Detailed information for compound 504195

Basic information

Technical information
  • TDR Targets ID: 504195
  • Name: 9-[2-[[3-(2,4-difluorophenyl)-1-oxo-2,6-dioxa -1$l^{5}-phosphacyclohex-1-yl]methoxy]ethyl]p urin-6-amine
  • MW: 425.326 | Formula: C17H18F2N5O4P
  • H donors: 1 H acceptors: 4 LogP: 0.7 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)F)C1CCOP(=O)(O1)COCCn1cnc2c1ncnc2N
  • InChi: 1S/C17H18F2N5O4P/c18-11-1-2-12(13(19)7-11)14-3-5-27-29(25,28-14)10-26-6-4-24-9-23-15-16(20)21-8-22-17(15)24/h1-2,7-9,14H,3-6,10H2,(H2,20,21,22)
  • InChiKey: VOCYHUBFCKNORO-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 9-[2-[[3-(2,4-difluorophenyl)-1-oxo-2,6-dioxa-1$l^{5}-phosphacyclohex-1-yl]methoxy]ethyl]-6-purinamine
  • [9-[2-[[3-(2,4-difluorophenyl)-1-keto-2,6-dioxa-1$l^{5}-phosphacyclohex-1-yl]methoxy]ethyl]purin-6-yl]amine
  • 9-[2-[[4-(2,4-difluorophenyl)-2-oxo-1,3-dioxa-2$l^{5}-phosphacyclohex-2-yl]methoxy]ethyl]purin-6-amine
  • 9-[2-[[4-(2,4-difluorophenyl)-2-oxo-1,3-dioxa-2$l^{5}-phosphacyclohex-2-yl]methoxy]ethyl]-6-purinamine
  • [9-[2-[[4-(2,4-difluorophenyl)-2-keto-1,3-dioxa-2$l^{5}-phosphacyclohex-2-yl]methoxy]ethyl]purin-6-yl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus sodium channel protein 0.0126 0.0409 0.078
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0045 0.0131
Schistosoma mansoni steroid dehydrogenase 0.002 0.0018 0.0027
Echinococcus multilocularis acetylcholinesterase 0.0347 0.1223 0.2347
Echinococcus multilocularis neuropeptide FF receptor 2 0.0056 0.015 0.0282
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0018 0.0027
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0121 0.0343
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0042 0.0038
Plasmodium falciparum ferrodoxin reductase-like protein 0.0199 0.0678 0.1971
Echinococcus granulosus carbonyl reductase 1 0.002 0.0018 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0041
Brugia malayi Death domain containing protein 0.003 0.0057 0.0155
Brugia malayi jmjC domain containing protein 0.006 0.0167 0.0477
Echinococcus multilocularis neuropeptide s receptor 0.0056 0.015 0.0282
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.015 0.0282
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0018 0.0014
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.002 0.0018 0.0014
Brugia malayi Uncoordinated protein 44 0.003 0.0057 0.0155
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.002 0.0018 0.0027
Echinococcus multilocularis neuroligin 0.0059 0.0161 0.0302
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0027 0.0045
Brugia malayi 6-phosphofructokinase 0.0112 0.0356 0.1029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.015 0.0282
Echinococcus multilocularis oxidoreductase 0.002 0.0018 0.0027
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0191 0.0187
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0121 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0049 0.0167
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0174 0.0447
Trichomonas vaginalis mercuric reductase, putative 0.075 0.2707 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0027 0.0045 0.008
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.015 0.0282
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0036 0.0078 0.0142
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0056 0.0151
Schistosoma mansoni hypothetical protein 0.0178 0.0602 0.1151
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0045 0.008
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0199 0.0678 0.1887
Schistosoma mansoni ap endonuclease 0.0038 0.0086 0.0159
Echinococcus granulosus intermediate filament protein 0.0057 0.0155 0.0291
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.015 0.0282
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Brugia malayi Carboxylesterase family protein 0.0059 0.0161 0.0458
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.075 0.2707 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0347 0.1223 0.3564
Brugia malayi hypothetical protein 0.0056 0.015 0.0427
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0174 0.017
Schistosoma mansoni steroid dehydrogenase 0.002 0.0018 0.0027
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0186 0.063 0.1206
Onchocerca volvulus 0.0056 0.015 0.0754
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0084 0.0155
Echinococcus multilocularis allatostatin A receptor 0.0056 0.015 0.0282
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0086 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.004 0.0133
Loa Loa (eye worm) hypothetical protein 0.0393 0.1391 0.4056
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0056 0.015 0.0282
Brugia malayi larval opioid receptor 0.0056 0.015 0.0427
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0027 0.0087
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.075 0.2707 0.5206
Echinococcus granulosus hypothetical protein 0.002 0.0018 0.0027
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.003 0.0057 0.0102
Brugia malayi Melatonin receptor type 1A 0.0056 0.015 0.0427
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0174 0.0328
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.002 0.0018 0.0052
Echinococcus granulosus neuropeptide receptor 0.0056 0.015 0.0282
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Schistosoma mansoni amine GPCR 0.0056 0.015 0.0282
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.015 0.0282
Schistosoma mansoni biogenic amine (5HT) receptor 0.0186 0.0628 0.1203
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.002 0.0018 0.0027
Loa Loa (eye worm) hypothetical protein 0.0201 0.0684 0.1988
Brugia malayi Cyclic-nucleotide gated cation channel 0.0019 0.0014 0.003
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.075 0.2707 0.7907
Echinococcus multilocularis g-protein coupled receptor 0.0056 0.015 0.0282
Echinococcus granulosus neuropeptide receptor A26 0.0056 0.015 0.0282
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0199 0.0678 0.2493
Echinococcus granulosus g protein coupled receptor 0.0056 0.015 0.0282
Onchocerca volvulus 0.0056 0.015 0.0754
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0458
Onchocerca volvulus Neuropeptide F receptor homolog 0.0056 0.015 0.0754
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.005 0.0171
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0122
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.0078 0.0074
Brugia malayi Thioredoxin reductase 0.0945 0.3424 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0019 0.0014 0.002
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0275 0.0959 0.2793
Trichomonas vaginalis glutathione reductase, putative 0.075 0.2707 1
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0421 0.0804
Trichomonas vaginalis apoptosis inducing factor, putative 0.0199 0.0678 0.2493
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0199 0.0678 0.0674
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.061 0.2243
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0199 0.0678 0.1298
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.075 0.2707 0.7905
Echinococcus multilocularis g protein coupled receptor 0.0056 0.015 0.0282
Trypanosoma brucei NADH dehydrogenase 0.0199 0.0678 0.0674
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.075 0.2707 0.2705
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0045 0.008
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.015 0.0282
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0199 0.0678 0.1298
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Brugia malayi AKH receptor 0.0056 0.015 0.0427
Trypanosoma cruzi NADH dehydrogenase, putative 0.0199 0.0678 0.0674
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0121 0.0117
Echinococcus granulosus hypothetical protein 0.0792 0.286 0.5501
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0042 0.0038
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Leishmania major C-8 sterol isomerase-like protein 0.0393 0.1391 0.1388
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0208 0.0597
Toxoplasma gondii NADPH-glutathione reductase 0.075 0.2707 0.7907
Loa Loa (eye worm) TYRA-2 protein 0.0056 0.015 0.0427
Echinococcus multilocularis RUN 0.0122 0.0393 0.0749
Loa Loa (eye worm) hypothetical protein 0.0347 0.1223 0.3564
Onchocerca volvulus 0.0056 0.015 0.0754
Brugia malayi sulfakinin receptor protein 0.0056 0.015 0.0427
Loa Loa (eye worm) phosphofructokinase 0.0112 0.0356 0.1028
Echinococcus granulosus neuroligin 0.0059 0.0161 0.0302
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0199 0.0678 0.0674
Leishmania major acetoin dehydrogenase e3 component-like protein 0.2003 0.7322 0.7321
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0018 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0121 0.0434
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0018 0.0014
Leishmania major dihydrolipoamide dehydrogenase, putative 0.075 0.2707 0.2705
Leishmania major hypothetical protein, conserved 0.0199 0.0678 0.0674
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.015 0.0282
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0199 0.0678 0.0674
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0078 0.0233 0.3258
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0191 0.2625
Loa Loa (eye worm) oxidoreductase 0.002 0.0018 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0076 0.0267
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0044 0.0128
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0233 0.0847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0076 0.0267
Trypanosoma cruzi short chain dehydrogenase, putative 0.002 0.0018 0.0014
Echinococcus multilocularis carbonyl reductase 1 0.002 0.0018 0.0027
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.075 0.2707 0.2705
Brugia malayi neuropeptide F receptor 0.0056 0.015 0.0427
Schistosoma mansoni hypothetical protein 0.0038 0.0084 0.0155
Schistosoma mansoni lipoxygenase 0.0469 0.1671 0.3211
