Detailed information for compound 504635

Basic information

Technical information
  • TDR Targets ID: 504635
  • Name: [(3R)-3-[5-chloro-N-(4-chlorophenyl)sulfonyl- 2-(hydroxymethyl)anilino]butyl] N-(3-imidazol -1-ylpropyl)carbamate
  • MW: 555.474 | Formula: C24H28Cl2N4O5S
  • H donors: 2 H acceptors: 5 LogP: 3.58 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCc1ccc(cc1N(S(=O)(=O)c1ccc(cc1)Cl)[C@@H](CCOC(=O)NCCCn1ccnc1)C)Cl
  • InChi: 1S/C24H28Cl2N4O5S/c1-18(9-14-35-24(32)28-10-2-12-29-13-11-27-17-29)30(23-15-21(26)4-3-19(23)16-31)36(33,34)22-7-5-20(25)6-8-22/h3-8,11,13,15,17-18,31H,2,9-10,12,14,16H2,1H3,(H,28,32)/t18-/m1/s1
  • InChiKey: XGXYZPGKHOYPJR-GOSISDBHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-(1-imidazolyl)propyl]carbamic acid [(3R)-3-[5-chloro-N-(4-chlorophenyl)sulfonyl-2-(hydroxymethyl)anilino]butyl] ester
  • [(3R)-3-[[5-chloro-2-(hydroxymethyl)phenyl]-(4-chlorophenyl)sulfonyl-amino]butyl] N-(3-imidazol-1-ylpropyl)carbamate
  • N-(3-imidazol-1-ylpropyl)carbamic acid [(3R)-3-(5-chloro-N-(4-chlorophenyl)sulfonyl-2-methylol-anilino)butyl] ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APH1B gamma secretase subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis gamma secretase subunit aph 1 Get druggable targets OG5_130831 All targets in OG5_130831
Loa Loa (eye worm) gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Schistosoma mansoni gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Brugia malayi gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Echinococcus granulosus gamma secretase subunit aph 1 Get druggable targets OG5_130831 All targets in OG5_130831
Schistosoma japonicum ko:K06172 anterior pharynx defective 1, putative Get druggable targets OG5_130831 All targets in OG5_130831
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0026 0.0384 0.2634
Mycobacterium leprae Possible regulatory protein 0.0013 0.0069 0.0153
Brugia malayi hypothetical protein 0.0026 0.0384 0.056
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0821 0.1072
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0069 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0782 0.308
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0146 0.014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.7075 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0224 0.255
Trypanosoma cruzi Aph-1 protein, putative 0.0115 0.2524 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0168 0.0656
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0861 0.113
Echinococcus multilocularis thyroid hormone receptor alpha 0.0142 0.316 0.3158
Onchocerca volvulus 0.0013 0.0069 0.0112
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0384 0.1503
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0006 0.0004
Brugia malayi Cell death protein 3 precursor 0.0089 0.1893 0.2757
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.1232 0.9672
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0006 0.0009
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1274 0.1269
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.1407 0.5567
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0115 0.011
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0472 0.0684
Brugia malayi DnaJ domain containing protein 0.0064 0.1287 0.1875
Echinococcus granulosus dna polymerase kappa 0.0043 0.0782 0.0779
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.1274 0.1271
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0782 0.308
Brugia malayi gamma-secretase subunit aph-1 0.0296 0.6865 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0224 0.0221
Schistosoma mansoni caspase-7 (C14 family) 0.0089 0.1893 0.1888
Loa Loa (eye worm) CYP4Cod1 0.002 0.0238 0.0343
Trypanosoma cruzi Aph-1 protein, putative 0.0115 0.2524 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0238 0.0333
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.3384 0.3382
Schistosoma mansoni hypothetical protein 0.0426 1 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0019 0.0063
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.1407 0.5562
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0782 0.308
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0146 0.0208
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0019 0.0051
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0073 0.0265
Trypanosoma brucei cytochrome P450, putative 0.002 0.0238 0.0934
Leishmania major DNA polymerase eta, putative 0.0015 0.0115 0.0696
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0115 0.0113
Schistosoma mansoni tyrosine kinase 0.0103 0.2236 0.2231
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0146 0.014
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0249 0.1661
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0006 0.0009
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.1274 0.9045
Mycobacterium ulcerans glutaminase 0.0285 0.6601 1
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.0785 0.0782
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0146 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0006 0.0009
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0655 0.0954
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0146 0.014
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0249 0.0363
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0006 0.0003
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0146 0.0143
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0238 0.0343
Loa Loa (eye worm) hypothetical protein 0.0013 0.0073 0.0102
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0612 0.0887
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0224 0.0221
Schistosoma mansoni caspase-7 (C14 family) 0.0122 0.2683 0.2679
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0782 0.3088
Brugia malayi nuclear hormone receptor 0.0011 0.0006 0.0009
