Detailed information for compound 506693

Basic information

Technical information
  • TDR Targets ID: 506693
  • Name: 3-(2-acetylphenyl)-5-ethoxy-N-[(2S,3R)-3-hydr oxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]me thylamino]butan-2-yl]benzamide
  • MW: 604.659 | Formula: C35H35F3N2O4
  • H donors: 3 H acceptors: 3 LogP: 6.2 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOc1cc(cc(c1)c1ccccc1C(=O)C)C(=O)N[C@H]([C@@H](CNCc1cccc(c1)C(F)(F)F)O)Cc1ccccc1
  • InChi: 1S/C35H35F3N2O4/c1-3-44-29-19-26(31-15-8-7-14-30(31)23(2)41)18-27(20-29)34(43)40-32(17-24-10-5-4-6-11-24)33(42)22-39-21-25-12-9-13-28(16-25)35(36,37)38/h4-16,18-20,32-33,39,42H,3,17,21-22H2,1-2H3,(H,40,43)/t32-,33+/m0/s1
  • InChiKey: YJKAWDNPEIHQRW-JHOUSYSJSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(2-acetylphenyl)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[3-(trifluoromethyl)phenyl]methylamino]propyl]-5-ethoxy-benzamide
  • 3-(2-acetylphenyl)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[3-(trifluoromethyl)phenyl]methylamino]propyl]-5-ethoxybenzamide
  • 3-(2-ethanoylphenyl)-5-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]benzamide
  • 3-(2-acetylphenyl)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[3-(trifluoromethyl)benzyl]amino]propyl]-5-ethoxy-benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin D Starlite/ChEMBL References
Homo sapiens beta-site APP-cleaving enzyme 2 Starlite/ChEMBL References
Homo sapiens beta-site APP-cleaving enzyme 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Babesia bovis eukaryotic aspartyl protease family protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl protease ASP1 Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii plasmepsin Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum ko:K07747 beta-site APP-cleaving enzyme 2 (memapsin 1) [EC3.4.23.45], putative Get druggable targets OG5_135830 All targets in OG5_135830
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax aspartyl proteinase, putative Get druggable targets OG5_126885 All targets in OG5_126885
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi aspartyl protease, putative Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium parvum membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva cathepsin E, putative Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva pepsinogen, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin II Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) aspartic protease BmAsp-2 Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni memapsin-2 (A01 family) Get druggable targets OG5_135830 All targets in OG5_135830
Echinococcus granulosus cathepsin d lysosomal aspartyl protease Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Renin, related Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium hominis aspartyl protease precursor Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl proteinase (eimepsin), putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin I Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum Cathepsin D precursor, putative Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Pepsinogen A1, related Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum ko:K01379 cathepsin D [EC3.4.23.5], putative Get druggable targets OG5_126885 All targets in OG5_126885
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum plasmepsin VII beta-site APP-cleaving enzyme 1 401 aa 352 aa 21.3 %
Plasmodium falciparum plasmepsin X cathepsin D 412 aa 339 aa 28.9 %
Plasmodium falciparum plasmepsin V beta-site APP-cleaving enzyme 2 518 aa 439 aa 21.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear receptor NHR-67 0.0097 0.1352 0.1472
Echinococcus multilocularis Rac GTPase activating protein 1 0.0043 0.0449 0.0449
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0306 0.0333
Loa Loa (eye worm) hypothetical protein 0.004 0.0394 0.0429
Schistosoma mansoni hypothetical protein 0.0035 0.0306 0.0303
Loa Loa (eye worm) hypothetical protein 0.004 0.0394 0.0429
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.1035 0.1559
Schistosoma mansoni myosin xvIII 0.0035 0.0306 0.0303
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0306 0.0303
Schistosoma mansoni hypothetical protein 0.0039 0.037 0.0367
Echinococcus multilocularis transcription factor btf3 0.0017 0.0003 0.0003
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0012 0.0041
Plasmodium vivax telomerase reverse transcriptase, putative 0.014 0.2077 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0101 0.142 0.1418
