Detailed information for compound 504712

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 391.916 | Formula: C22H18ClN3S
  • H donors: 0 H acceptors: 2 LogP: 5.65 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccccc1c1nnc(n1Cc1ccccc1)SCc1ccccc1
  • InChi: 1S/C22H18ClN3S/c23-20-14-8-7-13-19(20)21-24-25-22(27-16-18-11-5-2-6-12-18)26(21)15-17-9-3-1-4-10-17/h1-14H,15-16H2
  • InChiKey: UOSATTILCDLWAY-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii aldehyde dehydrogenase 0.013 0.0789 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.008 0.2855
Brugia malayi hypoxia-induced factor 1 0.0146 0.0898 0.0981
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.0088
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0058 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0148 0.0932
Schistosoma mansoni voltage-gated potassium channel 0.0086 0.0495 0.0622
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0185
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0041 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0264 0.1685 0.1851
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0022 0.0028
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0789 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0041 0.0248
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0022 0.0014
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0058 0.0474
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0013 0.0155
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.005 0.0064
Echinococcus granulosus mitogen activated protein kinase 11 0.0123 0.0744 0.0951
Echinococcus multilocularis ecdysone induced protein 78C 0.0264 0.1685 0.2447
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0044
Schistosoma mansoni ap endonuclease 0.0018 0.0038 0.0037
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.008 0.0983
Echinococcus multilocularis GPCR, family 2 0.0034 0.0142 0.0206
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0021 0.0058 0.0474
Leishmania major DNA polymerase eta, putative 0.0019 0.0041 0.0432
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.011 0.0129
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0013 0.0006
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.011 0.0652 0.0719
Brugia malayi Thioredoxin reductase 0.0046 0.0224 0.0237
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0079 0.0446 0.0648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0073 0.0415
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0013 0.0084
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.0226 0.3016
Leishmania major cytochrome p450-like protein 0.0021 0.0058 0.0654
Schistosoma mansoni nuclear hormone receptor 0.0124 0.075 0.0949
Leishmania major hypothetical protein, conserved 0.0024 0.008 0.0925
Schistosoma mansoni hypothetical protein 0.0021 0.0058 0.0063
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0022 0.0017
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0058 0.0761
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0022 0.0271
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0009 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0264 0.1685 0.1851
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.0226 0.2966
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0058 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0208 0.1347
Brugia malayi nuclear receptor NHR-88 0.0124 0.075 0.0818
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.008 0.328
Echinococcus multilocularis mitogen activated protein kinase 14 0.0123 0.0744 0.108
Echinococcus granulosus Nuclear hormone receptor HR96 0.0124 0.075 0.0959
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0124 0.075 0.1089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0089 0.0519
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0022 0.0059
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.008 0.1047
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0789 1
Onchocerca volvulus 0.0035 0.015 0.0141
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0022 0.0201
Schistosoma mansoni nuclear hormone receptor 0.0124 0.075 0.0949
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0264 0.1685 0.1851
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0619 0.7781
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0139 0.085 0.1087
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0264 0.1685 0.2145
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.013 0.0789 0.1146
Loa Loa (eye worm) hypothetical protein 0.0264 0.1685 0.1859
Brugia malayi hypothetical protein 0.0042 0.0199 0.021
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0224 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0199 0.0254
Echinococcus granulosus FTZ F1 alpha 0.0264 0.1685 0.2154
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0226 0.1466
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0038 0.0484
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0041 0.0527
Brugia malayi hypothetical protein 0.0139 0.085 0.0929
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.013 0.0789 0.1009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0264 0.1685 0.1851
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0046 0.0226 0.0277
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0009 0.000000031331
Brugia malayi Doublecortin family protein 0.0042 0.0199 0.021
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0208 0.0255
Echinococcus multilocularis geminin 0.0165 0.1021 0.1482
Loa Loa (eye worm) hypothetical protein 0.0139 0.085 0.0938
Echinococcus granulosus lamin dm0 0.0026 0.0091 0.0116
Toxoplasma gondii thioredoxin reductase 0.0046 0.0224 0.276
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0527
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.008 0.0915
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0009 0.0001
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0396 0.0574
Loa Loa (eye worm) hypothetical protein 0.0124 0.075 0.0828