Schistosoma mansoni hypothetical protein 0.0056 0.015 0.0282
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0199 0.0678 0.0674
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0018 0.0014
Leishmania major protein kinase, putative 0.0032 0.0064 0.006
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0078 0.0233 0.068
Echinococcus multilocularis aryl hydrocarbon receptor 0.0026 0.0042 0.0072
Loa Loa (eye worm) TAR-binding protein 0.0129 0.0421 0.1221
Brugia malayi oxidoreductase 0.002 0.0018 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.061 0.2243
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0018 0.0014
Onchocerca volvulus 0.0031 0.006 0.0243
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0105 0.0333 0.0329
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0056 0.015 0.0427
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.0356 0.0677
Brugia malayi hypoxia-induced factor 1 0.0313 0.1098 0.3198
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0085 0.0081
Brugia malayi Tachykinin-like peptides receptor 99D 0.0056 0.015 0.0427
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0121 0.0343
Leishmania major dehydrogenase-like protein 0.002 0.0018 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.005 0.0171
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0059 0.0161 0.058
Onchocerca volvulus 0.0056 0.015 0.0754
Trypanosoma cruzi oxidoreductase-like protein, putative 0.002 0.0018 0.0014
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.002 0.0018 0.0052
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.0356 0.0677
Onchocerca volvulus 0.0059 0.0161 0.0814
Schistosoma mansoni hypothetical protein 0.003 0.0057 0.0102
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.097 0.3515 1
Schistosoma mansoni short-chain dehydrogenase/reductase 0.002 0.0018 0.0027
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0356 0.5116
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0026 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0041
Echinococcus multilocularis chromobox protein 1 0.0072 0.0208 0.0393
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0041
Echinococcus granulosus death domain containing protein 0.003 0.0057 0.0102
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0233 0.0847
Loa Loa (eye worm) hepatopoietin HPO2 0.0036 0.0078 0.0216
Brugia malayi hypothetical protein 0.0122 0.0393 0.1138
Leishmania major short chain dehydrogenase, putative 0.002 0.0018 0.0014
Schistosoma mansoni retinal dehydrogenase 0.002 0.0018 0.0027
Echinococcus multilocularis g protein coupled receptor 0.0056 0.015 0.0282
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0333 0.1216
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0027 0.0045
Echinococcus granulosus G protein coupled receptor 139 0.0056 0.015 0.0282
Loa Loa (eye worm) hypothetical protein 0.0497 0.1776 0.5182
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0356 0.1301
Echinococcus granulosus WW domain containing oxidoreductase 0.002 0.0018 0.0027
Leishmania major hypothetical protein, conserved 0.0036 0.0078 0.0074
Schistosoma mansoni amine GPCR 0.0586 0.2102 0.4039
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0333 0.1216
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0056 0.015 0.0282
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0174 0.0509
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.075 0.2707 0.7907
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.015 0.0282
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0056 0.015 0.0282
Brugia malayi G-protein coupled receptor 0.0056 0.015 0.0427
Onchocerca volvulus 0.0199 0.0678 0.3764
Mycobacterium ulcerans NADH dehydrogenase 0.0199 0.0678 0.2454
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0551 0.1974 0.5761
Schistosoma mansoni short chain dehydrogenase 0.002 0.0018 0.0027
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0026 0.0042 0.0139
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0959 0.3533
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.003 0.0057 0.0155
Schistosoma mansoni biogenic amine receptor 0.0056 0.015 0.0282
Brugia malayi dehydrogenases, short chain protein 9 0.002 0.0018 0.0041
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0056 0.0163
Brugia malayi intermediate filament protein 0.0057 0.0155 0.0442
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0192
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.0045 0.008
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0056 0.0151
Plasmodium falciparum glutathione reductase 0.0945 0.3424 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0174 0.0328
Brugia malayi Carboxylesterase family protein 0.0347 0.1223 0.3564
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.002 0.0018 0.0052
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Schistosoma mansoni short chain dehydrogenase 0.002 0.0018 0.0027
Loa Loa (eye worm) thioredoxin reductase 0.0945 0.3424 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.005 0.0129 0.0365
Brugia malayi Dopamine receptor protein 2 0.0056 0.015 0.0427
Brugia malayi G-protein coupled receptor 0.0056 0.015 0.0427
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0018 0.0014
Onchocerca volvulus 0.0027 0.0045 0.0157
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.015 0.0282
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Loa Loa (eye worm) hypothetical protein 0.0122 0.0393 0.1138
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.075 0.2707 0.2705
Brugia malayi neuropeptide F receptor 0.0056 0.015 0.0427
Leishmania major hypothetical protein, conserved 0.0027 0.0044 0.004
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Echinococcus granulosus lamin 0.0057 0.0155 0.0291
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0199 0.0678 0.2454
Schistosoma mansoni neuroligin 3 (S09 family) 0.0059 0.0161 0.0302
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.015 0.0282
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0199 0.0678 0.1298
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0045 0.0041
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0027 0.0045 0.008
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0199 0.0678 0.1298
Plasmodium vivax glutathione reductase, putative 0.0945 0.3424 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0086 0.0254
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.015 0.0282
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0393 0.1391 0.1388
Echinococcus multilocularis fmrfamide receptor 0.0056 0.015 0.0282
Echinococcus granulosus serotonin receptor 0.0056 0.015 0.0282
Echinococcus granulosus netrin receptor unc 5 0.003 0.0057 0.0102
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0199 0.0678 0.2493
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.015 0.0282
Echinococcus granulosus tm gpcr rhodopsin 0.0939 0.3402 0.6545
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.097 0.3515 1
Plasmodium falciparum transporter, putative 0.0027 0.0045 0.0121
Echinococcus granulosus Ankyrin 0.0031 0.0058 0.0104
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0312 0.09
Brugia malayi PAS domain containing protein 0.0101 0.0317 0.0916
Trypanosoma brucei protein kinase, putative 0.0105 0.0333 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0076 0.0267
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0068
Brugia malayi Pre-SET motif family protein 0.0436 0.1549 0.4517
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0078 0.0233 0.08
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0121 0.0117
Schistosoma mansoni disulfide oxidoreductase 0.0199 0.0678 0.1298
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0199 0.0678 0.198
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0945 0.3424 0.9739
Echinococcus multilocularis retinol dehydrogenase 11 0.002 0.0018 0.0027
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0166 0.0313
Echinococcus multilocularis sex peptide receptor 0.0056 0.015 0.0282
Loa Loa (eye worm) serotonin transporter b 0.0161 0.0538 0.1562
Trypanosoma cruzi trypanothione reductase, putative 0.075 0.2707 0.2705
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0018 0.0014
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0052
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0191 0.0548
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0056 0.015 0.0754
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.004 0.0134
Onchocerca volvulus 0.0059 0.0161 0.0814
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0421 0.0804
Echinococcus granulosus Polycystic kidney disease protein 0.0122 0.0393 0.0749
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0105 0.0333 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0121 0.0434
Schistosoma mansoni carbonyl reductase 0.002 0.0018 0.0027
Schistosoma mansoni steroid dehydrogenase 0.002 0.0018 0.0027
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0019 0.0014 0.002
Brugia malayi hypothetical protein 0.0489 0.1744 0.5089
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.002 0.0018 0.0027
Leishmania major hypothetical protein, conserved 0.0199 0.0678 0.0674
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Brugia malayi hypothetical protein 0.0027 0.0044 0.0116
Loa Loa (eye worm) hypothetical protein 0.0256 0.0887 0.2582
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.002 0.0018 0.0014
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0008 0.0009
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0469 0.1671 0.3211
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.015 0.0282
Schistosoma mansoni loxhd1 0.0122 0.0393 0.0749
Plasmodium falciparum LCCL domain-containing protein 0.0122 0.0393 0.1137
Schistosoma mansoni neuropeptide receptor 0.0056 0.015 0.0282
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0056 0.015 0.0427
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0018 0.0052
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0018 0.0014
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0056 0.0163