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0306 0.0461
Echinococcus granulosus dro:myosuppressin receptor 0.0035 0.0306 0.0461
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Loa Loa (eye worm) hypothetical protein 0.0205 0.3178 0.3459
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0661 0.0659
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0205 0.3178 0.3459
Plasmodium vivax plasmepsin IV, putative 0.0101 0.142 0.6834
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0252 0.3976 0.3976
Schistosoma mansoni hypothetical protein 0.0039 0.037 0.0367
Mycobacterium ulcerans lipase LipD 0.0035 0.0312 0.0716
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0155 0.0343
Loa Loa (eye worm) hypothetical protein 0.0066 0.0833 0.0906
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0101 0.142 0.1546
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0035 0.0306 0.0333
Schistosoma mansoni jun-related protein 0.0205 0.3179 0.3177
Mycobacterium tuberculosis Conserved protein 0.0035 0.0312 0.0862
Echinococcus granulosus transcription factor btf3 0.0017 0.0003 0.0005
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0097 0.1352 0.162
Schistosoma mansoni neuropeptide f receptor 76f 0.0035 0.0306 0.0303
Echinococcus multilocularis lamin dm0 0.008 0.1063 0.1063
Brugia malayi cytochrome P450 0.0017 0.0012 0.0013
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0116 0.0546
Onchocerca volvulus 0.0035 0.0306 0.0367
Onchocerca volvulus 0.0205 0.3178 0.3808
Brugia malayi Peroxidasin 0.0051 0.0583 0.0635
Onchocerca volvulus Bile acid receptor homolog 0.0205 0.3178 0.3808
Brugia malayi CXXC zinc finger family protein 0.0038 0.0366 0.0399
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0306 0.0306
Brugia malayi beta-lactamase family protein 0.0035 0.0312 0.0339
Brugia malayi MH2 domain containing protein 0.0025 0.0144 0.0157
Echinococcus granulosus neuropeptide receptor 0.0035 0.0306 0.0461
Schistosoma mansoni tyrosine kinase 0.0078 0.1035 0.1032
Loa Loa (eye worm) hypothetical protein 0.004 0.0394 0.0429
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Echinococcus multilocularis Polycystic kidney disease protein 0.0058 0.0691 0.0691
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0101 0.142 0.3376
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0726 0.0791
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0047 0.0517 0.078
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.004 0.0394 0.0394
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0312 0.0735
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0205 0.3178 0.3178
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0306 0.0306
Loa Loa (eye worm) serotonin transporter b 0.0235 0.3684 0.401
Echinococcus granulosus thyroid hormone receptor alpha 0.0097 0.1352 0.2037
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0208 0.0208
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0312 0.0309
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0035 0.0306 0.0306
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0394 0.1886
Schistosoma mansoni lamin 0.008 0.1063 0.106
Entamoeba histolytica hypothetical protein 0.0107 0.1525 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Plasmodium falciparum plasmepsin X 0.0056 0.0661 0.3175
Brugia malayi jmjC domain containing protein 0.0037 0.0347 0.0378
Loa Loa (eye worm) glutaminase 0.0266 0.4202 0.4573
Loa Loa (eye worm) hypothetical protein 0.0108 0.1548 0.1684
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0132 0.1948 0.212
Loa Loa (eye worm) hypothetical protein 0.0562 0.9188 1
Echinococcus granulosus insulin receptor 0.0046 0.0503 0.0757
Schistosoma mansoni hypothetical protein 0.0083 0.1123 0.112
Schistosoma mansoni histamine h1 receptor 0.0035 0.0306 0.0303
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0312 0.1488
Schistosoma mansoni biogenic amine receptor 0.0035 0.0306 0.0303
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0306 0.0303
Loa Loa (eye worm) norepinephrine transporter 0.0235 0.3684 0.401
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0059 0.0722 0.2042
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.044 0.0479
Loa Loa (eye worm) hypothetical protein 0.0097 0.1352 0.1472
Loa Loa (eye worm) hypothetical protein 0.004 0.0394 0.0429
Loa Loa (eye worm) hypothetical protein 0.0097 0.1352 0.1472
Brugia malayi Thioredoxin reductase 0.0023 0.0116 0.0126
Echinococcus granulosus GPCR family 2 0.0039 0.037 0.0558