Schistosoma mansoni hypothetical protein 0.0034 0.0142 0.0171
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0022 0.0189
Echinococcus multilocularis lamin dm0 0.0026 0.0091 0.0132
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.011 0.0652 0.8752
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.004 0.0044
Leishmania major DNA polymerase kappa, putative 0.0019 0.0041 0.0432
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0264 0.1685 0.2145
Echinococcus multilocularis mitogen activated protein kinase 11 0.0123 0.0744 0.108
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0208 0.2783
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0142 0.0157
Giardia lamblia GTOR 0.0044 0.0208 0.296
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.004 0.0051
Schistosoma mansoni lipoxygenase 0.0118 0.071 0.0897
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0124 0.075 0.0828
Giardia lamblia Kinase, CMGC MAPK 0.011 0.0652 1
Entamoeba histolytica hypothetical protein 0.0035 0.015 0.5968
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.0502 0.0631
Brugia malayi ecdysone receptor 0.0124 0.075 0.0818
Loa Loa (eye worm) hypothetical protein 0.0264 0.1685 0.1859
Schistosoma mansoni RAR-like nuclear receptor 0.0264 0.1685 0.2145
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0038 0.1333
Echinococcus multilocularis fatty acid binding protein FABP2 0.0148 0.0909 0.1319
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0058 0.0474
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.0199 0.8846
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.011 0.0129
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0021 0.0058 0.0474
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0079 0.0446 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.009 0.0531
Schistosoma mansoni nuclear receptor 0.0124 0.075 0.0949
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.004 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0058 0.0474
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0022 0.0201
Brugia malayi nuclear hormone receptor family member nhr-6 0.0124 0.075 0.0818
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0079 0.0446 0.0483
Mycobacterium ulcerans putative regulatory protein 0.0035 0.015 0.1669
Brugia malayi nuclear hormone receptor family member odr-7 0.0124 0.075 0.0818
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0021 0.0058 0.0474
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0038 0.0168
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0037 0.0764
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0124 0.075 0.0959
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0022 0.0201
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0023 0.0069 0.01
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.008 0.2855
Schistosoma mansoni nuclear hormone receptor 0.0264 0.1685 0.2145
Schistosoma mansoni hypothetical protein 0.0034 0.0142 0.0171
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0013 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0264 0.1685 0.1851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0073 0.0413
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0016 0.002 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0022 0.0201
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0224 0.0286
Brugia malayi hypothetical protein 0.0019 0.004 0.0035
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0038 0.0415
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0058 0.0695
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0527
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0021 0.0058 0.0474
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0016 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0044
Schistosoma mansoni hypothetical protein 0.0035 0.015 0.018
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0058 0.0075
Echinococcus granulosus retinoic acid receptor rxr beta a 0.1178 0.7823 1
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0087 0.0502 0.0728
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0013 0.0017
Brugia malayi hypothetical protein 0.0016 0.0021 0.0014
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0058 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0133 0.0827
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.011 0.016
Loa Loa (eye worm) hypothetical protein 0.0264 0.1685 0.1859
Echinococcus multilocularis conserved hypothetical protein 0.0671 0.4419 0.6416
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0022 0.0596
Brugia malayi Nuclear hormone receptor E75 0.0124 0.075 0.0818
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0054 0.0079
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0021 0.0058 0.0474
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0022 0.5
Brugia malayi Cytochrome P450 family protein 0.004 0.0185 0.0194
Brugia malayi PAS domain containing protein 0.0047 0.0233 0.0247
Trypanosoma brucei cytochrome P450, putative 0.004 0.0185 0.2462
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0013 0.0015
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0041 0.0052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0264 0.1685 0.2154
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0022 0.0201
Schistosoma mansoni lipoxygenase 0.0042 0.0199 0.0243
Entamoeba histolytica hypothetical protein 0.0019 0.004 0.0126
Loa Loa (eye worm) hypothetical protein 0.0099 0.0577 0.0636
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0148 0.0932
Brugia malayi Nuclear hormone receptor E75 0.0124 0.075 0.0818
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0041 0.0191
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0016 0.002 0.0026
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0038 0.0251
Loa Loa (eye worm) hypothetical protein 0.0124 0.075 0.0828
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0009 0.001
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.004 0.0058
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0124 0.075 0.0949
