Detailed information for compound 505568

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1606.66 | Formula: C75H91N13O25S
  • H donors: 15 H acceptors: 21 LogP: -0.27 Rotable bonds: 45
    Rule of 5 violations (Lipinski): 4
  • SMILES: OCc1ccc(o1)/C=N\O[C@@H]1C[C@H](N(C1)C(=O)C1CCCCN1C(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CCCCNC(=S)Nc1ccc2c(c1)C1(OC2=O)c2ccc(cc2Oc2c1ccc(c2)O)O)CCC(=O)O)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CCC(=O)O)CCC(=O)O
  • InChi: 1S/C75H91N13O25S/c1-38(70(106)87-28-6-4-9-55(87)72(108)88-36-45(113-78-35-43-16-17-44(37-89)110-43)34-56(88)68(104)82-51(22-25-61(96)97)65(101)81-50(64(76)100)21-24-60(94)95)79-69(105)63(39(2)90)84-67(103)54-11-8-30-86(54)71(107)52(23-26-62(98)99)83-66(102)53-10-7-29-85(53)59(93)12-3-5-27-77-74(114)80-40-13-18-46-49(31-40)75(112-73(46)109)47-19-14-41(91)32-57(47)111-58-33-42(92)15-20-48(58)75/h13-20,31-33,35,38-39,45,50-56,63,89-92H,3-12,21-30,34,36-37H2,1-2H3,(H2,76,100)(H,79,105)(H,81,101)(H,82,104)(H,83,102)(H,84,103)(H,94,95)(H,96,97)(H,98,99)(H2,77,80,114)/b78-35-/t38-,39+,45+,50-,51-,52-,53-,54-,55?,56-,63-/m0/s1
  • InChiKey: ICKWYDBMMGBBMP-VOJXITEBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0182 0.1351 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0031 0.006
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0636 0.7377
Echinococcus granulosus lamin dm0 0.0028 0.0114 0.0284
Plasmodium falciparum glutathione reductase 0.0037 0.0182 0.5244
Leishmania major trypanothione reductase 0.0037 0.0182 0.1733
Brugia malayi Steroid receptor seven-up type 2 0.0143 0.1036 0.1247
Schistosoma mansoni nAChR subunit 0.0018 0.0031 0.0031
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0031 0.006
Loa Loa (eye worm) hypothetical protein 0.0048 0.0271 0.0326
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0048 0.0271 0.0526
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0143 0.1036 0.1247
Echinococcus multilocularis synaptic glycoprotein sc2 0.0048 0.0271 0.0526
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0143 0.1036 0.1247
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0084 0.0211
Trypanosoma brucei carbonic anhydrase-like protein 0.0145 0.1048 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0271 0.1386
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0143 0.1036 0.2009
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0031 0.0077
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0031 0.0037
Brugia malayi Bromodomain containing protein 0.0039 0.0201 0.0242
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0084 0.0164
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0143 0.1036 0.1036
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0343 0.398
Schistosoma mansoni thyroid hormone receptor 0.0656 0.5157 0.5157
Loa Loa (eye worm) hypothetical protein 0.0067 0.0428 0.0515
Onchocerca volvulus 0.0028 0.0114 0.0479
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0317 0.0382
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0076 0.0493 0.1231
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0145 0.1048 0.1261
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0385 0.0385
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0032 0.0304
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0145 0.1048 0.1048
Echinococcus granulosus synaptic glycoprotein sc2 0.0048 0.0271 0.0677
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0012
Brugia malayi nuclear receptor NHR-88 0.0143 0.1036 0.1247
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0008 0.001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0143 0.1036 0.1036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0143 0.1036 0.2009
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0143 0.0172
Loa Loa (eye worm) hypothetical protein 0.0072 0.0468 0.0563
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0031 0.006
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0054 0.0317 0.0382
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0032 0.5
Loa Loa (eye worm) hypothetical protein 0.0067 0.0428 0.0515
Onchocerca volvulus 0.0067 0.0428 0.23
Trypanosoma cruzi ISWI complex protein 0.0016 0.0012 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0143 0.1036 0.1247
Brugia malayi Nuclear hormone receptor-like 1 0.0076 0.0493 0.0594
Schistosoma mansoni hypothetical protein 0.0021 0.0056 0.0056
Echinococcus granulosus carbonic anhydrase 0.0054 0.0317 0.0792
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0031 0.0077
Schistosoma mansoni nuclear receptor 0.0067 0.0428 0.0428
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0048 0.0271 0.0326
Schistosoma mansoni nuclear hormone receptor 0.0067 0.0428 0.0428
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0031 0.0031
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0031 0.006
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0008 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.0143 0.1036 0.1247
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0182 0.1733
Brugia malayi PHD-finger family protein 0.0027 0.0104 0.0125
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0317 0.0382
Loa Loa (eye worm) hypothetical protein 0.0076 0.0493 0.0594
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0112 0.0135
Loa Loa (eye worm) hypothetical protein 0.0076 0.0493 0.0594
