Detailed information for compound 504393

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 303.353 | Formula: C17H21NO4
  • H donors: 2 H acceptors: 2 LogP: 0.86 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c3c1O[C@@H]1[C@]3(C=C[C@H](C1)O)[C@H](O)CN(C2)C
  • InChi: 1S/C17H21NO4/c1-18-8-10-3-4-12(21-2)16-15(10)17(13(20)9-18)6-5-11(19)7-14(17)22-16/h3-6,11,13-14,19-20H,7-9H2,1-2H3/t11-,13-,14+,17+/m1/s1
  • InChiKey: YLFKDWVECRVHGB-CVGURMSBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens acetylcholinesterase (Yt blood group) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carboxylesterase family protein acetylcholinesterase (Yt blood group) 614 aa 510 aa 26.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0043 0.0535 0.0533
Brugia malayi polk-prov protein 0.0037 0.0445 0.0443
Brugia malayi hypothetical protein 0.0017 0.0141 0.0139
Trichomonas vaginalis tubulin epsilon chain, putative 0.0061 0.0802 0.1548
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0147 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0432 0.0429
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0535 0.0533
Loa Loa (eye worm) tubulin beta chain 0.0026 0.0281 0.0279
Loa Loa (eye worm) hypothetical protein 0.0017 0.0141 0.0139
Echinococcus multilocularis tubulin subunit beta 0.0061 0.0802 0.08
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0432 0.0429
Plasmodium vivax tubulin gamma chain, putative 0.0061 0.0802 0.154
Echinococcus multilocularis tubulin epsilon chain 0.0061 0.0802 0.08
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0011 0.0009
Echinococcus multilocularis Tubulin beta 2C chain 0.0061 0.0802 0.08
Loa Loa (eye worm) BEN-1 protein 0.0061 0.0802 0.08
Loa Loa (eye worm) carboxylesterase 0.0082 0.112 0.1117
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0432 0.0429
Loa Loa (eye worm) acetyltransferase 0.0174 0.2509 0.2507
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0432 0.0429
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0432 0.0429
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0535 0.0533
Brugia malayi Tubulin alpha chain 0.0061 0.0802 0.08
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0141 0.0139
Loa Loa (eye worm) hypothetical protein 0.0017 0.0141 0.0139
Trichomonas vaginalis DNA helicase recq1, putative 0.0049 0.0628 0.1213
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0281 0.0543
Schistosoma mansoni tubulin subunit beta 0.0061 0.0802 0.08
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0432 0.0429
Leishmania major alpha tubulin 0.0061 0.0802 0.1525
Trichomonas vaginalis tubulin gamma chain, putative 0.0026 0.0281 0.0543
Trichomonas vaginalis tubulin beta chain, putative 0.0061 0.0802 0.1548
Toxoplasma gondii alpha tubulin TUBA1 0.0061 0.0802 0.1644
Echinococcus multilocularis Tubulin beta 2C chain 0.0061 0.0802 0.08
Schistosoma mansoni BC026374 protein (S09 family) 0.0014 0.0091 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0183 0.0272
Loa Loa (eye worm) hypothetical protein 0.0036 0.0432 0.0429
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0079 0.1079 0.1076
Mycobacterium ulcerans DNA polymerase IV 0.0049 0.0626 0.054
Echinococcus multilocularis acetylcholinesterase 0.0082 0.112 0.1117
Onchocerca volvulus 0.0043 0.0535 0.1168
Loa Loa (eye worm) tubulin alpha-3 chain 0.0026 0.0281 0.0279
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0432 0.0896
Giardia lamblia Epsilon tubulin 0.0026 0.0281 0.0118
Loa Loa (eye worm) tubulin alpha 2 0.0034 0.0403 0.04
Toxoplasma gondii alpha-tubulin I, putative 0.0061 0.0802 0.1644
Treponema pallidum fructose-bisphosphate aldolase 0.035 0.518 1
Entamoeba histolytica tubulin alpha-1 chain 0.0061 0.0802 0.132
Schistosoma mansoni nuclear receptor 0.0017 0.0141 0.0139
Brugia malayi nuclear hormone receptor 0.0017 0.0141 0.0139
Leishmania major alpha tubulin 0.0061 0.0802 0.1525
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0655 0.1307
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0432 0.0429
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0432 0.0429
Schistosoma mansoni tubulin subunit beta 0.0061 0.0802 0.08
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0655 0.0652
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0144 0.0142
Brugia malayi tailless protein 0.0017 0.0141 0.0139
Chlamydia trachomatis dihydrofolate reductase 0.0669 1 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0432 0.0429
Loa Loa (eye worm) hypothetical protein 0.0014 0.0091 0.0089
Leishmania major alpha tubulin 0.0061 0.0802 0.1525
Schistosoma mansoni alpha tubulin 0.0061 0.0802 0.08
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0151 0.2164 0.2162
Trypanosoma cruzi DNA polymerase kappa, putative 0.0049 0.0626 0.1118
Echinococcus granulosus tubulin alpha chain 0.0061 0.0802 0.08
Plasmodium vivax tubulin alpha chain, putative 0.0061 0.0802 0.154
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0144 0.0142
Loa Loa (eye worm) hypothetical protein 0.0043 0.0535 0.0532
Schistosoma mansoni tubulin subunit beta 0.0061 0.0802 0.08
Brugia malayi nuclear receptor RXR 0.0017 0.0141 0.0139
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0432 0.0429
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0141 0.0139
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Brugia malayi nuclear receptor RXR 0.0019 0.0172 0.017
Trypanosoma cruzi beta tubulin, putative 0.0061 0.0802 0.1525
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0223 0.02