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.002 0.0018 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0027 0.0045
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0027 0.0069
Echinococcus granulosus carbonyl reductase 1 0.002 0.0018 0.0027
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.002 0.0018 0.0027
Echinococcus multilocularis neuropeptide receptor 0.0056 0.015 0.0282
Schistosoma mansoni amine GPCR 0.0056 0.015 0.0282
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0056 0.0053
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0041
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Schistosoma mansoni lipoxygenase 0.025 0.0864 0.1657
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0056 0.015 0.0427
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0186 0.063 0.2276
Onchocerca volvulus 0.0207 0.0706 0.3922
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0057 0.0157
Echinococcus multilocularis retinol dehydrogenase 11 0.002 0.0018 0.0027
Echinococcus multilocularis jun protein 0.0263 0.0914 0.1752
Loa Loa (eye worm) hypothetical protein 0.0026 0.0042 0.011
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.002 0.0018 0.0041
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0042 0.0139
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0052
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0086 0.0082
Schistosoma mansoni sodium/chloride dependent transporter 0.0028 0.0049 0.0087
Schistosoma mansoni sodium/chloride dependent transporter 0.0161 0.0538 0.1029
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.061 0.2243
Echinococcus multilocularis Polycystic kidney disease protein 0.0122 0.0393 0.0749
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0085 0.03
Trypanosoma cruzi NADH dehydrogenase, putative 0.0199 0.0678 0.0674
Treponema pallidum thioredoxin reductase (trxB) 0.0199 0.0678 0.2347
Echinococcus multilocularis lipoxygenase domain containing protein 0.0122 0.0393 0.0749
Brugia malayi RE15519p 0.0056 0.015 0.0427
Onchocerca volvulus 0.0056 0.015 0.0754
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.004 0.0134
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.273 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0084 0.0155
Echinococcus multilocularis carboxylesterase 5A 0.0347 0.1223 0.2347
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.015 0.0282
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.0421 0.1221
Brugia malayi hypothetical protein 0.0056 0.015 0.0427
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0085 0.0081
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0186 0.063 0.175
Onchocerca volvulus 0.0027 0.0045 0.0157
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0092 0.0424
Brugia malayi jmjC domain containing protein 0.006 0.0167 0.0477
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0161 0.0538 0.1562
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0199 0.0678 0.198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.004 0.0134
Brugia malayi Carboxylesterase family protein 0.0059 0.0161 0.0458
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.273 1 1
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0018 0.0014
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0199 0.0678 0.1971
Onchocerca volvulus 0.0056 0.015 0.0754
Echinococcus granulosus carboxylesterase 5A 0.0347 0.1223 0.2347
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0333 0.1216
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0186 0.063 0.1206
Echinococcus granulosus chromobox protein 1 0.0072 0.0208 0.0393
Onchocerca volvulus 0.0059 0.0161 0.0814
Mycobacterium tuberculosis Carboxylesterase LipT 0.0059 0.0161 0.0408
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.0356 0.1028
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.0161 0.0302
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.003
Schistosoma mansoni single-minded 0.0101 0.0317 0.0603
Leishmania major hypothetical protein, conserved 0.002 0.0018 0.0014
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0056 0.015 0.0427
Mycobacterium ulcerans glutamate synthase subunit beta 0.0199 0.0678 0.2454
Loa Loa (eye worm) oxidoreductase 0.002 0.0018 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0175 0.0329
Schistosoma mansoni histamine h1 receptor 0.0056 0.015 0.0282
Echinococcus multilocularis transfer RNA-Lys 0.0075 0.022 0.0417
Echinococcus multilocularis G protein coupled receptor 139 0.0056 0.015 0.0282
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0122
Loa Loa (eye worm) hypothetical protein 0.0122 0.0393 0.1138
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0105 0.0333 0.0329
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0076 0.0222
Schistosoma mansoni rab6-interacting 0.0122 0.0393 0.0749
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0121 0.0117
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.015 0.0282
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0004 0.0000096692
Brugia malayi Heterochromatin protein 1 0.0072 0.0208 0.0597
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0056 0.015 0.0427
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.002 0.0018 0.0027
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0199 0.0678 0.0674
Schistosoma mansoni biogenic amine receptor 0.0056 0.015 0.0282
Brugia malayi putative neuropeptide receptor NPR1 0.0056 0.015 0.0427
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0046 0.0082
Schistosoma mansoni hypothetical protein 0.01 0.0312 0.0593
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0056 0.015 0.0282
Brugia malayi hypothetical protein 0.0207 0.0706 0.2052
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.015 0.0282
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0199 0.0678 0.1298
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0056 0.015 0.0427
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0263 0.0914 0.1752
Leishmania major trypanothione reductase 0.0945 0.3424 0.3421
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Schistosoma mansoni short chain dehydrogenase 0.002 0.0018 0.0027
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0191 0.0187
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.005 0.0129 0.0241
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0421 0.0804
Schistosoma mansoni neuropeptide f receptor 76f 0.0056 0.015 0.0282
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.015 0.0282
Brugia malayi Dehydrogenases, short chain protein 2 0.002 0.0018 0.0041
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0057 0.0157
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0356 0.1301
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.015 0.0282
Brugia malayi Protein kinase domain containing protein 0.0031 0.006 0.0165
Brugia malayi hypothetical protein 0.0056 0.015 0.0427
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0027 0.0045 0.008
Echinococcus multilocularis fmrfamide receptor 0.0056 0.015 0.0282
Brugia malayi hypothetical protein 0.0056 0.015 0.0427
Loa Loa (eye worm) hypothetical protein 0.0186 0.0628 0.1826
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.0356 0.1131
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0018 0.0052
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.0356 0.0677
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.005 0.0129 0.0365
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0959 0.3533
Mycobacterium tuberculosis Probable oxidoreductase 0.097 0.3515 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.002 0.0018 0.0014
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0004 0.0012
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.015 0.0282
Loa Loa (eye worm) hypothetical protein 0.004 0.0092 0.0259
Echinococcus granulosus mitogen activated protein kinase 0.0105 0.0333 0.0633
Schistosoma mansoni BC026374 protein (S09 family) 0.0059 0.0161 0.0302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0063 0.0219
Mycobacterium leprae Possible regulatory protein 0.0026 0.0042 0.0067
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0019 0.0014 0.002
Onchocerca volvulus 0.0056 0.015 0.0754
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.015 0.0282
Echinococcus multilocularis conserved hypothetical protein 0.002 0.0018 0.0027
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0646 0.2375
Schistosoma mansoni amine GPCR 0.0056 0.015 0.0282
Echinococcus multilocularis neuropeptide receptor 0.0056 0.015 0.0282
Schistosoma mansoni rab6-interacting 0.0122 0.0393 0.0749
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.015 0.0282
Brugia malayi ORL1-like opioid receptor 0.0056 0.015 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0085 0.03
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0026 0.0042 0.011
Echinococcus granulosus peptide allatostatin:somatostatin 0.0056 0.015 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0049 0.0167
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.015 0.0427
Trichomonas vaginalis steroid dehydrogenase, putative 0.002 0.0018 0.0052
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0199 0.0678 0.2454
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0045 0.0133
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0045 0.0133
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0019 0.0014 0.0038
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0042 0.0139
Loa Loa (eye worm) hypothetical protein 0.0186 0.0628 0.1826
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0044 0.004
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0175 0.0329
Echinococcus multilocularis microtubule associated protein 2 0.1426 0.5197 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0192
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0458
Trypanosoma cruzi hypothetical protein, conserved 0.0199 0.0678 0.0674
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0046 0.0082
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.015 0.0282
Echinococcus multilocularis thioredoxin glutathione reductase 0.0945 0.3424 0.6586