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0394 0.1886
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.004 0.0394 0.0594
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0312 0.0339
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0803 0.0874
Treponema pallidum sodium- and chloride- dependent transporter 0.0235 0.3684 0.5
Brugia malayi hypothetical protein 0.0035 0.0306 0.0333
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.004 0.0394 0.0391
Loa Loa (eye worm) hypothetical protein 0.0043 0.0449 0.0489
Entamoeba histolytica hypothetical protein 0.0107 0.1525 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0035 0.0306 0.0306
Echinococcus multilocularis epidermal growth factor receptor 0.0145 0.2166 0.2166
Brugia malayi ORL1-like opioid receptor 0.0035 0.0306 0.0333
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0205 0.3178 0.4789
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0394 0.1886
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0803 0.5259
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0023 0.0116 0.0301
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Brugia malayi Blistered cuticle protein 3 0.0051 0.0583 0.0635
Loa Loa (eye worm) hypothetical protein 0.0108 0.1548 0.1684
Schistosoma mansoni hypothetical protein 0.0332 0.5319 0.5318
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0035 0.0306 0.0333
Schistosoma mansoni hypothetical protein 0.0039 0.037 0.0367
Schistosoma mansoni retinoic acid receptor RXR 0.0301 0.4794 0.4792
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Loa Loa (eye worm) hypothetical protein 0.0037 0.0344 0.0375
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0108 0.1548 0.1545
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0108 0.1548 0.1545
Onchocerca volvulus 0.0035 0.0306 0.0367
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Echinococcus granulosus g protein coupled receptor 0.0035 0.0306 0.0461
Onchocerca volvulus Chorion peroxidase homolog 0.0051 0.0583 0.0699
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0012 0.0041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0132 0.1948 0.1948
Loa Loa (eye worm) hypothetical protein 0.0097 0.1352 0.1472
Schistosoma mansoni laminin gamma-3 chain 0.0065 0.0824 0.0821
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0306 0.0306
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0306 0.0306
Brugia malayi beta-NAC-like protein 0.0017 0.0003 0.0003
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0059 0.0722 1
Onchocerca volvulus 0.004 0.0394 0.0472
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0208 0.0989
Leishmania major trypanothione reductase 0.0023 0.0116 0.0546
Mycobacterium tuberculosis Probable reductase 0.0053 0.0622 0.1753
Brugia malayi tailless protein 0.0097 0.1352 0.1472
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Onchocerca volvulus 0.0198 0.3062 0.3669
Loa Loa (eye worm) runx1 0.0036 0.0331 0.036
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0205 0.3178 0.4789
Schistosoma mansoni tyrosine kinase 0.0077 0.1021 0.1018
Onchocerca volvulus 0.0035 0.0306 0.0367
Echinococcus granulosus somatostatin receptor 0.0035 0.0306 0.0461
Loa Loa (eye worm) hypothetical protein 0.0058 0.0691 0.0752
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0394 0.0391
Mycobacterium ulcerans aldehyde dehydrogenase 0.0029 0.021 0.0474
Mycobacterium tuberculosis Conserved protein 0.0035 0.0312 0.0862
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0053 0.0622 0.1753
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0208 0.0314
Loa Loa (eye worm) hypothetical protein 0.0235 0.3684 0.401
Brugia malayi RhoGAP domain containing protein 0.0043 0.0449 0.0489
Leishmania major cytochrome p450-like protein 0.0017 0.0012 0.0041
Schistosoma mansoni cell polarity protein 0.0049 0.0546 0.0543
Brugia malayi Protein kinase domain containing protein 0.0045 0.0474 0.0516
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Trichomonas vaginalis CAMK family protein kinase 0.0024 0.0119 0.0277
Echinococcus multilocularis sex peptide receptor 0.0035 0.0306 0.0306
Brugia malayi AKH receptor 0.0035 0.0306 0.0333
Echinococcus multilocularis allatostatin A receptor 0.0035 0.0306 0.0306
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0053 0.0622 0.1753
Echinococcus granulosus jun protein 0.0252 0.3976 0.5991
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0035 0.0306 0.0333
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0029 0.021 0.0571