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.1079 0.2166
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0535 0.0532
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.00000000021397 0.00000000041307
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0303 0.4457 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0091 0.0089
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.00000000021397 0.00000000041307
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Brugia malayi conserved hypotetical protein 0.0017 0.0141 0.0139
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0171 0.247 0.2469
Echinococcus granulosus Tubulin alpha 1 chain 0.0061 0.0802 0.08
Echinococcus multilocularis tubulin alpha chain 0.0061 0.0802 0.08
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0034 0.0401 0.0398
Leishmania major alpha tubulin 0.0061 0.0802 0.1525
Schistosoma mansoni tubulin subunit beta 0.0061 0.0802 0.08
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0141 0.0132
Schistosoma mansoni cpg binding protein 0.0034 0.0403 0.04
Entamoeba histolytica tubulin family protein 0.0061 0.0802 0.132
Brugia malayi Carboxylesterase family protein 0.0014 0.0091 0.0089
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0432 0.0429
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0079 0.1079 0.1076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0432 0.0429
Echinococcus multilocularis tubulin alpha chain 0.0061 0.0802 0.08
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Echinococcus multilocularis Tubulin alpha 1 chain 0.0061 0.0802 0.08
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0303 0.4457 1
Echinococcus multilocularis tubulin subunit TubB 0.0061 0.0802 0.08
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0432 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0281 0.0543
Loa Loa (eye worm) hypothetical protein 0.0033 0.0374 0.0371
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0183 0.0272
Echinococcus granulosus tubulin alpha chain 0.0061 0.0802 0.08
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.0091 0.0089
Trichomonas vaginalis tubulin epsilon chain, putative 0.0061 0.0802 0.1548
Trichomonas vaginalis tubulin alpha chain, putative 0.0034 0.0403 0.0777
Schistosoma mansoni vesicular acetylcholine transporter 0.0265 0.389 0.3888
Echinococcus multilocularis tubulin beta 1 chain 0.0061 0.0802 0.08
Mycobacterium ulcerans lipase LipD 0.0043 0.0535 0.0448
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0626 0.1282
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0061 0.0802 0.1548
Trypanosoma brucei alpha tubulin 0.0061 0.0802 0.1682
Trypanosoma cruzi DNA polymerase kappa, putative 0.0049 0.0626 0.1118
Trichomonas vaginalis tubulin, putative 0.0061 0.0802 0.1548
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0669 1 1
Echinococcus multilocularis tubulin alpha chain 0.0061 0.0802 0.08
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0172 0.017
Leishmania major hypothetical protein, conserved 0.0043 0.0535 0.0905
Echinococcus multilocularis Tubulin beta 2C chain 0.0061 0.0802 0.08
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0432 0.0429
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0141 0.0139
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0535 0.0533
Echinococcus multilocularis tubulin alpha chain 0.0061 0.0802 0.08
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0141 0.0139
Loa Loa (eye worm) beta-tubulin 0.0061 0.0802 0.08
Echinococcus granulosus Tubulin beta 2C chain 0.0061 0.0802 0.08
Trichomonas vaginalis tubulin alpha chain, putative 0.0034 0.0403 0.0777
Schistosoma mansoni cpg binding protein 0.0036 0.0432 0.043
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0276 0.4052 0.4051
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0626 0.1282
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0147 0.0145
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0144 0.0142
Echinococcus multilocularis Tubulin alpha 1 chain 0.0061 0.0802 0.08
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0535 0.0922
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0061 0.0802 0.1644
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0141 0.0139
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0432 0.0429
Echinococcus granulosus tubulin subunit TubB 0.0061 0.0802 0.08
Trichomonas vaginalis tubulin alpha chain, putative 0.0034 0.0403 0.0777
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0014 0.0091 0.0176
Loa Loa (eye worm) tubulin gamma chain 0.0061 0.0802 0.08
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.035 0.518 1
Trypanosoma cruzi zeta tubulin, putative 0.0026 0.0281 0.0318
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0029 0.0327 0.044
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0079 0.1079 0.1076
Schistosoma mansoni tubulin subunit beta 0.0061 0.0802 0.08
Echinococcus granulosus dnaJ subfamily B 0.049 0.7296 0.7295
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0011 0.0009
Brugia malayi CXXC zinc finger family protein 0.0034 0.0403 0.04
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.035 0.518 1
Echinococcus granulosus tubulin epsilon chain 0.0061 0.0802 0.08
Trypanosoma brucei beta tubulin 0.0061 0.0802 0.1682
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0079 0.1079 0.1076
Echinococcus granulosus dihydrofolate reductase 0.0669 1 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0151 0.2164 0.2162
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0223 0.022