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0126 0.0409 0.078
Leishmania major hypothetical protein, conserved 0.002 0.0018 0.0014
Loa Loa (eye worm) dehydrogenase 0.002 0.0018 0.0041
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0056 0.0573
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0041
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0004 0.0000096692
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.004 0.0133
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0086 0.0305
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.002 0.0018 0.0014
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.2003 0.7322 0.7321
Giardia lamblia Thioredoxin reductase 0.0199 0.0678 0.2454
Brugia malayi hypothetical protein 0.002 0.0018 0.0041
Echinococcus granulosus carbonyl reductase 1 0.002 0.0018 0.0027
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.015 0.0427
Loa Loa (eye worm) carboxylesterase 0.0347 0.1223 0.3564
Loa Loa (eye worm) oxidoreductase 0.002 0.0018 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0092 0.0327
Echinococcus multilocularis lamin 0.0057 0.0155 0.0291
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0041
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.0045 0.008
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.002 0.0018 0.0014
Schistosoma mansoni steroid dehydrogenase 0.002 0.0018 0.0027
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0191 0.0361
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.0421 0.1221
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.0356 0.0352
Leishmania major hypothetical protein, conserved 0.0016 0.0004 0.0000096692
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0458
Echinococcus granulosus acetylcholinesterase 0.0347 0.1223 0.2347
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.061 0.2243
Schistosoma mansoni carbonyl reductase 0.002 0.0018 0.0027
Schistosoma mansoni microtubule-associated protein tau 0.1426 0.5197 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0042 0.0038
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0044 0.004
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0121 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0095 0.0338
Schistosoma mansoni short chain dehydrogenase 0.002 0.0018 0.0027
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.015 0.0282
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0199 0.0678 0.1887
Loa Loa (eye worm) solute carrier family 6 member 4 0.0161 0.0538 0.1562
Brugia malayi Augmenter of liver regeneration 0.0036 0.0078 0.0216
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2295 0.8396 0.8395
Brugia malayi bHLH-PAS transcription factor 0.0075 0.022 0.0633
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0199 0.0678 0.0674
Leishmania major hypothetical protein, conserved 0.002 0.0018 0.0014
Schistosoma mansoni short chain dehydrogenase 0.002 0.0018 0.0027
Echinococcus multilocularis hyperpolarization activated cyclic 0.0019 0.0014 0.002
Plasmodium vivax hypothetical protein, conserved 0.002 0.0018 0.005
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0192
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Schistosoma mansoni hypothetical protein 0.0056 0.015 0.0282
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Schistosoma mansoni intermediate filament proteins 0.0057 0.0155 0.0291
Schistosoma mansoni aryl hydrocarbon receptor 0.0101 0.0317 0.0603
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0027 0.0045 0.0122
Echinococcus granulosus sex peptide receptor 0.0056 0.015 0.0282
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0175 0.0329
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0199 0.0678 0.1887
Toxoplasma gondii exonuclease III APE 0.0038 0.0086 0.0252
Onchocerca volvulus Glucosylceramidase homolog 0.0181 0.061 0.3378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0085 0.03
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0156 0.0519 0.0993
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0199 0.0678 0.2454
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0174 0.0581
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0458
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Onchocerca volvulus 0.0059 0.0161 0.0814
Echinococcus granulosus neuropeptide receptor 0.0056 0.015 0.0282
Loa Loa (eye worm) carboxylesterase 0.0059 0.0161 0.0458
Brugia malayi Inositol-1 0.0078 0.0233 0.067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0122
Echinococcus multilocularis steroid dehydrogenase 0.002 0.0018 0.0027
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0356 0.5116
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0167 0.0314
Brugia malayi hypothetical protein 0.0056 0.015 0.0427
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0199 0.0678 0.0674
Echinococcus granulosus g protein coupled receptor 0.0056 0.015 0.0282
Echinococcus granulosus serotonin transporter 0.0161 0.0538 0.1029
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0045 0.0041
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.015 0.0282
Mycobacterium tuberculosis Probable reductase 0.0418 0.1486 0.4197
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0056 0.015 0.0282
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0018 0.0052
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0042 0.0139
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0199 0.0678 0.1887
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Brugia malayi hypothetical protein 0.0125 0.0405 0.1172
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Echinococcus granulosus nuclear factor of activated T cells 5 0.0156 0.0519 0.0993
Schistosoma mansoni amine GPCR 0.0056 0.015 0.0282
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0041
Plasmodium vivax SET domain protein, putative 0.0062 0.0175 0.0509
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0233 0.0229
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0086 0.0241
Leishmania major short chain dehydrogenase/reductase, putative 0.002 0.0018 0.0014
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0199 0.0678 0.198
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0052
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.097 0.3515 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.075 0.2707 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.075 0.2707 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0056 0.015 0.0282
Onchocerca volvulus 0.0057 0.0155 0.0783
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0199 0.0678 0.2454
Echinococcus granulosus para nitrobenzyl esterase 0.0059 0.0161 0.0302
Onchocerca volvulus 0.0056 0.015 0.0754
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0121 0.1565
Echinococcus multilocularis conserved hypothetical protein 0.0736 0.2655 0.5105
Echinococcus multilocularis serotonin receptor 0.0186 0.0628 0.1203
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0116
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.015 0.0282
Echinococcus multilocularis dro:myosuppressin receptor 0.0056 0.015 0.0282
Echinococcus granulosus somatostatin receptor 0.0056 0.015 0.0282
Trypanosoma brucei oxidoreductase-like protein 0.002 0.0018 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.061 0.2243
Schistosoma mansoni opsin-like receptor 0.0056 0.015 0.0282
Echinococcus multilocularis serotonin receptor 0.0186 0.0628 0.1203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.015 0.0282
Schistosoma mansoni voltage-gated potassium channel 0.0054 0.0142 0.0266
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Echinococcus multilocularis somatostatin receptor 0.0056 0.015 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.005 0.0171
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0199 0.0678 0.198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.004 0.0134
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.015 0.0282
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0036 0.0078 0.0142
Loa Loa (eye worm) hypothetical protein 0.0057 0.0155 0.0442
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.002 0.0018 0.0014
Schistosoma mansoni jumonji domain containing protein 0.006 0.0167 0.0314
Echinococcus granulosus single minded 2 0.0078 0.0234 0.0442
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0105 0.0333 0.0971
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0105 0.0333 0.0329
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0199 0.0678 0.1979
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0052
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0019 0.0014 0.002
Onchocerca volvulus 0.0074 0.0218 0.114
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.002 0.0018 0.0041
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.061 0.2243
Loa Loa (eye worm) hypothetical protein 0.0031 0.006 0.0165
Schistosoma mansoni short chain dehydrogenase 0.002 0.0018 0.0027
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0458
Schistosoma mansoni adenoreceptor 0.0056 0.015 0.0282
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.0045 0.008
Schistosoma mansoni short chain dehydrogenase 0.002 0.0018 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0076 0.0267
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0059 0.0161 0.0302
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.2295 0.8396 0.8395
Schistosoma mansoni biogenic amine receptor 0.0056 0.015 0.0282
Schistosoma mansoni short chain dehydrogenase 0.002 0.0018 0.0027
Loa Loa (eye worm) hypothetical protein 0.0489 0.1744 0.5089
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0199 0.0678 0.2493
Echinococcus multilocularis mitogen activated protein kinase 0.0105 0.0333 0.0633
Loa Loa (eye worm) programmed cell death 8 0.0199 0.0678 0.1971
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0122
Schistosoma mansoni glutamate synthase 0.0199 0.0678 0.1298
Trypanosoma cruzi short-chain dehydrogenase, putative 0.002 0.0018 0.0014
Echinococcus granulosus BC026374 protein S09 family 0.0059 0.0161 0.0302