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0142 0.0147
Echinococcus multilocularis dna polymerase eta 0.0019 0.0041 0.006
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0021 0.0058 0.0474
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.005 0.0072
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0021 0.0058 0.0474
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0021 0.0058 0.0474
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0058 0.0474
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0264 0.1685 0.1859
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0041 0.0191
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0142 0.0147
Schistosoma mansoni serine/threonine protein kinase 0.002 0.005 0.0052
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0054 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0264 0.1685 0.1859
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0199 0.0254
Giardia lamblia DINP protein human, muc B family 0.0019 0.0041 0.0302
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0633 0.0698
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0264 0.1685 0.2145
Loa Loa (eye worm) hypothetical protein 0.0139 0.085 0.0938
Brugia malayi Pre-SET motif family protein 0.0029 0.011 0.0112
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.013 0.0789 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0633 0.0698
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0022 0.0201
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0016 0.002 0.0046
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.004 0.0058
Brugia malayi hypothetical protein 0.0124 0.075 0.0818
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0208 0.023
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.004 0.0051
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0013 0.0084
Entamoeba histolytica hypothetical protein 0.0019 0.004 0.0126
Schistosoma mansoni serine/threonine protein kinase 0.002 0.005 0.0052
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0233 0.0286
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.015 0.0192
Mycobacterium tuberculosis Probable reductase 0.0105 0.0619 0.7781
Onchocerca volvulus 0.004 0.0184 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0208 0.1347
Entamoeba histolytica hypothetical protein 0.0019 0.004 0.0126
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0038 0.0055
Brugia malayi PXA domain containing protein 0.0019 0.004 0.0035
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0124 0.075 0.0818
Echinococcus granulosus intermediate filament protein 0.0026 0.0091 0.0116
Onchocerca volvulus 0.0124 0.075 0.0742
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0208 0.2572
Schistosoma mansoni axis inhibition protein axin 0.0019 0.004 0.004
Plasmodium vivax glutathione reductase, putative 0.0046 0.0224 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0016 0.002 0.0029
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0619 0.7781
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.0148 0.0909 0.1002
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0199 0.0289
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0016 0.002 0.0014
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0041 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0527
Plasmodium falciparum glutathione reductase 0.0046 0.0224 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0185
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.0226 0.1466
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.005 0.0045
Echinococcus granulosus dna polymerase kappa 0.0019 0.0041 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0264 0.1685 0.1859
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0185 0.0204
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0016 0.002 0.0014
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0016 0.002 0.0022
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0009 0.0011
Loa Loa (eye worm) RGS-3 protein 0.0019 0.004 0.0044
Loa Loa (eye worm) hypothetical protein 0.0046 0.0226 0.0249
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0021 0.0058 0.0474
Schistosoma mansoni regulator of G protein signaling 0.0019 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0122 0.0737 0.0931
Loa Loa (eye worm) DR-78 0.0124 0.075 0.0828
Loa Loa (eye worm) hypothetical protein 0.0264 0.1685 0.1859
Schistosoma mansoni retinoic acid receptor RXR 0.1178 0.7823 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.011 0.0652 0.8752
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0142 0.0206
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0041 0.0041
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.0226 0.2966
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0022 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0264 0.1685 0.1851
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0307 0.0339
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0789 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.004 0.0051
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0058 0.0474
Brugia malayi hypothetical protein 0.0042 0.0199 0.021
Schistosoma mansoni survival motor neuron protein 0.0047 0.023 0.0283
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0069 0.0077
Loa Loa (eye worm) nuclear receptor NHR-67 0.0124 0.075 0.0828
Echinococcus multilocularis mitogen activated protein kinase 14 0.0123 0.0744 0.108
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0044
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0123 0.0744 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0264 0.1685 0.2447
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0527
Schistosoma mansoni intermediate filament proteins 0.0026 0.0091 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0264 0.1685 0.1851
Brugia malayi P38 map kinase family protein 2 0.0123 0.0744 0.0811
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0041 0.0459