Echinococcus granulosus nuclear receptor nhr 48 0.0067 0.0428 0.1069
Schistosoma mansoni hypothetical protein 0.0337 0.2597 0.2597
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0143 0.1036 0.1247
Echinococcus granulosus Nuclear hormone receptor HR96 0.0067 0.0428 0.1069
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0067 0.0428 0.0831
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0271 0.1386
Schistosoma mansoni nAChR subunit 0.0018 0.0031 0.0031
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0143 0.1036 0.2586
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0031 0.0077
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0031 0.0037
Schistosoma mansoni ap endonuclease 0.0018 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0143 0.1036 0.1247
Entamoeba histolytica hypothetical protein 0.0048 0.0271 0.1814
Brugia malayi Cation transporter family protein 0.0018 0.0031 0.0037
Schistosoma mansoni hypothetical protein 0.0513 0.4007 0.4007
Schistosoma mansoni ap endonuclease 0.0018 0.0032 0.0032
Schistosoma mansoni nAChR subunit 0.0018 0.0031 0.0031
Trichomonas vaginalis set domain proteins, putative 0.0233 0.1759 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0067 0.0428 0.0515
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0143 0.0172
Loa Loa (eye worm) hypothetical protein 0.0048 0.0271 0.0326
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0067 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0076 0.0493 0.0594
Echinococcus granulosus FTZ F1 alpha 0.0143 0.1036 0.2586
Echinococcus multilocularis carbonic anhydrase 0.0054 0.0317 0.0615
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0143 0.0332
Onchocerca volvulus Protein ultraspiracle homolog 0.0143 0.1036 0.5816
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0026 0.0051
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.043 0.4098
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0067 0.0428 0.0515
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0031 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0143 0.1036 0.2586
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0031 0.0037
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0513 0.4007 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.1036 0.1247
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0067 0.0428 0.0831
Loa Loa (eye worm) hypothetical protein 0.0067 0.0428 0.0515
Echinococcus multilocularis cpg binding protein 0.0032 0.0141 0.0273
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0114 0.0137
Brugia malayi hypothetical protein 0.0182 0.1351 0.1626
Onchocerca volvulus 0.0048 0.0271 0.139
Echinococcus multilocularis lamin dm0 0.0028 0.0114 0.0221
Schistosoma mansoni bromodomain containing protein 0.0066 0.042 0.042
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0143 0.1036 0.2586
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0067 0.0428 0.0515
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.0862 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.1036 0.1247
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0271 0.1386
Onchocerca volvulus 0.003 0.0126 0.0551
Schistosoma mansoni hypothetical protein 0.0054 0.0317 0.0317
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0031 0.0037
Echinococcus multilocularis FTZ F1 alpha 0.0143 0.1036 0.2009
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0267 0.0517
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0067 0.0428 0.1069
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0561 0.6503
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0143 0.1036 0.1036
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0031 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0143 0.1036 0.1247
Echinococcus granulosus intermediate filament protein 0.0028 0.0114 0.0284
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0048 0.0271 0.0326
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0048 0.0271 0.1814
Echinococcus granulosus tar DNA binding protein 0.0062 0.0385 0.0962
Loa Loa (eye worm) glutathione reductase 0.0037 0.0182 0.0219
Brugia malayi tailless protein 0.0067 0.0428 0.0515
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.0317 0.0317
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0031 0.0037
Schistosoma mansoni transcription factor LCR-F1 0.0182 0.1351 0.1351
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0067 0.0428 0.0515
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0031 0.0037
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0862 0.2005
Brugia malayi Nuclear hormone receptor E75 0.0067 0.0428 0.0515
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Echinococcus multilocularis carbonic anhydrase II 0.0145 0.1048 0.2032
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0048 0.0271 0.3146
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0561 0.6503
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0034
Brugia malayi nuclear receptor NHR-67 0.0067 0.0428 0.0515
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0143 0.1036 0.2586
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0182 0.0219
Echinococcus granulosus carbonic anhydrase 0.0054 0.0317 0.0792
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0271 0.1386
Loa Loa (eye worm) hypothetical protein 0.0076 0.0493 0.0594
