Detailed information for compound 506435

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 198.242 | Formula: C8H10N2O2S
  • H donors: 1 H acceptors: 2 LogP: 1.64 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]1NCc2c(C1)sc(c2)[N+](=O)[O-]
  • InChi: 1S/C8H10N2O2S/c1-5-2-7-6(4-9-5)3-8(13-7)10(11)12/h3,5,9H,2,4H2,1H3/t5-/m1/s1
  • InChiKey: PIQHBFJHMJHGHJ-RXMQYKEDSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phenylethanolamine N-methyltransferase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi NNMT/PNMT/TEMT family protein phenylethanolamine N-methyltransferase 282 aa 257 aa 26.5 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0028 0.008
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0123 0.0353 0.0457
Plasmodium vivax ferrodoxin reductase, putative 0.0207 0.065 0.1907
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0123 0.0353 0.0457
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0123 0.0353 0.0457
Schistosoma mansoni neuropeptide receptor 0.0123 0.0353 0.0457
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0053 0.0103 0.038
Echinococcus granulosus geminin 0.0704 0.2414 0.3125
Onchocerca volvulus 0.0123 0.0353 0.1249
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0043 0.007 0.0255
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0144 0.0186
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.0338 0.0437
Echinococcus granulosus lamin 0.0088 0.0226 0.0293
Trichomonas vaginalis glutathione reductase, putative 0.0781 0.2685 1
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.096 0.3575
Giardia lamblia NADH oxidase lateral transfer candidate 0.0781 0.2685 1
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0143 0.0186
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0054 0.0107 0.0139
Echinococcus granulosus serotonin receptor 0.0123 0.0353 0.0457
Echinococcus multilocularis neuropeptide receptor 0.0123 0.0353 0.0457
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0123 0.0353 0.0457
Echinococcus granulosus 7TM GPCR rhodopsin 0.0123 0.0353 0.0457
Echinococcus granulosus aryl hydrocarbon receptor 0.0053 0.0103 0.0133
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0601 0.2237
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0054 0.0107 0.0281
Echinococcus multilocularis carboxylesterase 5A 0.037 0.1228 0.159
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0338 0.1256
Mycobacterium ulcerans dehydrogenase 0.0207 0.065 0.242
Brugia malayi AKH receptor 0.0123 0.0353 0.0929
Echinococcus multilocularis neuropeptide FF receptor 2 0.0123 0.0353 0.0457
Echinococcus multilocularis neuropeptide Y receptor 0.0123 0.0353 0.0457
Schistosoma mansoni netrin receptor unc5 0.0033 0.0031 0.004
Echinococcus multilocularis neuropeptide s receptor 0.0123 0.0353 0.0457
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0059 0.0076
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0168 0.0167
Echinococcus granulosus lipoxygenase domain containing protein 0.013 0.0376 0.0487
Echinococcus multilocularis microtubule associated protein 2 0.2202 0.7725 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0123 0.0353 0.0457
Echinococcus multilocularis rhodopsin orphan GPCR 0.0123 0.0353 0.0457
Schistosoma mansoni hypothetical protein 0.0109 0.0302 0.0391
Schistosoma mansoni hypothetical protein 0.0043 0.007 0.009
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0086 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0028 0.0103
Echinococcus granulosus Polycystic kidney disease protein 0.013 0.0376 0.0487
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0244 0.0315
Echinococcus multilocularis serotonin receptor 0.038 0.1264 0.1637
Onchocerca volvulus 0.0063 0.0137 0.0412
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0029 0.0108
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0151 0.0559
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0314 0.1168
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0167 0.0507 0.0656
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0353 0.0457
Brugia malayi neuropeptide F receptor 0.0123 0.0353 0.0929
Plasmodium falciparum glutathione reductase 0.0984 0.3406 1
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0143 0.0186
Schistosoma mansoni opsin-like receptor 0.0123 0.0353 0.0457
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0053 0.0103 0.0296
Echinococcus multilocularis BC026374 protein (S09 family) 0.0063 0.0137 0.0178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0244 0.0315
Loa Loa (eye worm) hypothetical protein 0.0681 0.2332 0.6755
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0573 0.195 0.5135
Onchocerca volvulus 0.0108 0.0299 0.104
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0123 0.1878
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0123 0.0353 0.0457
Brugia malayi hypothetical protein 0.0123 0.0353 0.0929
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0043 0.007 0.0255
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0104 0.0103
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0054 0.0107 0.0139
Schistosoma mansoni amine GPCR 0.0123 0.0353 0.0457
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0205 0.0712
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0207 0.065 0.0842
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0338 0.0977
Echinococcus granulosus lamin dm0 0.0088 0.0226 0.0293
Schistosoma mansoni neuropeptide receptor 0.0123 0.0353 0.0457
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0095 0.0252 0.0251
Schistosoma mansoni survival motor neuron protein 0.0106 0.0293 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0166 0.0615
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0123 0.0353 0.0457
Echinococcus granulosus chromobox protein 1 0.0076 0.0186 0.0241
Schistosoma mansoni biogenic amine receptor 0.0123 0.0353 0.0457
Schistosoma mansoni ankyrin 23/unc44 0.0033 0.0031 0.004
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0039 0.0052 0.0051
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.0205 0.0543
Echinococcus granulosus glutamate synthase 0.0207 0.065 0.0842
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0207 0.065 0.0842
Trichomonas vaginalis spcc417.12 protein, putative 0.0063 0.0137 0.0509
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0123 0.0353 0.0457
Echinococcus granulosus g protein coupled receptor 0.0123 0.0353 0.0457
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0573 0.195 0.5135
Mycobacterium ulcerans hypothetical protein 0.0207 0.065 0.242
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0168 0.0486
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.0338 0.0336
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0207 0.065 0.0842
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0207 0.065 0.0649
Onchocerca volvulus 0.0063 0.0137 0.0412
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0123 0.0353 0.0457
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0353 0.0457
Echinococcus granulosus peptide allatostatin:somatostatin 0.0123 0.0353 0.0457
Brugia malayi hypothetical protein 0.0123 0.0353 0.0929
Loa Loa (eye worm) hypothetical protein 0.0063 0.0137 0.0396
Echinococcus granulosus mitogen activated protein kinase 0.0112 0.0314 0.0406
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0104 0.0302
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0043 0.007 0.0255
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0781 0.2685 0.7882
Brugia malayi hypothetical protein 0.0123 0.0353 0.0929
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0168 0.0442
Echinococcus multilocularis lipoxygenase domain containing protein 0.013 0.0376 0.0487
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0781 0.2685 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0281 0.0912 0.1181
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0338 0.5181
Mycobacterium leprae Possible regulatory protein 0.0053 0.0103 0.0249
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0295 0.096 0.2528
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0207 0.065 0.0842
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0207 0.065 0.1685
Brugia malayi hypothetical protein 0.0123 0.0353 0.0929
Plasmodium vivax SET domain protein, putative 0.0096 0.0255 0.0745
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0134 0.0496
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0442 0.1482 0.4098
Mycobacterium tuberculosis Carboxylesterase LipT 0.0063 0.0137 0.0196
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0119 0.0339 0.0338
Onchocerca volvulus 0.0054 0.0107 0.0297
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0023 0.0083
Plasmodium falciparum amino acid transporter, putative 0.0054 0.0107 0.0312
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0781 0.2685 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0123 0.0353 0.0457
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0338 0.5181
Echinococcus multilocularis rhodopsin orphan GPCR 0.0123 0.0353 0.0457
Loa Loa (eye worm) norepinephrine transporter 0.0319 0.1046 0.303
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0205 0.0761
Brugia malayi Tachykinin-like peptides receptor 99D 0.0123 0.0353 0.0929
Loa Loa (eye worm) hypothetical protein 0.0319 0.1046 0.303
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0119 0.0339 0.1262
Brugia malayi hypothetical protein 0.0123 0.0353 0.0929
Brugia malayi Protein kinase domain containing protein 0.0034 0.0035 0.009
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0777 0.2671 0.7036
Plasmodium falciparum transporter, putative 0.0054 0.0107 0.0312
