Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.2822 | 0.2616 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.2822 | 0.2616 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0299 | 0.0021 |
Schistosoma mansoni | lamin | 0.0031 | 0.2822 | 0.2616 |
Echinococcus granulosus | lamin | 0.0031 | 0.2822 | 0.2616 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.2822 | 0.2616 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0018 | 0.0279 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0018 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0299 | 0.0299 |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.2711 | 0.2711 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.2822 | 0.2822 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0299 | 0.0021 |
Toxoplasma gondii | histone lysine demethylase JMJD6a | 0.0018 | 0.0279 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0299 | 0.0299 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.798 | 0.798 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0018 | 0.0279 | 0.0279 |
Onchocerca volvulus | 0.0031 | 0.2822 | 0.5 | |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0299 | 0.0021 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0068 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0068 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0068 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0018 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.798 | 0.798 |
Onchocerca volvulus | 0.0031 | 0.2822 | 0.5 | |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0299 | 0.0299 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0018 | 0.0279 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.2822 | 0.2822 |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0279 | 0.0279 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.2822 | 0.2822 |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0279 | 0.0279 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0018 | 0.0279 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0299 | 0.0021 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.2822 | 0.2616 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0299 | 0.0021 |
Echinococcus multilocularis | musashi | 0.0031 | 0.2822 | 0.2616 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0299 | 0.0299 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0279 | 0.0279 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.2822 | 0.2822 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0299 | 0.0021 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0299 | 0.0021 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.4425 | 0.4425 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4425 | 0.4425 |
Echinococcus multilocularis | lamin | 0.0031 | 0.2822 | 0.2616 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.798 | 0.798 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.4425 | 0.4265 |
Schistosoma mansoni | lamin | 0.0031 | 0.2822 | 0.2616 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0279 | 0.0279 |
Plasmodium vivax | JmjC domain containing protein | 0.0018 | 0.0279 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0279 | 0.0279 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.2822 | 0.2822 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.798 | 0.798 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0299 | 0.0021 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0.0279 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0068 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0299 | 0.0021 |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0279 | 0.0279 |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0018 | 0.0279 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0068 | 1 | 1 |
Toxoplasma gondii | histone lysine demethylase JMJC1/KDM5D/JARID1D | 0.0018 | 0.0279 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0299 | 0.0021 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CD100 (functional) | = 50 uM | Cytotoxicity against human PANC1 cells in nutrient deprived medium after 24 hrs | ChEMBL. | 17950610 |
CD100 (functional) | = 50 uM | Cytotoxicity against human PANC1 cells in nutrient deprived medium after 24 hrs | ChEMBL. | 17950610 |
IC50 (functional) | = 61.2 uM | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay | ChEMBL. | 18440233 |
IC50 (functional) | > 100 uM | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | ChEMBL. | 18440233 |
IC50 (functional) | > 100 uM | Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay | ChEMBL. | 18440233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.