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0184 0.0224
Schistosoma mansoni fatty acid binding protein 0.0148 0.0909 0.1151
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0038 0.0042
Loa Loa (eye worm) nuclear hormone receptor 0.0124 0.075 0.0828
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0264 0.1685 0.1859
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0022 0.0271
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.005 0.0055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0041 0.0459
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0652 0.4409
Leishmania major cytochrome p450-like protein 0.004 0.0185 0.2267
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0091 0.01
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0022 0.0059
Loa Loa (eye worm) cytochrome P450 0.0021 0.0058 0.0064
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0021 0.0058 0.0474
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0054 0.0283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.009 0.0531
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0264 0.1685 0.2154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0148 0.0932
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.004 0.004
Schistosoma mansoni fatty acid binding protein 0.0148 0.0909 0.1151
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0208 0.022
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0124 0.075 0.0959
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0091 0.0091
Schistosoma mansoni voltage-gated potassium channel 0.0086 0.0495 0.0622
Loa Loa (eye worm) CYP4Cod1 0.004 0.0185 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0527
Schistosoma mansoni rab6-interacting 0.0042 0.0199 0.0243
Echinococcus granulosus Nuclear hormone receptor HR96 0.0124 0.075 0.0959
Brugia malayi orphan nuclear receptor NR2E1 0.0124 0.075 0.0818
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.005 0.0055
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0199 0.0289
Echinococcus granulosus microtubule associated protein 2 0.0671 0.4419 0.5649
Schistosoma mansoni hypothetical protein 0.0165 0.1021 0.1295
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.004 0.0035
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0069 0.0077
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0208 0.2783
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0021 0.0058 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0105 0.0636
Loa Loa (eye worm) hypothetical protein 0.0124 0.075 0.0828
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0208 0.1347
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0124 0.075 0.0742
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0185 0.2408
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.011 0.0652 0.8241
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0264 0.1685 0.2447
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0264 0.1685 0.2154
Echinococcus multilocularis fatty acid binding protein FABP2 0.0148 0.0909 0.1319
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0633 0.0689
Brugia malayi M-phase phosphoprotein, mpp8 0.0098 0.0576 0.0626
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.0226 0.1466
Schistosoma mansoni single-minded 0.0047 0.0233 0.0286
Loa Loa (eye worm) hypothetical protein 0.0264 0.1685 0.1859
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0037 0.0471
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.0898 0.099
Schistosoma mansoni regulator of G protein signaling 0.0019 0.004 0.004
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0041 0.0527
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0224 0.0247
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0058 0.0695
Brugia malayi hypothetical protein 0.0024 0.008 0.0078
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0038 0.0784
Loa Loa (eye worm) hypothetical protein 0.0029 0.011 0.0121
Onchocerca volvulus 0.0124 0.075 0.0742
Loa Loa (eye worm) steroid hormone receptor 0.0403 0.262 0.289
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0208 0.2572
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0038 0.0415
Schistosoma mansoni steroid hormone receptor ad4bp 0.0264 0.1685 0.2145
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0016 0.002 0.0026
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0023 0.0069 0.0088
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0046 0.0226 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0041 0.0248
Brugia malayi Uncoordinated protein 44 0.0014 0.0009 0.000000027034
Entamoeba histolytica hypothetical protein 0.0035 0.015 0.5968
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.0199 0.0254
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0058 0.0474
Brugia malayi photoreceptor-specific nuclear receptor 0.0264 0.1685 0.1851
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0633 0.0689
Echinococcus granulosus RUN 0.0042 0.0199 0.0254
Loa Loa (eye worm) hypothetical protein 0.0124 0.075 0.0828
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0074 0.0411 0.2748
Schistosoma mansoni hypothetical protein 0.0047 0.023 0.0283
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0652 0.4409
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0058 0.0474
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0124 0.075 0.1089
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0698 0.8805
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0022 0.0596
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.004 0.0058
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0123 0.0744 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0133 0.1601
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0011
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0619 0.8771
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0009 0.0011
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0046 0.0226 0.0288
Brugia malayi bHLH-PAS transcription factor 0.0035 0.015 0.0156