Loa Loa (eye worm) tubulin beta-2A chain 0.0061 0.0802 0.08
Trichomonas vaginalis DNA polymerase eta, putative 0.0049 0.0626 0.1209
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0432 0.0896
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0432 0.0429
Loa Loa (eye worm) hypothetical protein 0.0017 0.0141 0.0139
Schistosoma mansoni alpha tubulin 0.0061 0.0802 0.08
Trichomonas vaginalis tubulin beta chain, putative 0.0061 0.0802 0.1548
Brugia malayi Tubulin beta chain 0.0026 0.0281 0.0279
Trypanosoma brucei zeta tubulin, putative 0.0026 0.0281 0.0497
Schistosoma mansoni dihydrofolate reductase 0.0669 1 1
Echinococcus granulosus tubulin subunit beta 0.0061 0.0802 0.08
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0535 0.1032
Mycobacterium ulcerans cell division protein FtsZ 0.0026 0.0281 0.0192
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0172 0.017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0432 0.0429
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Brugia malayi ecdysone receptor 0.0017 0.0141 0.0139
Trichomonas vaginalis tubulin epsilon chain, putative 0.0061 0.0802 0.1548
Toxoplasma gondii beta tubulin 0.0061 0.0802 0.1644
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0655 0.1307
Toxoplasma gondii beta-tubulin, putative 0.0061 0.0802 0.1644
Echinococcus multilocularis carboxylesterase 5A 0.0082 0.112 0.1117
Trichomonas vaginalis spcc417.12 protein, putative 0.0014 0.0091 0.0176
Echinococcus multilocularis tubulin alpha 1C chain 0.0061 0.0802 0.08
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0034 0.0401 0.0398
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0432 0.0429
Schistosoma mansoni acetylcholinesterase 0.0014 0.0091 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0626 0.1282
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Brugia malayi Bloom's syndrome protein homolog 0.0049 0.0628 0.0626
Loa Loa (eye worm) hypothetical protein 0.0017 0.0141 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0445 0.087
Brugia malayi Carboxylesterase family protein 0.0082 0.112 0.1117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0432 0.0429
Schistosoma mansoni coup transcription factor 0.0036 0.0432 0.0429
Brugia malayi hypothetical protein 0.0019 0.0172 0.017
Echinococcus multilocularis dnaJ subfamily B 0.049 0.7296 0.7295
Trichomonas vaginalis tubulin beta chain, putative 0.0061 0.0802 0.1548
Leishmania major delta tubulin, putative 0.0026 0.0281 0.0318
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0432 0.0429
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0049 0.0626 0.1209
Echinococcus multilocularis tubulin delta chain 0.0026 0.0281 0.0279
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0986 0.0984
Brugia malayi MH2 domain containing protein 0.0117 0.1652 0.165
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0014 0.0091 0.009
Trichomonas vaginalis tubulin epsilon chain, putative 0.0061 0.0802 0.1548
Loa Loa (eye worm) hypothetical protein 0.0017 0.0141 0.0139
Echinococcus granulosus tubulin alpha 0.0061 0.0802 0.08
Loa Loa (eye worm) tubulin alpha chain 0.0061 0.0802 0.08
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0141 0.0139
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0144 0.0143
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Echinococcus granulosus peroxisome assembly protein 26 0.0061 0.0802 0.08
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0432 0.0429
Trypanosoma brucei DNA polymerase IV, putative 0.0049 0.0626 0.1282
Echinococcus multilocularis para nitrobenzyl esterase 0.0014 0.0091 0.0089
Loa Loa (eye worm) tubulin beta chain 0.0061 0.0802 0.08
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0432 0.0429
Echinococcus granulosus carboxylesterase 5A 0.0082 0.112 0.1117
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0171 0.247 0.2401
Echinococcus granulosus BC026374 protein S09 family 0.0014 0.0091 0.0089
Echinococcus multilocularis dna polymerase eta 0.0017 0.0144 0.0142
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.035 0.518 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0037 0.0448 0.0704
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0933 0.1942
Mycobacterium ulcerans beta-lactamase 0.0043 0.0535 0.0448
Echinococcus granulosus para nitrobenzyl esterase 0.0014 0.0091 0.0089
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0223 0.0182
Trichomonas vaginalis DNA helicase recq, putative 0.0037 0.0448 0.0865
Loa Loa (eye worm) tubulin alpha 2 0.0034 0.0403 0.04
Echinococcus granulosus dna polymerase eta 0.0017 0.0144 0.0142
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0432 0.0429
Schistosoma mansoni ap endonuclease 0.0023 0.0223 0.022
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0432 0.0429
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0432 0.0429
Brugia malayi Dihydrofolate reductase 0.0669 1 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0317 0.0534
Brugia malayi Tubulin alpha-2 chain 0.0061 0.0802 0.08
Trypanosoma cruzi epsilon tubulin, putative 0.0061 0.0802 0.1525
Giardia lamblia Gamma tubulin 0.0061 0.0802 0.1168
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.00000000021397 0.00000000041307
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.035 0.518 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0043 0.004
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0223 0.022
Trypanosoma brucei alpha tubulin 0.0061 0.0802 0.1682