Entamoeba histolytica hypothetical protein 0.004 0.0059 0.0891
Schistosoma mansoni disulfide oxidoreductase 0.0207 0.065 0.0842
Trypanosoma brucei hypothetical protein, conserved 0.0207 0.065 0.0649
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0207 0.065 0.2421
Brugia malayi hypoxia-induced factor 1 0.0628 0.2145 0.5649
Brugia malayi 6-phosphofructokinase 0.0119 0.0339 0.0891
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0781 0.2685 0.3475
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0079 0.0185
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0667 0.2281 0.6609
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0207 0.065 0.0649
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0123 0.0353 0.0457
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0207 0.065 0.242
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0104 0.0302
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0123 0.0353 0.0457
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0029 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0183 0.0679
Echinococcus multilocularis jun protein 0.0281 0.0912 0.1181
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0207 0.065 0.0649
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0006 0.0019
Plasmodium falciparum thioredoxin reductase 0.0781 0.2685 0.7882
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0028 0.0103
Brugia malayi hypothetical protein 0.0221 0.0698 0.1838
Toxoplasma gondii thioredoxin reductase 0.0984 0.3406 1
Entamoeba histolytica thioredoxin reductase, putative 0.0207 0.065 1
Chlamydia trachomatis thioredoxin reductase 0.0207 0.065 0.2339
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.0012 0.0015
Leishmania major hypothetical protein, conserved 0.0207 0.065 0.0649
Schistosoma mansoni lipoxygenase 0.0266 0.086 0.1113
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0781 0.2685 0.2684
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0781 0.2685 0.7072
Mycobacterium leprae putative cytochrome p450 0.0043 0.007 0.0155
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0112 0.0314 0.0919
Loa Loa (eye worm) hypothetical protein 0.0054 0.0107 0.031
Echinococcus granulosus carboxylesterase 5A 0.037 0.1228 0.159
Loa Loa (eye worm) phosphofructokinase 0.0119 0.0338 0.0977
Brugia malayi glutamate synthase 0.0207 0.065 0.1712
Onchocerca volvulus 0.0054 0.0107 0.0297
Trypanosoma brucei trypanothione reductase 0.0984 0.3406 0.3405
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0207 0.065 0.0842
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Echinococcus granulosus hyperpolarization activated cyclic 0.0027 0.0012 0.0015
Mycobacterium ulcerans NADH dehydrogenase 0.0207 0.065 0.242
Echinococcus granulosus rhodopsin orphan GPCR 0.0123 0.0353 0.0457
Onchocerca volvulus 0.0063 0.0137 0.0412
Echinococcus multilocularis inositol monophosphatase 1 0.0119 0.0339 0.0439
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0054 0.0107 0.0294
Loa Loa (eye worm) hypothetical protein 0.0055 0.0111 0.0319
Onchocerca volvulus 0.0123 0.0353 0.1249
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0281 0.0912 0.1181
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0047 0.0082 0.0236
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0207 0.065 0.2421
Loa Loa (eye worm) hypothetical protein 0.037 0.1228 0.3558
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0207 0.065 0.1907
Entamoeba histolytica hypothetical protein 0.004 0.0059 0.0891
Giardia lamblia Glutamate synthase 0.0207 0.065 0.2423
Echinococcus granulosus inositol monophosphatase 1 0.0119 0.0339 0.0439
Schistosoma mansoni hypothetical protein 0.0106 0.0293 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0141 0.0523
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0043 0.007 0.0255
Echinococcus granulosus g protein coupled receptor 0.0123 0.0353 0.0457
Loa Loa (eye worm) glutaminase 0.0286 0.0928 0.2689
Echinococcus granulosus neuropeptide receptor A26 0.0123 0.0353 0.0457
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0151 0.0441
Brugia malayi hypothetical protein 0.0123 0.0353 0.0929
Plasmodium falciparum LCCL domain-containing protein 0.013 0.0376 0.1101
Loa Loa (eye worm) hypothetical protein 0.0041 0.006 0.0171
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0123 0.0353 0.1249
Echinococcus multilocularis orexin receptor type 2 0.0123 0.0353 0.0457
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.0205 0.0321
Brugia malayi Doublecortin family protein 0.013 0.0376 0.0989
Loa Loa (eye worm) hypothetical protein 0.0655 0.2238 0.6484
Brugia malayi Death domain containing protein 0.0033 0.0031 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0067 0.0248
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.0255 0.033
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0207 0.065 0.1907
Loa Loa (eye worm) hypothetical protein 0.0054 0.0107 0.031
Loa Loa (eye worm) hypothetical protein 0.038 0.1264 0.3662
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0442 0.1482 0.4098
Trichomonas vaginalis set domain proteins, putative 0.0759 0.2608 0.9714
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0144 0.0186
Onchocerca volvulus 0.0123 0.0353 0.1249
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0123 0.0122
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0043 0.007 0.0255
Echinococcus granulosus rhodopsin orphan GPCR 0.0123 0.0353 0.0457
Brugia malayi Carboxylesterase family protein 0.037 0.1228 0.3235
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0029 0.0083
Brugia malayi Carboxylesterase family protein 0.0063 0.0137 0.036
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0205 0.06
Loa Loa (eye worm) G-protein coupled receptor 0.0123 0.0353 0.1021
Brugia malayi hypothetical protein 0.0053 0.0104 0.0273
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2843 1 1
Brugia malayi G protein-coupled receptor 0.0123 0.0353 0.0929
Schistosoma mansoni growth hormone secretagogue receptor 0.0123 0.0353 0.0457
Brugia malayi Carboxylesterase family protein 0.0063 0.0137 0.036
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0601 0.2237
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0255 0.033
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0314 0.1168
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0029 0.0053
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0053 0.0103 0.0275
Brugia malayi hypothetical protein 0.004 0.0059 0.0154
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0123 0.0353 0.0457
Treponema pallidum sodium- and chloride- dependent transporter 0.0319 0.1046 0.3863
Leishmania major C-8 sterol isomerase-like protein 0.0777 0.2671 0.267
Loa Loa (eye worm) hypothetical protein 0.0063 0.0137 0.0396
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0338 0.1256
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0075 0.0183 0.0182
Loa Loa (eye worm) hypothetical protein 0.0027 0.0012 0.0033
Schistosoma mansoni neuropeptide F-like receptor 0.0123 0.0353 0.0457
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0144 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0097 0.0359
Echinococcus multilocularis para nitrobenzyl esterase 0.0063 0.0137 0.0178
Echinococcus granulosus GPCR family 2 0.0048 0.0086 0.0111
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0207 0.065 0.242
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0207 0.065 0.1907
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0777 0.2671 0.267
Echinococcus multilocularis dro:myosuppressin receptor 0.0123 0.0353 0.0457
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0086 0.0248
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0168 0.0486
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0123 0.0353 0.0457
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0244 0.078 0.0779
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0119 0.0339 0.1262
Onchocerca volvulus 0.0123 0.0353 0.1249
Schistosoma mansoni rab6-interacting 0.013 0.0376 0.0487
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0123 0.0456
Echinococcus granulosus single minded 2 0.0154 0.0462 0.0598
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0053 0.0103 0.038
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0207 0.065 0.0842
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0059 0.0076
Loa Loa (eye worm) CYP4Cod1 0.0061 0.013 0.0376
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0123 0.0355
Schistosoma mansoni hypothetical protein 0.0033 0.0031 0.004
Toxoplasma gondii Erv1 / Alr family protein 0.0039 0.0052 0.015
Schistosoma mansoni aryl hydrocarbon receptor 0.0203 0.0636 0.0823
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0207 0.065 0.242
Loa Loa (eye worm) hypothetical protein 0.0054 0.0107 0.031
Brugia malayi Pre-SET motif family protein 0.0096 0.0255 0.067
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0207 0.065 0.0649
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0029 0.0108
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0123 0.0122
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0151 0.0196
Echinococcus granulosus sodium and chloride dependent glycine 0.0054 0.0107 0.0139
Loa Loa (eye worm) hypothetical protein 0.0333 0.1098 0.3179
Mycobacterium leprae Conserved hypothetical protein 0.0043 0.007 0.0155
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0095 0.0252 0.0251
Echinococcus granulosus ATP binding cassette sub family G 0.0024 0.0001 0.0001
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0104 0.0302
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0033 0.0032 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0028 0.0103
