TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 386.552 | Formula: C25H26N2S
H donors: 1 H acceptors: 0 LogP: 6.27 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: C(Cc1cc2c(s1)cccc2)CCN1C2CCC1c1c(C2)[nH]c2c1cccc2
InChi: 1S/C25H26N2S/c1-4-11-24-17(7-1)15-19(28-24)8-5-6-14-27-18-12-13-23(27)25-20-9-2-3-10-21(20)26-22(25)16-18/h1-4,7,9-11,15,18,23,26H,5-6,8,12-14,16H2
InChiKey: NFZHTJRJDDMXHV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Dopamine D2 receptor	Starlite/ChEMBL	References
Mus musculus	5-hydroxytryptamine (serotonin) receptor 2A		References
Mus musculus	5-hydroxytryptamine (serotonin) receptor 2C		References
Mus musculus	5-hydroxytryptamine (serotonin) receptor 2B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Serotonin receptor	Get druggable targets OG5_135430	All targets in OG5_135430
Echinococcus granulosus	hypothetical protein	Get druggable targets OG5_144688	All targets in OG5_144688
Echinococcus multilocularis	conserved hypothetical protein	Get druggable targets OG5_144688	All targets in OG5_144688

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	biogenic amine 5HT receptor	Dopamine D2 receptor	444 aa	429 aa	31.7 %
Echinococcus multilocularis	serotonin receptor	Dopamine D2 receptor	444 aa	428 aa	31.3 %
Loa Loa (eye worm)	hypothetical protein	Dopamine D2 receptor	444 aa	433 aa	21.2 %
Onchocerca volvulus	RB1-inducible coiled-coil protein 1 homolog	Dopamine D2 receptor	444 aa	474 aa	23.4 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Dopamine D2 receptor	444 aa	440 aa	30.0 %
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Dopamine D2 receptor	444 aa	386 aa	19.7 %
Schistosoma japonicum	Octopamine receptor, putative	Dopamine D2 receptor	444 aa	456 aa	29.4 %
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	Dopamine D2 receptor	444 aa	487 aa	23.8 %
Echinococcus multilocularis	g protein coupled receptor	Dopamine D2 receptor	444 aa	465 aa	21.5 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Dopamine D2 receptor	444 aa	432 aa	30.8 %
Echinococcus granulosus	g protein coupled receptor	Dopamine D2 receptor	444 aa	457 aa	21.0 %
Schistosoma mansoni	biogenic amine (dopamine) receptor	Dopamine D2 receptor	444 aa	494 aa	26.3 %
Onchocerca volvulus	Glycoprotein hormone beta 5 homolog	Dopamine D2 receptor	444 aa	476 aa	24.2 %
Schistosoma mansoni	biogenic amine receptor	Dopamine D2 receptor	444 aa	452 aa	30.1 %
Onchocerca volvulus		Dopamine D2 receptor	444 aa	418 aa	23.0 %
Schistosoma mansoni	amine GPCR	Dopamine D2 receptor	444 aa	424 aa	32.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0005	0.006
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0035	0.0446
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.0035	0.0116
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0022	0.0035	0.0113
Schistosoma mansoni	retinoic acid receptor RXR	0.0105	0.0343	0.5882
Schistosoma mansoni	amine GPCR	0.0022	0.0035	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus granulosus	neuropeptide receptor	0.0022	0.0035	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0022	0.0035	0.0401
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.0035	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0035	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Schistosoma mansoni	histamine h1 receptor	0.0022	0.0035	0.0446
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.0035	0.0446
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0022	0.0035	0.0116
Echinococcus granulosus	neuropeptide FF receptor 2	0.0022	0.0035	0.0113
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.001	0.0023
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0021	0.1253
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0022	0.0035	0.0116
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0185	0.0593
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.0035	0.0446
Brugia malayi	Dopamine receptor protein 1	0.0022	0.0035	0.0144
Schistosoma mansoni	ap endonuclease	0.0019	0.0021	0.0197
Schistosoma mansoni	opsin-like receptor	0.0022	0.0035	0.0446
Brugia malayi	hypothetical protein	0.0022	0.0035	0.0144
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0035	0.0116
Echinococcus multilocularis	transcription factor btf3	0.0035	0.0081	0.0265
Schistosoma mansoni	growth hormone secretagogue receptor	0.0022	0.0035	0.0446
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0021	0.1253
Brugia malayi	TAR-binding protein	0.0063	0.0185	0.0861
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0035	0.0446
Echinococcus granulosus	neuropeptide receptor A26	0.0022	0.0035	0.0113
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0035	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Entamoeba histolytica	hypothetical protein	0.0035	0.0081	0.7694
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0185	0.3096