Echinococcus granulosus voltage gated potassium channel 0.0023 0.0069 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0264 0.1685 0.1859
Brugia malayi MAP kinase sur-1 0.011 0.0652 0.071
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0041 0.0527
Echinococcus multilocularis ubiquitin specific protease 41 0.0046 0.0226 0.0328
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0016 0.002 0.0029
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0123 0.0744 1
Brugia malayi Death domain containing protein 0.0014 0.0009 0.000000027034
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0208 0.9082
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0087 0.0502 0.0641
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0022 0.0201
Brugia malayi glutathione reductase 0.0046 0.0224 0.0237
Brugia malayi tailless protein 0.0124 0.075 0.0818
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0133 0.0827
Loa Loa (eye worm) hypothetical protein 0.0139 0.085 0.0938
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.071 0.0907
Brugia malayi nuclear hormone receptor 0.1363 0.9065 1
Schistosoma mansoni loxhd1 0.0042 0.0199 0.0243
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.004 0.0058
Brugia malayi hypothetical protein 0.0099 0.0577 0.0627
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0208 0.2732
Onchocerca volvulus 0.0098 0.0576 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0527
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0021 0.0058 0.0474
Onchocerca volvulus 0.0026 0.0091 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0264 0.1685 0.1851
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0041 0.0045
Brugia malayi hypothetical protein 0.0139 0.085 0.0929
Brugia malayi nuclear receptor RXR 0.0139 0.085 0.0929
Trypanosoma brucei unspecified product 0.0019 0.0041 0.0527
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0046 0.0226 0.3233
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0619 0.7781
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.004 0.0035
Onchocerca volvulus 0.0042 0.0199 0.019
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.004 0.0051
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0139 0.085 0.0938
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.0097
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0038 0.0391
Brugia malayi nuclear receptor RXR 0.0124 0.075 0.0818
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0264 0.1685 0.1851
Schistosoma mansoni hypothetical protein 0.0034 0.0142 0.0171
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0149 0.1978
Brugia malayi Cytochrome P450 family protein 0.0058 0.0307 0.033
Echinococcus multilocularis mitogen activated protein kinase 0.011 0.0652 0.0946
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0074 0.0411 0.2748
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0142 0.0182
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0264 0.1685 0.2145
Brugia malayi Cytochrome P450 family protein 0.0021 0.0058 0.0055
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0021 0.0058 0.0474
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0124 0.075 0.1089
Echinococcus multilocularis Ankyrin 0.0014 0.001 0.0014
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0139 0.085 0.1077
Schistosoma mansoni regulator of G protein signaling 0.0019 0.004 0.004
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0038 1
Brugia malayi nuclear receptor NHR-67 0.0124 0.075 0.0818
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0264 0.1685 0.2145
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0023 0.0069 0.0066
Schistosoma mansoni hypothetical protein 0.0034 0.0142 0.0171
Schistosoma mansoni cytochrome P450 0.0021 0.0058 0.0063
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0046 0.0226 0.2792
Echinococcus multilocularis nuclear receptor nhr 48 0.0124 0.075 0.1089
Schistosoma mansoni hypothetical protein 0.0165 0.1021 0.1295
Echinococcus granulosus GPCR family 2 0.0034 0.0142 0.0182
Echinococcus granulosus axis inhibition protein axin 0.0019 0.004 0.0051
Loa Loa (eye worm) hypothetical protein 0.1238 0.823 0.9079
Loa Loa (eye worm) hypothetical protein 0.0124 0.075 0.0828
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0058 0.0474
Loa Loa (eye worm) doublecortin family protein 0.0042 0.0199 0.0219
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0058 0.0474
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0124 0.075 0.0949
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0021 0.0058 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0112 0.068
Echinococcus multilocularis mitogen activated protein kinase 3 0.011 0.0652 0.0946
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0527
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0264 0.1685 0.1851
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.023 0.0244
Onchocerca volvulus 0.0264 0.1685 0.1678
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0264 0.1685 0.2154
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.0789 0.0999
Brugia malayi Cyclic-nucleotide gated cation channel 0.0016 0.002 0.0012
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0159 0.098 0.1081
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0022 0.0032
Brugia malayi intermediate filament protein 0.0026 0.0091 0.0091
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.004 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0073 0.0415
Loa Loa (eye worm) hypothetical protein 0.0124 0.075 0.0828
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0013 0.0079
Loa Loa (eye worm) RecQ helicase 0.0021 0.0054 0.006
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0124 0.075 0.1089
Brugia malayi nuclear hormone receptor 0.0264 0.1685 0.1851
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0058 0.0474
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.4419 0.6416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0073 0.0413
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0022 0.0178