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0207 0.065 0.2421
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0054 0.0107 0.0139
Loa Loa (eye worm) neuropeptide F receptor 0.0123 0.0353 0.1021
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0108 0.0299 0.0387
Echinococcus granulosus neuropeptide Y receptor 0.0123 0.0353 0.0457
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.013 0.0376
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0027 0.0012 0.0033
Echinococcus granulosus dro:myosuppressin receptor 0.0123 0.0353 0.0457
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0031 0.0025 0.0066
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0032 0.0028 0.0036
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0207 0.065 0.1814
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0338 0.0336
Brugia malayi jmjC domain containing protein 0.0064 0.0144 0.0377
Loa Loa (eye worm) hypothetical protein 0.0048 0.0086 0.0248
Schistosoma mansoni chromobox protein 0.0076 0.0186 0.0241
Onchocerca volvulus 0.015 0.0448 0.162
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0027 0.0012 0.0015
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0168 0.0167
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0054 0.0107 0.0281
Schistosoma mansoni hypothetical protein 0.0123 0.0353 0.0457
Schistosoma mansoni hypothetical protein 0.004 0.0059 0.0076
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0043 0.007 0.0255
Echinococcus granulosus serotonin transporter 0.0319 0.1046 0.1354
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.013 0.0376
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0207 0.065 1
Echinococcus granulosus jun protein 0.0281 0.0912 0.1181
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.2086 0.7314 0.7313
Loa Loa (eye worm) glutathione reductase 0.0984 0.3406 0.9867
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Echinococcus multilocularis acetylcholinesterase 0.037 0.1228 0.159
Plasmodium falciparum glutathione reductase 0.0781 0.2685 0.7882
Leishmania major cytochrome p450-like protein 0.0043 0.007 0.0069
Schistosoma mansoni hypothetical protein 0.0207 0.065 0.0842
Echinococcus granulosus rhodopsin orphan GPCR 0.0123 0.0353 0.0457
Brugia malayi Pre-SET motif family protein 0.0667 0.2281 0.6009
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0043 0.007 0.0255
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0168 0.0218
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0601 0.2237
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0207 0.065 0.1712
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0207 0.065 0.1712
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0086 0.0111
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0112 0.0314 0.0313
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0025 0.0033
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0063 0.0137 0.0178
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0353 0.0457
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0207 0.065 0.0649
Schistosoma mansoni 60S ribosomal protein L21 0.0026 0.0006 0.0008
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0123 0.0353 0.0929
Schistosoma mansoni acetylcholinesterase 0.0063 0.0137 0.0178
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0199 0.062 0.2306
Brugia malayi cytochrome P450 0.0043 0.007 0.0182
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0207 0.065 0.1907
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0053 0.0103 0.0133
Echinococcus multilocularis mitogen activated protein kinase 3 0.0112 0.0314 0.0406
Leishmania major trypanothione reductase 0.0984 0.3406 0.3405
Brugia malayi bHLH-PAS transcription factor 0.015 0.0448 0.118
Leishmania major NADH dehydrogenase, putative 0.0207 0.065 0.0649
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0207 0.065 0.0842
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1015 0.3516 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0123 0.0353 0.0457
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0338 0.0437
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Leishmania major protein kinase, putative 0.0054 0.0106 0.0105
Loa Loa (eye worm) hypothetical protein 0.0273 0.0885 0.2562
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0053 0.0103 0.0102
Echinococcus multilocularis serotonin receptor 0.038 0.1264 0.1637
Schistosoma mansoni amine GPCR 0.0123 0.0353 0.0457
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0063 0.0137 0.0178
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0207 0.065 0.0842
Echinococcus multilocularis rhodopsin orphan GPCR 0.0123 0.0353 0.0457
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0123 0.0353 0.0457
Schistosoma mansoni biogenic amine (5HT) receptor 0.038 0.1264 0.1637
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0029 0.0083
Brugia malayi hypothetical protein 0.0251 0.0807 0.2124
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.0205 0.0266
Brugia malayi Cytochrome P450 family protein 0.0043 0.007 0.0182
Echinococcus multilocularis chromobox protein 1 0.0076 0.0186 0.0241
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0033 0.0031 0.004
Schistosoma mansoni rab6-interacting 0.013 0.0376 0.0487
Onchocerca volvulus 0.0123 0.0353 0.1249
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0207 0.065 0.1907
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0252 0.0936
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0346 0.1144 0.3313
Schistosoma mansoni neuropeptide f receptor 76f 0.0123 0.0353 0.0457
Toxoplasma gondii cytochrome p450 superfamily protein 0.0043 0.007 0.0201
Toxoplasma gondii NADPH-glutathione reductase 0.0781 0.2685 0.7882
Brugia malayi Probable ClpP-like protease 0.0082 0.0205 0.0539
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0333 0.1098 0.3179
Onchocerca volvulus 0.0123 0.0353 0.1249
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0177 0.0545 0.1577
Loa Loa (eye worm) doublecortin family protein 0.013 0.0376 0.1088
Echinococcus granulosus sex peptide receptor 0.0123 0.0353 0.0457
Schistosoma mansoni hypothetical protein 0.0704 0.2414 0.3125
Echinococcus granulosus sodium channel protein 0.0244 0.078 0.101
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0168 0.0218
Echinococcus granulosus arachidonate 5 lipoxygenase 0.05 0.1689 0.2187
Giardia lamblia GTOR 0.0095 0.0252 0.0937
Brugia malayi Augmenter of liver regeneration 0.0039 0.0052 0.0136
Onchocerca volvulus 0.0106 0.0293 0.1015
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0103 0.038
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0205 0.0761
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0063 0.0137 0.0509
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0168 0.0218
Treponema pallidum thioredoxin reductase (trxB) 0.0207 0.065 0.238
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2389 0.8391 0.8391
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0123 0.0353 0.0457
Echinococcus granulosus neuropeptide FF receptor 2 0.0123 0.0353 0.0457
Onchocerca volvulus 0.0123 0.0353 0.1249
Echinococcus multilocularis rhodopsin orphan GPCR 0.0123 0.0353 0.0457
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0104 0.0103
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0112 0.0314 0.0313
Loa Loa (eye worm) carboxylesterase 0.037 0.1228 0.3558
Echinococcus granulosus neuropeptide Y receptor 0.0123 0.0353 0.0457
Echinococcus granulosus rhodopsin orphan GPCR 0.0123 0.0353 0.0457
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0123 0.0353 0.0457
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0123 0.0353 0.0929
Echinococcus granulosus neuropeptide receptor 0.0123 0.0353 0.0457
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0207 0.065 0.0842
Echinococcus granulosus para nitrobenzyl esterase 0.0063 0.0137 0.0178
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0054 0.0107 0.0139
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0034 0.0034 0.0098
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0054 0.0107 0.0139
Schistosoma mansoni gliotactin 0.0063 0.0137 0.0178
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0039 0.0052 0.0051
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0053 0.0103 0.038
Trichomonas vaginalis mercuric reductase, putative 0.0781 0.2685 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0054 0.0107 0.0139
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0053 0.0195
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0119 0.0339 0.5207
Leishmania major hypothetical protein, conserved 0.0053 0.0104 0.0103
Loa Loa (eye worm) hypothetical protein 0.0082 0.0205 0.0593
Toxoplasma gondii exonuclease III APE 0.0059 0.0123 0.0358
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.096 0.3575
Schistosoma mansoni jun-related protein 0.0228 0.0725 0.0939
Schistosoma mansoni histamine h1 receptor 0.0123 0.0353 0.0457
Plasmodium vivax thioredoxin reductase, putative 0.0984 0.3406 1
Schistosoma mansoni neuropeptide receptor 0.0123 0.0353 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0166 0.0615
Schistosoma mansoni hypothetical protein 0.0048 0.0086 0.0111
Brugia malayi ORL1-like opioid receptor 0.0123 0.0353 0.0929
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0027 0.0012 0.0015
Schistosoma mansoni lamin 0.0088 0.0226 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0067 0.0248
Echinococcus granulosus voltage gated potassium channel 0.0031 0.0025 0.0033
Echinococcus granulosus neuropeptides capa receptor 0.0123 0.0353 0.0457
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0984 0.3406 0.9679
Echinococcus multilocularis ATP binding cassette sub family G 0.0024 0.0001 0.0001
