Detailed information for compound 506044

Basic information

Technical information
  • TDR Targets ID: 506044
  • Name: 2-[3-(dimethylamino)-4-methoxyphenyl]isoindol e-1,3-dione
  • MW: 296.321 | Formula: C17H16N2O3
  • H donors: 0 H acceptors: 2 LogP: 2.55 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1N(C)C)N1C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C17H16N2O3/c1-18(2)14-10-11(8-9-15(14)22-3)19-16(20)12-6-4-5-7-13(12)17(19)21/h4-10H,1-3H3
  • InChiKey: DWTTWGPSTKIBNF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[3-(dimethylamino)-4-methoxy-phenyl]isoindoline-1,3-dione
  • 2-[3-(dimethylamino)-4-methoxyphenyl]isoindoline-1,3-dione
  • 2-[3-(dimethylamino)-4-methoxy-phenyl]isoindole-1,3-dione
  • 2-[3-(dimethylamino)-4-methoxy-phenyl]isoindoline-1,3-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis esterase, putative 0.0039 0.031 0.2543
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.025 0.0289
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0044 0.0063
Brugia malayi glutathione reductase 0.0041 0.0341 0.0489
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.025 0.0289
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0227 0.1681
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.025 0.0358
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.025 0.0228
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.0198
Brugia malayi Sodium Bile acid symporter family protein 0.061 0.6971 1
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0044 0.0051
Loa Loa (eye worm) hypothetical protein 0.0018 0.0066 0.0094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0658 0.5385
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0066 0.0076
Echinococcus granulosus axis inhibition protein axin 0.0021 0.01 0.0115
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.01 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.025 0.0358
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.1219 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0027 0.0198
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.1219 0.1199
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0817
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0568
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0143
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.01 0.0143
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1061 0.8704
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.01 0.0817
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0069 0.008
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0105 0.108 0.8465
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.1219 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0568
Loa Loa (eye worm) hypothetical protein 0.0029 0.0202 0.029
Onchocerca volvulus 0.0039 0.031 0.0445
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0094 0.0957 0.3434
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0044 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0568
Echinococcus multilocularis sodium bile acid cotransporter 0.061 0.6971 0.6964
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0069 0.1358
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0069 0.0568
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0632 0.5175
Loa Loa (eye worm) hypothetical protein 0.0039 0.031 0.0445
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.2736 1
Entamoeba histolytica hypothetical protein 0.0021 0.01 0.0817
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0044 0.0021
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.0198
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0099 0.0812
Loa Loa (eye worm) RGS-3 protein 0.0021 0.01 0.0143
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0069 0.008
Echinococcus multilocularis cysteine protease 0.0018 0.0069 0.0047
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.1219 0.1412
Onchocerca volvulus 0.0018 0.0069 0.0099
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0071 0.0082
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0069 0.0099
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0069 0.0549
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0143
Loa Loa (eye worm) hypothetical protein 0.061 0.6971 1
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0069 0.0568
Brugia malayi PXA domain containing protein 0.0021 0.01 0.0143
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.1219 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.031 0.2543
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0063
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0029 0.0202 0.018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.0198
Echinococcus multilocularis sodium bile acid cotransporter 0.061 0.6971 0.6964
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0063
Echinococcus granulosus geminin 0.0182 0.1979 0.2292
Leishmania major cathepsin L-like protease 0.0068 0.0658 0.5385
Schistosoma mansoni nuclear receptor 0.0016 0.0044 0.0051
Brugia malayi Phospholipase A2 family protein 0.0097 0.099 0.142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0568
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0063
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.01 0.0077
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.01 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0817
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0044 0.0051
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0044 0.0021
Brugia malayi hypothetical protein 0.0029 0.0202 0.029
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.031 0.2543
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0027 0.0031
Echinococcus multilocularis lamin 0.0029 0.0197 0.0175
Loa Loa (eye worm) hypothetical protein 0.0018 0.0066 0.0094
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0632 0.5077
Mycobacterium tuberculosis Conserved protein 0.0039 0.031 0.1046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0568
Loa Loa (eye worm) hypothetical protein 0.0461 0.5227 0.7499
Schistosoma mansoni regulator of G protein signaling 0.0021 0.01 0.0115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0044 0.0051
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0341 0.116
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.025 0.0289
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0568
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0044 0.0063
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.01 0.0077
