Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0117 | 0.183 | 0.1788 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.0273 | 0.0223 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0048 | 0.0565 | 0.0871 |
Brugia malayi | RNA binding protein | 0.0146 | 0.2352 | 0.467 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0118 | 0.0234 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0431 | 0.0761 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.3195 | 0.6308 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0028 | 0.0189 | 0.0138 |
Mycobacterium ulcerans | hypothetical protein | 0.018 | 0.2981 | 1 |
Mycobacterium tuberculosis | Probable thioredoxin reductase TrxB2 (TRXR) (TR) | 0.0171 | 0.2813 | 0.5926 |
Onchocerca volvulus | 0.0041 | 0.0431 | 0.0539 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.3195 | 0.6308 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.0431 | 0.0855 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.3195 | 0.6308 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0431 | 0.0855 |
Loa Loa (eye worm) | RNA binding protein | 0.0146 | 0.2352 | 0.467 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.0273 | 0.0543 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0431 | 0.0381 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0117 | 0.183 | 0.3634 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0117 | 0.183 | 0.3019 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0072 | 0.101 | 0.2271 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.0273 | 0.0223 |
Loa Loa (eye worm) | TAR-binding protein | 0.0146 | 0.2352 | 0.467 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0292 | 0.5035 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0117 | 0.183 | 0.3019 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0117 | 0.183 | 0.6441 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0189 | 0.0275 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0292 | 0.5035 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0342 | 0.5942 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0342 | 0.5942 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0342 | 0.5942 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0117 | 0.183 | 0.3568 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0431 | 0.0855 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0072 | 0.101 | 0.5388 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0202 | 0.3384 | 0.6688 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0048 | 0.0565 | 0.0871 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0431 | 0.0761 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0431 | 0.0855 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.2714 | 0.539 |
Leishmania major | phosphatidylinositol kinase related protein, putative | 0.002 | 0.0052 | 0.0001 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0028 | 0.0189 | 0.0374 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0117 | 0.183 | 0.3019 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.0273 | 0.0543 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0171 | 0.2813 | 0.554 |
Echinococcus granulosus | serine protein kinase ATM | 0.0028 | 0.0189 | 0.0138 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0431 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0117 | 0.183 | 0.3019 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0292 | 0.5035 | 1 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0028 | 0.0189 | 0.0233 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.002 | 0.0052 | 0.0102 |
Schistosoma mansoni | lamin | 0.0032 | 0.0273 | 0.0223 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0146 | 0.2352 | 0.467 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0171 | 0.2813 | 0.554 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.3195 | 0.6308 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.015 | 0.2432 | 0.2393 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0202 | 0.3384 | 0.6688 |
Brugia malayi | MAP kinase sur-1 | 0.0117 | 0.183 | 0.3634 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.0431 | 0.0855 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.018 | 0.2981 | 0.6343 |
Schistosoma mansoni | tar DNA-binding protein | 0.0146 | 0.2352 | 0.2312 |
Trypanosoma brucei | protein kinase, putative | 0.0117 | 0.183 | 0.3019 |
Brugia malayi | Muscleblind-like protein | 0.0166 | 0.2714 | 0.539 |
Brugia malayi | TAR-binding protein | 0.0146 | 0.2352 | 0.467 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0117 | 0.183 | 0.3019 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0192 | 0.3195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0262 | 0.0521 |
Echinococcus multilocularis | geminin | 0.0564 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0292 | 0.5035 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0146 | 0.2352 | 0.2312 |
Wolbachia endosymbiont of Brugia malayi | thioredoxin reductase | 0.0171 | 0.2813 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0117 | 0.183 | 0.3019 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0273 | 0.0543 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0276 | 0.4739 | 0.9411 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.0431 | 0.0855 |
Echinococcus multilocularis | tar DNA binding protein | 0.0146 | 0.2352 | 0.2312 |
Onchocerca volvulus | 0.0041 | 0.0431 | 0.0539 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0431 | 0.0761 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0292 | 0.5035 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0292 | 0.5035 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0162 | 0.2646 | 0.4405 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0171 | 0.2813 | 0.554 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0162 | 0.2652 | 0.2614 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.0028 | 0.0189 | 0.0233 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0342 | 0.5942 | 1 |
Trichomonas vaginalis | dihydrolipoamide dehydrogenase, putative | 0.0171 | 0.2813 | 0.554 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0162 | 0.2646 | 0.4405 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0431 | 0.0855 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0059 | 0.0757 | 0.1198 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0072 | 0.101 | 0.0963 |