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0029 0.0083
Loa Loa (eye worm) TYRA-2 protein 0.0123 0.0353 0.1021
Schistosoma mansoni neuropeptide F-like receptor 0.0123 0.0353 0.0457
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0063 0.0137 0.0178
Schistosoma mansoni hypothetical protein 0.0048 0.0086 0.0111
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0054 0.0107 0.0312
Loa Loa (eye worm) G-protein coupled receptor 0.0123 0.0353 0.1021
Echinococcus multilocularis Ankyrin 0.0033 0.0032 0.0041
Onchocerca volvulus 0.0207 0.065 0.2403
Trichomonas vaginalis glutamate synthase, putative 0.0207 0.065 0.2421
Brugia malayi hypothetical protein 0.0034 0.0037 0.0097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2086 0.7314 0.7313
Echinococcus granulosus alpha 1A adrenergic receptor 0.0123 0.0353 0.0457
Brugia malayi hypothetical protein 0.0123 0.0353 0.0929
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0053 0.0195
Brugia malayi Serotonin receptor 0.1094 0.3796 1
Toxoplasma gondii Erv1 / Alr family protein 0.0039 0.0052 0.015
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0207 0.065 0.1685
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0601 0.2237
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0207 0.065 0.1814
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0079 0.0291
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0207 0.065 0.1907
Schistosoma mansoni chromobox protein 0.0076 0.0186 0.0241
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0039 0.0052 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0116 0.0431
Schistosoma mansoni glutamate synthase 0.0207 0.065 0.0842
Echinococcus granulosus ATP binding cassette sub family G 0.0024 0.0001 0.0001
Echinococcus granulosus neuropeptides capa receptor 0.0123 0.0353 0.0457
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0039 0.0052 0.0051
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0284 0.0747
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0123 0.0353 0.0457
Loa Loa (eye worm) acetylcholinesterase 1 0.037 0.1228 0.3558
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0043 0.007 0.0255
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0095 0.0252 0.0326
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0168 0.0218
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0205 0.0662
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0207 0.065 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0054 0.0107 0.031
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0123 0.0122
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0061 0.013 0.0482
Schistosoma mansoni sodium-dependent amino acid transporter 0.0054 0.0107 0.0139
Schistosoma mansoni adenoreceptor 0.0123 0.0353 0.0457
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0054 0.0107 0.0281
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0207 0.065 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0151 0.0559
Loa Loa (eye worm) hypothetical protein 0.0063 0.0137 0.0396
Schistosoma mansoni sulfide quinone reductase 0.0207 0.065 0.0842
Echinococcus multilocularis sodium and chloride dependent glycine 0.0054 0.0107 0.0139
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0338 0.0336
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0119 0.0339 0.0993
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0119 0.0339 0.126
Leishmania major cytochrome p450-like protein 0.0043 0.007 0.0069
Brugia malayi glutaminase DH11.1 0.0286 0.0928 0.2445
Toxoplasma gondii hypothetical protein 0.0028 0.0015 0.0042
Toxoplasma gondii hypothetical protein 0.0054 0.0107 0.0312
Leishmania major phosphatidylinositol 3-kinase, putative 0.0032 0.0028 0.0027
Brugia malayi hypothetical protein 0.0063 0.0137 0.036
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Brugia malayi hypothetical protein 0.0522 0.1765 0.465
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0144 0.0186
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0029 0.0083
Trypanosoma cruzi NADH dehydrogenase, putative 0.0207 0.065 0.0649
Echinococcus multilocularis Polycystic kidney disease protein 0.013 0.0376 0.0487
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0207 0.065 0.0649
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0123 0.0454
Echinococcus granulosus somatostatin receptor 0.0123 0.0353 0.0457
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0319 0.1046 0.1354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0183 0.0679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0116 0.0431
Brugia malayi G protein-coupled receptor F59B2.13 0.0123 0.0353 0.0929
Echinococcus granulosus neuroligin 0.0063 0.0137 0.0178
Brugia malayi PAS domain containing protein 0.0203 0.0636 0.1673
Loa Loa (eye worm) hypothetical protein 0.0041 0.006 0.0171
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0207 0.065 0.1907
Schistosoma mansoni hypothetical protein 0.0048 0.0086 0.0111
Schistosoma mansoni BC026374 protein (S09 family) 0.0063 0.0137 0.0178
Echinococcus multilocularis transfer RNA-Lys 0.015 0.0448 0.0581
Echinococcus granulosus chromobox protein 1 0.0076 0.0186 0.0241
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0151 0.0196
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0199 0.062 0.0802
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0353 0.0457
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0065 0.0085
Leishmania major hypothetical protein, conserved 0.0207 0.065 0.0649
Onchocerca volvulus Neuropeptide F receptor homolog 0.0123 0.0353 0.1249
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0105 0.0104
Echinococcus granulosus netrin receptor unc 5 0.0033 0.0031 0.004
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0199 0.062 0.1597
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.065 0.0649
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0207 0.065 0.1685
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0105 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0252 0.0936
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0025 0.0033
Echinococcus multilocularis hyperpolarization activated cyclic 0.0027 0.0012 0.0015
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0107 0.0295 0.0798
Loa Loa (eye worm) hypothetical protein 0.0397 0.1324 0.3834
Loa Loa (eye worm) hypothetical protein 0.0319 0.1046 0.303
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0123 0.0353 0.1021
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0015 0.0042
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0207 0.065 0.0649
Loa Loa (eye worm) hypothetical protein 0.0096 0.0255 0.0737
Loa Loa (eye worm) hypothetical protein 0.0054 0.0107 0.031
Loa Loa (eye worm) melatonin receptor type 1A 0.0123 0.0353 0.1021
Echinococcus multilocularis somatostatin receptor 0.0123 0.0353 0.0457
Onchocerca volvulus 0.0034 0.0034 0.0013
Echinococcus multilocularis g protein coupled receptor 0.0123 0.0353 0.0457
Schistosoma mansoni cytochrome P450 0.0043 0.007 0.009
Loa Loa (eye worm) hypothetical protein 0.0997 0.3451 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0053 0.0103 0.038
Entamoeba histolytica disulphide oxidoreductase, putative 0.0207 0.065 1
Schistosoma mansoni hypothetical protein 0.013 0.0376 0.0487
Echinococcus granulosus RUN 0.013 0.0376 0.0487
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.2389 0.8391 0.8391
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0107 0.0295 0.0653
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0207 0.065 0.2059
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0338 0.1256
Echinococcus granulosus BC026374 protein S09 family 0.0063 0.0137 0.0178
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0045 0.0074 0.0073
Loa Loa (eye worm) hypothetical protein 0.0063 0.0137 0.0396
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0043 0.007 0.0255
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0043 0.007 0.0255
Loa Loa (eye worm) hypothetical protein 0.0054 0.0107 0.031
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0781 0.2685 0.3475
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0054 0.0107 0.0139
Trypanosoma cruzi cytochrome P450, putative 0.0061 0.013 0.0129
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0033 0.0031 0.0088
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.0186 0.0537
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0151 0.0196
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0095 0.0252 0.0251
Trichomonas vaginalis guanylate cyclase, putative 0.0053 0.0103 0.038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0244 0.0315
Echinococcus granulosus cytochrome P450 2K1 0.0043 0.007 0.009
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0053 0.0103 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0023 0.0083
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0027 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.013 0.0376 0.1088
Loa Loa (eye worm) hypothetical protein 0.037 0.1228 0.3558
Echinococcus multilocularis survival motor neuron protein 1 0.0522 0.1765 0.2285
Schistosoma mansoni amine GPCR 0.0123 0.0353 0.0457
Trypanosoma cruzi NADH dehydrogenase, putative 0.0207 0.065 0.0649
Echinococcus multilocularis G-protein coupled receptor, putative 0.0123 0.0353 0.0457
Loa Loa (eye worm) RNA binding protein 0.0071 0.0168 0.0486
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0075 0.0183 0.0182
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0338 0.0977
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0168 0.0167
Echinococcus multilocularis 0.0043 0.007 0.009