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0079 0.1079 0.1868
Brugia malayi ecdysteroid receptor 0.0036 0.0432 0.0429
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0626 0.1282
Brugia malayi hypothetical protein 0.0019 0.0172 0.017
Trichomonas vaginalis esterase, putative 0.0043 0.0535 0.1032
Leishmania major DNA polymerase kappa, putative 0.0025 0.0264 0.0277
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0141 0.0139
Loa Loa (eye worm) hypothetical protein 0.0036 0.0432 0.0429
Leishmania major alpha tubulin 0.0061 0.0802 0.1525
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0432 0.0429
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0432 0.0429
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0014 0.0091 0.0089
Toxoplasma gondii exonuclease III APE 0.0023 0.0223 0.032
Onchocerca volvulus 0.0017 0.0141 0.0132
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0046 0.0581 0.0846
Plasmodium falciparum tubulin delta chain, putative 0.0026 0.0281 0.0138
Echinococcus multilocularis tubulin gamma 1 chain 0.0061 0.0802 0.08
Trichomonas vaginalis tubulin gamma chain, putative 0.0061 0.0802 0.1548
Trichomonas vaginalis tubulin beta chain, putative 0.0061 0.0802 0.1548
Echinococcus multilocularis tubulin alpha 3 chain 0.0061 0.0802 0.08
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0432 0.0429
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0403 0.04
Brugia malayi Carboxylesterase family protein 0.0014 0.0091 0.0089
Brugia malayi nuclear receptor NHR-67 0.0017 0.0141 0.0139
Leishmania major alpha tubulin 0.0061 0.0802 0.1525
Brugia malayi Carboxylesterase family protein 0.0082 0.112 0.1117
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0183 0.0272
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0535 0.0261
Schistosoma mansoni tubulin subunit alpha 0.0061 0.0802 0.08
Giardia lamblia DINP protein human, muc B family 0.0025 0.0264 0.0083
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0079 0.1079 0.1076
Brugia malayi Tubulin alpha chain 0.0026 0.0281 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0626 0.1282
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0535 0.0448
Schistosoma mansoni DNA helicase recq5 0.0034 0.0401 0.0398
Loa Loa (eye worm) hypothetical protein 0.0019 0.0172 0.017
Trichomonas vaginalis tubulin beta chain, putative 0.0061 0.0802 0.1548
Loa Loa (eye worm) hypothetical protein 0.0043 0.0535 0.0532
Loa Loa (eye worm) hypothetical protein 0.0036 0.0432 0.0429
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0575 0.0572
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0535 0.0448
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0026 0.0281 0.0454
Loa Loa (eye worm) hypothetical protein 0.0037 0.0445 0.0443
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0265 0.389 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0141 0.0132
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Trypanosoma brucei beta tubulin 0.0061 0.0802 0.1682
Schistosoma mansoni thyroid hormone receptor 0.0187 0.2714 0.2712
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0535 0.1032
Brugia malayi Cell division protein ftsZ 0.0026 0.0281 0.0279
Loa Loa (eye worm) hypothetical protein 0.0034 0.0401 0.0398
Loa Loa (eye worm) hypothetical protein 0.0017 0.0141 0.0139
Brugia malayi beta-tubulin, identical 0.0061 0.0802 0.08
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0172 0.017
Echinococcus multilocularis beta tubulin 0.0061 0.0802 0.08
Mycobacterium ulcerans hypothetical protein 0.0043 0.0535 0.0448
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0141 0.0139
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0223 0.0182
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0535 0.0533
Trypanosoma brucei beta tubulin 0.0061 0.0802 0.1682
Brugia malayi Carboxylesterase family protein 0.0014 0.0091 0.0089
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.00000000021397 0.00000000041307
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0535 0.0532
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.059 0.0868
Loa Loa (eye worm) hypothetical protein 0.0017 0.0141 0.0139
Echinococcus multilocularis beta tubulin 0.0061 0.0802 0.08
Loa Loa (eye worm) alpha-tubulin 0.0061 0.0802 0.08
Mycobacterium tuberculosis Carboxylesterase LipT 0.0014 0.0091 0.009
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0432 0.0429
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0141 0.0139
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0432 0.0429
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0174 0.2509 0.2507
Schistosoma mansoni DNA polymerase eta 0.0017 0.0144 0.0142
Echinococcus granulosus Tubulin alpha 1 chain 0.0061 0.0802 0.08
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.035 0.518 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.0091 0.0089
Schistosoma mansoni tubulin subunit alpha 0.0026 0.0281 0.0279
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0141 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0432 0.0429
Echinococcus multilocularis hypothetical protein 0.0061 0.0802 0.08
Brugia malayi alpha-tubulin 0.0061 0.0802 0.08
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0141 0.0139
Loa Loa (eye worm) tubulin alpha chain 0.0061 0.0802 0.08
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.1079 0.2311
Schistosoma mansoni hypothetical protein 0.049 0.7296 0.7295
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0223 0.0171
Giardia lamblia Fructose-bisphosphate aldolase 0.035 0.518 1
