Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.3136 | 0.3136 |
Schistosoma mansoni | hypothetical protein | 0.0382 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0019 | 0.0019 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0136 | 0.0136 |
Echinococcus multilocularis | geminin | 0.0382 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0425 | 0.2508 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0019 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1694 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0136 | 0.0136 |
Onchocerca volvulus | 0.0042 | 0 | 0.5 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0136 | 0.0804 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0136 | 0.0136 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0136 | 0.0136 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0042 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0019 | 0.5 |
Brugia malayi | hypothetical protein | 0.0099 | 0.1694 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0019 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.019 | 0.4364 | 0.4364 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0136 | 0.0136 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0019 | 0.0019 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0019 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0425 | 0.2508 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0425 | 0.2508 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0019 | 0.0019 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0149 | 0.3136 | 0.3136 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0019 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.019 | 0.4364 | 0.4364 |
Schistosoma mansoni | eyes absent homolog | 0.0099 | 0.1694 | 0.1694 |
Schistosoma mansoni | thyroid hormone receptor | 0.019 | 0.4364 | 0.4364 |
Schistosoma mansoni | hypothetical protein | 0.0382 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0425 | 0.2508 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1694 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0042 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0149 | 0.3136 | 0.3136 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0136 | 0.0136 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0136 | 0.0804 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0136 | 0.0136 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | < 1 nmol/min/mg | Prodrug activation in Wistar rat liver microsome assessed as formation of adefovir at 250 uM after 5 mins | ChEMBL. | 18173234 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.