Toxoplasma gondii ABC1 family protein 0.0039 0.031 0.4683
Echinococcus granulosus follistatin 0.002 0.0094 0.0108
Echinococcus granulosus bloom syndrome protein 0.0023 0.0127 0.0147
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.0104
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0227 0.6379
Echinococcus multilocularis sodium bile acid cotransporter 0.061 0.6971 0.6964
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0568
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0227 0.6379
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.025 0.0358
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.031 0.0359
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0099 0.0794
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1061 0.8704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0568
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.025 0.0289
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.025 0.0289
Echinococcus multilocularis agrin 0.002 0.0094 0.0071
Loa Loa (eye worm) hypothetical protein 0.0033 0.025 0.0358
Echinococcus multilocularis expressed protein 0.0401 0.4527 0.4515
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0066 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0568
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0099
Schistosoma mansoni hypothetical protein 0.0182 0.1979 0.2292
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.1061 0.8701
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0099 0.0142
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.1219 1
Echinococcus granulosus lamin 0.0029 0.0197 0.0228
Schistosoma mansoni ap endonuclease 0.0021 0.0099 0.0115
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.01 0.0143
Loa Loa (eye worm) hypothetical protein 0.0033 0.025 0.0358
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.025 0.0289
Brugia malayi conserved hypotetical protein 0.0016 0.0044 0.0063
Echinococcus granulosus sodium bile acid cotransporter 0.061 0.6971 0.8072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0658 0.5385
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0032
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0069 0.0047
Brugia malayi prostaglandin transporter 0.0029 0.0202 0.029
Brugia malayi hypothetical protein 0.0016 0.0044 0.0063
Brugia malayi hypothetical protein 0.0018 0.0066 0.0094
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0487 0.3982
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0044 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0658 0.5385
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0069 0.008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0202 0.029
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0103 0.012
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.002 0.0094 0.0134
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0099 0.0812
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.0198
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0027 0.0198
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1061 0.8704
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.1219 1
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0103 0.012
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.025 0.0358
Echinococcus multilocularis geminin 0.0182 0.1979 0.1961
Loa Loa (eye worm) hypothetical protein 0.0029 0.0197 0.0283
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0044 0.0063
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0063
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0044 0.0051
Brugia malayi Thioredoxin reductase 0.0041 0.0341 0.0489
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.1061 0.8701
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0027 0.0198
Echinococcus granulosus sodium bile acid cotransporter 0.061 0.6971 0.8072
Loa Loa (eye worm) hypothetical protein 0.0097 0.099 0.142
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0027 0.0218
Loa Loa (eye worm) RecQ helicase 0.0023 0.0127 0.0182
Echinococcus granulosus cathepsin l1 0.0018 0.0069 0.008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0099 0.0794
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.025 0.0358
Entamoeba histolytica cysteine protease, putative 0.0018 0.0069 0.0568
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1061 0.8704
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.025 0.0358
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0103 0.0148
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0099
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.01 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.025 0.0358
Brugia malayi steroid hormone receptor 0.0033 0.025 0.0358
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0658 0.5385
Echinococcus granulosus intermediate filament protein 0.0029 0.0197 0.0228
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0066 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.025 0.0358
Loa Loa (eye worm) hypothetical protein 0.0033 0.025 0.0358
Brugia malayi SPARC precursor 0.002 0.0094 0.0134
Onchocerca volvulus 0.0018 0.0069 0.0099
Loa Loa (eye worm) hypothetical protein 0.0029 0.0202 0.029
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0134
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0069 0.0099
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0044 0.0051
Schistosoma mansoni microtubule-associated protein tau 0.0753 0.8635 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0063
Brugia malayi ecdysteroid receptor 0.0033 0.025 0.0358
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0023 0.0026
Brugia malayi beta-lactamase family protein 0.0039 0.031 0.0445
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.01 0.0143
Onchocerca volvulus 0.0029 0.0202 0.029
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.01 0.0077
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.1219 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.025 0.0289
Loa Loa (eye worm) agrin synaptic family protein 0.002 0.0094 0.0134
Onchocerca volvulus 0.0018 0.0069 0.0099
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0044 0.0063
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0044 0.0063
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0227 0.1863
Loa Loa (eye worm) hypothetical protein 0.0029 0.0202 0.029
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0454 0.3728
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0044 0.0051
