TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 279.785 | Formula: C15H20ClN2O-
H donors: 0 H acceptors: 1 LogP: 2.8 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)C1CCc2c(C1=O)cccc2.[Cl-]
InChi: 1S/C15H20N2O.ClH/c1-16-8-10-17(11-9-16)14-7-6-12-4-2-3-5-13(12)15(14)18;/h2-5,14H,6-11H2,1H3;1H/p-1
InChiKey: RMXUNGRQVFMYDU-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	thyroid hormone receptor	0.0147	0.9698	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0947	0.1026
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.2118	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0025	0.0947	0.1026
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0025	0.0947	0.0976
Onchocerca volvulus	Bile acid receptor homolog	0.0025	0.0947	0.1529
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0151	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0025	0.0947	0.0947
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0025	0.0947	0.1026
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0025	0.0947	0.1026
Schistosoma mansoni	tyrosinase precursor	0.0098	0.6191	0.6383
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Schistosoma mansoni	RAR-like nuclear receptor	0.0025	0.0947	0.0976
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.1871	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0025	0.0947	0.0947
Brugia malayi	Steroid receptor seven-up type 2	0.0025	0.0947	0.1026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0019	0.0538	0.4987
Loa Loa (eye worm)	hypothetical protein	0.003	0.129	0.1398
Echinococcus multilocularis	serine protein kinase ATM	0.0026	0.1054	0.1054
Brugia malayi	hypothetical protein	0.0072	0.4325	0.4686
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0026	0.1054	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.6191	0.6707
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0136	0.8948	0.8948
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0098	0.6191	0.6707
Onchocerca volvulus		0.0098	0.6191	1
Echinococcus multilocularis	acetylcholinesterase	0.0065	0.3867	0.3867
Brugia malayi	Nuclear hormone receptor-like 1	0.0025	0.0947	0.1026
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0019	0.0538	0.0582
Loa Loa (eye worm)	phosphatidylinositol 3	0.0019	0.0538	0.0582
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.7906	0.7906
Brugia malayi	nuclear hormone receptor	0.0025	0.0947	0.1026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0101	0.011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0025	0.0947	0.0947
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.2118	1
Brugia malayi	hypothetical protein	0.0013	0.0101	0.011
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0019	0.0538	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0947	0.1026
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0019	0.0538	0.0554
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0019	0.0538	0.0538
Schistosoma mansoni	nuclear hormone receptor	0.0025	0.0947	0.0976
Brugia malayi	Common central domain of tyrosinase family protein	0.0098	0.6191	0.6707
Brugia malayi	Nuclear hormone receptor-like 1	0.0013	0.0101	0.011
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0025	0.0947	0.1026
Brugia malayi	photoreceptor-specific nuclear receptor	0.0025	0.0947	0.1026
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0013	0.0101	0.0105
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0026	0.1054	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0025	0.0947	0.1026
Loa Loa (eye worm)	hypothetical protein	0.0098	0.6191	0.6707
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0147	0.9698	0.9698
Echinococcus granulosus	Ankyrin	0.003	0.129	0.129
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0947	0.1026
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0947	0.1026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0025	0.0947	0.1026
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.1155	0.1251
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0025	0.0947	0.1026
Brugia malayi	Uncoordinated protein 44	0.0029	0.1272	0.1378
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0025	0.0947	0.0947
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0025	0.0947	0.0976
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.1871	0.352
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0029	0.1272	0.1378
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0019	0.0538	0.4987
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0098	0.6191	0.6707
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0023	0.0788	0.4849
Onchocerca volvulus		0.0098	0.6191	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0029	0.1272	0.1272
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0101	0.011
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0101	0.011
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0101	0.011