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0535 0.1032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0432 0.0429
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0034 0.0403 0.0777
Echinococcus granulosus Tubulin beta 2C chain 0.0061 0.0802 0.08
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0144 0.0142
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0303 0.4457 1
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0432 0.0429
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0626 0.1282
Schistosoma mansoni hypothetical protein 0.0151 0.2164 0.2162
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.00000000021397 0.00000000041307
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0034 0.0401 0.042
Brugia malayi Carboxylesterase family protein 0.0014 0.0091 0.0089
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0141 0.0139
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.0264 0.0277
Trypanosoma brucei zeta tubulin 0.0026 0.0281 0.0497
Schistosoma mansoni zinc finger protein 0.0017 0.0141 0.0139
Loa Loa (eye worm) DR-78 0.0017 0.0141 0.0139
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0669 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0432 0.0429
Schistosoma mansoni ap endonuclease 0.0023 0.0223 0.022
Echinococcus multilocularis thyroid hormone receptor alpha 0.0187 0.2714 0.2712
Echinococcus granulosus tubulin alpha chain 0.0061 0.0802 0.08
Brugia malayi Tubulin beta-1 chain 0.0061 0.0802 0.08
Echinococcus multilocularis cpg binding protein 0.0036 0.0432 0.043
Echinococcus granulosus vesicular acetylcholine transporter 0.0265 0.389 0.3888
Brugia malayi nuclear hormone receptor 0.0036 0.0432 0.0429
Loa Loa (eye worm) hypothetical protein 0.0014 0.0091 0.0089
Trichomonas vaginalis tubulin, putative 0.0026 0.0281 0.0543
Schistosoma mansoni tubulin subunit alpha 0.0061 0.0802 0.08
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0535 0.0532
Brugia malayi Tubulin alpha-2 chain 0.0061 0.0802 0.08
Schistosoma mansoni cpg binding protein 0.0036 0.0432 0.043
Leishmania major zeta tubulin, putative 0.0026 0.0281 0.0318
Echinococcus granulosus tubulin beta 4A class IVa 0.0061 0.0802 0.08
Echinococcus granulosus tubulin beta 1 chain 0.0061 0.0802 0.08
Trypanosoma cruzi tubulin delta chain 0.0026 0.0281 0.0318
Loa Loa (eye worm) hypothetical protein 0.0014 0.0091 0.0089
Trichomonas vaginalis tubulin, putative 0.0034 0.0403 0.0777
Loa Loa (eye worm) hypothetical protein 0.0014 0.0091 0.0089
Echinococcus granulosus tubulin alpha 1C chain 0.0061 0.0802 0.08
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0014 0.0091 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0432 0.0429
Plasmodium falciparum alpha tubulin 2 0.0061 0.0802 0.1368
Echinococcus granulosus alpha tubulin 0.0061 0.0802 0.08
Brugia malayi Tubulin beta chain 0.0034 0.0403 0.04
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0034 0.0401 0.0398
Trypanosoma brucei epsilon tubulin 0.0061 0.0802 0.1682
Echinococcus multilocularis Tubulin beta 2C chain 0.0061 0.0802 0.08
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0432 0.0429
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0061 0.0802 0.08
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0141 0.0139
Loa Loa (eye worm) hypothetical protein 0.0017 0.0141 0.0139
Loa Loa (eye worm) hypothetical protein 0.0014 0.0091 0.0089
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0014 0.0091 0.009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0141 0.0139
Trichomonas vaginalis tubulin alpha chain, putative 0.0061 0.0802 0.1548
Onchocerca volvulus 0.0036 0.0432 0.0896
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0026 0.0281 0.0543
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0223 0.0133
Trichomonas vaginalis tubulin beta chain, putative 0.0034 0.0403 0.0777
Echinococcus granulosus tubulin delta chain 0.0026 0.0281 0.0279
Treponema pallidum cell division protein FtsZ 0.0026 0.0281 0.0268
Loa Loa (eye worm) hypothetical protein 0.0082 0.112 0.1117
Loa Loa (eye worm) hypothetical protein 0.0019 0.0172 0.017
Schistosoma mansoni tubulin subunit delta 0.0026 0.0281 0.0279
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.035 0.518 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0432 0.0429
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0223 0.022
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0535 0.0905
Brugia malayi tubulin alpha chain - mouse 0.0061 0.0802 0.08
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0432 0.0429
Trypanosoma cruzi zeta tubulin, putative 0.0026 0.0281 0.0318
Echinococcus multilocularis acetylcholinesterase 0.0082 0.112 0.1117
Brugia malayi nuclear receptor NHR-88 0.0036 0.0432 0.0429
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.00000000021397 0.00000000041307
Echinococcus multilocularis dihydrofolate reductase 0.0669 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0061 0.0802 0.08
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0264 0.0457
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.0264 0.0262
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0535 0.0532
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0655 0.1264
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0043 0.004
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1652 0.165
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0141 0.0139
Trypanosoma brucei unspecified product 0.0041 0.0507 0.101
Brugia malayi beta-lactamase 0.0043 0.0535 0.0532