Onchocerca volvulus 0.0016 0.0044 0.0063
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0549
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.031 0.0445
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0029 0.0202 0.018
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0099 0.0794
Echinococcus granulosus lamin dm0 0.0029 0.0197 0.0228
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.025 0.0358
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0099
Plasmodium vivax vivapain-2 0.0018 0.0069 0.1358
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.025 0.0358
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0027 0.0031
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0044 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0143
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0099
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.1219 0.1749
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0099
Brugia malayi nuclear receptor NHR-88 0.0016 0.0044 0.0063
Trypanosoma cruzi MFS transporter, putative 0.0029 0.0202 0.1643
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0069 0.0047
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.01 0.0115
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.031 0.2378
Schistosoma mansoni thyroid hormone receptor 0.0033 0.025 0.0289
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0069 0.0047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0568
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.025 0.0289
Loa Loa (eye worm) phosphofructokinase 0.0117 0.1219 0.1749
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.002 0.0094 0.0134
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.025 0.0228
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0066 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.025 0.0358
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0632 0.0732
Mycobacterium ulcerans beta-lactamase 0.0039 0.031 0.2378
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0197 0.0283
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.025 0.0228
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.0198
Brugia malayi tailless protein 0.0016 0.0044 0.0063
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.1061 0.1229
Onchocerca volvulus 0.002 0.0094 0.0134
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0044 0.0063
Onchocerca volvulus 0.0018 0.0069 0.0099
Schistosoma mansoni ap endonuclease 0.0021 0.0099 0.0115
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0069 0.0568
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0143
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0227 0.6379
Onchocerca volvulus 0.0018 0.0069 0.0099
Schistosoma mansoni axis inhibition protein axin 0.0021 0.01 0.0115
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0103 0.0148
Onchocerca volvulus 0.0029 0.0202 0.029
Giardia lamblia Kinase, PLK 0.0103 0.1061 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0105 0.108 0.3886
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.01 0.0115
Brugia malayi beta-lactamase family protein 0.0039 0.031 0.0445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0568
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0227 0.1863
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0568
Echinococcus granulosus expressed protein 0.0401 0.4527 0.5243
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0127 0.1039
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0227 0.1863
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.1219 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0099 0.0608
Brugia malayi nuclear hormone receptor 0.0033 0.025 0.0358
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0094 0.0957 0.3434
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.1219 1
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0027 0.0198
Loa Loa (eye worm) hypothetical protein 0.0029 0.0202 0.029
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0143
Echinococcus granulosus agrin 0.002 0.0094 0.0108
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.031 0.1046
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0027 0.0198
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0227 0.3312
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.002 0.0094 0.0134
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0044 0.0063
Loa Loa (eye worm) hypothetical protein 0.0018 0.0066 0.0094
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.025 0.0289
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0069 0.0047
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0632 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.025 0.0358
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0044 0.0063
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0105 0.108 0.3886
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.025 0.0358
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1061 0.8704
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.1219 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0066 0.0094
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.031 0.2543
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0658 0.5385
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0094 0.0957 0.7118
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.025 0.0358
Loa Loa (eye worm) hypothetical protein 0.0033 0.025 0.0358
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0044 0.0051
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0099 0.0608
Mycobacterium ulcerans lipase LipD 0.0039 0.031 0.2378
Loa Loa (eye worm) hypothetical protein 0.0039 0.031 0.0445
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0099 0.2305
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0127 0.1039
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0027 0.0218
Brugia malayi hypothetical protein 0.0018 0.0066 0.0094
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.025 0.0289
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.01 0.0115
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0027 0.0198
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.025 0.0358
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.025 0.0289
Echinococcus granulosus axis inhibition protein axin 0.0021 0.01 0.0115
Brugia malayi PXA domain containing protein 0.0021 0.01 0.0143
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0227 0.1863
