	0.0063	0.0437	0.1243
Schistosoma mansoni	biogenic amine receptor	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Onchocerca volvulus		0.0063	0.0437	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0063	0.0437	0.0828
Brugia malayi	hypothetical protein	0.0063	0.0437	0.0437
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0063	0.0437	0.0828
Echinococcus granulosus	g protein coupled receptor	0.0063	0.0437	0.1243
Schistosoma mansoni	opsin-like receptor	0.0063	0.0437	0.0828
Echinococcus granulosus	g protein coupled receptor	0.0063	0.0437	0.1243
Brugia malayi	neuropeptide F receptor	0.0063	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus multilocularis	g protein coupled receptor	0.0063	0.0437	0.0828
Echinococcus multilocularis	neuropeptide Y receptor	0.0063	0.0437	0.0828
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0437	0.0828
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0063	0.0437	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Schistosoma mansoni	amine GPCR	0.0063	0.0437	0.0828
Schistosoma mansoni	hypothetical protein	0.0063	0.0437	0.0828
Echinococcus granulosus	neuropeptide Y receptor	0.0063	0.0437	0.1243
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0063	0.0437	0.0828
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0315	0.9168	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0063	0.0437	0.1243
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0063	0.0437	0.0828
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0063	0.0437	0.0828
Echinococcus multilocularis	dro:myosuppressin receptor	0.0063	0.0437	0.0828
Brugia malayi	hypothetical protein	0.0063	0.0437	0.0437
Echinococcus multilocularis	g protein coupled receptor	0.0063	0.0437	0.0828
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0063	0.0437	0.1243
Schistosoma mansoni	thyroid hormone receptor	0.0203	0.528	1
Onchocerca volvulus		0.0063	0.0437	1
Brugia malayi	Dopamine receptor protein 2	0.0063	0.0437	0.0437
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0437	0.0828
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0437	0.1243
Schistosoma mansoni	neuropeptide receptor	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Brugia malayi	GnHR receptor homolog	0.0063	0.0437	0.0437
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0437	0.0828
Brugia malayi	larval opioid receptor	0.0063	0.0437	0.0437
Echinococcus multilocularis	neuropeptide receptor A26	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Loa Loa (eye worm)	neuropeptide F receptor	0.0063	0.0437	0.0477
Echinococcus granulosus	neuropeptides capa receptor	0.0063	0.0437	0.1243
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Brugia malayi	putative neuropeptide receptor NPR1	0.0063	0.0437	0.0437
Schistosoma mansoni	myosin xvIII	0.0063	0.0437	0.0828
Schistosoma mansoni	histamine h1 receptor	0.0063	0.0437	0.0828
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0063	0.0437	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0063	0.0437	0.0828
Onchocerca volvulus		0.0063	0.0437	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0437	0.0828
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0437	0.0828
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0063	0.0437	0.0828
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus multilocularis	sex peptide receptor	0.0063	0.0437	0.0828
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0063	0.0437	0.0828
Loa Loa (eye worm)	G-protein coupled receptor	0.0063	0.0437	0.0477
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0063	0.0437	0.1243
Echinococcus multilocularis	somatostatin receptor	0.0063	0.0437	0.0828
Schistosoma mansoni	amine GPCR	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0063	0.0437	0.0437
Brugia malayi	follicle stimulating hormone receptor	0.0063	0.0437	0.0437
Brugia malayi	Nuclear hormone receptor-like 1	0.0315	0.9168	0.9168
Echinococcus multilocularis	G protein coupled receptor 139	0.0063	0.0437	0.0828
Brugia malayi	putative neuropeptide receptor	0.0063	0.0437	0.0437
Onchocerca volvulus		0.0063	0.0437	1