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0123 0.0353 0.1021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.0455 0.1197
Onchocerca volvulus 0.0221 0.0698 0.2588
Loa Loa (eye worm) intermediate filament protein 0.0088 0.0226 0.0654
Echinococcus multilocularis neuropeptide receptor A26 0.0123 0.0353 0.0457
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1015 0.3516 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0095 0.0252 0.0326
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0207 0.065 0.0649
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0199 0.062 0.1632
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0781 0.2685 0.3475
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.037 0.1228 0.159
Loa Loa (eye worm) hypothetical protein 0.0997 0.3451 1
Echinococcus multilocularis neuroligin 0.0063 0.0137 0.0178
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0053 0.0103 0.038
Toxoplasma gondii hypothetical protein 0.0054 0.0107 0.0312
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0168 0.0218
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Brugia malayi 6-phosphofructokinase 0.0119 0.0338 0.0888
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0039 0.0052 0.0068
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0053 0.0103 0.0102
Loa Loa (eye worm) thioredoxin reductase 0.0984 0.3406 0.9867
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.096 0.3575
Loa Loa (eye worm) hypothetical protein 0.0086 0.022 0.0637
Leishmania major hypothetical protein, conserved 0.0207 0.065 0.0649
Echinococcus granulosus thioredoxin glutathione reductase 0.0984 0.3406 0.4409
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0207 0.065 0.242
Onchocerca volvulus 0.0319 0.1046 0.3939
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0207 0.065 0.1814
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0166 0.0615
Trichomonas vaginalis glutaminase, putative 0.0286 0.0928 0.3457
Echinococcus multilocularis g protein coupled receptor 0.0123 0.0353 0.0457
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0244 0.0315
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0207 0.065 1
Echinococcus granulosus microtubule associated protein 2 0.2202 0.7725 1
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.096 0.3575
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0123 0.0353 0.1021
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0123 0.0353 0.0929
Echinococcus multilocularis neuropeptide receptor 0.0123 0.0353 0.0457
Brugia malayi TAR-binding protein 0.0071 0.0168 0.0442
Mycobacterium tuberculosis Probable reductase 0.0442 0.1482 0.4098
Schistosoma mansoni loxhd1 0.013 0.0376 0.0487
Loa Loa (eye worm) phosphatidylinositol 3 0.0095 0.0252 0.0728
Trypanosoma cruzi trypanothione reductase, putative 0.0781 0.2685 0.2684
Schistosoma mansoni hypothetical protein 0.0123 0.0353 0.0457
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.0255 0.033
Echinococcus granulosus survival motor neuron protein 1 0.0522 0.1765 0.2285
Plasmodium vivax glutathione reductase, putative 0.0984 0.3406 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0097 0.0359
Echinococcus multilocularis serotonin transporter 0.0319 0.1046 0.1354
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.096 0.3575
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0123 0.0353 0.0457
Echinococcus multilocularis thioredoxin glutathione reductase 0.0984 0.3406 0.4409
Leishmania major hypothetical protein, conserved 0.0039 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.0104 0.0284 0.0822
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0024 0.0001 0.0001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0151 0.0237
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0039 0.0052 0.015
Brugia malayi Cytochrome P450 family protein 0.0061 0.013 0.0342
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0353 0.0457
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0054 0.0107 0.0139
Trypanosoma cruzi cytochrome P450, putative 0.0061 0.013 0.0129
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0123 0.0353 0.0457
Schistosoma mansoni alpha-1 adrenergic receptor 0.0123 0.0353 0.0457
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0123 0.0353 0.0457
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.006 0.013 0.0375
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.096 0.3575
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0067 0.014
Schistosoma mansoni hypothetical protein 0.0704 0.2414 0.3125
Onchocerca volvulus 0.0123 0.0353 0.1249
Schistosoma mansoni neuroligin 3 (S09 family) 0.0063 0.0137 0.0178
Echinococcus multilocularis rhodopsin orphan GPCR 0.0123 0.0353 0.0457
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0781 0.2685 0.7882
Echinococcus multilocularis G protein coupled receptor 139 0.0123 0.0353 0.0457
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0144 0.0186
Brugia malayi Carboxylesterase family protein 0.037 0.1228 0.3235
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0095 0.0252 0.0251
Brugia malayi neuropeptide F receptor 0.0123 0.0353 0.0929
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0123 0.0353 0.0929
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0123 0.0358
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0043 0.007 0.0255
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0207 0.065 0.2421
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0199 0.062 0.2306
Brugia malayi Uncoordinated protein 44 0.0033 0.0031 0.008
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0079 0.0291
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0123 0.0404
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0027 0.0012 0.0015
Schistosoma mansoni sodium/chloride dependent transporter 0.0319 0.1046 0.1354
Onchocerca volvulus 0.0053 0.0103 0.0278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0166 0.0615
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0186 0.0691
Loa Loa (eye worm) hypothetical protein 0.038 0.1264 0.3662
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0029 0.0108
Echinococcus multilocularis sodium and chloride dependent glycine 0.0054 0.0107 0.0139
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0601 0.2237
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0012 0.0015
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0123 0.0159
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0039 0.0052 0.0068
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0059 0.0076
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0095 0.0252 0.0251
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.0338 0.0921
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.0205 0.0266
Echinococcus granulosus orexin receptor type 2 0.0123 0.0353 0.0457
Onchocerca volvulus 0.0054 0.0107 0.0297
Treponema pallidum NADH oxidase 0.0781 0.2685 1
Echinococcus granulosus g-protein coupled receptor 0.0123 0.0353 0.0457
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0054 0.0107 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0166 0.0615
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0123 0.0353 0.0457
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0119 0.0339 0.0338
Loa Loa (eye worm) hypothetical protein 0.013 0.0376 0.1088
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0043 0.007 0.0069
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0012 0.0015
Trichomonas vaginalis glutamate synthase, putative 0.0207 0.065 0.2421
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0123 0.0353 0.0457
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0123 0.0353 0.0457
Mycobacterium tuberculosis Probable dehydrogenase 0.0442 0.1482 0.4098
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0123 0.0353 0.0457
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0781 0.2685 0.2684
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0095 0.0252 0.0251
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0112 0.0314 0.0313
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Brugia malayi Carboxylesterase family protein 0.0063 0.0137 0.036
Loa Loa (eye worm) serotonin transporter b 0.0319 0.1046 0.303
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0105 0.0257
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0207 0.065 0.242
Schistosoma mansoni ap endonuclease 0.0059 0.0123 0.0159
Echinococcus granulosus potassium voltage gated channel subfamily H 0.006 0.013 0.0168
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0112 0.0314 0.0908
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0123 0.0353 0.0457
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.0205 0.0266
Schistosoma mansoni lipoxygenase 0.05 0.1689 0.2187
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0086 0.0225
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0063 0.0137 0.0196
Schistosoma mansoni lamin 0.0088 0.0226 0.0293
Mycobacterium ulcerans carboxylesterase, LipT 0.0063 0.0137 0.0507
Toxoplasma gondii target of rapamycin (TOR), putative 0.0071 0.0166 0.0483
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0123 0.0353 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0114 0.0424
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0027 0.0012 0.0015
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0781 0.2685 0.7882
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0043 0.007 0.0069
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0207 0.065 0.2421
Brugia malayi MAP kinase sur-1 0.0112 0.0314 0.0826
Onchocerca volvulus 0.0123 0.0353 0.1249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0252 0.0936
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0112 0.0314 0.0313