Plasmodium falciparum glutathione reductase 0.0023 0.0116 0.0546
Loa Loa (eye worm) hypothetical protein 0.0035 0.0312 0.0339
Echinococcus multilocularis Smad4 0.0025 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0097 0.1352 0.1472
Loa Loa (eye worm) nuclear hormone receptor 0.0097 0.1352 0.1472
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Echinococcus multilocularis G-protein coupled receptor, putative 0.0035 0.0306 0.0306
Brugia malayi nuclear hormone receptor 0.0097 0.1352 0.1472
Echinococcus multilocularis serotonin receptor 0.0035 0.0306 0.0306
Plasmodium vivax aspartyl proteinase, putative 0.0101 0.142 0.6834
Brugia malayi nuclear receptor NHR-88 0.0205 0.3178 0.3459
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0144 0.0157
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0144 0.0157
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0205 0.3178 0.3176
Plasmodium falciparum LCCL domain-containing protein 0.0058 0.0691 0.3317
Brugia malayi bZIP transcription factor family protein 0.0252 0.3976 0.4327
Plasmodium falciparum plasmepsin II 0.0101 0.142 0.6834
Loa Loa (eye worm) beta-lactamase 0.0035 0.0312 0.0339
Echinococcus granulosus alpha 1A adrenergic receptor 0.0035 0.0306 0.0461
Schistosoma mansoni aldehyde dehydrogenase 0.0029 0.021 0.0207
Loa Loa (eye worm) hypothetical protein 0.0183 0.2803 0.305
Onchocerca volvulus 0.0056 0.0661 0.0793
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.008 0.1063 0.1157
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0122 0.1772 0.1928
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0306 0.0461
Echinococcus multilocularis insulin receptor 0.0046 0.0503 0.0503
Onchocerca volvulus Peroxidase homolog 0.0051 0.0583 0.0699
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0306 0.0461
Onchocerca volvulus 0.008 0.1063 0.1273
Brugia malayi Serotonin receptor 0.0482 0.7846 0.8539
Loa Loa (eye worm) hypothetical protein 0.0065 0.0824 0.0897
Schistosoma mansoni rac gtpase activating protein 0.0043 0.0449 0.0446
Schistosoma mansoni RAR-like nuclear receptor 0.0205 0.3178 0.3176
Brugia malayi G-protein coupled receptor 0.0035 0.0306 0.0333
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0833 0.083
Trypanosoma brucei telomerase reverse transcriptase 0.014 0.2077 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.014 0.2077 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0306 0.0461
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.1525 0.2298
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0833 0.1255
Leishmania major telomerase reverse transcriptase, putative 0.014 0.2077 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.1352 0.1472
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0097 0.1352 0.1349
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0101 0.142 0.214
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0517 0.1225
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0344 0.5513 0.5513
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.0691 0.0691
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0833 0.0833
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0306 0.0333
Brugia malayi intermediate filament protein 0.008 0.1063 0.1157
Loa Loa (eye worm) hypothetical protein 0.004 0.0394 0.0429
Echinococcus granulosus sex peptide receptor 0.0035 0.0306 0.0461
Brugia malayi glutaminase DH11.1 0.0266 0.4202 0.4573
Brugia malayi G protein-coupled receptor 0.0035 0.0306 0.0333
Onchocerca volvulus Peroxidase homolog 0.0051 0.0583 0.0699
Schistosoma mansoni tyrosine kinase 0.0077 0.1021 0.1018
Brugia malayi hypothetical protein 0.0035 0.0306 0.0333
Onchocerca volvulus Protein ultraspiracle homolog 0.0205 0.3178 0.3808
Loa Loa (eye worm) ICD-1 protein 0.0017 0.0003 0.0003
Onchocerca volvulus 0.0056 0.0661 0.0793
Schistosoma mansoni hypothetical protein 0.0405 0.6544 0.6543
Trichomonas vaginalis CAMK family protein kinase 0.0024 0.0119 0.0277
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0144 0.0217
Brugia malayi RE15519p 0.0035 0.0306 0.0333
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0394 0.0391
Onchocerca volvulus 0.0097 0.1352 0.162
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0039 0.037 0.0558
Echinococcus granulosus neurogenic locus notch protein 0.0049 0.0546 0.0822
Loa Loa (eye worm) hypothetical protein 0.0051 0.0583 0.0635
Echinococcus granulosus ecdysone induced protein 78C 0.0205 0.3178 0.4789