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0971 0.0966
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.1274 0.1271
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0782 0.1016
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0224 0.5
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0073 0.0005
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0249 0.0246
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.1407 0.5562
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0006 0.0009
Echinococcus multilocularis epidermal growth factor receptor 0.0103 0.2236 0.2233
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0247 0.0244
Loa Loa (eye worm) cytochrome P450 0.0011 0.0019 0.0023
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0249 0.0037
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.3624 0.3622
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0238 0.0343
Brugia malayi cytochrome P450 0.0011 0.0019 0.0027
Brugia malayi Cytochrome P450 family protein 0.002 0.0238 0.0347
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.1274 1
Brugia malayi jmjC domain containing protein 0.0016 0.0146 0.0212
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0249 0.0246
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0247 0.0244
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0019 0.0051
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0006 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0861 0.113
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.3624 0.5276
Echinococcus multilocularis transcription factor Dp 1 0.004 0.071 0.0707
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0019 0.0016
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0238 0.0923
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0612 0.2406
Schistosoma mansoni cpg binding protein 0.0032 0.0513 0.0508
Loa Loa (eye worm) hypothetical protein 0.0021 0.0247 0.0355
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0224 0.022
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0612 0.4273
Loa Loa (eye worm) hypothetical protein 0.0016 0.0146 0.0208
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.1407 0.1981
Schistosoma mansoni loxhd1 0.0021 0.0247 0.0241
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0612 0.0774
Echinococcus granulosus dna polymerase eta 0.0015 0.0115 0.0113
Loa Loa (eye worm) DnaJ domain-containing protein 0.0064 0.1287 0.1872
Brugia malayi ecdysteroid receptor 0.0011 0.0006 0.0009
Schistosoma mansoni tyrosine kinase 0.0103 0.2236 0.2231
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0612 0.0857
Trypanosoma brucei Metacaspase-4 0.0046 0.0861 0.3404
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.3624 0.3622
Plasmodium vivax JmjC domain containing protein 0.0016 0.0146 0.1635
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0046 0.0861 0.1254
Echinococcus granulosus gamma secretase subunit aph 1 0.0296 0.6865 0.6864
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0975 0.1416
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0073 0.0265
Onchocerca volvulus 0.0043 0.0785 0.1367
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.7075 1
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0296 0.6865 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0073 0.0005
Echinococcus granulosus bloom syndrome protein 0.0021 0.0249 0.0246
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0531 0.2097
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0073 0.0389
Brugia malayi steroid hormone receptor 0.0011 0.0006 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1274 0.1907
Leishmania major cytochrome p450-like protein 0.002 0.0238 0.1582
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0249 0.1448
Schistosoma mansoni DNA helicase recq5 0.0021 0.0249 0.0244
Brugia malayi jmjC domain containing protein 0.0016 0.0146 0.0212
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0146 0.014
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0115 0.0446
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.1407 0.1404
Brugia malayi hypothetical protein 0.0021 0.0247 0.0359
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0612 0.0774
Loa Loa (eye worm) hypothetical protein 0.0043 0.0785 0.114
Echinococcus granulosus caspase 3 0.0076 0.1575 0.1572
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0516 0.0511
Echinococcus granulosus caspase 0.0122 0.2683 0.2681
Brugia malayi hypoxia-induced factor 1 0.0157 0.3525 0.5134
Schistosoma mansoni ap endonuclease 0.002 0.0224 0.0218
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0516 0.4026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.1306 0.1301
Echinococcus multilocularis caspase 3 0.0076 0.1575 0.1572
Plasmodium vivax metacaspase 1, putative 0.0046 0.0861 1
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0782 0.1159
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0782 0.3088
Echinococcus granulosus phd:f box containing protein 0.0016 0.0146 0.0143
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0004
Giardia lamblia DINP protein human, muc B family 0.0022 0.0281 0.0083
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.1407 0.1402
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0006 0.0009
Onchocerca volvulus 0.003 0.0472 0.0819
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0004
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0122 0.2683 0.2681
Schistosoma mansoni rab6-interacting 0.0021 0.0247 0.0241
Onchocerca volvulus 0.0093 0.1992 0.3485
Brugia malayi hypothetical protein 0.0017 0.016 0.0234
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0782 0.308
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0516 0.0514
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0069 0.0067
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.1407 0.1404
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0146 0.014