Schistosoma mansoni nuclear receptor 0.0017 0.0141 0.0139
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0034 0.0401 0.0398
Plasmodium falciparum tubulin epsilon chain, putative 0.0061 0.0802 0.1368
Trichomonas vaginalis tubulin, putative 0.0034 0.0403 0.0777
Trypanosoma cruzi DNA polymerase kappa, putative 0.0049 0.0626 0.1118
Echinococcus granulosus Tubulin beta 2C chain 0.0061 0.0802 0.08
Mycobacterium tuberculosis Cell division protein FtsZ 0.0026 0.0281 0.028
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0223 0.0364
Schistosoma mansoni tubulin subunit beta 0.0026 0.0281 0.0279
Loa Loa (eye worm) hypothetical protein 0.0082 0.112 0.1117
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0626 0.1282
Brugia malayi hypothetical protein 0.0014 0.0091 0.0089
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0026 0.0281 0.0454
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0535 0.1032
Loa Loa (eye worm) hypothetical protein 0.0034 0.0403 0.04
Trypanosoma brucei beta tubulin 0.0061 0.0802 0.1682
Plasmodium vivax tubulin beta chain, putative 0.0061 0.0802 0.154
Onchocerca volvulus 0.0034 0.0403 0.082
Giardia lamblia Beta tubulin 0.0061 0.0802 0.1168
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0026 0.0281 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0034 0.0403 0.04
Loa Loa (eye worm) hypothetical protein 0.0019 0.0172 0.017
Plasmodium falciparum tubulin beta chain 0.0061 0.0802 0.1368
Loa Loa (eye worm) hypothetical protein 0.0036 0.0432 0.0429
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.00000000021397 0.00000000041307
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.035 0.518 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0141 0.0139
Loa Loa (eye worm) hypothetical protein 0.0026 0.0281 0.0279
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0223 0.043
Loa Loa (eye worm) hypothetical protein 0.0019 0.0172 0.017
Entamoeba histolytica tubulin alpha chain, putative 0.0061 0.0802 0.132
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0034 0.0403 0.0777
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0432 0.0429
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0141 0.0139
Loa Loa (eye worm) hypothetical protein 0.0036 0.0432 0.0429
Trypanosoma brucei alpha tubulin, putative 0.0034 0.0403 0.0773
Echinococcus multilocularis tubulin alpha 0.0061 0.0802 0.08
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.035 0.518 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0141 0.0139
Echinococcus multilocularis neuroligin 0.0014 0.0091 0.0089
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Loa Loa (eye worm) RecQ helicase 0.0049 0.0628 0.0626
Giardia lamblia Beta tubulin 0.0061 0.0802 0.1168
Loa Loa (eye worm) BEN-1 protein 0.0061 0.0802 0.08
Onchocerca volvulus 0.0043 0.0535 0.1168
Brugia malayi hypothetical protein 0.0017 0.0141 0.0139
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0034 0.0401 0.0727
Mycobacterium ulcerans DNA polymerase IV 0.0049 0.0626 0.054
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0432 0.0429
Echinococcus multilocularis peroxisome assembly protein 26 0.0061 0.0802 0.08
Schistosoma mansoni tubulin subunit alpha 0.0061 0.0802 0.08
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0432 0.0429
Leishmania major alpha tubulin 0.0061 0.0802 0.1525
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0432 0.0896
Trypanosoma brucei epsilon tubulin 0.0061 0.0802 0.1682
Loa Loa (eye worm) hypothetical protein 0.0017 0.0141 0.0139
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0144 0.0142
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0303 0.4457 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0535 0.1032
Entamoeba histolytica recQ family DNA helicase 0.0017 0.0147 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0432 0.0429
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0535 0.0533
Trichomonas vaginalis tubulin alpha chain, putative 0.0061 0.0802 0.1548
Leishmania major alpha tubulin 0.0061 0.0802 0.1525
Echinococcus multilocularis Tubulin alpha 1 chain 0.0061 0.0802 0.08
Trypanosoma cruzi epsilon tubulin, putative 0.0061 0.0802 0.1525
Echinococcus granulosus tubulin alpha 3 chain 0.0061 0.0802 0.08
Trichomonas vaginalis tubulin beta chain, putative 0.0061 0.0802 0.1548
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0034 0.0401 0.0727
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.00000000021397 0.00000000041307
Echinococcus granulosus cpg binding protein 0.0036 0.0432 0.043
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0445 0.087
Echinococcus granulosus beta tubulin 0.0061 0.0802 0.08
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.1079 0.2166
Giardia lamblia Alpha-tubulin 0.0061 0.0802 0.1168
Echinococcus granulosus Tubulin alpha 1 chain 0.0061 0.0802 0.08
Brugia malayi vesicular acetylcholine transporter unc-17 0.0265 0.389 0.3888
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0265 0.389 0.3888
Plasmodium falciparum tubulin gamma chain 0.0061 0.0802 0.1368
Schistosoma mansoni tubulin subunit epsilon 0.0061 0.0802 0.08
Plasmodium vivax tubulin alpha chain, putative 0.0061 0.0802 0.154
Loa Loa (eye worm) beta-lactamase 0.0043 0.0535 0.0532
Mycobacterium leprae Probable lipase LipE 0.0043 0.0535 0.0261
Echinococcus granulosus dna polymerase kappa 0.0049 0.0626 0.0624
Echinococcus multilocularis dna polymerase kappa 0.0049 0.0626 0.0624
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0303 0.4457 1