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0035	0.0113
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0021	0.0077
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0136	0.1537
Echinococcus granulosus	orexin receptor type 2	0.0022	0.0035	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Schistosoma mansoni	hypothetical protein	0.0022	0.0035	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.001	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0081	0.7694
Echinococcus multilocularis	GPCR, family 2	0.0016	0.001	0.0033
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.0035	0.0446
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0035	0.0446
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0021	0.1253
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0035	0.0446
Brugia malayi	cysteinyl tRNA synthetase protein 1	0.004	0.0099	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus multilocularis	allatostatin A receptor	0.0022	0.0035	0.0116
Plasmodium vivax	basic transcription factor 3b, putative	0.0035	0.0081	0.7982
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0022	0.0035	0.0116
Brugia malayi	RE15519p	0.0022	0.0035	0.0144
Echinococcus granulosus	sex peptide receptor	0.0022	0.0035	0.0113
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.001	0.0033
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0022	0.0035	0.0446
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0035	0.0446
Echinococcus granulosus	neuropeptide s receptor	0.0022	0.0035	0.0113
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0185	0.3096
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0051	0.0582
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.001	0.0032
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0022	0.0035	0.0446
Echinococcus granulosus	transcription factor btf3	0.0035	0.0081	0.0258
Loa Loa (eye worm)	cysteinyl tRNA synthetase 1	0.004	0.0099	0.1118
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0185	0.3096
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0022	0.0035	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0021	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0185	0.21
Trichomonas vaginalis	cysteinyl-tRNA synthetase, putative	0.004	0.0099	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.0035	0.0113
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0022	0.0035	0.0446
Brugia malayi	follicle stimulating hormone receptor	0.0251	0.0882	0.4194
Brugia malayi	putative neuropeptide receptor	0.0022	0.0035	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0078	0.0879
Echinococcus granulosus	7TM GPCR rhodopsin	0.0022	0.0035	0.0113
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0035	0.0116
Onchocerca volvulus		0.0027	0.0051	0.2527
Schistosoma mansoni	hypothetical protein	0.0168	0.0576	1
Echinococcus granulosus	GPCR family 2	0.0016	0.001	0.0032
Wolbachia endosymbiont of Brugia malayi	cysteinyl-tRNA synthetase	0.004	0.0099	1
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0081	0.7982
Schistosoma mansoni	ap endonuclease	0.0019	0.0021	0.0197
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0035	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0185	0.3096
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0051	0.0582
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0035	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0035	0.0113
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0035	0.0116
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0136	0.0623
Echinococcus multilocularis	geminin	0.0168	0.0576	0.1892
Brugia malayi	putative neuropeptide receptor NPR1	0.0022	0.0035	0.0144
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0022	0.0035	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0022	0.0035	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0185	0.21
Loa Loa (eye worm)	ICD-1 protein	0.0035	0.0081	0.0916
Plasmodium falciparum	cysteine--tRNA ligase	0.004	0.0099	1
Echinococcus multilocularis	sex peptide receptor	0.0022	0.0035	0.0116
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0022	0.0035	0.0446
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0021	0.1253
Brugia malayi	beta-NAC-like protein	0.0035	0.0081	0.0361
Giardia lamblia	Cysteinyl-tRNA synthetase	0.004	0.0099	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0035	0.0116
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.0035	0.0401
Schistosoma mansoni	amine GPCR	0.0022	0.0035	0.0446
Brugia malayi	Dopamine receptor protein 2	0.0022	0.0035	0.0144
Schistosoma mansoni	hypothetical protein	0.0022	0.0035	0.0446
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0251	0.0882	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0022	0.0035	0.0144
Schistosoma mansoni	lamin	0.0027	0.0051	0.0728
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.0035	0.0116
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.0035	0.0113