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0028 0.0073
Echinococcus granulosus neuropeptide receptor 0.0123 0.0353 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0183 0.0679
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0043 0.007 0.0255
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0314 0.0406
Toxoplasma gondii selenide, water dikinase 0.0207 0.065 0.1907
Giardia lamblia Kinase, CMGC MAPK 0.0112 0.0314 0.1169
Brugia malayi Cytochrome P450 family protein 0.0081 0.0202 0.0531
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0781 0.2685 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0319 0.1046 0.2755
Echinococcus multilocularis rhodopsin orphan GPCR 0.0123 0.0353 0.0457
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0063 0.0137 0.0196
Plasmodium falciparum thioredoxin reductase 0.0984 0.3406 1
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.065 0.0649
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0103 0.038
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0054 0.0107 0.0139
Echinococcus multilocularis conserved hypothetical protein 0.1456 0.5079 0.6575
Brugia malayi Thioredoxin reductase 0.0984 0.3406 0.8972
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0186 0.0691
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0244 0.0315
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0207 0.065 0.1712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0116 0.0431
Loa Loa (eye worm) inositol-1 0.0119 0.0339 0.0981
Schistosoma mansoni intermediate filament proteins 0.0088 0.0226 0.0293
Loa Loa (eye worm) hypothetical protein 0.0522 0.1765 0.5114
Mycobacterium tuberculosis Probable oxidoreductase 0.1015 0.3516 1
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0207 0.065 0.1685
Trypanosoma brucei NADH dehydrogenase 0.0207 0.065 0.0649
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0166 0.0615
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0123 0.0353 0.0457
Brugia malayi hypothetical protein 0.0681 0.2332 0.6143
Brugia malayi chromobox protein homolog 3 0.0043 0.0067 0.0175
Brugia malayi Cytochrome P450 family protein 0.0061 0.013 0.0342
Brugia malayi hypothetical protein 0.0123 0.0353 0.0929
Brugia malayi RE15519p 0.0123 0.0353 0.0929
Schistosoma mansoni amine GPCR 0.0123 0.0353 0.0457
Leishmania major protein kinase, putative 0.0059 0.0126 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0183 0.0679
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0353 0.0457
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0043 0.007 0.0255
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0032 0.0028 0.0036
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0781 0.2685 0.7587
Echinococcus multilocularis glutamate synthase 0.0207 0.065 0.0842
Brugia malayi Heterochromatin protein 1 0.0076 0.0186 0.0489
Echinococcus granulosus rhodopsin orphan GPCR 0.0123 0.0353 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0028 0.0103
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0029 0.0108
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0168 0.0218
Brugia malayi hypothetical protein 0.0123 0.0353 0.0929
Mycobacterium ulcerans putative regulatory protein 0.015 0.0448 0.1667
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0199 0.062 0.0802
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0123 0.0353 0.1021
Loa Loa (eye worm) hypothetical protein 0.0048 0.0085 0.0246
Loa Loa (eye worm) hypothetical protein 0.0054 0.0107 0.031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0244 0.0315
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0295 0.096 0.2781
Loa Loa (eye worm) hypothetical protein 0.0031 0.0025 0.0072
Loa Loa (eye worm) hypothetical protein 0.0777 0.2671 0.7738
Loa Loa (eye worm) hypothetical protein 0.0043 0.0067 0.0193
Brugia malayi NNMT/PNMT/TEMT family protein 0.0333 0.1098 0.2891
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0123 0.0458
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0043 0.007 0.0255
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0096 0.0255 0.0745
Echinococcus multilocularis hyperpolarization activated cyclic 0.0027 0.0012 0.0015
Echinococcus multilocularis fmrfamide receptor 0.0123 0.0353 0.0457
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0119 0.0339 0.0338
Onchocerca volvulus Glucosylceramidase homolog 0.0193 0.0601 0.2211
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.0455 0.1316
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0205 0.06
Echinococcus multilocularis geminin 0.0704 0.2414 0.3125
Echinococcus granulosus ATP binding cassette sub family G 0.0024 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.004 0.0059 0.0891
Brugia malayi RNA binding protein 0.0071 0.0168 0.0442
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0088
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0054 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0042 0.0065 0.0188
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0244 0.0315
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0151 0.015
Schistosoma mansoni opsin-like receptor 0.0123 0.0353 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0097 0.0359
Brugia malayi G-protein coupled receptor 0.0123 0.0353 0.0929
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0029 0.0108
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.187 0.655 0.8479
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0106 0.0293 0.077
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0123 0.0159
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Echinococcus multilocularis lipoxygenase domain containing protein 0.013 0.0376 0.0487
Brugia malayi G-protein coupled receptor 0.0123 0.0353 0.0929
Trypanosoma brucei C-8 sterol isomerase, putative 0.0777 0.2671 0.267
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0314 0.1168
Brugia malayi Dopamine receptor protein 1 0.0123 0.0353 0.0929
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0043 0.007 0.0069
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0205 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0028 0.0103
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0043 0.007 0.0255
Echinococcus granulosus nuclear factor of activated T cells 5 0.0167 0.0507 0.0656
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.006 0.013 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0114 0.0424
Schistosoma mansoni myosin xvIII 0.0123 0.0353 0.0457
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0781 0.2685 0.2684
Echinococcus granulosus 7tm_1 domain containing protein 0.0123 0.0353 0.0457
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0244 0.0641
Onchocerca volvulus 0.0123 0.0353 0.1249
Brugia malayi GnHR receptor homolog 0.0123 0.0353 0.0929
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0781 0.2685 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0063 0.0137 0.0178
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0012 0.0015
Brugia malayi hypothetical protein 0.0054 0.0107 0.0281
Echinococcus granulosus acetylcholinesterase 0.037 0.1228 0.159
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0086 0.0225
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0015 0.0042
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0781 0.2685 1
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0207 0.065 0.0842
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0207 0.065 1
Loa Loa (eye worm) neuropeptide F receptor 0.0123 0.0353 0.1021
Onchocerca volvulus 0.0123 0.0353 0.1249
Trypanosoma brucei protein kinase, putative 0.0112 0.0314 0.0313
Schistosoma mansoni amine GPCR 0.1172 0.4071 0.527
Echinococcus granulosus fmrfamide receptor 0.0123 0.0353 0.0457
Loa Loa (eye worm) hypothetical protein 0.0053 0.0103 0.0296
Schistosoma mansoni ap endonuclease 0.0059 0.0123 0.0159
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0054 0.0106 0.0105
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0123 0.0456
Onchocerca volvulus 0.0123 0.0353 0.1249
Echinococcus multilocularis netrin receptor unc 5 0.0033 0.0031 0.004
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.0338 0.0437
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0031 0.008
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0043 0.007 0.0255
Echinococcus multilocularis aryl hydrocarbon receptor 0.0053 0.0103 0.0133
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Echinococcus multilocularis g protein coupled receptor 0.0123 0.0353 0.0457
Echinococcus granulosus tar DNA binding protein 0.0071 0.0168 0.0218
Trypanosoma cruzi trypanothione reductase, putative 0.0984 0.3406 0.3405
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0031 0.0025 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0255 0.033
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0029 0.0083
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.05 0.1689 0.2187
Echinococcus granulosus sodium and chloride dependent glycine 0.0054 0.0107 0.0139
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0314 0.1168
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0207 0.065 0.2059
Echinococcus granulosus G protein coupled receptor 139 0.0123 0.0353 0.0457
Treponema pallidum oxidoreductase 0.0207 0.065 0.238
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0095 0.0252 0.0662
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0054 0.0107 0.0139
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0781 0.2685 0.7882
Echinococcus multilocularis fmrfamide receptor 0.0123 0.0353 0.0457
Brugia malayi hypothetical protein 0.013 0.0376 0.0989
Schistosoma mansoni biogenic amine receptor 0.0123 0.0353 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0203 0.0753