Echinococcus granulosus bloom syndrome protein 0.0049 0.0628 0.0626
Brugia malayi beta-lactamase family protein 0.0043 0.0535 0.0532
Echinococcus granulosus tubulin alpha chain 0.0061 0.0802 0.08
Echinococcus multilocularis BC026374 protein (S09 family) 0.0014 0.0091 0.0089
Loa Loa (eye worm) hypothetical protein 0.0017 0.0141 0.0139
Giardia lamblia Beta tubulin 0.0061 0.0802 0.1168
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0669 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0535 0.0532
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0223 0.0221
Echinococcus granulosus neuroligin 0.0014 0.0091 0.0089
Loa Loa (eye worm) tubulin alpha-2 chain 0.0061 0.0802 0.08
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0535 0.0532
Schistosoma mansoni tubulin subunit gamma 0.0061 0.0802 0.08
Schistosoma mansoni tubulin subunit beta 0.0061 0.0802 0.08
Trypanosoma cruzi tubulin delta chain 0.0026 0.0281 0.0318
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0034 0.0401 0.0398
Mycobacterium tuberculosis Conserved protein 0.0043 0.0535 0.0533
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0432 0.0429
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0575 0.0572
Trypanosoma cruzi tubulin gamma chain 0.0061 0.0802 0.1525
Echinococcus granulosus Tubulin beta 2C chain 0.0061 0.0802 0.08
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0079 0.1079 0.2166
Loa Loa (eye worm) hypothetical protein 0.0061 0.0802 0.08
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0037 0.0448 0.0876
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0174 0.2509 0.2507
Echinococcus multilocularis tubulin alpha 3 chain 0.0061 0.0802 0.08
Echinococcus granulosus tubulin alpha 1C chain 0.0061 0.0802 0.08
Echinococcus multilocularis tubulin alpha chain 0.0061 0.0802 0.08
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0655 0.1264
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0171 0.247 0.2252
Schistosoma mansoni gliotactin 0.0014 0.0091 0.0089
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0432 0.0429
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0011 0.0009
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0223 0.0152
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0026 0.0281 0.0543
Giardia lamblia Sgs1 DNA helicase, putative 0.0034 0.0401 0.0359
Brugia malayi steroid hormone receptor 0.0036 0.0432 0.0429
Echinococcus granulosus acetylcholinesterase 0.0082 0.112 0.1117
Loa Loa (eye worm) hypothetical protein 0.0036 0.0432 0.0429
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0144 0.0142
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0144 0.0142
Trichomonas vaginalis tubulin beta chain, putative 0.0061 0.0802 0.1548
Toxoplasma gondii beta-1 tubulin, putative 0.0061 0.0802 0.1644
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0535 0.1073
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0432 0.0429
Brugia malayi Tubulin gamma chain 0.0061 0.0802 0.08
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0507 0.101
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0141 0.0139
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0432 0.0429
Trypanosoma cruzi alpha tubulin, putative 0.0061 0.0802 0.1525
Trichomonas vaginalis tubulin gamma chain, putative 0.0061 0.0802 0.1548
Trichomonas vaginalis tubulin epsilon chain, putative 0.0026 0.0281 0.0543
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0172 0.017
Trypanosoma brucei tubulin gamma chain 0.0061 0.0802 0.1682
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0011 0.0009
Echinococcus multilocularis tubulin alpha 1C chain 0.0061 0.0802 0.08
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.059 0.09
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0034 0.0401 0.0398
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0037 0.0448 0.0704
Leishmania major alpha tubulin 0.0061 0.0802 0.1525
Loa Loa (eye worm) acetylcholinesterase 1 0.0082 0.112 0.1117
Loa Loa (eye worm) hypothetical protein 0.0017 0.0141 0.0139
Brugia malayi nuclear receptor NHR-88 0.0017 0.0141 0.0139
Trypanosoma cruzi DNA polymerase kappa, putative 0.0049 0.0626 0.1118
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.0144 0.0016
Schistosoma mansoni DNA helicase recq1 0.0034 0.0401 0.0398
Schistosoma mansoni blooms syndrome DNA helicase 0.0032 0.0364 0.0361
Plasmodium vivax tubulin epsilon chain, putative 0.0061 0.0802 0.154
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0432 0.0429
Entamoeba histolytica tubulin family protein 0.0061 0.0802 0.132
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.035 0.518 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0014 0.0091 0.0089
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0041 0.0038
Schistosoma mansoni thyroid hormone receptor 0.0187 0.2714 0.2712
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0034 0.0401 0.0398
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0535 0.0533
Loa Loa (eye worm) carboxylesterase 0.0014 0.0091 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0626 0.1282
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0141 0.0139
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0432 0.0429
Loa Loa (eye worm) hypothetical protein 0.0043 0.0535 0.0532
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Giardia lamblia Delta tubulin 0.0026 0.0281 0.0118
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.035 0.518 1
Toxoplasma gondii ABC1 family protein 0.0043 0.0535 0.1032
Trypanosoma brucei beta tubulin 0.0061 0.0802 0.1682