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0224 0.0312
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0006 0.0003
Schistosoma mansoni tyrosine kinase 0.0061 0.1219 0.1214
Echinococcus multilocularis gamma secretase subunit aph 1 0.0296 0.6865 0.6864
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0069 0.0253
Schistosoma mansoni hypothetical protein 0.0064 0.1287 0.1282
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0782 0.3088
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0384 0.4425
Leishmania major metacaspase, putative 0.0046 0.0861 0.6069
Schistosoma mansoni single-minded 0.0051 0.0971 0.0966
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.333 1
Onchocerca volvulus 0.0032 0.0516 0.0896
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0069 0.0253
Giardia lamblia Fructose-bisphosphate aldolase 0.0305 0.7075 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0782 0.1016
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0146 0.0555
Schistosoma mansoni tyrosine kinase 0.0103 0.2236 0.2231
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0006 0.0009
Trypanosoma cruzi metacaspase, putative 0.0046 0.0861 0.3396
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0249 0.192
Echinococcus multilocularis caspase 2 0.0089 0.1893 0.1891
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0861 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0782 0.3088
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0073 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0782 0.3088
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1274 0.1269
Loa Loa (eye worm) acetyltransferase 0.0151 0.3384 0.4927
Brugia malayi Pre-SET motif family protein 0.0032 0.0516 0.0752
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0249 0.0363
Trichomonas vaginalis set domain proteins, putative 0.0247 0.5703 0.8041
Schistosoma mansoni tyrosine kinase 0.0061 0.1219 0.1214
Schistosoma mansoni tyrosine kinase 0.0103 0.2236 0.2231
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0146 0.0208
Schistosoma mansoni ap endonuclease 0.002 0.0224 0.0218
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.1287 0.1926
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0073 0.0095
Brugia malayi jmjC domain containing protein 0.0063 0.1267 0.1846
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0861 0.113
Echinococcus multilocularis epidermal growth factor receptor 0.0193 0.4397 0.4395
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0036 0.0033
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0516 0.0514
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0732 0.0741
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0146 0.0567
Onchocerca volvulus 0.0247 0.5703 1
Plasmodium vivax SET domain protein, putative 0.0032 0.0516 0.597
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0006 0.0003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0006 0.0003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0861 0.113
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0146 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0782 0.3088
Echinococcus multilocularis dnaJ subfamily B 0.0426 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.1267 0.1262
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0247 0.1412
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0612 0.0609
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0612 0.0774
Echinococcus multilocularis RUN 0.0021 0.0247 0.0244
Loa Loa (eye worm) hypothetical protein 0.0026 0.0384 0.0556
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0861 0.3396
Echinococcus granulosus RUN 0.0021 0.0247 0.0244
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0616 0.2433
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0281 0.1887
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0061 0.1219 0.1216
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0612 0.0609
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0249 0.0246
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0073 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0006 0.0004
Loa Loa (eye worm) TK/EGFR protein kinase 0.0193 0.4397 0.6403
Trichomonas vaginalis protein kinase inhibitor, putative 0.0064 0.1287 0.1738
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1274 0.1907
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0281 0.0791
Plasmodium falciparum metacaspase-like protein 0.0046 0.0861 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0069 0.0366
Echinococcus multilocularis dnaJ subfamily C 6 0.0064 0.1287 0.1285
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0115 0.0164
Trypanosoma cruzi metacaspase, putative 0.0046 0.0861 0.3396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.7075 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.3282 0.328
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0821 0.9528
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0103 0.2236 0.2233
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.7075 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0006 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0006 0.0009
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0046 0.0861 0.0856
Brugia malayi glutaminase DH11.1 0.0285 0.6601 0.9615
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0073 0.0106
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.7075 1
Schistosoma mansoni tyrosine kinase 0.0103 0.2236 0.2231
Trypanosoma brucei metacaspase MCA3 0.0046 0.0861 0.3404
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.1407 0.2049
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0146 0.1103
Treponema pallidum fructose-bisphosphate aldolase 0.0305 0.7075 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0861 0.113
Onchocerca volvulus 0.0021 0.0247 0.0423