Echinococcus multilocularis G protein coupled receptor 139 0.0035 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Echinococcus granulosus uncharacterized sodium dependent transporter 0.004 0.0394 0.0594
Echinococcus multilocularis tar DNA binding protein 0.0107 0.153 0.153
Loa Loa (eye worm) hypothetical protein 0.0235 0.3684 0.401
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0144 0.0217
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0029 0.021 0.1
Onchocerca volvulus 0.0051 0.0583 0.0699
Schistosoma mansoni rab6-interacting 0.0058 0.0691 0.0688
Schistosoma mansoni lamin 0.008 0.1063 0.106
Brugia malayi nuclear hormone receptor family member odr-7 0.0097 0.1352 0.1472
Echinococcus granulosus neuropeptide s receptor 0.0035 0.0306 0.0461
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0312 0.047
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0306 0.0333
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0041 0.0038
Brugia malayi Bromodomain containing protein 0.0029 0.0208 0.0227
Schistosoma mansoni smad1 5 8 and 0.0025 0.0144 0.0141
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0312 0.0339
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0661 0.0659
Onchocerca volvulus 0.0035 0.0306 0.0367
Brugia malayi TAR-binding protein 0.0107 0.153 0.1665
Loa Loa (eye worm) hypothetical protein 0.0183 0.2803 0.305
Brugia malayi serine/threonine-protein kinase plk-2 0.0047 0.0517 0.0563
Plasmodium vivax hypothetical protein, conserved 0.004 0.0394 0.1886
Brugia malayi Nuclear hormone receptor-like 1 0.0108 0.1548 0.1684
Brugia malayi hypothetical protein 0.0035 0.0306 0.0333
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0035 0.0306 0.0461
Loa Loa (eye worm) DR-78 0.0097 0.1352 0.1472
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0306 0.0306
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0306 0.0303
Entamoeba histolytica hypothetical protein 0.0107 0.1525 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0583 0.0635
Schistosoma mansoni hypothetical protein 0.005 0.0569 0.0566
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0661 0.0659
Echinococcus multilocularis cpg binding protein 0.004 0.0403 0.0403
Brugia malayi aspartic protease BmAsp-1, identical 0.0056 0.0661 0.072
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0344 0.5513 0.6001
Loa Loa (eye worm) hypothetical protein 0.0108 0.1548 0.1684
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0155 0.0734
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0347 0.0344
Brugia malayi larval opioid receptor 0.0035 0.0306 0.0333
Echinococcus granulosus thioredoxin glutathione reductase 0.0023 0.0116 0.0175
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0035 0.0306 0.0303
Giardia lamblia Kinase, PLK 0.0047 0.0517 0.1655
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0306 0.0303
Plasmodium falciparum amino acid transporter, putative 0.004 0.0394 0.1886
Echinococcus multilocularis FTZ F1 alpha 0.0205 0.3178 0.3178
Schistosoma mansoni cpg binding protein 0.004 0.0403 0.04
Mycobacterium leprae Probable lipase LipE 0.0035 0.0312 0.4223
Loa Loa (eye worm) transcription factor SMAD2 0.0368 0.5923 0.6447
Schistosoma mansoni smad1 5 8 and 0.0025 0.0144 0.0141
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0347 0.0344
Brugia malayi hypothetical protein 0.0097 0.1352 0.1472
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.0394 0.0391
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0306 0.0461
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0035 0.0306 0.0461
Schistosoma mansoni hypothetical protein 0.0058 0.0691 0.0688
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Trypanosoma cruzi polo-like protein kinase, putative 0.0047 0.0517 0.248
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0583 0.0635
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0205 0.3178 0.4789
Loa Loa (eye worm) hypothetical protein 0.0051 0.0583 0.0635
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0205 0.3178 0.3178
Echinococcus granulosus g protein coupled receptor 0.0035 0.0306 0.0461
Loa Loa (eye worm) hypothetical protein 0.0051 0.0583 0.0635
Schistosoma mansoni lipoxygenase 0.0119 0.1719 0.1717
Trypanosoma brucei trypanothione reductase 0.0023 0.0116 0.0546
Onchocerca volvulus Neuropeptide F receptor homolog 0.0035 0.0306 0.0367
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0047 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.008 0.1063 0.1157
Plasmodium falciparum thioredoxin reductase 0.0023 0.0116 0.0546