Brugia malayi Dopamine receptor protein 1 0.0056 0.015 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0085 0.03
Mycobacterium ulcerans ferredoxin reductase 0.0199 0.0678 0.2454
Mycobacterium ulcerans monoxygenase 0.0199 0.0678 0.2454
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0018 0.0014
Echinococcus multilocularis g protein coupled receptor 0.0056 0.015 0.0282
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0014 0.002
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.002 0.0018 0.0041
Loa Loa (eye worm) inositol-1 0.0078 0.0233 0.067
Echinococcus multilocularis orexin receptor type 2 0.0056 0.015 0.0282
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0208 0.0755
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.007 0.0203 0.0529
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.0078 0.0074
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0199 0.0678 1
Mycobacterium ulcerans hypothetical protein 0.0199 0.0678 0.2454
Schistosoma mansoni hypothetical protein 0.0056 0.015 0.0282
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0121 0.1565
Echinococcus multilocularis geminin 0.0178 0.0602 0.1151
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0418 0.1486 0.4197
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0175 0.0511
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0019 0.0014 0.003
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.0356 0.1028
Plasmodium falciparum glutathione reductase 0.075 0.2707 0.7905
Leishmania major pteridine reductase 1 0.002 0.0018 0.0014
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0045 0.008
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.015 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0085 0.03
Brugia malayi MAP kinase sur-1 0.0105 0.0333 0.0961
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0174 0.0328
Schistosoma mansoni hypothetical protein 0.0199 0.0678 0.1298
Loa Loa (eye worm) hypothetical protein 0.0161 0.0538 0.1562
Trypanosoma brucei hypothetical protein, conserved 0.0199 0.0678 0.0674
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.0045 0.008
Echinococcus granulosus 7tm_1 domain containing protein 0.0056 0.015 0.0282
Trypanosoma cruzi hypothetical protein, conserved 0.0199 0.0678 0.0674
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.075 0.2707 0.7907
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.0356 0.0677
Onchocerca volvulus 0.0056 0.015 0.0754
Loa Loa (eye worm) hypothetical protein 0.0062 0.0175 0.05
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0551 0.1974 0.5761
Schistosoma mansoni short chain dehydrogenase 0.002 0.0018 0.0027
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0192
Schistosoma mansoni opsin-like receptor 0.0056 0.015 0.0282
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.0045 0.008
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.0078 0.0074
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0347 0.1223 0.2347
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.0078 0.0227
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Echinococcus granulosus mitogen activated protein kinase 3 0.0105 0.0333 0.0633
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0199 0.0678 0.1887
Giardia lamblia Kinase, CMGC MAPK 0.0105 0.0333 0.117
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.015 0.0282
Schistosoma mansoni neuropeptide receptor 0.0056 0.015 0.0282
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0199 0.0678 0.1887
Echinococcus granulosus neuropeptide s receptor 0.0056 0.015 0.0282
Onchocerca volvulus 0.0057 0.0155 0.0783
Schistosoma mansoni sulfide quinone reductase 0.0199 0.0678 0.1298
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0199 0.0678 0.2454
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.002 0.0018 0.0014
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0056 0.0192
Onchocerca volvulus 0.0496 0.1771 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0105 0.0333 0.0961
Echinococcus granulosus g protein coupled receptor 0.0056 0.015 0.0282
Schistosoma mansoni inositol monophosphatase 0.0078 0.0233 0.0441
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0028 0.0024
Schistosoma mansoni glutamate synthase 0.0199 0.0678 0.1298
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0418 0.1486 0.4197
Plasmodium falciparum thioredoxin reductase 0.075 0.2707 0.7905
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0056 0.015 0.0282
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0418 0.1486 0.4197
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0186 0.063 0.2276
Brugia malayi hypothetical protein 0.0017 0.0009 0.0014
Brugia malayi putative neuropeptide receptor 0.0056 0.015 0.0427
Schistosoma mansoni chromobox protein 0.0072 0.0208 0.0393
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0199 0.0678 0.1971
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0155 0.0442
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0175 0.0329
Schistosoma mansoni steroid dehydrogenase 0.002 0.0018 0.0027
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0087 0.0161
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.075 0.2707 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0199 0.0678 0.0674
Echinococcus granulosus hyperpolarization activated cyclic 0.0019 0.0014 0.002
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0056 0.015 0.0282
Mycobacterium ulcerans flavoprotein disulfide reductase 0.075 0.2707 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.015 0.0282
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0086 0.0195
Leishmania major short chain dehydrogenase-like protein 0.002 0.0018 0.0014
Schistosoma mansoni myosin xvIII 0.0056 0.015 0.0282
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0041
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0469 0.1671 0.3211
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0019 0.0014 0.002
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0078 0.0233 0.08
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.0045 0.0122
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0126 0.0409 0.0405
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0122
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0174 0.0328
Brugia malayi hypothetical protein 0.0056 0.015 0.0427
Echinococcus multilocularis hyperpolarization activated cyclic 0.0019 0.0014 0.002
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0056 0.015 0.0282
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0019 0.0014 0.002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0174 0.0581
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0049 0.0168
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.0356 0.0352
Brugia malayi GnHR receptor homolog 0.0056 0.015 0.0427
Trypanosoma cruzi short-chain dehydrogenase, putative 0.002 0.0018 0.0014
Onchocerca volvulus 0.0056 0.015 0.0754
Brugia malayi dehydrogenases, short chain protein 2 0.002 0.0018 0.0041
Brugia malayi G protein-coupled receptor F59B2.13 0.0056 0.015 0.0427
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.015 0.0282
Echinococcus multilocularis mitogen activated protein kinase 3 0.0105 0.0333 0.0633
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0056 0.015 0.0282
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0161 0.0538 0.1029
Echinococcus granulosus jun protein 0.0263 0.0914 0.1752
Echinococcus multilocularis netrin receptor unc 5 0.003 0.0057 0.0102
Toxoplasma gondii thioredoxin reductase 0.0945 0.3424 1
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0333 0.0633
Schistosoma mansoni survival motor neuron protein 0.01 0.0312 0.0593
Brugia malayi hypothetical protein 0.0122 0.0393 0.1138
Echinococcus granulosus alpha 1A adrenergic receptor 0.0056 0.015 0.0282
Brugia malayi chromobox protein homolog 3 0.004 0.0092 0.0259
Schistosoma mansoni steroid dehydrogenase 0.002 0.0018 0.0027
Echinococcus multilocularis carbonyl reductase 1 0.002 0.0018 0.0027
Plasmodium vivax JmjC domain containing protein 0.0016 0.0004 0.001
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0078 0.0225
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0056 0.015 0.0427
Loa Loa (eye worm) hypothetical protein 0.0326 0.1144 0.3333
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.0139
Schistosoma mansoni short chain dehydrogenase 0.002 0.0018 0.0027
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.0356 0.0966
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0017 0.0039
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Brugia malayi hypothetical protein 0.0056 0.015 0.0427
Brugia malayi Dopamine receptor 0.0056 0.015 0.0427
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2003 0.7322 0.7321
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Mycobacterium tuberculosis Probable dehydrogenase 0.0418 0.1486 0.4197
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0436 0.1549 0.4517
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.015 0.0427
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.0078 0.0074
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0027 0.0045 0.008
Onchocerca volvulus 0.01 0.0312 0.1676
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0086 0.0241
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0045 0.008
Leishmania major 3-keto-dihydrosphingosine reductase 0.002 0.0018 0.0014
Brugia malayi hypothetical protein 0.0056 0.015 0.0427
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0105 0.0333 0.0329
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.002
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0057 0.0155
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0059 0.0161 0.0408
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0121 0.0117
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0431
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0074 0.0218 0.0412
Echinococcus granulosus tachykinin peptides receptor 99D 0.0056 0.015 0.0282
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.015 0.0282