Leishmania major hypothetical protein, conserved 0.0039 0.031 0.2529
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0347 0.0402
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1061 0.8704
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.01 0.0115
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.004 0.0437
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.01 0.0115
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0099 0.0077
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0341 1
Toxoplasma gondii thioredoxin reductase 0.0041 0.0341 0.5192
Schistosoma mansoni organic anion transporter 0.0029 0.0202 0.0234
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.1219 1
Schistosoma mansoni nuclear receptor 0.0016 0.0044 0.0051
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.01 0.0143
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0143
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0549
Leishmania major trypanothione reductase 0.0041 0.0341 0.2782
Schistosoma mansoni lamin 0.0029 0.0197 0.0228
Loa Loa (eye worm) hypothetical protein 0.0039 0.031 0.0445
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0027 0.0198
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.031 0.1046
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.01 0.0115
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0063
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.025 0.0289
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.1061 0.1041
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0817
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.1219 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0105 0.108 0.3886
Onchocerca volvulus Phospholipase A2 homolog 0.0097 0.099 0.142
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.01 0.0077
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.025 0.0358
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0069 0.008
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.031 0.1046
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0069 0.0568
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0568
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.025 0.0289
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0197 0.0283
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.002 0.0094 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0568
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0347 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0817
Echinococcus granulosus Solute carrier organic anion transporter family 0.0029 0.0202 0.0234
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0227 0.1938
Loa Loa (eye worm) cysteine protease 0.0018 0.0069 0.0099
Brugia malayi 6-phosphofructokinase 0.0117 0.1219 0.1749
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0103 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0063
Brugia malayi nuclear receptor NHR-67 0.0016 0.0044 0.0063
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0099
Brugia malayi hypothetical protein 0.0016 0.0044 0.0063
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0658 0.5385
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.025 0.0289
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.025 0.0228
Schistosoma mansoni organic anion transporter 0.0029 0.0202 0.0234
Brugia malayi hypothetical protein 0.0029 0.0202 0.029
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.025 0.0358
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.1219 1
Onchocerca volvulus 0.0018 0.0069 0.0099
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.025 0.0358
Loa Loa (eye worm) fibroinase 0.0018 0.0069 0.0099
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.01 0.0143
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0069 0.1358
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.002 0.0094 0.1108
Plasmodium vivax vivapain-2 0.0018 0.0069 0.1358
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.025 0.0358
Onchocerca volvulus Putative organic anion transporter 0.0029 0.0202 0.029
Schistosoma mansoni zinc finger protein 0.0016 0.0044 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0817
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0066 0.0043
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0202 0.2903
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.004 0.0058
Schistosoma mansoni coup transcription factor 0.0033 0.025 0.0289
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.025 0.0228
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0227 1
Schistosoma mansoni regulator of G protein signaling 0.0021 0.01 0.0115
Mycobacterium tuberculosis Probable reductase 0.0094 0.0957 0.3434
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1061 0.8704
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0127 0.0104
Brugia malayi phosphofructokinase 0.0117 0.1219 0.1749
Brugia malayi nuclear receptor NHR-88 0.0033 0.025 0.0358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0568
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.002 0.0094 0.1108
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.031 0.0445
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0094 0.0957 0.3434
Echinococcus multilocularis microtubule associated protein 2 0.0753 0.8635 0.8632
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0134
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0658 0.5385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0658 0.5385
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0632 0.2234
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.031 0.2378
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0103 0.012
Loa Loa (eye worm) hypothetical protein 0.0029 0.0202 0.029
Loa Loa (eye worm) DR-78 0.0016 0.0044 0.0063
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0227 0.1863
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0658 0.5385
Schistosoma mansoni kinase 0.0052 0.047 0.0545
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0127 0.0182
Brugia malayi nuclear hormone receptor 0.0016 0.0044 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.1061 0.1229
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0094 0.2155
Loa Loa (eye worm) hypothetical protein 0.0028 0.0191 0.0274
Schistosoma mansoni sodium-bile acid cotransporter 0.0259 0.2875 0.3329
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.031 0.0359
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0063
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0568