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0264 0.1685 0.2154
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0016 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0124 0.075 0.0828
Echinococcus multilocularis mitogen activated protein kinase 11 0.0123 0.0744 0.108
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0022 0.0189
Schistosoma mansoni thyroid hormone receptor 0.0386 0.2507 0.3197
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0264 0.1685 0.2447
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0123 0.0744 0.9416
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.1038 0.6888 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0264 0.1685 0.2447
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.004 0.004
Plasmodium vivax SET domain protein, putative 0.0029 0.011 0.4694
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.011 0.0652 0.8752
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.001 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0058 0.0474
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0046 0.0226 0.0328
Schistosoma mansoni hypothetical protein 0.0161 0.0997 0.1265
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0058 0.0474
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1458 0.2117
Loa Loa (eye worm) hypothetical protein 0.0124 0.075 0.0828
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0737 0.107
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0264 0.1685 0.1851
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0038 0.0206
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0041 0.006
Entamoeba histolytica hypothetical protein 0.0035 0.015 0.5968
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0046 0.0226 0.0277
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0058 0.0474
Echinococcus granulosus thyroid hormone receptor alpha 0.0264 0.1685 0.2154
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0208 0.0303
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0527
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.013 0.0789 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0041 0.0041
Echinococcus multilocularis RUN 0.0042 0.0199 0.0289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0165 0.105
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0208 0.2732
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0133 0.0827
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0406 0.0438
Echinococcus granulosus dna polymerase eta 0.0019 0.0041 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.009 0.0531
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0021 0.0058 0.0474
Echinococcus granulosus hyperpolarization activated cyclic 0.0016 0.002 0.0026
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0009 0.0013
Onchocerca volvulus 0.023 0.1462 0.1454
Loa Loa (eye worm) hypothetical protein 0.0073 0.0406 0.0448
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0264 0.1685 0.1851
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0264 0.1685 0.1859
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0148 0.0932
Loa Loa (eye worm) hypothetical protein 0.0069 0.0376 0.0415
Brugia malayi hypothetical protein 0.0159 0.098 0.1073
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.011 0.016
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0103 0.0131
Brugia malayi Pre-SET motif family protein 0.0202 0.1273 0.1396
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0208 0.9082
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0619 0.7781
Brugia malayi hypothetical protein 0.0019 0.004 0.0035
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0652 0.4409
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0199 0.8773
Trichomonas vaginalis set domain proteins, putative 0.023 0.1461 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0041 0.0035
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0124 0.075 0.0742
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0185
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.011 0.0652 0.8239
Loa Loa (eye worm) hypothetical protein 0.0034 0.0142 0.0157
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0041 0.0432
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0054 0.0699
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0264 0.1685 0.1851
Schistosoma mansoni zinc finger protein 0.0124 0.075 0.0949
Echinococcus granulosus axis inhibition protein axin 0.0019 0.004 0.0051
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0022 0.0271
Echinococcus granulosus single minded 2 0.0042 0.0199 0.0254
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0038 0.0168
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0016 0.002 0.0026
Schistosoma mansoni coup transcription factor 0.0264 0.1685 0.2145
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.004 0.0051
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.011 0.0652 0.8241
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0652 0.0823
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0264 0.1685 0.2447
Brugia malayi Nuclear hormone receptor-like 1 0.0139 0.085 0.0929
Schistosoma mansoni hypothetical protein 0.0073 0.0406 0.0508
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0149 0.192
Brugia malayi cytochrome P450 0.0021 0.0058 0.0055
Brugia malayi conserved hypotetical protein 0.0124 0.075 0.0818
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0527
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0045
Echinococcus multilocularis thyroid hormone receptor alpha 0.0386 0.2507 0.364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0073 0.0415
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein 0.0148 0.0909 0.0993
Echinococcus granulosus mitogen activated protein kinase 3 0.011 0.0652 0.0833
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.01
Leishmania major trypanothione reductase 0.0046 0.0224 0.2768
Echinococcus granulosus geminin 0.0165 0.1021 0.1305
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.011 0.0129