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0136	0.0623
Echinococcus multilocularis	cysteinyl tRNA synthetase	0.004	0.0099	0.0324
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0021	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Brugia malayi	RNA binding protein	0.0063	0.0185	0.0861
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0021	0.0068
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0022	0.0035	0.0113
Brugia malayi	G protein-coupled receptor	0.0022	0.0035	0.0144
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0078	0.0346
Schistosoma mansoni	hypothetical protein	0.0034	0.0078	0.1191
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0051	0.022
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.001	0.0023
Echinococcus granulosus	lamin dm0	0.0027	0.0051	0.0164
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.2709	1	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.001	0.0034
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0022	0.0035	0.0113
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.0035	0.0401
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.0035	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Schistosoma mansoni	amine GPCR	0.0022	0.0035	0.0446
Schistosoma mansoni	amine GPCR	0.0022	0.0035	0.0446
Brugia malayi	Melatonin receptor type 1A	0.0022	0.0035	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus multilocularis	dro:myosuppressin receptor	0.0022	0.0035	0.0116
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0035	0.0113
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0101	0.0328	0.1078
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0022	0.0035	0.0116
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.0035	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus granulosus	lamin	0.0027	0.0051	0.0164
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0022	0.0035	0.0116
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0035	0.0446
Leishmania major	basic transcription factor 3a, putative	0.0035	0.0081	0.7982
Brugia malayi	AKH receptor	0.0022	0.0035	0.0144
Schistosoma mansoni	hypothetical protein	0.0168	0.0576	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0022	0.0035	0.0144
Echinococcus granulosus	7tm_1 domain containing protein	0.0022	0.0035	0.0113
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.001	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0016	0.001	0.0115
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0035	0.0446
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.0035	0.0113
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.004	0.0099	0.1564
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0021	0.1253
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0021	0.1253
Echinococcus granulosus	leucyl tRNA synthetase	0.004	0.0099	0.0315
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.001	0.0002
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0035	0.0446
Echinococcus multilocularis	neuropeptide receptor A26	0.0022	0.0035	0.0116
Brugia malayi	Serotonin receptor	0.0578	0.2096	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0022	0.0035	0.0144
Schistosoma mansoni	myosin xvIII	0.0022	0.0035	0.0446
Echinococcus granulosus	neuropeptide receptor	0.0022	0.0035	0.0113
Schistosoma mansoni	lamin	0.0027	0.0051	0.0728
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0105	0.0343	0.1097
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0136	0.1537
Schistosoma mansoni	hypothetical protein	0.0022	0.0035	0.0446
Plasmodium falciparum	basic transcription factor 3b, putative	0.0035	0.0081	0.7982
Brugia malayi	G protein-coupled receptor F59B2.13	0.0022	0.0035	0.0144
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0185	0.21
Echinococcus granulosus	intermediate filament protein	0.0027	0.0051	0.0164
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0035	0.0116
Brugia malayi	hypothetical protein	0.0022	0.0035	0.0144
Echinococcus multilocularis	G protein coupled receptor 139	0.0022	0.0035	0.0116
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.0035	0.0401
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0035	0.0113
Brugia malayi	G-protein coupled receptor	0.0022	0.0035	0.0144
Brugia malayi	hypothetical protein	0.0022	0.0035	0.0144
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0022	0.0035	0.0113
Echinococcus granulosus	dro:myosuppressin receptor	0.0022	0.0035	0.0113
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0022	0.0035	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Onchocerca volvulus		0.004	0.0099	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0022	0.0035	0.0401
Echinococcus multilocularis	serotonin receptor	0.0022	0.0035	0.0116
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0035	0.0116
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0022	0.0035	0.0401