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.025 0.0289
Schistosoma mansoni regulator of G protein signaling 0.0021 0.01 0.0115
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.002 0.0094 0.0134
Echinococcus multilocularis expressed protein 0.002 0.0094 0.0071
Entamoeba histolytica hypothetical protein 0.0021 0.01 0.0817
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0099 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0202 0.029
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0632 0.5077
Schistosoma mansoni regulator of G protein signaling 0.0021 0.01 0.0115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0658 0.5385
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0099 0.0812
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0197 0.0283
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.025 0.0289
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0002 0.002
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.031 0.0288
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0069 0.0549
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0454 0.3728
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0817
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.0198
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0341 0.0489
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0588 0.4816
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.01 0.0077
Brugia malayi beta-lactamase 0.0039 0.031 0.0445
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0632 0.0611
Onchocerca volvulus 0.0018 0.0069 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.025 0.0358
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0038 0.0191
Loa Loa (eye worm) hypothetical protein 0.0033 0.025 0.0358
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0099 0.07
Loa Loa (eye worm) hypothetical protein 0.0033 0.025 0.0358
Onchocerca volvulus 0.0029 0.0197 0.0283
Brugia malayi hypothetical protein 0.0021 0.01 0.0143
Plasmodium vivax glutathione reductase, putative 0.0041 0.0341 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0099 0.0794
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0341 0.2782
Onchocerca volvulus Phospholipase A2 homolog 0.0461 0.5227 0.7499
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0099
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0066 0.0076
Onchocerca volvulus 0.061 0.6971 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.025 0.0358
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0103 0.012
Brugia malayi intermediate filament protein 0.0029 0.0197 0.0283
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0063
Schistosoma mansoni nuclear hormone receptor 0.0033 0.025 0.0289
Brugia malayi nuclear receptor RXR 0.0016 0.0044 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0658 0.5385
Plasmodium vivax hypothetical protein, conserved 0.0039 0.031 0.902
Brugia malayi sodium-independent organic anion transporter family protein 0.0029 0.0202 0.029
Mycobacterium ulcerans hypothetical protein 0.0039 0.031 0.2378
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.025 0.0358
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.1061 0.1522
Toxoplasma gondii exonuclease III APE 0.0021 0.0099 0.1197
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.025 0.0228
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.01 0.0077
Schistosoma mansoni thyroid hormone receptor 0.0033 0.025 0.0289
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.1219 0.1412
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0027 0.0004
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.031 0.2543
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0027 0.0198
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.025 0.0228
Toxoplasma gondii protease inhibitor PI2 0.002 0.0094 0.1108
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.01 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.025 0.0358
Schistosoma mansoni hypothetical protein 0.0182 0.1979 0.2292
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.01 0.0115
Brugia malayi ecdysone receptor 0.0016 0.0044 0.0063
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0227 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.1219 0.1749
Onchocerca volvulus Putative organic anion transporter 0.0029 0.0202 0.029
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0069 0.0099
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0094 0.0957 0.3434
Onchocerca volvulus 0.0029 0.0197 0.0283
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.1061 0.8701
Leishmania major cathepsin L-like protease 0.0068 0.0658 0.5385
Entamoeba histolytica hypothetical protein 0.0021 0.01 0.0817
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0069 0.0099
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0044 0.0021
Mycobacterium tuberculosis Probable dehydrogenase 0.0094 0.0957 0.3434
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.01 0.0115
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0069 0.1358
Echinococcus multilocularis musashi 0.0029 0.0197 0.0175
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0044 0.0063
Echinococcus granulosus sodium bile acid cotransporter 0.061 0.6971 0.8072
Brugia malayi sodium-independent organic anion transporter family protein 0.0029 0.0202 0.029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0066 0.0094
Loa Loa (eye worm) hypothetical protein 0.0033 0.025 0.0358
Onchocerca volvulus 0.0039 0.031 0.0445
Trypanosoma brucei trypanothione reductase 0.0041 0.0341 0.2782
Onchocerca volvulus 0.0039 0.031 0.0445
Plasmodium falciparum glutathione reductase 0.0041 0.0341 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.031 0.2543
Echinococcus multilocularis follistatin 0.002 0.0094 0.0071
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0103 0.0148
Onchocerca volvulus 0.0029 0.0202 0.029
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.025 0.0358
Echinococcus multilocularis cysteine protease 0.0018 0.0069 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0063
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0069 0.0099
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.031 0.1046
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0227 0.1863
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0568
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0227 0.6379
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.1219 1