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.004 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0044
Onchocerca volvulus 0.0047 0.023 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0089 0.0519
Echinococcus granulosus hypothetical protein 0.0678 0.4465 0.5708
Schistosoma mansoni axis inhibition protein axin 0.0019 0.004 0.004
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0698 1
Plasmodium falciparum thioredoxin reductase 0.0046 0.0224 1
Schistosoma mansoni nuclear receptor 0.0124 0.075 0.0949
Loa Loa (eye worm) hypothetical protein 0.0124 0.075 0.0828
Loa Loa (eye worm) hypothetical protein 0.0264 0.1685 0.1859
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0139 0.085 0.1077
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.004 0.0058
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0022 0.0201
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.015 0.0218
Loa Loa (eye worm) hypothetical protein 0.0042 0.0199 0.0219
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0046 0.0226 0.0239
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0264 0.1685 0.2145
Brugia malayi Cytochrome P450 family protein 0.004 0.0185 0.0194
Onchocerca volvulus 0.0042 0.0199 0.019
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0058 0.0474
Schistosoma mansoni nuclear receptor nhr-48 0.0124 0.075 0.0949
Loa Loa (eye worm) hypothetical protein 0.0264 0.1685 0.1859
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0041 0.0171
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.011 0.0652 0.876
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0208 0.0266
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0021 0.0058 0.0474
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0041 0.0527
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0058 0.0474
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0021 0.0058 0.0474
Loa Loa (eye worm) hypothetical protein 0.0124 0.075 0.0828
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0009 0.001
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0139 0.085 0.1234
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0123 0.0744 0.082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0073 0.0415
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0149 0.1808
Onchocerca volvulus 0.0098 0.0576 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0185
Brugia malayi Steroid receptor seven-up type 2 0.0264 0.1685 0.1851
Schistosoma mansoni ap endonuclease 0.0018 0.0038 0.0037
Echinococcus granulosus mitogen activated protein kinase 0.011 0.0652 0.0833
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.004 0.0058
Brugia malayi hypothetical protein 0.023 0.1458 0.1601
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0264 0.1685 0.1851
Leishmania major cytochrome p450-like protein 0.0021 0.0058 0.0654
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.0199 0.0289
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0021 0.0058 0.0474
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0185 0.2408
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0016 0.002 0.0014
Echinococcus multilocularis voltage gated potassium channel 0.0023 0.0069 0.01
Echinococcus granulosus ubiquitin specific protease 41 0.0046 0.0226 0.0288
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0264 0.1685 0.1859
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0041 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0133 0.0827
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0013 0.0005
Loa Loa (eye worm) hypothetical protein 0.0124 0.075 0.0828
Schistosoma mansoni thyroid hormone receptor 0.0386 0.2507 0.3197
Schistosoma mansoni regulator of G protein signaling 0.0019 0.004 0.004
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.004 0.0058
Echinococcus multilocularis musashi 0.0026 0.0091 0.0132
Echinococcus granulosus fatty acid binding protein FABP2 0.0148 0.0909 0.1161
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0038 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0058 0.0474
Loa Loa (eye worm) hypothetical protein 0.0264 0.1685 0.1859
Loa Loa (eye worm) hypothetical protein 0.0098 0.0576 0.0635
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0044
Echinococcus granulosus nuclear receptor nhr 48 0.0124 0.075 0.0959
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0698 0.8805
Brugia malayi steroid hormone receptor 0.0403 0.262 0.2883
Schistosoma mansoni serine/threonine protein kinase 0.002 0.005 0.0052
Echinococcus granulosus expressed protein 0.0363 0.2351 0.3006
Onchocerca volvulus 0.0026 0.0091 0.0082
Schistosoma mansoni polycystin 1-related 0.0042 0.0199 0.0243
Echinococcus multilocularis hyperpolarization activated cyclic 0.0016 0.002 0.0029
Brugia malayi hypothetical protein 0.0124 0.075 0.0818
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0041 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0073 0.0413
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0016 0.002 0.0022
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0079 0.0446 0.057
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.004 0.0185
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0396 0.0506
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0058 0.0474
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0185 0.0204
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0041 0.0248
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0025 0.0021
Schistosoma mansoni rab6-interacting 0.0042 0.0199 0.0243
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0619 0.7781
Brugia malayi Protein kinase domain containing protein 0.0015 0.0019 0.0011
Loa Loa (eye worm) glutathione reductase 0.0046 0.0224 0.0247
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0013 0.0155
Schistosoma mansoni hypothetical protein 0.0042 0.0199 0.0243
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0016 0.002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0133 0.0827
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.0502 0.0631