Onchocerca volvulus | 0.0041 | 0.0431 | 0.0539 | |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0117 | 0.183 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0072 | 0.101 | 0.1627 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0072 | 0.101 | 0.0963 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0431 | 0.0855 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.0273 | 0.0223 |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.0273 | 0.0223 |
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.0694 | 0.3612 |
Schistosoma mansoni | hypothetical protein | 0.0564 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0117 | 0.183 | 0.1788 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0.0431 | 0.2132 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0117 | 0.183 | 0.1788 |
Echinococcus granulosus | lamin | 0.0032 | 0.0273 | 0.0223 |
Treponema pallidum | thioredoxin reductase (trxB) | 0.0171 | 0.2813 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0166 | 0.2714 | 0.2676 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0431 | 0.0644 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.026 | 0.4451 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0146 | 0.2352 | 0.2312 |
Brugia malayi | follicle stimulating hormone receptor | 0.0276 | 0.4739 | 0.9411 |
Schistosoma mansoni | tar DNA-binding protein | 0.0146 | 0.2352 | 0.2312 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0028 | 0.0189 | 0.0138 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0117 | 0.183 | 0.3568 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0072 | 0.101 | 0.2271 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.0273 | 0.0543 |
Schistosoma mansoni | thyroid hormone receptor | 0.0162 | 0.2652 | 0.2614 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.2714 | 0.539 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0431 | 0.0644 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0117 | 0.183 | 0.1788 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0431 | 0.0855 |
Entamoeba histolytica | thioredoxin reductase, putative | 0.0171 | 0.2813 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.002 | 0.0052 | 0.0102 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0048 | 0.0565 | 0.0871 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0431 | 0.0644 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.0431 | 0.0761 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0024 | 0.0118 | 0.0113 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0292 | 0.5035 | 1 |
Brugia malayi | beta-lactamase | 0.0041 | 0.0431 | 0.0855 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.2432 | 0.2393 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.002 | 0.0052 | 0.0102 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.002 | 0.0052 | 0.0102 |
Schistosoma mansoni | lamin | 0.0032 | 0.0273 | 0.0223 |
Chlamydia trachomatis | thioredoxin reductase | 0.0171 | 0.2813 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.0431 | 0.0381 |
Toxoplasma gondii | FATC domain-containing protein | 0.0028 | 0.0189 | 0.077 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.3195 | 0.6308 |
Echinococcus multilocularis | musashi | 0.0032 | 0.0273 | 0.0223 |
Schistosoma mansoni | thyroid hormone receptor | 0.0162 | 0.2652 | 0.2614 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.002 | 0.0052 | 0.0001 |
Echinococcus multilocularis | lamin | 0.0032 | 0.0273 | 0.0223 |
Giardia lamblia | Thioredoxin reductase | 0.0171 | 0.2813 | 1 |
Mycobacterium leprae | THIOREDOXIN TRXC (TRX) (MPT46) | 0.0171 | 0.2813 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.0273 | 0.0543 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0292 | 0.5035 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0431 | 0.0761 |
Schistosoma mansoni | tar DNA-binding protein | 0.0146 | 0.2352 | 0.2312 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0431 | 0.0381 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0117 | 0.183 | 0.3568 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0431 | 0.0855 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0431 | 0.0644 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0189 | 0.0496 |
Mycobacterium ulcerans | thioredoxin reductase TrxB2 | 0.0171 | 0.2813 | 0.9341 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0162 | 0.2646 | 0.4405 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.015 | 0.2432 | 0.2393 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.3195 | 0.6308 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.0431 | 0.0381 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0072 | 0.101 | 0.0963 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0072 | 0.101 | 0.0963 |
Echinococcus granulosus | muscleblind protein | 0.0166 | 0.2714 | 0.2676 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0072 | 0.101 | 0.2271 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0171 | 0.2813 | 0.554 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0117 | 0.183 | 0.3568 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0431 | 0.0761 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0117 | 0.183 | 0.1788 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.3195 | 0.6308 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0431 | 0.0855 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0656 | 0.0607 |
Echinococcus multilocularis | muscleblind protein | 0.0166 | 0.2714 | 0.2676 |
Schistosoma mansoni | tar DNA-binding protein | 0.0146 | 0.2352 | 0.2312 |
Schistosoma mansoni | hypothetical protein | 0.0564 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0072 | 0.101 | 0.144 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0117 | 0.183 | 0.3019 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0146 | 0.2352 | 0.467 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0048 | 0.0565 | 0.0871 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 47 % | Parasiticidal activity against Rhipicephalus sanguineus assessed as mortality after 24 hrs by brown dog tick assay | ChEMBL. | 18006308 |
Activity (functional) | = 100 % | Parasiticidal activity against Ctenocephalides felis assessed as mortality after 24 hrs by cat flea assay | ChEMBL. | 18006308 |
LD99 (functional) | = 3.8 uM | Parasiticidal activity against Haemonchus contortus by larval assay | ChEMBL. | 18006308 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.