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0004
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0861 0.113
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0006 0.0003
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0006 0.0003
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0146 0.0143
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0004
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0384 0.1503
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0861 0.113
Onchocerca volvulus Cell death protein 3 homolog 0.0089 0.1893 0.3313
Schistosoma mansoni cpg binding protein 0.0032 0.0513 0.0508
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0122 0.2683 0.2681
Loa Loa (eye worm) hypothetical protein 0.0089 0.1893 0.2754
Schistosoma mansoni jumonji domain containing protein 0.0061 0.1226 0.1221
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0115 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0782 0.3088
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0115 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0861 0.113
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0249 0.0257
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.1136 0.1133
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0249 0.0977
Plasmodium falciparum metacaspase 1 0.0046 0.0861 1
Echinococcus granulosus caspase 8 0.0046 0.0861 0.0858
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.7075 1
Loa Loa (eye worm) RecQ helicase 0.0021 0.0249 0.0359
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0006 0.0009
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.1407 0.2045
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0036 0.0033
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0247 0.0355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0006 0.0004
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0516 0.0514
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0516 0.0511
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.3384 0.338
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0224 0.0326
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0732 0.8191
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.3384 0.4929
Echinococcus granulosus epidermal growth factor receptor 0.0103 0.2236 0.2233
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.1287 0.1282
Onchocerca volvulus 0.0038 0.0655 0.1139
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0612 0.0857
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0019 0.0051
Schistosoma mansoni hypothetical protein 0.0011 0.0019 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0006 0.0004
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0115 0.0155
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.2907 0.2905
Schistosoma mansoni DNA polymerase eta 0.0015 0.0115 0.011
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0115 0.011
Schistosoma mansoni alpha glucosidase 0.0036 0.0612 0.0606
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0224 0.1478
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0187 0.0184
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.1287 0.9137
Schistosoma mansoni DNA helicase recq1 0.0021 0.0249 0.0244
Loa Loa (eye worm) TK/INSR protein kinase 0.0061 0.1219 0.1772
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0612 0.0774
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0249 0.0363
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.1136 0.1133
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0006 0.0003
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.0785 0.0782
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0861 0.113
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0146 0.0143
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.2907 0.2905
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0782 0.0779
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0224 0.0877
Schistosoma mansoni hypothetical protein 0.0012 0.0036 0.003
Onchocerca volvulus 0.0021 0.0247 0.0423
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0073 0.0005
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.3624 0.5278
Brugia malayi Doublecortin family protein 0.0021 0.0247 0.0359
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.1287 0.1284
Leishmania major DNA polymerase kappa, putative 0.0022 0.0281 0.1887
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0019 0.0102
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0069 0.0067
Brugia malayi Protein kinase domain containing protein 0.0061 0.1219 0.1775
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0115 0.0435
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.7075 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0249 0.0967
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0861 0.6743
Brugia malayi polk-prov protein 0.0032 0.0531 0.0774
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0531 0.2097
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0782 0.3088
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0168 0.0656
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0247 0.0244
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0006 0.0009
Schistosoma mansoni glutaminase 0.0285 0.6601 0.6599
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0655 0.0652
Leishmania major protein kinase, putative 0.0013 0.0069 0.0366
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.1226 0.1224
Brugia malayi jmjC domain containing protein 0.0061 0.1226 0.1786
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0612 0.2406
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0187 0.0184
Toxoplasma gondii exonuclease III APE 0.002 0.0224 0.172
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0249 0.1448
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0249 0.0257
Schistosoma mansoni polycystin 1-related 0.0021 0.0247 0.0241