Brugia malayi PXA domain containing protein 0.0019 0.004 0.0035
Loa Loa (eye worm) hypothetical protein 0.023 0.1458 0.1609
Echinococcus granulosus lamin 0.0026 0.0091 0.0116
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0046 0.0226 0.0328
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0021 0.0058 0.0474
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0264 0.1685 0.2154
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.0789 0.0999
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0058 0.0654
Loa Loa (eye worm) hypothetical protein 0.0124 0.075 0.0828
Echinococcus granulosus ecdysone induced protein 78C 0.0264 0.1685 0.2154
Toxoplasma gondii exonuclease III APE 0.0018 0.0038 0.038
Echinococcus granulosus fatty acid binding protein FABP2 0.0148 0.0909 0.1161
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0041 0.0459
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0652 0.4409
Schistosoma mansoni regulator of G protein signaling 0.0019 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0139 0.085 0.0938
Trypanosoma brucei protein kinase, putative 0.011 0.0652 0.876
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.004 0.0051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0022 0.0201
Loa Loa (eye worm) hypothetical protein 0.0139 0.085 0.0938
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0013 0.0079
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1458 0.1864
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0224 0.0325
Echinococcus granulosus hyperpolarization activated cyclic 0.0016 0.002 0.0026
Echinococcus multilocularis lamin 0.0026 0.0091 0.0132
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.004 0.0044
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.008 0.0983
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.071 0.1031
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0224 0.2628
Schistosoma mansoni lamin 0.0026 0.0091 0.0105
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0038 0.0206
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0022 0.0189
Echinococcus granulosus mitogen activated protein kinase 14 0.0123 0.0744 0.0951
Trypanosoma brucei trypanothione reductase 0.0046 0.0224 0.299
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0016 0.002 0.0029
Brugia malayi hypothetical protein 0.0035 0.015 0.0156
Onchocerca volvulus Bile acid receptor homolog 0.0264 0.1685 0.1678
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.004 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0148 0.0932
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.011 0.1303
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.4419 0.5644
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0041 0.0459
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0021 0.0058 0.0474
Brugia malayi Nuclear hormone receptor-like 1 0.0139 0.085 0.0929
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0022 0.0271
Brugia malayi nuclear receptor NHR-88 0.0264 0.1685 0.1851
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0022 0.0178
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0737 0.0942
Echinococcus multilocularis FTZ F1 alpha 0.0264 0.1685 0.2447
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.011 0.014
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0046 0.0226 0.0288
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0041 0.0459
Echinococcus granulosus death domain containing protein 0.0014 0.0009 0.0011
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0058 0.0695
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0142 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0185
Echinococcus granulosus Ankyrin 0.0014 0.001 0.0012
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0185 0.2118
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0133 0.0827
Echinococcus multilocularis 0.0021 0.0058 0.0085
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0022
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.011 0.0652 0.8752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0133 0.0827
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0224 0.2939
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0041 0.0527
Onchocerca volvulus Protein ultraspiracle homolog 0.0264 0.1685 0.1678
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.015 0.018
Brugia malayi ecdysteroid receptor 0.0264 0.1685 0.1851
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0038 0.0032
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.004 0.0058
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.015 0.0218
Echinococcus multilocularis expressed protein 0.0363 0.2351 0.3414
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0264 0.1685 0.2447
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0038 0.0048
Loa Loa (eye worm) hypothetical protein 0.0042 0.0199 0.0219
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0142 0.0206
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.004 0.0058
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0054 0.0283
Echinococcus granulosus bloom syndrome protein 0.0021 0.0054 0.0069
Entamoeba histolytica hypothetical protein 0.0035 0.015 0.5968
Leishmania major protein kinase, putative 0.0024 0.0077 0.0897
Schistosoma mansoni lamin 0.0026 0.0091 0.0105
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0016 0.002 0.0046
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0091 0.01
Loa Loa (eye worm) nuclear receptor nhr-7B 0.1363 0.9065 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0058 0.0644
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1273 0.1405
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0698 0.8805

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 2.85 uM Antiviral activity against HIV1 in MT4 cells ChEMBL. 18083512
Selectivity index (ADMET) = 2.9 Selectivity index, ratio of EC50 for MT4 cells to EC50 for HIV1 ChEMBL. 18083512

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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