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Schistosoma mansoni lamin 0.0028 0.0114 0.0114
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0032 0.0304
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.1048 0.8312 1
Brugia malayi nuclear receptor NHR-88 0.0067 0.0428 0.0515
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.0862 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0054 0.0317 0.0382
Brugia malayi Cytochrome P450 family protein 0.0033 0.0153 0.0185
Toxoplasma gondii thioredoxin reductase 0.0037 0.0182 0.2107
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0317 0.0382
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.1812 0.218
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0032 0.0074
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0032 0.0038
Entamoeba histolytica hypothetical protein 0.0182 0.1351 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0561 0.8816
Brugia malayi steroid hormone receptor 0.0143 0.1036 0.1247
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0026 0.0026
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.0862 0.1671
Onchocerca volvulus 0.0233 0.1759 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0067 0.0428 0.0831
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0271 0.2587
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0031 0.0037
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0031 0.0077
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0032 0.0038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0067 0.0428 0.23
Echinococcus multilocularis carbonic anhydrase 0.0054 0.0317 0.0615
Brugia malayi Cytochrome P450 family protein 0.0032 0.0143 0.0172
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0048 0.0271 0.0271
Plasmodium falciparum thioredoxin reductase 0.0037 0.0182 0.5244
Brugia malayi photoreceptor-specific nuclear receptor 0.0143 0.1036 0.1247
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0143 0.1036 0.1036
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0143 0.1036 0.1247
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0031 0.0037
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0048 0.0271 0.0271
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0032 0.0304
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0271 0.1386
Brugia malayi hypothetical protein 0.0076 0.0493 0.0594
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.043 0.4098
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0031 0.0037
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0031 0.0038
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0031 0.006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0031 0.0037
Brugia malayi Pre-SET motif family protein 0.0205 0.1532 0.1844
Brugia malayi TAR-binding protein 0.0062 0.0385 0.0464
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.043 0.0517
Schistosoma mansoni zinc finger protein 0.0016 0.0012 0.0012
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0031 0.0037
Schistosoma mansoni hypothetical protein 0.0401 0.3112 0.3112
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0182 0.1351 0.3372
Brugia malayi nuclear hormone receptor 0.0067 0.0428 0.0515
Schistosoma mansoni coup transcription factor 0.0143 0.1036 0.1036
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.043 0.1072
Brugia malayi glutathione reductase 0.0037 0.0182 0.0219
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0031 0.0037
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0067 0.0428 0.23
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0182 0.6257
Schistosoma mansoni hypothetical protein 0.0337 0.2597 0.2597
Loa Loa (eye worm) hypothetical protein 0.0067 0.0428 0.0515
Loa Loa (eye worm) hypothetical protein 0.0143 0.1036 0.1247
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0076 0.0493 0.0957
Brugia malayi Nuclear hormone receptor E75 0.0067 0.0428 0.0515
Brugia malayi nuclear hormone receptor 0.0143 0.1036 0.1247
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0385 0.0385
Mycobacterium ulcerans hydrolase/amidase 0.0549 0.4299 1
Brugia malayi orphan nuclear receptor NR2E1 0.0067 0.0428 0.0515
Loa Loa (eye worm) hypothetical protein 0.0067 0.0428 0.0515
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0031 0.0077
Loa Loa (eye worm) hypothetical protein 0.0067 0.0428 0.0515
Plasmodium vivax polyprenol reductase, putative 0.0048 0.0271 1
Onchocerca volvulus 0.0067 0.0428 0.23
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0143 0.1036 0.2009
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0031 0.006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Mycobacterium tuberculosis Probable reductase 0.0084 0.0561 0.6503
Echinococcus granulosus thyroid hormone receptor alpha 0.0067 0.0428 0.1069
Echinococcus multilocularis thyroid hormone receptor alpha 0.0656 0.5157 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0153 0.0185
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0026 0.0066
Loa Loa (eye worm) hypothetical protein 0.0028 0.011 0.0132
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0031 0.0077
Loa Loa (eye worm) DR-78 0.0067 0.0428 0.0515
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0143 0.1036 0.2586
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0067 0.0428 0.0831
