Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.69 nM | Inhibition of cholesterol synthesis in rat hepatocyte | ChEMBL. | 18155906 |
IC50 (binding) | = 8 nM | Inhibition of rat microsomal HMGCoA reductase | ChEMBL. | 18155906 |
IC50 (binding) | = 8 nM | Inhibition of rat microsomal HMGCoA reductase | ChEMBL. | 18155906 |
IC50 (functional) | = 550 nM | Inhibition of cholesterol synthesis in rat L6 myocyte | ChEMBL. | 18155906 |
Inhibition (functional) | Inhibition of acute cholesterol synthesis in mouse at 1 mg/kg | ChEMBL. | 18155906 | |
Inhibition (functional) | 0 | Inhibition of acute cholesterol synthesis in mouse at 1 mg/kg | ChEMBL. | 18155906 |
Ratio IC50 (functional) | = 797 | Selectivity, ratio of IC50 for rat hepatocyte to IC50 for rat L6 myocyte | ChEMBL. | 18155906 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.