Schistosoma mansoni	hypothetical protein	0.0063	0.0437	0.0828
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0063	0.0437	0.0437
Brugia malayi	hypothetical protein	0.0063	0.0437	0.0437
Brugia malayi	Dopamine receptor protein 1	0.0063	0.0437	0.0437
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0152	0.3515	0.6658
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0063	0.0437	0.0477
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0437	0.0828
Echinococcus granulosus	somatostatin receptor	0.0063	0.0437	0.1243
Onchocerca volvulus		0.0063	0.0437	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus granulosus	tm gpcr rhodopsin	0.0063	0.0437	0.1243
Schistosoma mansoni	opsin-like receptor	0.0063	0.0437	0.0828
Brugia malayi	Dopamine receptor	0.0063	0.0437	0.0437
Brugia malayi	G-protein coupled receptor	0.0063	0.0437	0.0437
Echinococcus granulosus	biogenic amine 5HT receptor	0.0063	0.0437	0.1243
Onchocerca volvulus		0.0063	0.0437	1
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0152	0.3515	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0063	0.0437	0.0828
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0063	0.0437	0.0828
Onchocerca volvulus		0.0063	0.0437	1
Echinococcus multilocularis	fmrfamide receptor	0.0063	0.0437	0.0828
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0063	0.0437	0.0828
Schistosoma mansoni	neuropeptide receptor	0.0063	0.0437	0.0828
Onchocerca volvulus		0.0063	0.0437	1
Echinococcus granulosus	neuropeptide receptor A26	0.0063	0.0437	0.1243
Echinococcus multilocularis	serotonin receptor	0.0063	0.0437	0.0828
Echinococcus granulosus	fmrfamide receptor	0.0063	0.0437	0.1243
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0063	0.0437	0.0828
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0063	0.0437	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Brugia malayi	neuropeptide F receptor	0.0063	0.0437	0.0437
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0063	0.0437	0.0828
Echinococcus multilocularis	neuropeptide Y receptor	0.0063	0.0437	0.0828
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0063	0.0437	0.1243
Onchocerca volvulus		0.0063	0.0437	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0315	0.9168	0.9168
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus granulosus	hypothetical protein	0.0063	0.0437	0.1243
Echinococcus multilocularis	orexin receptor type 2	0.0063	0.0437	0.0828
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Brugia malayi	G protein-coupled receptor	0.0063	0.0437	0.0437
Echinococcus granulosus	orexin receptor type 2	0.0063	0.0437	0.1243
Schistosoma mansoni	neuropeptide F-like receptor	0.0063	0.0437	0.0828
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0063	0.0437	0.1243
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0063	0.0437	0.1243
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0063	0.0437	0.0828
Echinococcus granulosus	neuropeptide FF receptor 2	0.0063	0.0437	0.1243
Echinococcus granulosus	biogenic amine 5HT receptor	0.0063	0.0437	0.1243
Loa Loa (eye worm)	TYRA-2 protein	0.0063	0.0437	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0437	0.1243
Brugia malayi	hypothetical protein	0.0063	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0063	0.0437	0.0828
Echinococcus multilocularis	neuropeptide receptor	0.0063	0.0437	0.0828
Onchocerca volvulus		0.0063	0.0437	1
Echinococcus granulosus	neuropeptide receptor	0.0063	0.0437	0.1243
Echinococcus multilocularis	fmrfamide receptor	0.0063	0.0437	0.0828
Onchocerca volvulus		0.0063	0.0437	1
Echinococcus granulosus	serotonin receptor	0.0063	0.0437	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Schistosoma mansoni	neuropeptide receptor	0.0063	0.0437	0.0828
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0437	0.0828
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0437	0.0828
Brugia malayi	hypothetical protein	0.0063	0.0437	0.0437
Echinococcus multilocularis	serotonin receptor	0.0063	0.0437	0.0828
Brugia malayi	Serotonin receptor	0.0063	0.0437	0.0437