Schistosoma mansoni lipoxygenase 0.0222 0.3464 0.3462
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.1315 0.1982
Brugia malayi hypothetical protein 0.0035 0.0306 0.0333
Echinococcus granulosus g protein coupled receptor 0.0035 0.0306 0.0461
Schistosoma mansoni smad1 5 8 and 0.0025 0.0144 0.0141
Schistosoma mansoni opsin-like receptor 0.0035 0.0306 0.0303
Onchocerca volvulus Netrin receptor homolog 0.0044 0.0464 0.0556
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Schistosoma mansoni tyrosine kinase 0.0046 0.0503 0.05
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0306 0.0461
Loa Loa (eye worm) hypothetical protein 0.0051 0.0583 0.0635
Schistosoma mansoni intermediate filament proteins 0.008 0.1063 0.106
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0123 0.1788 0.8606
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0464 0.0505
Schistosoma mansoni opsin-like receptor 0.0035 0.0306 0.0303
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0029 0.021 0.021
Schistosoma mansoni nuclear receptor nhr-48 0.0097 0.1352 0.1349
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Loa Loa (eye worm) hypothetical protein 0.0051 0.0583 0.0635
Echinococcus granulosus 7tm_1 domain containing protein 0.0035 0.0306 0.0461
Brugia malayi Intermediate filament tail domain containing protein 0.008 0.1063 0.1157
Schistosoma mansoni hypothetical protein 0.0305 0.4866 0.4864
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0312 0.0862
Schistosoma mansoni slit 0.0065 0.0824 0.0821
Echinococcus granulosus Smad4 0.0025 0.0144 0.0217
Echinococcus granulosus cpg binding protein 0.004 0.0403 0.0607
Loa Loa (eye worm) hypothetical protein 0.0205 0.3178 0.3459
Brugia malayi hypothetical protein 0.0035 0.0306 0.0333
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0205 0.3178 0.3178
Loa Loa (eye worm) hypothetical protein 0.0097 0.1352 0.1472
Loa Loa (eye worm) carboxylesterase 0.0066 0.0833 0.0906
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0205 0.3178 0.3459
Echinococcus multilocularis slit 2 protein 0.0065 0.0824 0.0824
Loa Loa (eye worm) hypothetical protein 0.0097 0.1352 0.1472
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0301 0.4794 0.7224
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0205 0.3178 0.3178
Loa Loa (eye worm) hypothetical protein 0.0288 0.4577 0.4981
Brugia malayi Nuclear hormone receptor E75 0.0097 0.1352 0.1472
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0205 0.3178 0.3459
Schistosoma mansoni polycystin 1-related 0.0058 0.0691 0.0688
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0035 0.0306 0.0303
Echinococcus multilocularis mitogen activated protein kinase 14 0.0123 0.1788 0.1788
Schistosoma mansoni cathepsin D (A01 family) 0.0216 0.3357 0.3355
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0205 0.3178 0.3178
Echinococcus granulosus peregrin 0.0029 0.0208 0.0314
Loa Loa (eye worm) hypothetical protein 0.0051 0.0583 0.0635
Onchocerca volvulus 0.0035 0.0306 0.0367
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0306 0.0303
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0583 0.0635
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0132 0.1948 0.2936
Echinococcus multilocularis mitogen activated protein kinase 14 0.0123 0.1788 0.1788
Brugia malayi hypothetical protein 0.0108 0.1548 0.1684
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0306 0.0306
Brugia malayi Muscleblind-like protein 0.0183 0.2803 0.305
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Plasmodium falciparum plasmepsin I 0.0101 0.142 0.6834
Brugia malayi hypothetical protein 0.0107 0.1525 0.166
Schistosoma mansoni hypothetical protein 0.0029 0.0208 0.0205
Echinococcus granulosus g-protein coupled receptor 0.0035 0.0306 0.0461
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.004 0.0394 0.0394
Onchocerca volvulus 0.008 0.1063 0.1273
Mycobacterium ulcerans beta-lactamase 0.0035 0.0312 0.0716
Echinococcus multilocularis musashi 0.008 0.1063 0.1063
Brugia malayi hypothetical protein 0.0056 0.0661 0.072
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0012 0.0041
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0108 0.1548 0.1684
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0038 0.0369 0.0369
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.004 0.0394 0.0394
Echinococcus multilocularis geminin 0.0332 0.5319 0.5319
Echinococcus granulosus serotonin receptor 0.0035 0.0306 0.0461
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0053 0.0622 0.1753