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0031 0.0077
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0031 0.0077
Loa Loa (eye worm) hypothetical protein 0.0054 0.0317 0.0382
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0143 0.1036 0.2009
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.039 0.0757
Entamoeba histolytica hypothetical protein 0.0182 0.1351 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0636 0.7377
Loa Loa (eye worm) carbonic anhydrase 3 0.0145 0.1048 0.1261
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0126 0.0245
Plasmodium falciparum polyprenol reductase, putative 0.0048 0.0271 0.8381
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0143 0.1036 0.1247
Brugia malayi Cytochrome P450 family protein 0.0032 0.0143 0.0172
Loa Loa (eye worm) steroid hormone receptor 0.0143 0.1036 0.1247
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0143 0.1036 0.2009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0143 0.1036 0.1247
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0048 0.0271 0.2587
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0048 0.0271 0.2587
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0636 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.0862 0.2151
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0561 0.6503
Schistosoma mansoni hypothetical protein 0.0182 0.1351 0.1351
Loa Loa (eye worm) hypothetical protein 0.0047 0.0267 0.0321
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0143 0.1361
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0143 0.0172
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.043 0.0833
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.043 0.4098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0126 0.0126
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0513 0.4007 0.777
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0143 0.1036 0.1247
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0031 0.0077
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0031 0.0031
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0182 0.0352
Schistosoma mansoni nuclear hormone receptor 0.0067 0.0428 0.0428
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0048 0.0271 0.0677
Schistosoma mansoni nAChR subunit 0.0018 0.0031 0.0031
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0031 0.006
Brugia malayi hypothetical protein 0.0067 0.0428 0.0515
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0201 0.0389
Loa Loa (eye worm) hypothetical protein 0.0067 0.0428 0.0515
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0048 0.0271 0.3146
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0076 0.0493 0.0493
Schistosoma mansoni intermediate filament proteins 0.0028 0.0114 0.0114
Echinococcus multilocularis lamin 0.0028 0.0114 0.0221
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0385 0.0385
Onchocerca volvulus 0.0143 0.1036 0.5816
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0145 0.1048 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0143 0.1036 0.1036
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0143 0.1036 0.1247
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0031 0.006
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0385 0.0464
Echinococcus multilocularis carbonic anhydrase 0.0054 0.0317 0.0615
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0048 0.0271 0.1386
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0048 0.0271 0.1386
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0032 0.0304
Leishmania major carbonic anhydrase-like protein 0.0145 0.1048 1
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.3112 0.6034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0271 1
Onchocerca volvulus Bile acid receptor homolog 0.0143 0.1036 0.5816
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0031 0.0037
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0636 0.7377
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0032 0.008
Loa Loa (eye worm) nuclear hormone receptor 0.0067 0.0428 0.0515
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0031 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0143 0.1036 0.1247
Echinococcus granulosus ecdysone induced protein 78C 0.0143 0.1036 0.2586
Schistosoma mansoni zinc finger protein 0.0022 0.006 0.006
Brugia malayi ecdysteroid receptor 0.0143 0.1036 0.1247
Loa Loa (eye worm) nuclear receptor NHR-67 0.0067 0.0428 0.0515
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0862 0.0862
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0143 0.1036 0.1247
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.039 0.0974
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0182 0.2107
Loa Loa (eye worm) hypothetical protein 0.0076 0.0493 0.0594
Brugia malayi Cation transporter family protein 0.0018 0.0031 0.0037
Schistosoma mansoni carbonic anhydrase 0.0054 0.0317 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0143 0.1036 0.1247
Schistosoma mansoni cpg binding protein 0.0028 0.0112 0.0112
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0143 0.1036 0.2586
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0271 0.2587
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0031 0.0037
Brugia malayi hypothetical protein 0.0076 0.0493 0.0594
Loa Loa (eye worm) hypothetical protein 0.0067 0.0428 0.0515