Echinococcus multilocularis G-protein coupled receptor, putative 0.0056 0.015 0.0282
Loa Loa (eye worm) hypothetical protein 0.0161 0.0538 0.1562
Echinococcus multilocularis para nitrobenzyl esterase 0.0059 0.0161 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0049 0.0168
Echinococcus granulosus inositol monophosphatase 1 0.0078 0.0233 0.0441
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.015 0.0282
Loa Loa (eye worm) RNA binding protein 0.0129 0.0421 0.1221
Brugia malayi hypothetical protein 0.0038 0.0084 0.0235
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0233 0.0229
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0333 0.1216
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.273 1 1
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0027 0.0045 0.008
Onchocerca volvulus 0.0059 0.0161 0.0814
Onchocerca volvulus 0.0056 0.015 0.0754
Echinococcus granulosus retinol dehydrogenase 11 0.002 0.0018 0.0027
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0086 0.0159
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.015 0.0282
Loa Loa (eye worm) hypothetical protein 0.0497 0.1776 0.5182
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0199 0.0678 0.1887
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.002 0.0018 0.0014
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0191 0.0187
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.0045 0.008
Plasmodium vivax steroid dehydrogenase, putative 0.002 0.0018 0.005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0175 0.0329
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0059 0.0161 0.0302
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0121 0.0226
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0042 0.0139
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0056 0.015 0.0427
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0199 0.0678 0.2493
Trichomonas vaginalis set domain proteins, putative 0.0496 0.177 0.6534
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0166 0.0557 0.1617
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.0139
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0078 0.0216
Echinococcus granulosus aryl hydrocarbon receptor 0.0026 0.0042 0.0072
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0085 0.0081
Echinococcus multilocularis inositol monophosphatase 1 0.0078 0.0233 0.0441
Plasmodium vivax multidomain scavenger receptor, putative 0.0122 0.0393 0.1146
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0056 0.0163
Echinococcus multilocularis lipoxygenase domain containing protein 0.0122 0.0393 0.0749
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0056 0.015 0.0282
Echinococcus granulosus fmrfamide receptor 0.0056 0.015 0.0282
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0199 0.0678 0.1971
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0056 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0076 0.0267
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.002 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0161 0.0538 0.1562
Loa Loa (eye worm) hypothetical protein 0.0027 0.0042 0.0113
Schistosoma mansoni steroid dehydrogenase 0.002 0.0018 0.0027
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0199 0.0678 0.1298
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0045 0.0122
Echinococcus granulosus geminin 0.0178 0.0602 0.1151
Brugia malayi TAR-binding protein 0.0129 0.0421 0.1221
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.002 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0155 0.0442
Plasmodium vivax amine transporter, putative 0.0027 0.0045 0.0131
Echinococcus granulosus biogenic amine 5HT receptor 0.0186 0.0628 0.1203
Schistosoma mansoni short chain dehydrogenase 0.002 0.0018 0.0027
Echinococcus multilocularis retinol dehydrogenase 13 0.002 0.0018 0.0027
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0027 0.0045 0.0015
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0027 0.0045
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.002 0.0018 0.0052
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Schistosoma mansoni hypothetical protein 0.0214 0.0732 0.1402
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0045 0.0041
Loa Loa (eye worm) hypothetical protein 0.0045 0.011 0.031
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.0058 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.004 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0092 0.0327
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.015 0.0282
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0199 0.0678 0.2493
Schistosoma mansoni steroid dehydrogenase 0.002 0.0018 0.0027
Schistosoma mansoni short chain dehydrogenase 0.002 0.0018 0.0027
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0167 0.0314
Echinococcus granulosus hypothetical protein 0.002 0.0018 0.0027
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0078 0.0275
Brugia malayi hypothetical protein 0.0059 0.0161 0.0458
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0939 0.3402 0.6545
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0199 0.0678 0.1887
Schistosoma mansoni steroid dehydrogenase 0.002 0.0018 0.0027
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.075 0.2707 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0018 0.0052
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0199 0.0678 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0199 0.0678 0.0674
Onchocerca volvulus 0.0056 0.015 0.0754
Brugia malayi hypothetical protein 0.002 0.0018 0.0041
Schistosoma mansoni inositol monophosphatase 0.0078 0.0233 0.0441
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0044 0.0116
Schistosoma mansoni hypothetical protein 0.0178 0.0602 0.1151
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0056 0.015 0.0282
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0027 0.0045
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0019 0.0014 0.002
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.075 0.2707 0.5206
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.075 0.2707 0.7905
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0199 0.0678 0.2454
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0199 0.0678 0.1298
Echinococcus granulosus retinol dehydrogenase 11 0.002 0.0018 0.0027
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.061 0.2243
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0646 0.2375
Brugia malayi Carboxylesterase family protein 0.0059 0.0161 0.0458
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.0078 0.0227
Treponema pallidum sodium- and chloride- dependent transporter 0.0161 0.0538 0.182
Echinococcus granulosus steroid dehydrogenase 0.002 0.0018 0.0027
Mycobacterium ulcerans dehydrogenase 0.0199 0.0678 0.2454
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0458
Echinococcus multilocularis BC026374 protein (S09 family) 0.0059 0.0161 0.0302
Echinococcus granulosus thioredoxin glutathione reductase 0.0945 0.3424 0.6586
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0045 0.008
Giardia lamblia Glutamate synthase 0.0199 0.0678 0.2454
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.015 0.0282
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0959 0.3533
Toxoplasma gondii hypothetical protein 0.0027 0.0045 0.0133
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0275 0.0959 0.2793
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0186 0.063 0.1831
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0026 0.0042 0.0072
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0199 0.0678 0.2454
Schistosoma mansoni neuropeptide receptor 0.0056 0.015 0.0282
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0056 0.0141
Echinococcus granulosus orexin receptor type 2 0.0056 0.015 0.0282
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0045 0.0041
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0121 0.0226
Brugia malayi Carboxylesterase family protein 0.0059 0.0161 0.0458
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0014 0.002
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0199 0.0678 0.0674
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0059 0.0161 0.0408
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0018 0.0014
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0086 0.0082
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Echinococcus granulosus g-protein coupled receptor 0.0056 0.015 0.0282
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0186 0.063 0.0626
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.002 0.0018 0.0014
Chlamydia trachomatis thioredoxin reductase 0.0199 0.0678 0.2388
Loa Loa (eye worm) doublecortin family protein 0.0122 0.0393 0.1138
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0056 0.015 0.0282
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.015 0.0282
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.015 0.0282
Leishmania major short chain dehydrogenase/reductase, putative 0.002 0.0018 0.0014
Echinococcus granulosus lipoxygenase domain containing protein 0.0122 0.0393 0.0749
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.0356 0.1256
Echinococcus granulosus lamin dm0 0.0057 0.0155 0.0291
Echinococcus granulosus survival motor neuron protein 1 0.0489 0.1744 0.3352
Echinococcus granulosus acetylcholinesterase 0.0347 0.1223 0.2347
Brugia malayi hypothetical protein 0.0339 0.1194 0.3481
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0045 0.0122
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0199 0.0678 0.2493
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.002 0.0018 0.0014
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0418 0.1486 0.4197
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0056 0.015 0.0282
Loa Loa (eye worm) oxidoreductase 0.002 0.0018 0.0041
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0086 0.0241
Loa Loa (eye worm) hypoxia-induced factor 1 0.0313 0.1098 0.3198
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Schistosoma mansoni gliotactin 0.0059 0.0161 0.0302