Plasmodium falciparum plasmepsin VI 0.0101 0.142 0.6834
Echinococcus multilocularis neuropeptide FF receptor 2 0.0035 0.0306 0.0306
Echinococcus multilocularis orexin receptor type 2 0.0035 0.0306 0.0306
Schistosoma mansoni neuropeptide receptor 0.0035 0.0306 0.0303
Brugia malayi Eukaryotic aspartyl protease family protein 0.0056 0.0661 0.072
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0306 0.0461
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0035 0.0306 0.0306
Echinococcus multilocularis serotonin receptor 0.0035 0.0306 0.0306
Echinococcus granulosus nuclear receptor nhr 48 0.0097 0.1352 0.2037
Loa Loa (eye worm) TK/EGFR protein kinase 0.0145 0.2166 0.2357
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0012 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0306 0.0303
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0039 0.037 0.0403
Loa Loa (eye worm) hypothetical protein 0.0051 0.0583 0.0635
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0035 0.0306 0.0367
Echinococcus multilocularis nuclear receptor nhr 48 0.0097 0.1352 0.1352
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0583 0.0635
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0205 0.3178 0.3459
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0205 0.3178 0.3176
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.1035 0.1035
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0306 0.0461
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0123 0.1788 0.8606
Schistosoma mansoni hypothetical protein 0.0035 0.0306 0.0303
Onchocerca volvulus Peroxidasin homolog 0.0051 0.0583 0.0699
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0583 0.0635
Brugia malayi laminin alpha chain 0.0049 0.0546 0.0594
Echinococcus multilocularis RUN 0.0058 0.0691 0.0691
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0035 0.0306 0.0333
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0132 0.1948 0.2936
Brugia malayi hypothetical protein 0.0035 0.0306 0.0333
Schistosoma mansoni nuclear receptor 0.0097 0.1352 0.1349
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Echinococcus multilocularis muscleblind protein 0.0183 0.2803 0.2803
Brugia malayi hypothetical protein 0.0035 0.0306 0.0333
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0306 0.0303
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0517 0.1225
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0311 0.0311
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0123 0.1788 0.1946
Schistosoma mansoni nuclear hormone receptor 0.0097 0.1352 0.1349
Echinococcus granulosus neuropeptide receptor 0.0035 0.0306 0.0461
Loa Loa (eye worm) hypothetical protein 0.0035 0.0312 0.0339
Brugia malayi hypothetical protein 0.0051 0.0583 0.0635
Trypanosoma brucei polo-like protein kinase 0.0047 0.0517 0.248
Loa Loa (eye worm) aspartyl protease 6 0.0056 0.0661 0.072
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0306 0.0306
Brugia malayi sulfakinin receptor protein 0.0035 0.0306 0.0333
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0517 0.1225
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0205 0.3178 0.4789
Echinococcus granulosus acetylcholinesterase 0.0066 0.0833 0.1255
Loa Loa (eye worm) hypothetical protein 0.0288 0.4577 0.4981
Echinococcus granulosus muscleblind protein 0.0183 0.2803 0.4224
Trichomonas vaginalis glutaminase, putative 0.0266 0.4202 1
Brugia malayi orphan nuclear receptor NR2E1 0.0097 0.1352 0.1472
Schistosoma mansoni rab6-interacting 0.0058 0.0691 0.0688
Brugia malayi small heat shock protein 0.0562 0.9188 1
Loa Loa (eye worm) doublecortin family protein 0.0058 0.0691 0.0752
Loa Loa (eye worm) hypothetical protein 0.0044 0.0464 0.0505
Schistosoma mansoni hypothetical protein 0.0035 0.0306 0.0303
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0038 0.0369 0.0556
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0155 0.0169
Loa Loa (eye worm) thioredoxin reductase 0.0023 0.0116 0.0126
Loa Loa (eye worm) TK/INSR protein kinase 0.0046 0.0503 0.0547
Onchocerca volvulus 0.004 0.0394 0.0472
Echinococcus granulosus netrin receptor unc 5 0.0044 0.0464 0.0699
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0306 0.0306
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0035 0.0306 0.0333
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0155 0.0169
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.0012 0.0041
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0017 0.0012 0.0041
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0347 0.0378