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0031 0.0037
Brugia malayi hypothetical protein 0.0067 0.0428 0.0515
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0084 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0143 0.1036 0.1247
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0143 0.1036 0.5816
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0031 0.0077
Echinococcus granulosus geminin 0.0337 0.2597 0.6482
Echinococcus granulosus lamin 0.0028 0.0114 0.0284
Toxoplasma gondii hypothetical protein 0.0054 0.0317 0.3682
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0143 0.1036 0.1036
Plasmodium vivax SET domain protein, putative 0.003 0.0126 0.3942
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.0301
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0031 0.006
Onchocerca volvulus 0.0028 0.0114 0.0479
Toxoplasma gondii exonuclease III APE 0.0018 0.0032 0.037
Brugia malayi intermediate filament protein 0.0028 0.0114 0.0137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0031 0.0037
Echinococcus multilocularis nAChR subunit 0.0018 0.0031 0.006
Brugia malayi hypothetical protein 0.1048 0.8312 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0385 0.0464
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0143 0.1036 0.1247
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0031 0.0031
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0143 0.1036 0.1036
Loa Loa (eye worm) hypothetical protein 0.0067 0.0428 0.0515
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0143 0.1036 0.1247
Mycobacterium ulcerans hypothetical protein 0.0048 0.0271 0.0631
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0862 0.2005
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0031 0.0031
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0031 0.0037
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0229 0.1725 0.1725
Echinococcus granulosus nAChR subunit 0.0018 0.0031 0.0077
Brugia malayi Bromodomain containing protein 0.0078 0.0516 0.0621
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0401 0.3108 0.3108
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0067 0.0428 0.0831
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0186 0.0463
Schistosoma mansoni RAR-like nuclear receptor 0.0143 0.1036 0.1036
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0031 0.0077
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0145 0.1048 0.1261
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0267 0.0665
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0032 0.037
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0271 0.8381
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0056 0.0067
Echinococcus granulosus cpg binding protein 0.0032 0.0141 0.0352
Trypanosoma brucei ISWI complex protein 0.0016 0.0012 0.0113
Brugia malayi Cation transporter family protein 0.0018 0.0031 0.0037
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1532 0.1844
Loa Loa (eye worm) RNA binding protein 0.0062 0.0385 0.0464
Onchocerca volvulus 0.0028 0.0112 0.047
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0031 0.0077
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0385 0.0464
Schistosoma mansoni cpg binding protein 0.0032 0.0141 0.0141
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0048 0.0271 0.1814
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.043 0.4098
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.0317 0.0317
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0031 0.006
Loa Loa (eye worm) hypothetical protein 0.0039 0.0202 0.0243
Loa Loa (eye worm) hypothetical protein 0.0067 0.0428 0.0515
Echinococcus multilocularis zinc finger protein 0.0022 0.006 0.0116
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0385 0.0747
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0113 0.0281
Plasmodium vivax glutathione reductase, putative 0.0037 0.0182 0.6257
Brugia malayi nuclear receptor RXR 0.0076 0.0493 0.0594
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0862 0.0862
Brugia malayi nuclear hormone receptor family member nhr-6 0.0067 0.0428 0.0515
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Schistosoma mansoni nAChR subunit 0.0018 0.0031 0.0031
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0561 0.6503
Echinococcus granulosus carbonic anhydrase 0.0054 0.0317 0.0792
Echinococcus granulosus zinc finger protein 0.0022 0.006 0.015
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0076 0.0493 0.0493
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0143 0.1036 0.1247
Schistosoma mansoni nuclear receptor nhr-48 0.0067 0.0428 0.0428
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0143 0.1036 0.2586
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0186 0.036
Schistosoma mansoni retinoic acid receptor RXR 0.0143 0.1036 0.1036
Leishmania major cytochrome p450-like protein 0.0032 0.0143 0.1361
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0048 0.0271 0.3146
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0375 0.0375
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0143 0.1036 0.1247
Echinococcus multilocularis musashi 0.0028 0.0114 0.0221
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0143 0.1361
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0267 0.0267
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.0862 0.8224