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.0035	0.0113
Brugia malayi	Serotonin receptor	0.0022	0.0035	0.0144
Schistosoma mansoni	transcription factor btf3	0.0035	0.0081	0.1249
Toxoplasma gondii	exonuclease III APE	0.0019	0.0021	0.1253
Brugia malayi	intermediate filament protein	0.0027	0.0051	0.022
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0022	0.0035	0.0116
Chlamydia trachomatis	cysteine--tRNA ligase	0.004	0.0099	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0035	0.0113
Trypanosoma brucei	cysteinyl-tRNA synthetase, putative	0.004	0.0099	1
Leishmania major	cysteinyl-tRNA synthetase, putative	0.004	0.0099	1
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.0035	0.0113
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.001	0.0116
Brugia malayi	hypothetical protein	0.0022	0.0035	0.0144
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0035	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus granulosus	g-protein coupled receptor	0.0022	0.0035	0.0113
Schistosoma mansoni	opsin-like receptor	0.0022	0.0035	0.0446
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0185	0.0861
Brugia malayi	neuropeptide F receptor	0.0022	0.0035	0.0144
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.004	0.0099	0.0077
Brugia malayi	sulfakinin receptor protein	0.0022	0.0035	0.0144
Loa Loa (eye worm)	hypothetical protein	0.004	0.0099	0.1118
Echinococcus multilocularis	musashi	0.0027	0.0051	0.0169
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0035	0.0446
Brugia malayi	hypothetical protein	0.0022	0.0035	0.0144
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0035	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.0035	0.0113
Onchocerca volvulus		0.0027	0.0051	0.2527
Loa Loa (eye worm)	hypothetical protein	0.0026	0.005	0.0562
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.0035	0.0113
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0051	0.0728
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0035	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Trypanosoma brucei	transcription factor BTF3, putative	0.0035	0.0081	0.7982
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.0035	0.0446
Brugia malayi	G-protein coupled receptor	0.0022	0.0035	0.0144
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.0035	0.0116
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0035	0.0113
Toxoplasma gondii	NAC domain-containing protein	0.0035	0.0081	0.7982
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0081	0.7982
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0185	0.0609
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0035	0.0116
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.001	0.0024
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0035	0.0113
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0185	0.3096
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0035	0.0116
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.001	0.0033
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0035	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Loa Loa (eye worm)	melatonin receptor type 1A	0.0022	0.0035	0.0401
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0035	0.0446
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.004	0.0099	1
Echinococcus multilocularis	g-protein coupled receptor	0.0022	0.0035	0.0116
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0035	0.0446
Echinococcus multilocularis	lamin	0.0027	0.0051	0.0169
Brugia malayi	neuropeptide F receptor	0.0022	0.0035	0.0144
Brugia malayi	hypothetical protein	0.0022	0.0035	0.0144
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.0035	0.0116
Echinococcus granulosus	cysteinyl tRNA synthetase	0.004	0.0099	0.0315
Echinococcus granulosus	fmrfamide receptor	0.0022	0.0035	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus multilocularis	orexin receptor type 2	0.0022	0.0035	0.0116
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0035	0.0116
Schistosoma mansoni	hypothetical protein	0.0022	0.0035	0.0446
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0022	0.0035	0.0116
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0022	0.0035	0.0113
Brugia malayi	hypothetical protein	0.0022	0.0035	0.0144
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0035	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus multilocularis	somatostatin receptor	0.0022	0.0035	0.0116
Schistosoma mansoni	neuropeptide f receptor 76f	0.0022	0.0035	0.0446
Echinococcus granulosus	G protein coupled receptor 139	0.0022	0.0035	0.0113
Echinococcus granulosus	geminin	0.0168	0.0576	0.1842
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0035	0.0113
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0035	0.0113
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.0035	0.0116
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0022	0.0035	0.0116