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0384 0.3335
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0612 0.0774
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.1287 0.1284
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1274 0.1907
Echinococcus granulosus single minded 2 0.0038 0.0655 0.0652
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0655 0.0966
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.333 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.1267 0.1262
Brugia malayi jmjC domain containing protein 0.0016 0.0146 0.0212
Echinococcus granulosus cpg binding protein 0.0032 0.0513 0.0511
Trypanosoma brucei metacaspase 0.0046 0.0861 0.3404
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0247 0.0244
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0821 0.0818
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0821 0.6425
Brugia malayi Furin-like cysteine rich region family protein 0.0193 0.4397 0.6404
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0249 0.192
Loa Loa (eye worm) hypothetical protein 0.0032 0.0531 0.077
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0073 0.0005
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0861 0.3396
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0861 0.6743
Schistosoma mansoni thyroid hormone receptor 0.0142 0.316 0.3156
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0006 0.0003
Brugia malayi hypothetical protein 0.0043 0.0785 0.1143
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0238 0.0923
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0073 0.0277
Loa Loa (eye worm) glutaminase 0.0285 0.6601 0.9615
Schistosoma mansoni hypothetical protein 0.0043 0.0785 0.078
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0224 0.0866
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.1287 0.1874
Schistosoma mansoni alpha-glucosidase 0.0139 0.3085 0.3081
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0224 0.0309
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0249 0.0344
Schistosoma mansoni cpg binding protein 0.003 0.0472 0.0467
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0004
Brugia malayi CXXC zinc finger family protein 0.003 0.0472 0.0688
Schistosoma mansoni hypothetical protein 0.0131 0.2907 0.2903
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0516 0.0511
Echinococcus multilocularis insulin receptor 0.0061 0.1219 0.1216
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0782 0.3088
Loa Loa (eye worm) hypoxia-induced factor 1 0.0157 0.3525 0.5132
Trypanosoma brucei metacaspase MCA2 0.0046 0.0861 0.3404
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.7075 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0782 0.3088
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0146 0.0208
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0249 0.0257
Echinococcus multilocularis 0.0011 0.0019 0.0016
Echinococcus granulosus epidermal growth factor receptor 0.0193 0.4397 0.4395
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0146 0.0555
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.333 0.503
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0073 0.0117
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0384 0.1513
Brugia malayi Cytochrome P450 family protein 0.002 0.0238 0.0347
Brugia malayi nuclear receptor NHR-88 0.0011 0.0006 0.0009
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.7075 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0004
Echinococcus granulosus dnaJ subfamily C 6 0.0064 0.1287 0.1285
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0247 0.0244
Loa Loa (eye worm) hypothetical protein 0.0015 0.0115 0.0164
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0006 0.0003
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0612 0.4778
Echinococcus multilocularis dna polymerase eta 0.0015 0.0115 0.0113
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0224 0.0866
Schistosoma mansoni lipoxygenase 0.0058 0.1136 0.1131
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.3624 0.3622
Trypanosoma brucei unspecified product 0.0036 0.0616 0.2433
Loa Loa (eye worm) hypothetical protein 0.017 0.3841 0.5594
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0612 0.0774
Echinococcus multilocularis caspase 8 0.0046 0.0861 0.0858
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0168 0.0656
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0006 0.0003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0861 0.113
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0031 0.0195
Loa Loa (eye worm) hypothetical protein 0.0013 0.0069 0.0097
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0861 0.113
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0006 0.0009
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.1093 0.1589
Loa Loa (eye worm) hypothetical protein 0.0046 0.0861 0.125
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0146 0.0143
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0612 0.0774
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0224 0.1094
Brugia malayi PAS domain containing protein 0.0051 0.0971 0.1415
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0861 0.113
Schistosoma mansoni lipoxygenase 0.0021 0.0247 0.0241
Brugia malayi Cytochrome P450 family protein 0.0011 0.0019 0.0027
Schistosoma mansoni cytochrome P450 0.0011 0.0019 0.0013
Schistosoma mansoni alpha-glucosidase 0.0139 0.3085 0.3081
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0006 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0146 0.0208
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0006 0.0003
Loa Loa (eye worm) glutaminase 2 0.0285 0.6601 0.9615
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0115 0.0113
Echinococcus multilocularis caspase 0.0122 0.2683 0.2681
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.7075 1