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.0455 0.1197
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0168 0.2576
Onchocerca volvulus 0.0063 0.0137 0.0412
Brugia malayi putative neuropeptide receptor 0.0123 0.0353 0.0929
Echinococcus granulosus mitogen activated protein kinase 3 0.0112 0.0314 0.0406
Echinococcus granulosus tumor protein p63 0.0328 0.1077 0.1394
Onchocerca volvulus 0.0088 0.0226 0.0757
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0353 0.0457
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0054 0.0107 0.0139
Echinococcus multilocularis neuropeptides capa receptor 0.0123 0.0353 0.0457
Onchocerca volvulus 0.0123 0.0353 0.1249
Brugia malayi bZIP transcription factor family protein 0.0281 0.0912 0.2402
Echinococcus granulosus hyperpolarization activated cyclic 0.0027 0.0012 0.0015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0092 0.0242 0.0314
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0199 0.062 0.0619
Onchocerca volvulus 0.0123 0.0353 0.1249
Schistosoma mansoni biogenic amine (5HT) receptor 0.0123 0.0353 0.0457
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0244 0.0704
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0029 0.0109
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0168 0.0218
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1015 0.3516 1
Echinococcus multilocularis acetylcholinesterase 0.037 0.1228 0.159
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0207 0.065 0.0649
Echinococcus multilocularis mitogen activated protein kinase 0.0112 0.0314 0.0406
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0104 0.0103
Echinococcus multilocularis rhodopsin orphan GPCR 0.0123 0.0353 0.0457
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0123 0.0155
Loa Loa (eye worm) cytochrome P450 family protein 0.0081 0.0202 0.0584
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0123 0.0353 0.0929
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0123 0.0122
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0091
Echinococcus multilocularis lamin 0.0088 0.0226 0.0293
Echinococcus granulosus tm gpcr rhodopsin 0.187 0.655 0.8479
Echinococcus multilocularis RUN 0.013 0.0376 0.0487
Echinococcus granulosus acetylcholinesterase 0.037 0.1228 0.159
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0168 0.0218
Echinococcus granulosus bloom syndrome protein 0.0024 0.0001 0.0001
Onchocerca volvulus 0.013 0.0376 0.1339
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0207 0.065 0.2421
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0123 0.0353 0.0457
Echinococcus granulosus intermediate filament protein 0.0088 0.0226 0.0293
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0168 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0097 0.0358
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.006 0.013 0.0168
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Brugia malayi Dopamine receptor protein 2 0.0123 0.0353 0.0929
Brugia malayi jmjC domain containing protein 0.0064 0.0144 0.0377
Brugia malayi phosphofructokinase 0.0119 0.0338 0.0888
Loa Loa (eye worm) cytochrome P450 0.0043 0.007 0.02
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0095 0.0252 0.0326
Schistosoma mansoni sodium/chloride dependent transporter 0.0054 0.0107 0.0139
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.0338 0.1254
Brugia malayi cytoplasmic intermediate filament protein 0.0047 0.0082 0.0214
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Loa Loa (eye worm) hypothetical protein 0.0063 0.0137 0.0396
Echinococcus multilocularis neuropeptide Y receptor 0.0123 0.0353 0.0457
Loa Loa (eye worm) hypothetical protein 0.0152 0.0455 0.1316
Echinococcus multilocularis chromobox protein 1 0.0076 0.0186 0.0241
Giardia lamblia Thioredoxin reductase 0.0207 0.065 0.2423
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0119 0.0339 0.0844
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.0338 0.0777
Echinococcus granulosus tm gpcr rhodopsin 0.0123 0.0353 0.0457
Trichomonas vaginalis apoptosis inducing factor, putative 0.0207 0.065 0.2421
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0105 0.0136
Schistosoma mansoni hypothetical protein 0.0048 0.0086 0.0111
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0054 0.0107 0.0139
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0032 0.0028 0.0027
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0054 0.0107 0.031
Schistosoma mansoni glutamate synthase 0.0207 0.065 0.0842
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0027 0.0012 0.0015
Echinococcus multilocularis allatostatin A receptor 0.0123 0.0353 0.0457
Loa Loa (eye worm) hypothetical protein 0.0333 0.1098 0.3179
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0255 0.033
Echinococcus multilocularis ATP binding cassette sub family G 0.0024 0.0001 0.0001
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0119 0.0339 0.0338
Onchocerca volvulus 0.0088 0.0226 0.0757
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0054 0.0107 0.0281
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0012 0.0042
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0027 0.0012 0.0015
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0043 0.007 0.0069
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0043 0.007 0.0069
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0029 0.0083
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0144 0.0186
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0028 0.0027
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0086 0.0111
Echinococcus multilocularis ATP binding cassette sub family G 0.0024 0.0001 0.0001
Onchocerca volvulus 0.0048 0.0085 0.0211
Brugia malayi follicle stimulating hormone receptor 0.0346 0.1144 0.3012
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0123 0.0358
Echinococcus multilocularis tumor protein p63 0.0328 0.1077 0.1394
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0207 0.065 0.2421
Schistosoma mansoni polycystin 1-related 0.013 0.0376 0.0487
Mycobacterium ulcerans glutaminase 0.0286 0.0928 0.3456
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0207 0.065 0.0649
Loa Loa (eye worm) hypothetical protein 0.0063 0.0137 0.0396
Brugia malayi intermediate filament protein 0.0088 0.0226 0.0594
Plasmodium vivax multidomain scavenger receptor, putative 0.013 0.0376 0.1101
Loa Loa (eye worm) hypothetical protein 0.0207 0.065 0.1883
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0207 0.065 0.242
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0107 0.0312
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Schistosoma mansoni single-minded 0.0203 0.0636 0.0823
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0112 0.0314 0.0313
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0063 0.0137 0.0178
Echinococcus granulosus biogenic amine 5HT receptor 0.038 0.1264 0.1637
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.2843 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0097 0.0358
Echinococcus granulosus death domain containing protein 0.0033 0.0031 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0183 0.0679
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0123 0.0353 0.0457
Plasmodium falciparum ferrodoxin reductase-like protein 0.0207 0.065 0.1907
Mycobacterium ulcerans monoxygenase 0.0207 0.065 0.242
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0086 0.0111
Echinococcus granulosus biogenic amine 5HT receptor 0.0123 0.0353 0.0457
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0144 0.0186
Loa Loa (eye worm) hypothetical protein 0.0053 0.0104 0.03
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0207 0.065 0.2423
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0144 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0353 0.0457
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0207 0.065 0.2421
Brugia malayi Dopamine receptor 0.0123 0.0353 0.0929
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0442 0.1482 0.4098
Trypanosoma cruzi target of rapamycin kinase 3 0.0075 0.0183 0.0182
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0244 0.078 0.101
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0062 0.008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2843 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0123 0.0353 0.0457
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0338 0.0437
Echinococcus granulosus rhodopsin orphan GPCR 0.0123 0.0353 0.0457
Schistosoma mansoni sulfide quinone reductase 0.0207 0.065 0.0842
Echinococcus multilocularis neuropeptides capa receptor 0.0123 0.0353 0.0457
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0062 0.008
Brugia malayi putative neuropeptide receptor NPR1 0.0123 0.0353 0.0929
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Brugia malayi hypothetical protein 0.0123 0.0353 0.0929
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Brugia malayi hypothetical protein 0.013 0.0376 0.0989
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0104 0.0302
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0205 0.06
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0123 0.0353 0.0457
Loa Loa (eye worm) hypothetical protein 0.0088 0.0226 0.0654
Loa Loa (eye worm) hypoxia-induced factor 1 0.0628 0.2145 0.6213
Trichomonas vaginalis inositol monophosphatase, putative 0.0119 0.0339 0.1262
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0054 0.0107 0.0139
Mycobacterium ulcerans ferredoxin reductase 0.0207 0.065 0.242
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0338 0.5181
Loa Loa (eye worm) glutaminase 2 0.0286 0.0928 0.2689