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0035	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0035	0.0116
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.001	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Schistosoma mansoni	adenoreceptor	0.0022	0.0035	0.0446
Echinococcus granulosus	allatostatin A receptor	0.0022	0.0035	0.0113
Brugia malayi	ORL1-like opioid receptor	0.0022	0.0035	0.0144
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.0035	0.0116
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0022	0.0035	0.0446
Brugia malayi	hypothetical protein	0.0022	0.0035	0.0144
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0035	0.0446
Echinococcus granulosus	somatostatin receptor	0.0022	0.0035	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Brugia malayi	hypothetical protein	0.0022	0.0035	0.0144
Plasmodium vivax	cysteine--tRNA ligase, putative	0.004	0.0099	1
Mycobacterium tuberculosis	Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC	0.2709	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.0035	0.0446
Entamoeba histolytica	transcription factor BTF3, putative	0.0035	0.0081	0.7694
Echinococcus granulosus	serotonin receptor	0.0022	0.0035	0.0113
Echinococcus multilocularis	lamin dm0	0.0027	0.0051	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.0035	0.0116
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0021	0.007
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0022	0.0035	0.0144
Entamoeba histolytica	cysteinyl-tRNA synthetase, putative	0.004	0.0099	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0022	0.0035	0.0446
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.0035	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0051	0.0582
Schistosoma mansoni	amine GPCR	0.0022	0.0035	0.0446
Brugia malayi	larval opioid receptor	0.0022	0.0035	0.0144
Echinococcus multilocularis	neuropeptide s receptor	0.0022	0.0035	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.004	0.0099	0.1564
Treponema pallidum	cysteinyl-tRNA synthetase	0.004	0.0099	1
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0035	0.0446
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0081	0.7694
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.001	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0035	0.0116
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0035	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0022	0.0035	0.0116
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0022	0.0035	0.0446
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0081	0.7694
Echinococcus multilocularis	serotonin receptor	0.0022	0.0035	0.0116
Plasmodium falciparum	cysteine--tRNA ligase	0.004	0.0099	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.0035	0.0446
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0022	0.0035	0.0401
Echinococcus granulosus	hypothetical protein	0.0856	0.3126	1
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.0035	0.0116
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.001	0.0115
Echinococcus multilocularis	conserved hypothetical protein	0.0833	0.3043	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.001	0.0032
Brugia malayi	Dopamine receptor	0.0022	0.0035	0.0144
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.001	0.0034
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.0035	0.0116
Toxoplasma gondii	cysteine-tRNA synthetase (CysRS)	0.004	0.0099	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0022	0.0035	0.0144
Brugia malayi	hypothetical protein	0.0022	0.0035	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.004	0.0099	1
Brugia malayi	GnHR receptor homolog	0.0022	0.0035	0.0144
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0022	0.0035	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0035	0.0401
Schistosoma mansoni	opsin-like receptor	0.0022	0.0035	0.0446
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0035	0.0113
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.0035	0.0401
Brugia malayi	isocitrate dehydrogenase	0.0016	0.001	0.0024
Loa Loa (eye worm)	TYRA-2 protein	0.0022	0.0035	0.0401
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0035	0.0446

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 416 nM	Binding affinity against dopamine receptor D2 from rat corpus striatum by using radioligand [3H]-sulpiride	ChEMBL.	8496917
Ki (binding)	= 416 nM	Binding affinity against dopamine receptor D2 from rat corpus striatum by using radioligand [3H]-sulpiride	ChEMBL.	8496917
Ki (binding)	= 610 nM	Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]-ketanserin.	ChEMBL.	8496917
Ki (binding)	= 610 nM	Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]-ketanserin.	ChEMBL.	8496917

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL289563

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 50660