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0437	0.1243
Echinococcus granulosus	neuropeptide receptor	0.0063	0.0437	0.1243
Schistosoma mansoni	neuropeptide F-like receptor	0.0063	0.0437	0.0828
Loa Loa (eye worm)	G-protein coupled receptor	0.0063	0.0437	0.0477
Brugia malayi	ORL1-like opioid receptor	0.0063	0.0437	0.0437
Echinococcus granulosus	allatostatin A receptor	0.0063	0.0437	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0063	0.0437	0.0828
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0437	0.1243
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0063	0.0437	0.0828
Echinococcus multilocularis	g-protein coupled receptor	0.0063	0.0437	0.0828
Schistosoma mansoni	adenoreceptor	0.0063	0.0437	0.0828
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0063	0.0437	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Brugia malayi	hypothetical protein	0.0063	0.0437	0.0437
Echinococcus multilocularis	neuropeptides capa receptor	0.0063	0.0437	0.0828
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0063	0.0437	0.0828
Loa Loa (eye worm)	neuropeptide F receptor	0.0063	0.0437	0.0477
Brugia malayi	hypothetical protein	0.0063	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Brugia malayi	hypothetical protein	0.0063	0.0437	0.0437
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0063	0.0437	0.0437
Brugia malayi	Melatonin receptor type 1A	0.0063	0.0437	0.0437
Schistosoma mansoni	amine GPCR	0.0063	0.0437	0.0828
Echinococcus granulosus	7tm_1 domain containing protein	0.0063	0.0437	0.1243
Echinococcus multilocularis	neuropeptide s receptor	0.0063	0.0437	0.0828
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0437	0.0828
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus granulosus	dro:myosuppressin receptor	0.0063	0.0437	0.1243
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0203	0.528	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0063	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Schistosoma mansoni	biogenic amine receptor	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus granulosus	tm gpcr rhodopsin	0.0063	0.0437	0.1243
Schistosoma mansoni	biogenic amine receptor	0.0063	0.0437	0.0828
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0437	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Echinococcus multilocularis	neuropeptides capa receptor	0.0063	0.0437	0.0828
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0063	0.0437	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477
Brugia malayi	AKH receptor	0.0063	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0437	0.0477

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)		Efficacy against TRAFalpha1 reporter cells	ChEMBL.	16338239
EC50 (functional)		Efficacy against TRAFbeta1 reporter cells	ChEMBL.	16338239
EC50 (functional)	0	Efficacy against TRAFalpha1 reporter cells	ChEMBL.	16338239
EC50 (functional)	0	Efficacy against TRAFbeta1 reporter cells	ChEMBL.	16338239
IC50 (binding)	= 5.46	Inhibition of thyroid hormone receptor alpha (unknown origin)	ChEMBL.	17467994
IC50 (binding)	= 7.82	Inhibition of thyroid hormone receptor beta (unknown origin)	ChEMBL.	17467994
IC50 (binding)	= 870 nM	Inhibition of human TRbeta1 by radioligand binding assay	ChEMBL.	16338239
IC50 (binding)	= 870 nM	Inhibition of human TRbeta1 by radioligand binding assay	ChEMBL.	16338239
IC50 (binding)	= 3500 nM	Inhibition of human TRalpha1 by radioligand binding assay	ChEMBL.	16338239
IC50 (binding)	= 3500 nM	Inhibition of human TRalpha1 by radioligand binding assay	ChEMBL.	16338239
Log IC50 (binding)	= 5.46	Inhibition of thyroid hormone receptor alpha (unknown origin)	ChEMBL.	17467994
Log IC50 (binding)	= 7.82	Inhibition of thyroid hormone receptor beta (unknown origin)	ChEMBL.	17467994
Ratio (binding)	= 2.4	Selectivity ratio of human TRalpha1 over TRbeta1	ChEMBL.	16338239
Ratio (binding)	= 2.4	Selectivity ratio of human TRalpha1 over TRbeta1	ChEMBL.	16338239

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL250880

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 504060