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.7906	0.7906
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Onchocerca volvulus		0.0025	0.0947	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0788	0.0854
Schistosoma mansoni	netrin receptor unc5	0.0029	0.1272	0.1312
Brugia malayi	Carboxylesterase family protein	0.0065	0.3867	0.4189
Echinococcus multilocularis	ecdysone induced protein 78C	0.0025	0.0947	0.0947
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0025	0.0947	0.1026
Echinococcus granulosus	netrin receptor unc 5	0.0029	0.1272	0.1272
Entamoeba histolytica	hypothetical protein	0.0072	0.4325	1
Loa Loa (eye worm)	acetylcholinesterase 1	0.0065	0.3867	0.4189
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0026
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0025	0.0947	0.0947
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0025	0.0947	0.1026
Loa Loa (eye worm)	tyrosinase 1	0.0098	0.6191	0.6707
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.2118	1
Echinococcus granulosus	serine protein kinase ATM	0.0026	0.1054	0.1054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0025	0.0947	0.1026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Brugia malayi	acetyltransferase, GNAT family protein	0.014	0.923	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0019	0.0538	0.0554
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0019	0.0538	0.4987
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.4325	0.4325
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0025	0.0947	0.0947
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0025	0.0947	0.1026
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0025	0.0947	0.1026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0029	0.1272	0.1272
Entamoeba histolytica	hypothetical protein	0.0072	0.4325	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.1871	0.5
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0019	0.054	1
Echinococcus granulosus	FTZ F1 alpha	0.0025	0.0947	0.0947
Entamoeba histolytica	hypothetical protein	0.0026	0.1054	0.1364
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0025	0.0947	0.0947
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0013	0.0101	0.011
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0013	0.0101	0.0105
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0025	0.0947	0.0947
Loa Loa (eye worm)	acetyltransferase	0.014	0.923	1
Brugia malayi	nuclear receptor RXR	0.0013	0.0101	0.011
Brugia malayi	hypothetical protein	0.0013	0.0101	0.011
Brugia malayi	Nuclear hormone receptor-like 1	0.0013	0.0101	0.011
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0025	0.0947	0.0947
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0025	0.0947	0.0947
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0065	0.3867	0.3987
Echinococcus multilocularis	carboxylesterase 5A	0.0065	0.3867	0.3867
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0019	0.0538	0.2454
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0947	0.1026
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0025	0.0947	0.0976
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0025	0.0947	0.1026
Brugia malayi	Carboxylesterase family protein	0.0065	0.3867	0.4189
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0025	0.0947	0.0976
Brugia malayi	ecdysteroid receptor	0.0025	0.0947	0.1026
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0019	0.0538	0.0538
Entamoeba histolytica	hypothetical protein	0.0072	0.4325	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0025	0.0947	0.1026
Loa Loa (eye worm)	ShTK domain-containing protein	0.0098	0.6191	0.6707
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0025	0.0947	0.1026
Loa Loa (eye worm)	phosphatidylinositol 3	0.0019	0.0538	0.0582
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0019	0.0538	0.4987
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.2118	0.2118
Loa Loa (eye worm)	hypothetical protein	0.0029	0.1272	0.1378
Echinococcus granulosus	ecdysone induced protein 78C	0.0025	0.0947	0.0947
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0026	0.1054	0.1142
Schistosoma mansoni	tyrosinase precursor	0.0098	0.6191	0.6383
Loa Loa (eye worm)	steroid hormone receptor	0.0025	0.0947	0.1026
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.003	0.129	0.133
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0025	0.0947	0.1026
Brugia malayi	ShTK domain containing protein	0.0098	0.6191	0.6707
Echinococcus granulosus	acetylcholinesterase	0.0065	0.3867	0.3867
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.014	0.923	0.923
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0026	0.1054	0.1087
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0025	0.0947	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0065	0.3867	0.4189
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0013	0.0101	0.0101