Leishmania major hypothetical protein, conserved 0.002 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0158
Schistosoma mansoni alpha-1 adrenergic receptor 0.0056 0.015 0.0282
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0004 0.0000096692
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0087 0.0161
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.015 0.0282
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0122
Loa Loa (eye worm) melatonin receptor type 1A 0.0056 0.015 0.0427
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Brugia malayi Carboxylesterase family protein 0.0347 0.1223 0.3564
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0121 0.0434
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0199 0.0678 0.1971
Echinococcus multilocularis survival motor neuron protein 1 0.0489 0.1744 0.3352
Brugia malayi Pre-SET motif family protein 0.0062 0.0175 0.05
Brugia malayi phosphofructokinase 0.0112 0.0356 0.1028
Brugia malayi Doublecortin family protein 0.0122 0.0393 0.1138
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0056 0.015 0.0282
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0167 0.0314
Schistosoma mansoni chromobox protein 0.0072 0.0208 0.0393
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2295 0.8396 0.8395
Echinococcus granulosus hyperpolarization activated cyclic 0.0019 0.0014 0.002
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0199 0.0678 0.1298
Echinococcus multilocularis carbonyl reductase 1 0.002 0.0018 0.0027
Schistosoma mansoni hypothetical protein 0.0055 0.0148 0.0277
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0086 0.0254
Plasmodium falciparum amino acid transporter, putative 0.0027 0.0045 0.0121
Entamoeba histolytica hypothetical protein 0.0038 0.0084 0.1004
Toxoplasma gondii oxidoreductase, putative 0.002 0.0018 0.0052
Mycobacterium ulcerans carboxylesterase, LipT 0.0059 0.0161 0.0531
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0044 0.0116
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Loa Loa (eye worm) norepinephrine transporter 0.0161 0.0538 0.1562
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0167 0.0477
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0356 0.1301
Onchocerca volvulus 0.0075 0.022 0.1155
Echinococcus multilocularis steroid dehydrogenase 0.002 0.0018 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0175 0.0329
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0167 0.0314
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0959 0.3533
Echinococcus granulosus dro:myosuppressin receptor 0.0056 0.015 0.0282
Brugia malayi hypothetical protein 0.0056 0.015 0.0427
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.0045 0.008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.015 0.0282
Echinococcus granulosus 7TM GPCR rhodopsin 0.0056 0.015 0.0282
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0045 0.008
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.0045 0.0122
Trypanosoma cruzi oxidoreductase-like protein, putative 0.002 0.0018 0.0014
Leishmania major protein kinase, putative 0.0027 0.0045 0.0041
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.075 0.2707 0.5206
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.002 0.0018 0.0014
Schistosoma mansoni ap endonuclease 0.0038 0.0086 0.0159
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.075 0.2707 0.7905
Echinococcus multilocularis chromobox protein 1 0.0072 0.0208 0.0393
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0191 0.0361
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0199 0.0678 0.1887
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.002 0.0018 0.0027
Leishmania major NADH dehydrogenase, putative 0.0199 0.0678 0.0674
Echinococcus multilocularis Ankyrin 0.0031 0.0058 0.0104
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0167 0.0314
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.002 0.0018 0.0027
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.002 0.0018 0.0041
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0018 0.0052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.015 0.0282
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0356 0.1301
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0121 0.0117
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0042 0.0139
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0086 0.0115
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0233 0.0229
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0155 0.0442
Toxoplasma gondii oxidoreductase, putative 0.002 0.0018 0.0052
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.0161 0.0302
Echinococcus granulosus carbonyl reductase 1 0.002 0.0018 0.0027
Loa Loa (eye worm) dehydrogenase 0.002 0.0018 0.0041
Plasmodium vivax thioredoxin reductase, putative 0.0945 0.3424 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0186 0.063 0.1206
Onchocerca volvulus 0.0161 0.0538 0.2967
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Echinococcus multilocularis musashi 0.0057 0.0155 0.0291
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.003 0.0057 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.0139
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0199 0.0678 0.0674
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2003 0.7322 0.7321
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0199 0.0678 0.1298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0076 0.0267
Schistosoma mansoni lamin 0.0057 0.0155 0.0291
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0199 0.0678 0.1971
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0018 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0018 0.0014
Mycobacterium ulcerans putative regulatory protein 0.0075 0.022 0.0753
Loa Loa (eye worm) hypothetical protein 0.003 0.0057 0.0155
Onchocerca volvulus 0.0056 0.015 0.0754
Echinococcus granulosus oxidoreductase 0.002 0.0018 0.0027
Schistosoma mansoni 60S ribosomal protein L21 0.0017 0.0008 0.0009
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0056 0.015 0.0282
Echinococcus granulosus RUN 0.0122 0.0393 0.0749
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.075 0.2707 1
Echinococcus granulosus bloom syndrome protein 0.0022 0.0027 0.0045
Echinococcus multilocularis carbonyl reductase 1 0.002 0.0018 0.0027
Brugia malayi bZIP transcription factor family protein 0.0263 0.0914 0.266
Echinococcus multilocularis lamin dm0 0.0057 0.0155 0.0291
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.075 0.2707 0.769
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0233 0.0229
Entamoeba histolytica disulphide oxidoreductase, putative 0.0199 0.0678 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0086 0.1035
Schistosoma mansoni carbonyl reductase 0.002 0.0018 0.0027
Echinococcus granulosus allatostatin A receptor 0.0056 0.015 0.0282
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0026 0.0042 0.0139
Trichomonas vaginalis glutamate synthase, putative 0.0199 0.0678 0.2493
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.002 0.0018 0.0027
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0199 0.0678 0.2493
Echinococcus multilocularis tar DNA binding protein 0.0129 0.0421 0.0804
Echinococcus granulosus potassium voltage gated channel subfamily H 0.005 0.0129 0.0241
Leishmania major short chain dehydrogenase, putative 0.002 0.0018 0.0014
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0418 0.1486 0.4197
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0174 0.0581
Loa Loa (eye worm) hypothetical protein 0.0199 0.0678 0.1971
Onchocerca volvulus 0.0027 0.0045 0.0157
Trichomonas vaginalis glutamate synthase, putative 0.0199 0.0678 0.2493
Loa Loa (eye worm) RecQ helicase 0.0022 0.0027 0.0069
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0019 0.0014 0.002
Echinococcus granulosus tar DNA binding protein 0.0129 0.0421 0.0804
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0084 0.0155
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0019 0.0014 0.0038
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0105 0.0333 0.0329
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.002 0.0018 0.0052
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0458
Brugia malayi Serotonin receptor 0.0056 0.015 0.0427
Schistosoma mansoni hypothetical protein 0.0056 0.015 0.0282
Trypanosoma brucei trypanothione reductase 0.0945 0.3424 0.3421
Echinococcus multilocularis serotonin transporter 0.0161 0.0538 0.1029
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0199 0.0678 0.1298
Schistosoma mansoni hypothetical protein 0.0122 0.0393 0.0749
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.002 0.0018 0.0027
Loa Loa (eye worm) glutathione reductase 0.0945 0.3424 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0191 0.0548
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.015 0.0282
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0199 0.0678 0.2454
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.007 0.0203 0.0529
Entamoeba histolytica hypothetical protein 0.0038 0.0084 0.1004
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0339 0.1194 0.3481
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.0045 0.008
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0192
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0199 0.0678 0.2454
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0041
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0263 0.0914 0.1752
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0199 0.0678 0.2493
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.015 0.0282
Onchocerca volvulus 0.0122 0.0393 0.2139
Brugia malayi Retinol dehydrogenase 12 0.002 0.0018 0.0041
Onchocerca volvulus 0.0056 0.015 0.0754
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0056 0.015 0.0282
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0027 0.0087
Brugia malayi glutamate synthase 0.0199 0.0678 0.1971
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0052
Echinococcus multilocularis acetylcholinesterase 0.0347 0.1223 0.2347
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0004 0.0012