Plasmodium falciparum alpha tubulin 1 0.0061 0.0802 0.1368
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0655 0.1199
Leishmania major alpha tubulin 0.0061 0.0802 0.1525
Onchocerca volvulus 0.0043 0.0535 0.1168
Onchocerca volvulus 0.0017 0.0141 0.0132
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Loa Loa (eye worm) hypothetical protein 0.0036 0.0432 0.0429
Brugia malayi beta-lactamase family protein 0.0043 0.0535 0.0532
Loa Loa (eye worm) hypothetical protein 0.0014 0.0091 0.0089
Entamoeba histolytica tubulin gamma chain 0.0061 0.0802 0.132
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0432 0.0429
Giardia lamblia Alpha-tubulin 0.0061 0.0802 0.1168
Loa Loa (eye worm) hypothetical protein 0.0017 0.0147 0.0144
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0535 0.0533
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Loa Loa (eye worm) tubulin beta-4 chain 0.0061 0.0802 0.08
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0141 0.0139
Echinococcus multilocularis bloom syndrome protein 0.0049 0.0628 0.0626
Loa Loa (eye worm) hypothetical protein 0.0043 0.0535 0.0532
Leishmania major alpha tubulin 0.0061 0.0802 0.1525
Echinococcus granulosus histone acetyltransferase KAT2B 0.0169 0.2436 0.2434
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0017 0.0147 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0432 0.0429
Trichomonas vaginalis tubulin gamma chain, putative 0.0061 0.0802 0.1548
Echinococcus granulosus beta tubulin 0.0061 0.0802 0.08
Leishmania major epsilon tubulin, putative 0.0061 0.0802 0.1525
Mycobacterium tuberculosis Conserved protein 0.0043 0.0535 0.0533
Schistosoma mansoni alpha tubulin 0.0061 0.0802 0.08
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0141 0.0139
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0144 0.0185
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0141 0.0139
Brugia malayi tubulin alpha-2 chain 0.0061 0.0802 0.08
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0223 0.043
Loa Loa (eye worm) hypothetical protein 0.0043 0.0535 0.0532
Echinococcus granulosus tubulin alpha 3 chain 0.0061 0.0802 0.08
Onchocerca volvulus 0.0034 0.0403 0.082
Trypanosoma brucei alpha tubulin 0.0061 0.0802 0.1682
Loa Loa (eye worm) hypothetical protein 0.0017 0.0141 0.0139
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Leishmania major alpha tubulin 0.0061 0.0802 0.1525
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0017 0.0147 0.0005
Echinococcus multilocularis vesicular acetylcholine transporter 0.0265 0.389 0.3888
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0432 0.0429
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0303 0.4457 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0061 0.0802 0.08
Loa Loa (eye worm) tubulin beta-1 chain 0.0061 0.0802 0.08
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0172 0.017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0535 0.0532
Echinococcus granulosus tubulin alpha chain 0.0061 0.0802 0.08
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.0091 0.0089
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0535 0.0905
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1652 0.165
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0043 0.004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0223 0.0182
Leishmania major beta tubulin 0.0061 0.0802 0.1525
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0172 0.017
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0141 0.0139
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0011 0.0009
Trypanosoma brucei DNA polymerase IV, putative 0.0049 0.0626 0.1282
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0223 0.022
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0141 0.0139
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0141 0.0139
Trichomonas vaginalis DNA helicase recq, putative 0.0049 0.0628 0.1213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0172 0.017
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.112 0.1117
Entamoeba histolytica recQ family helicase, putative 0.0037 0.0448 0.0618
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0626 0.1282
Loa Loa (eye worm) carboxylesterase 0.0014 0.0091 0.0089
Loa Loa (eye worm) alpha-tubulin 0.0061 0.0802 0.08
Trypanosoma brucei alpha tubulin 0.0061 0.0802 0.1682
Brugia malayi acetyltransferase, GNAT family protein 0.0174 0.2509 0.2507
Loa Loa (eye worm) hypothetical protein 0.0017 0.0144 0.0142
Loa Loa (eye worm) dihydrofolate reductase 0.0669 1 1
Trypanosoma brucei tubulin delta chain 0.0026 0.0281 0.0497
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0172 0.017
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.059 0.0741
Leishmania major gamma-tubulin 0.0061 0.0802 0.1525
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0432 0.0429
Echinococcus granulosus acetylcholinesterase 0.0082 0.112 0.1117
Trypanosoma brucei epsilon tubulin 0.0061 0.0802 0.1682
Plasmodium vivax delta tubulin, putative 0.0026 0.0281 0.0336
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0141 0.0139
Echinococcus granulosus tubulin gamma 1 chain 0.0061 0.0802 0.08

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 9.01 uM Inhibition of AChE (unknown origin) by Ellman method ChEMBL. 17822295
IC50 (binding) = 9.01 uM Inhibition of AChE (unknown origin) by Ellman method ChEMBL. 17822295

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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