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0025	0.0947	0.1026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Schistosoma mansoni	hypothetical protein	0.0029	0.1272	0.1312
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0098	0.6191	0.6707
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.4325	0.4325
Onchocerca volvulus		0.0098	0.6191	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0025	0.0947	0.0976
Echinococcus granulosus	death domain containing protein	0.0029	0.1272	0.1272
Entamoeba histolytica	hypothetical protein	0.0072	0.4325	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Onchocerca volvulus	Netrin receptor homolog	0.0029	0.1272	0.2055
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0019	0.054	0.0052
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.4325	0.446
Echinococcus multilocularis	FTZ F1 alpha	0.0025	0.0947	0.0947
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0025	0.0947	0.1026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0019	0.0538	0.0538
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.014	0.923	0.9518
Brugia malayi	Death domain containing protein	0.0029	0.1272	0.1378
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0029	0.1272	0.1378
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0025	0.0947	0.0947
Schistosoma mansoni	thyroid hormone receptor	0.0147	0.9698	1
Loa Loa (eye worm)	carboxylesterase	0.0065	0.3867	0.4189
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Echinococcus multilocularis	netrin receptor unc 5	0.0029	0.1272	0.1272
Echinococcus multilocularis	acetylcholinesterase	0.0065	0.3867	0.3867
Brugia malayi	Protein kinase domain containing protein	0.0029	0.1272	0.1378
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.2118	1
Brugia malayi	steroid hormone receptor	0.0025	0.0947	0.1026
Schistosoma mansoni	hypothetical protein	0.0072	0.4325	0.446
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Schistosoma mansoni	hypothetical protein	0.0122	0.7906	0.8152
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0025	0.0947	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0947	0.1026
Onchocerca volvulus	Protein ultraspiracle homolog	0.0025	0.0947	0.1529
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Echinococcus multilocularis	Ankyrin	0.003	0.129	0.129
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.2118	0.5
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0019	0.0538	0.4987
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0947	0.1026
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0019	0.0538	0.0538
Onchocerca volvulus		0.0098	0.6191	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0025	0.0947	0.1026
Loa Loa (eye worm)	ShTK domain-containing protein	0.0098	0.6191	0.6707
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0947	0.1026
Schistosoma mansoni	retinoic acid receptor RXR	0.0025	0.0947	0.0976
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0025	0.0947	0.0947
Brugia malayi	Cytochrome P450 family protein	0.0028	0.1155	0.1251
Schistosoma mansoni	ankyrin 23/unc44	0.0029	0.1272	0.1312
Toxoplasma gondii	FATC domain-containing protein	0.0026	0.1054	0.4921
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0025	0.0947	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0065	0.3867	0.4189
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.1054	0.4921
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0025	0.0947	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0101	0.011
Echinococcus granulosus	acetylcholinesterase	0.0065	0.3867	0.3867
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0098	0.6191	0.6707
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0538	0.2454
Schistosoma mansoni	coup transcription factor	0.0025	0.0947	0.0976
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0013	0.0101	0.0101
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0025	0.0947	0.1026
Brugia malayi	nuclear receptor NHR-88	0.0025	0.0947	0.1026
Echinococcus granulosus	carboxylesterase 5A	0.0065	0.3867	0.3867

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	0	Inhibition of Escherichia coli MurA C115D mutant	ChEMBL.	18261901
Activity (binding)	0	Inhibition of MDH (unknown origin)	ChEMBL.	18261901
Activity (binding)	0	Inhibition of chymotrypsin (unknown origin)	ChEMBL.	18261901
IC50 (binding)	= 8.53 uM	Inhibition of Escherichia coli MurA	ChEMBL.	18261901
IC50 (binding)	= 12.04 uM	Inhibition of Staphylococccus aureus MurA	ChEMBL.	18261901
IC50 (binding)	= 22.91 uM	Inhibition of Staphylococccus aureus MurZ	ChEMBL.	18261901
MIC (functional)	= 64 ug ml-1	Antibacterial activity against Staphylococcus aureus SH1000	ChEMBL.	18261901
MIC (functional)	= 128 ug ml-1	Antibacterial activity against Escherichia coli JM109	ChEMBL.	18261901

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 523524

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 506458