Schistosoma mansoni neuropeptide receptor 0.0056 0.015 0.0282
Schistosoma mansoni jun-related protein 0.0214 0.0732 0.1402
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.015 0.0282
Treponema pallidum NADH oxidase 0.075 0.2707 1
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0027 0.0045
Trichomonas vaginalis inositol monophosphatase, putative 0.0078 0.0233 0.0847
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0018 0.0014
Echinococcus granulosus glutamate synthase 0.0199 0.0678 0.1298
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0208 0.0755
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0421 0.0804
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0104 0.0369
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.015 0.0282
Echinococcus granulosus lipoxygenase domain containing protein 0.0122 0.0393 0.0749
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0042 0.0139
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0086 0.0159
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0199 0.0678 0.2493
Loa Loa (eye worm) hypothetical protein 0.0347 0.1223 0.3564
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0018 0.0052
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0056 0.015 0.0427
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.001 0.0012
Schistosoma mansoni steroid dehydrogenase 0.002 0.0018 0.0027
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0044 0.0126
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0199 0.0678 1
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0199 0.0678 0.1979
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0421 0.0804
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0045 0.008
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0056 0.015 0.0282
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.002 0.0018 0.0041
Brugia malayi glutathione reductase 0.0945 0.3424 1
Brugia malayi hypothetical protein 0.0056 0.015 0.0427
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Brugia malayi follicle stimulating hormone receptor 0.0056 0.015 0.0427
Loa Loa (eye worm) carboxylesterase 0.0059 0.0161 0.0458
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0045 0.0122
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Schistosoma mansoni glutamate synthase 0.0199 0.0678 0.1298
Schistosoma mansoni short chain dehydrogenase 0.002 0.0018 0.0027
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0056 0.015 0.0427
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0199 0.0678 0.1887
Entamoeba histolytica hypothetical protein 0.0038 0.0084 0.1004
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.015 0.0282
Entamoeba histolytica thioredoxin reductase, putative 0.0199 0.0678 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.2295 0.8396 0.8395
Onchocerca volvulus 0.0122 0.0393 0.2139
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.0356 0.0352
Echinococcus multilocularis glutamate synthase 0.0199 0.0678 0.1298
Loa Loa (eye worm) hypothetical protein 0.0027 0.0042 0.0113
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0044 0.004
Brugia malayi Serotonin receptor 0.0546 0.1957 0.5711
Toxoplasma gondii hypothetical protein 0.0027 0.0045 0.0133
Leishmania major hypothetical protein, conserved 0.002 0.0018 0.0014
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.002 0.0018 0.0014
Loa Loa (eye worm) oxidoreductase 0.002 0.0018 0.0041
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0086 0.0254
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0022 0.0027 0.0068
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0027 0.0045 0.008
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0019 0.0014 0.002
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0019 0.0014 0.003
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.015 0.0427
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0104 0.0369
Echinococcus multilocularis neuropeptide receptor A26 0.0056 0.015 0.0282
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0078 0.0275
Onchocerca volvulus 0.0056 0.015 0.0754
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0056 0.015 0.0282
Giardia lamblia GTOR 0.0048 0.0121 0.0384
Brugia malayi G protein-coupled receptor 0.0056 0.015 0.0427
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0199 0.0678 1
Echinococcus granulosus chromobox protein 1 0.0072 0.0208 0.0393
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0393 0.1391 0.4056
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0959 0.3533
Brugia malayi 6-phosphofructokinase 0.0112 0.0356 0.1028
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0018 0.0052
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0122
Schistosoma mansoni short chain dehydrogenase 0.002 0.0018 0.0027
Plasmodium falciparum steroid dehydrogenase, putative 0.002 0.0018 0.0041
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Schistosoma mansoni sulfide quinone reductase 0.0199 0.0678 0.1298
Trypanosoma cruzi trypanothione reductase, putative 0.0945 0.3424 0.3421
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0056 0.015 0.0282
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.015 0.0282
Toxoplasma gondii selenide, water dikinase 0.0199 0.0678 0.198
Schistosoma mansoni polycystin 1-related 0.0122 0.0393 0.0749
Schistosoma mansoni acetylcholinesterase 0.0059 0.0161 0.0302
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0018 0.0014
Onchocerca volvulus 0.0056 0.015 0.0754
Echinococcus multilocularis sodium channel protein 0.0126 0.0409 0.078
Plasmodium vivax ferrodoxin reductase, putative 0.0199 0.0678 0.1979
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.002 0.0018 0.0014
Plasmodium falciparum thioredoxin reductase 0.0945 0.3424 1
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0018 0.0014
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.0161 0.0302
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0356 0.5116
Echinococcus granulosus microtubule associated protein 2 0.1426 0.5197 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0018 0.0041
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0191 0.0361
Trypanosoma cruzi short chain dehydrogenase, putative 0.002 0.0018 0.0014
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0018 0.0014
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0199 0.0678 0.2454
Schistosoma mansoni ankyrin 23/unc44 0.003 0.0057 0.0102
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.002 0.0018 0.0014
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0056 0.015 0.0282
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0199 0.0678 0.198
Onchocerca volvulus 0.0026 0.0042 0.0135
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0199 0.0678 0.2493
Loa Loa (eye worm) oxidoreductase 0.002 0.0018 0.0041
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0056 0.015 0.0282
Schistosoma mansoni voltage-gated potassium channel 0.0054 0.0142 0.0266
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0427
Loa Loa (eye worm) oxidoreductase 0.002 0.0018 0.0041
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0018 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0959 0.3533
Schistosoma mansoni growth hormone secretagogue receptor 0.0056 0.015 0.0282
Loa Loa (eye worm) oxidoreductase 0.002 0.0018 0.0041
Schistosoma mansoni lamin 0.0057 0.0155 0.0291
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0086 0.0305
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0104 0.0488
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0199 0.0678 0.1298
Loa Loa (eye worm) oxidoreductase 0.002 0.0018 0.0041
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0056 0.0053
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0191 0.0187
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0076 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0059 0.0205
Brugia malayi hypothetical protein 0.0027 0.0045 0.0122
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0199 0.0678 0.1298
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0027 0.0045
Leishmania major hypothetical protein, conserved 0.0199 0.0678 0.0674
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.015 0.0282
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.015 0.0282
Schistosoma mansoni opsin-like receptor 0.0056 0.015 0.0282
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0045 0.0133
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0199 0.0678 0.2454
Trypanosoma brucei C-8 sterol isomerase, putative 0.0393 0.1391 0.1388
Trichomonas vaginalis spcc417.12 protein, putative 0.0059 0.0161 0.058
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0086 0.025
Brugia malayi Dehydrogenases, short chain protein 30 0.002 0.0018 0.0041
Onchocerca volvulus Netrin receptor homolog 0.003 0.0057 0.0222
Schistosoma mansoni short chain dehydrogenase 0.002 0.0018 0.0027
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.0356 0.0966
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0041
Treponema pallidum oxidoreductase 0.0199 0.0678 0.2347
Toxoplasma gondii carbonyl reductase 1, putative 0.002 0.0018 0.0052
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0086 0.0082
Leishmania major oxidoreductase-like protein 0.002 0.0018 0.0014
Brugia malayi RNA binding protein 0.0129 0.0421 0.1221
Entamoeba histolytica hypothetical protein 0.0038 0.0084 0.1004
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0105 0.0333 0.0329
Schistosoma mansoni netrin receptor unc5 0.003 0.0057 0.0102
Onchocerca volvulus 0.0056 0.015 0.0754
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0199 0.0678 0.1971
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0167 0.0314
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0199 0.0678 1
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0056 0.0161

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 2.5 nmol/min/mg Prodrug activation in Wistar rat liver microsome assessed as formation of adefovir at 250 uM after 5 mins ChEMBL. 18173234

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.