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0143 0.1036 0.1247
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0032 0.0062
Loa Loa (eye worm) hypothetical protein 0.0143 0.1036 0.1247
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0031 0.0077
Schistosoma mansoni cpg binding protein 0.0032 0.0141 0.0141
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0201 0.05
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0862 0.2005
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0145 0.1048 0.1048
Leishmania major hypothetical protein, conserved 0.0016 0.0012 0.0113
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0114 0.0137
Brugia malayi Pre-SET motif family protein 0.003 0.0126 0.0152
Brugia malayi RNA binding protein 0.0062 0.0385 0.0464
Brugia malayi conserved hypotetical protein 0.0067 0.0428 0.0515
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0145 0.1048 0.1261
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.043 0.0517
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0182 0.0454
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0385 0.0385
Brugia malayi Thioredoxin reductase 0.0037 0.0182 0.0219
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0271 0.2587
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0031 0.0037
Trypanosoma cruzi ISWI complex protein 0.0016 0.0012 0.0113
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0143 0.1361
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0054 0.0317 0.0382
Giardia lamblia Synaptic glycoprotein SC2 0.0048 0.0271 1
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0048 0.0271 0.1386
Schistosoma mansoni nuclear receptor 0.0067 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Brugia malayi ecdysone receptor 0.0067 0.0428 0.0515
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0067 0.0428 0.0515
Loa Loa (eye worm) hypothetical protein 0.0028 0.0114 0.0137
Entamoeba histolytica hypothetical protein 0.0182 0.1351 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0032 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0182 0.1351 0.262
Brugia malayi nuclear receptor RXR 0.0067 0.0428 0.0515
Brugia malayi CXXC zinc finger family protein 0.0028 0.0112 0.0135
Trypanosoma brucei trypanothione reductase 0.0037 0.0182 0.1733
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0054 0.0317 0.0382
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0143 0.1036 0.2009
Loa Loa (eye worm) hypothetical protein 0.0042 0.0221 0.0266
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0126 0.1464
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0076 0.0493 0.0594
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0143 0.1036 0.1247
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0067 0.0428 0.1069
Plasmodium falciparum carbonic anhydrase 0.0054 0.0317 1
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0114 0.0137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0143 0.1036 0.1247
Echinococcus granulosus carbonic anhydrase II 0.0145 0.1048 0.2616
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0031 0.0037
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0048 0.0271 0.1814
Schistosoma mansoni zinc finger protein 0.0067 0.0428 0.0428
Echinococcus multilocularis geminin 0.0337 0.2597 0.5036
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0271 0.2587
Loa Loa (eye worm) hypothetical protein 0.0143 0.1036 0.1247
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0031 0.0037
Schistosoma mansoni lamin 0.0028 0.0114 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0143 0.1036 0.1247
Schistosoma mansoni nuclear hormone receptor 0.0143 0.1036 0.1036
Brugia malayi Synaptic glycoprotein SC2 0.0048 0.0271 0.0326
Loa Loa (eye worm) hypothetical protein 0.0054 0.0317 0.0382
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.043 0.043
Echinococcus granulosus Nuclear hormone receptor HR96 0.0067 0.0428 0.1069
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0145 0.1048 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.043 0.3014
Echinococcus granulosus dnaJ subfamily B 0.0401 0.3112 0.7766
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0067 0.0428 0.0831
Schistosoma mansoni thyroid hormone receptor 0.0656 0.5157 0.5157
Brugia malayi follicle stimulating hormone receptor 0.024 0.1812 0.218
Schistosoma mansoni nAChR subunit 0.0018 0.0031 0.0031
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0067 0.0428 0.0515
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0031 0.006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0126 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0267 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0271 0.1386
Echinococcus multilocularis ecdysone induced protein 78C 0.0143 0.1036 0.2009
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0561 0.6503
Brugia malayi Nuclear hormone receptor-like 1 0.0076 0.0493 0.0594
Schistosoma mansoni nAChR subunit 0.0018 0.0031 0.0031
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0026 0.0026

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 26 uM Binding affinity to Tsg101 (unknown origin) ChEMBL. 18083557
IC50 (binding) = 26 uM Binding affinity to Tsg101 (unknown origin) ChEMBL. 18083557

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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