Trypanosoma brucei glucosidase, putative 0.0036 0.0612 0.2415
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0006 0.0004
Brugia malayi jmjC domain containing protein 0.0016 0.0146 0.0212
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0224 0.0309
Schistosoma mansoni thyroid hormone receptor 0.0142 0.316 0.3156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0249 0.0359
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0861 0.6743
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0006 0.0009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0006 0.0003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0224 0.0322
Echinococcus multilocularis cpg binding protein 0.0032 0.0513 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0006 0.0009
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0006 0.0004
Schistosoma mansoni caspase-3 (C14 family) 0.0122 0.2683 0.2679
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0281 0.1102
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0612 0.0774
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0073 0.0005
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0249 0.0359
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0006 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0861 0.113
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0069 0.0067
Loa Loa (eye worm) hypothetical protein 0.0021 0.0247 0.0355
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0004
Trypanosoma cruzi metacaspase, putative 0.0046 0.0861 0.3396
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0073 0.0005
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0224 0.022
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0612 0.0891
Schistosoma mansoni gamma-secretase subunit aph-1 0.0296 0.6865 0.6864
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0069 0.5
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.1226 0.1224
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.1287 0.383
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0069 0.0067
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0006 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0782 0.3088
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0384 0.2984
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.1226 0.1224
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0004
Trichomonas vaginalis glutaminase, putative 0.0285 0.6601 0.9324
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0821 0.1072
Leishmania major hypothetical protein, conserved 0.0016 0.0146 0.0915
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0146 0.1103
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0069 0.0253
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0006 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0516 0.0511
Brugia malayi Cytochrome P450 family protein 0.0051 0.0975 0.142
Schistosoma mansoni hypothetical protein 0.0021 0.0247 0.0241
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.1407 1
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.1267 0.1265
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0384 0.3335
Leishmania major protein kinase, putative 0.0013 0.0069 0.0366
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0069 0.0253
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0146 0.0143
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0249 0.0246
Schistosoma mansoni rab6-interacting 0.0021 0.0247 0.0241
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0782 0.1159
Echinococcus multilocularis 0.006 0.1198 0.1196
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0732 0.1027
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0146 0.0208
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0115 0.0292
Echinococcus granulosus transcription factor Dp 1 0.004 0.071 0.0707
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.4982 0.7256
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0821 0.6425
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0069 0.0253
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0069 0.0253
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0061 0.1219 0.1216
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0224 0.062
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0861 0.113
Trypanosoma brucei Aph-1 protein, putative 0.0115 0.2524 1
Trypanosoma cruzi metacaspase, putative 0.0046 0.0861 0.3396
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0861 0.113
Trypanosoma brucei metacaspase 5, putative 0.0046 0.0861 0.3404
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0473 0.047
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.1267 0.1842
Echinococcus granulosus insulin receptor 0.0061 0.1219 0.1216
Brugia malayi Pre-SET motif family protein 0.0217 0.4982 0.7257
Brugia malayi hypothetical protein 0.0021 0.0247 0.0359
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0247 0.0244
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0612 0.0774
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.1287 0.1926
Schistosoma mansoni tyrosine kinase 0.0193 0.4397 0.4393
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.1274 0.3791
Brugia malayi hypothetical protein 0.017 0.3841 0.5595
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0247 0.2817
Loa Loa (eye worm) hypothetical protein 0.0032 0.0516 0.0748
Echinococcus granulosus caspase 2 0.0089 0.1893 0.1891
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0249 0.0246

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.7 nM Inhibition of gamma secretase in human H4 cells assessed as reduction in amyloid beta40 level by ELISA ChEMBL. 18178084
IC50 (binding) = 7.7 nM Inhibition of gamma secretase in human H4 cells assessed as reduction in amyloid beta40 level by ELISA ChEMBL. 18178084

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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