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0123 0.0353 0.0457
Echinococcus granulosus tm gpcr rhodopsin 0.0123 0.0353 0.0457
Loa Loa (eye worm) hypothetical protein 0.0063 0.0137 0.0396
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0123 0.0353 0.0457
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0043 0.007 0.0255
Echinococcus granulosus neuropeptide s receptor 0.0123 0.0353 0.0457
Echinococcus multilocularis g-protein coupled receptor 0.0123 0.0353 0.0457
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.0638 0.2374
Schistosoma mansoni hypothetical protein 0.0104 0.0284 0.0368
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0095 0.0252 0.3859
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0601 0.2237
Schistosoma mansoni hypothetical protein 0.0228 0.0725 0.0939
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0085 0.0111
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0006 0.0008
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0168 0.0167
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0207 0.065 0.0842
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0781 0.2685 0.2684
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0112 0.0314 0.0313
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0781 0.2685 0.7882
Echinococcus granulosus hypothetical protein 0.1579 0.5517 0.7142
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0027 0.0012 0.0033
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0207 0.065 0.1685
Onchocerca volvulus 0.0123 0.0353 0.1249
Echinococcus multilocularis musashi 0.0088 0.0226 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0103 0.038
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0781 0.2685 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0207 0.065 0.2421
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0168 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0097 0.0358
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0207 0.065 0.1907
Echinococcus multilocularis lamin dm0 0.0088 0.0226 0.0293
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0054 0.0107 0.0312
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0095 0.0252 0.3859
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0168 0.0218
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0205 0.06
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0207 0.065 0.2421
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0207 0.065 0.1883
Echinococcus multilocularis sex peptide receptor 0.0123 0.0353 0.0457
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0043 0.007 0.0255
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0112 0.0314 0.0313
Brugia malayi sulfakinin receptor protein 0.0123 0.0353 0.0929
Schistosoma mansoni hypothetical protein 0.0123 0.0353 0.0457
Brugia malayi larval opioid receptor 0.0123 0.0353 0.0929
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0043 0.007 0.0255
Echinococcus granulosus allatostatin A receptor 0.0123 0.0353 0.0457
Trypanosoma brucei cytochrome P450, putative 0.0061 0.013 0.0129
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Schistosoma mansoni inositol monophosphatase 0.0119 0.0339 0.0439
Leishmania major cytochrome p450-like protein 0.0061 0.013 0.0129
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0029 0.0437
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0105 0.0104
Brugia malayi Inositol-1 0.0119 0.0339 0.0892
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0123 0.0323
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.0012 0.0015
Loa Loa (eye worm) programmed cell death 8 0.0207 0.065 0.1883
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0054 0.0106 0.0105
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0033 0.0031 0.004
Schistosoma mansoni neuropeptide receptor 0.0123 0.0353 0.0457
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0032 0.0028 0.0027
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0207 0.065 0.1685
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Entamoeba histolytica hypothetical protein 0.004 0.0059 0.0891
Trichomonas vaginalis guanylate cyclase, putative 0.0053 0.0103 0.038
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0207 0.065 0.1907
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0207 0.065 0.0649
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0207 0.065 0.1814
Brugia malayi Melatonin receptor type 1A 0.0123 0.0353 0.0929
Onchocerca volvulus 0.0759 0.2609 1
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0029 0.0108
Onchocerca volvulus 0.0123 0.0353 0.1249
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.2389 0.8391 0.8391
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0065 0.0085
Brugia malayi glutathione reductase 0.0984 0.3406 0.8972
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0601 0.2237
Schistosoma mansoni inositol monophosphatase 0.0119 0.0339 0.0439
Plasmodium vivax amine transporter, putative 0.0054 0.0107 0.0312
Schistosoma mansoni glutaminase 0.0286 0.0928 0.1202
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0054 0.0106 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2086 0.7314 0.7313
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0207 0.065 0.2059
Schistosoma mansoni microtubule-associated protein tau 0.2202 0.7725 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0039 0.0052 0.0051
Loa Loa (eye worm) carboxylesterase 0.0063 0.0137 0.0396
Echinococcus multilocularis GPCR, family 2 0.0048 0.0086 0.0111
Schistosoma mansoni sodium/chloride dependent transporter 0.0055 0.0111 0.0144
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0039 0.0055 0.0054
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0053 0.0103 0.0102
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0151 0.0196
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0442 0.1482 0.419
Brugia malayi Intermediate filament tail domain containing protein 0.0088 0.0226 0.0594
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0012 0.0042
Echinococcus granulosus Ankyrin 0.0033 0.0032 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0097 0.0359
Leishmania major acetoin dehydrogenase e3 component-like protein 0.2086 0.7314 0.7313
Echinococcus multilocularis voltage gated potassium channel 0.0031 0.0025 0.0033
Mycobacterium ulcerans glutamate synthase subunit beta 0.0207 0.065 0.242
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0442 0.1482 0.4098
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Echinococcus granulosus lipoxygenase domain containing protein 0.013 0.0376 0.0487
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0199 0.062 0.0802
Schistosoma mansoni opsin-like receptor 0.0123 0.0353 0.0457
Brugia malayi Cyclic-nucleotide gated cation channel 0.0027 0.0012 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2389 0.8391 0.8391
Onchocerca volvulus 0.0063 0.0137 0.0412
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0207 0.065 0.0842
Echinococcus multilocularis sodium channel protein 0.0244 0.078 0.101
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0088 0.0226 0.0654
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0029 0.0108
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0151 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0166 0.0615
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0054 0.0107 0.0139
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0096 0.0255 0.033
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0054 0.0106 0.0105
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0032 0.0028 0.0036
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0031 0.0025 0.0033
Loa Loa (eye worm) solute carrier family 6 member 4 0.0319 0.1046 0.303
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0043 0.007 0.0255
Schistosoma mansoni biogenic amine receptor 0.0123 0.0353 0.0457
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.0638 0.2374
Loa Loa (eye worm) carboxylesterase 0.0063 0.0137 0.0396
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0207 0.065 0.242
Brugia malayi Carboxylesterase family protein 0.0063 0.0137 0.036
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.0338 0.1207
Loa Loa (eye worm) hypothetical protein 0.0319 0.1046 0.303
Echinococcus granulosus g protein coupled receptor 0.0123 0.0353 0.0457
Brugia malayi Serotonin receptor 0.0123 0.0353 0.0929
Loa Loa (eye worm) hypothetical protein 0.0054 0.0107 0.031
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0032 0.0028 0.0027
Onchocerca volvulus 0.0123 0.0353 0.1249
Onchocerca volvulus 0.013 0.0376 0.1339
Trichomonas vaginalis adenylate cyclase, putative 0.0053 0.0103 0.038
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0353 0.0457
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0338 0.1256
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Loa Loa (eye worm) hepatopoietin HPO2 0.0039 0.0052 0.015
Echinococcus granulosus tachykinin peptides receptor 99D 0.0123 0.0353 0.0457
Loa Loa (eye worm) hypothetical protein 0.0123 0.0353 0.1021
Schistosoma mansoni glutamate synthase 0.0207 0.065 0.0842

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 9.6 uM Inhibition of human PNMT by radiochemical assay ChEMBL. 18024134
Ki (binding) = 9.6 uM Inhibition of human PNMT by radiochemical assay ChEMBL. 18024134
Ki (binding) = 13 uM Displacement of [3H]clonidine from adrenergic alpha1 receptor in Sprague-Dawley rat cortex ChEMBL. 18024134
Ratio Ki (binding) = 1.4 Selectivity of Ki for human PNMT over Ki for rat alpha2 adrenoreceptor ChEMBL. 18024134

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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