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0227 0.1863
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0632 0.0732
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.031 0.2529
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.031 0.2529
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0063
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0029 0.0202 0.0234
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.025 0.0289
Mycobacterium tuberculosis Conserved protein 0.0039 0.031 0.1046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0568
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.1219 0.1412
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0044 0.0063
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0044 0.0021
Brugia malayi hypothetical protein 0.0021 0.01 0.0143
Trypanosoma brucei polo-like protein kinase 0.0103 0.1061 0.8701
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0002 0.002
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0027 0.0198
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0099 0.0115
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.004 0.0058
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.01 0.0077
Loa Loa (eye worm) hypothetical protein 0.0039 0.031 0.0445
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.01 0.0143
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.025 0.0358
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0069 0.0099
Loa Loa (eye worm) beta-lactamase 0.0039 0.031 0.0445
Echinococcus granulosus microtubule associated protein 2 0.0753 0.8635 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.031 0.0445
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.025 0.0228
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.1061 0.1522
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0632 0.5077
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0099 0.0142
Schistosoma mansoni sodium-bile acid cotransporter related 0.061 0.6971 0.8072
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0044 0.0051
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0099 0.0267
Onchocerca volvulus Putative organic anion transporter 0.0029 0.0202 0.029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0568
Toxoplasma gondii cathepsin CPL 0.0018 0.0069 0.0705
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0227 0.3312
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0568
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.025 0.0228
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0134
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.031 0.2529
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.025 0.0358
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0044 0.0021
Leishmania major cathepsin L-like protease 0.0068 0.0658 0.5385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0658 0.5385
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0658 0.5385
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0658 0.5385
Schistosoma mansoni axis inhibition protein axin 0.0021 0.01 0.0115
Loa Loa (eye worm) glutathione reductase 0.0041 0.0341 0.0489
Schistosoma mansoni regulator of G protein signaling 0.0021 0.01 0.0115
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.031 0.1046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0568
Mycobacterium tuberculosis Conserved protein 0.0039 0.031 0.1046
Brugia malayi secreted modular calcium-binding protein 1 0.002 0.0094 0.0134
Onchocerca volvulus 0.0033 0.025 0.0358
Onchocerca volvulus 0.0029 0.0202 0.029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.025 0.0358
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0658 0.5385
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.0198
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0029 0.0202 0.029
Brugia malayi sodium-independent organic anion transporter family protein 0.0029 0.0202 0.029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0568
Plasmodium falciparum thioredoxin reductase 0.0041 0.0341 1
Schistosoma mansoni agrin 0.002 0.0094 0.0108
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.031 0.1046
Schistosoma mansoni lamin 0.0029 0.0197 0.0228
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0099 0.2305
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0027 0.0038
Loa Loa (eye worm) ctsf protein 0.0018 0.0069 0.0099
Brugia malayi 6-phosphofructokinase 0.0117 0.1219 0.1749
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0227 0.1863
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0044 0.0063
Brugia malayi nuclear receptor RXR 0.0018 0.0066 0.0094
Onchocerca volvulus 0.0029 0.0202 0.029
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.031 0.1046
Schistosoma mansoni intermediate filament proteins 0.0029 0.0197 0.0228
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0227 0.3312
Loa Loa (eye worm) hypothetical protein 0.0039 0.031 0.0445
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0632 0.0732
Loa Loa (eye worm) hypothetical protein 0.0018 0.0066 0.0094
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.002 0.0094 0.1108
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.025 0.0358
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.1061 0.8704
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0549
Echinococcus granulosus FTZ F1 alpha 0.0033 0.025 0.0289
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0134
Schistosoma mansoni sodium-bile acid cotransporter related 0.0352 0.3956 0.4581
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.1061 0.1522
Echinococcus multilocularis lamin dm0 0.0029 0.0197 0.0175
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.031 0.0359
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0044 0.0051
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.1219 0.4401
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.002 0.0094 0.1108
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0063
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0063
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0549
Onchocerca volvulus 0.0016 0.0044 0.0063
Schistosoma mansoni follistatin 0.002 0.0094 0.0108
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.01 0.0115
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0549

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.44 nM Displacement of [125I]TZDM from beta amyloid 42 fibril (unknown origin) ChEMBL. 18242990

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.