Schistosoma mansoni biogenic amine receptor 0.0035 0.0306 0.0303
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0097 0.1352 0.1352
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0235 0.3684 0.401
Onchocerca volvulus 0.0035 0.0312 0.0373
Toxoplasma gondii ABC1 family protein 0.0035 0.0312 0.1488
Onchocerca volvulus Dual oxidase homolog 0.0051 0.0583 0.0699
Echinococcus granulosus dnaJ subfamily B 0.0305 0.4866 0.7333
Schistosoma mansoni adenoreceptor 0.0035 0.0306 0.0303
Plasmodium falciparum plasmepsin VIII, putative 0.0056 0.0661 0.3175
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0306 0.0306
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0312 0.0716
Echinococcus granulosus slit 2 protein 0.0065 0.0824 0.1242
Loa Loa (eye worm) hypothetical protein 0.004 0.0394 0.0429
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0035 0.0306 0.0303
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0235 0.3684 0.3682
Brugia malayi glutathione reductase 0.0023 0.0116 0.0126
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.0394 0.0394
Mycobacterium tuberculosis Probable oxidoreductase 0.0059 0.0722 0.2042
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0312 0.0309
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0803 0.0801
Loa Loa (eye worm) hypothetical protein 0.0097 0.1352 0.1472
Brugia malayi GnHR receptor homolog 0.0035 0.0306 0.0333
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0208 0.0989
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0132 0.1948 0.212
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0044 0.0464 0.0699
Schistosoma mansoni ankyrin 23/unc44 0.0044 0.0464 0.0461
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0306 0.0306
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0312 0.1488
Loa Loa (eye worm) hypothetical protein 0.0437 0.7092 0.7719
Loa Loa (eye worm) solute carrier family 6 member 4 0.0235 0.3684 0.401
Loa Loa (eye worm) hypothetical protein 0.0056 0.0661 0.072
Toxoplasma gondii aspartyl protease ASP3 0.0056 0.0661 0.3175
Entamoeba histolytica serine/threonine protein kinase, putative 0.0047 0.0517 0.338
Schistosoma mansoni neuropeptide receptor 0.0035 0.0306 0.0303
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0097 0.1352 0.1472
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0306 0.0303
Schistosoma mansoni kinase 0.0024 0.013 0.0127
Onchocerca volvulus 0.0035 0.0306 0.0367
Loa Loa (eye worm) hypothetical protein 0.0066 0.0833 0.0906
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Loa Loa (eye worm) hypothetical protein 0.0049 0.0546 0.0594
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0344 0.5513 0.5512
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.044 0.0479
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0208 0.0989
Plasmodium falciparum plasmepsin V 0.0056 0.0661 0.3175
Schistosoma mansoni tyrosine kinase 0.0046 0.0503 0.05
Brugia malayi laminin-like protein K08C7.3 precursor 0.0049 0.0546 0.0594
Loa Loa (eye worm) hypothetical protein 0.0235 0.3684 0.401
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0394 0.0391
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0047 0.0517 0.248
Echinococcus multilocularis 0.0045 0.0478 0.0478
Echinococcus granulosus Rac GTPase activating protein 1 0.0043 0.0449 0.0677
Onchocerca volvulus 0.0035 0.0306 0.0367
Echinococcus granulosus jumonji domain containing protein 0.004 0.0399 0.0601
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0132 0.1948 0.1948
Brugia malayi aspartic protease BmAsp-2, identical 0.0056 0.0661 0.072
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0306 0.0306
Brugia malayi Calcitonin receptor-like protein seb-1 0.0122 0.1772 0.1928
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0039 0.037 0.0558
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0306 0.0461
Schistosoma mansoni cpg binding protein 0.0038 0.0366 0.0363
Brugia malayi hypothetical protein 0.0035 0.0306 0.0333
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0009
Brugia malayi Dopamine receptor 0.0035 0.0306 0.0333
Trichomonas vaginalis esterase, putative 0.0035 0.0312 0.0735
Brugia malayi Furin-like cysteine rich region family protein 0.0145 0.2166 0.2357
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0306 0.0306
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0035 0.0312 0.0339
Brugia malayi nuclear receptor NHR-67 0.0097 0.1352 0.1472
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.0691 0.1041
Echinococcus granulosus allatostatin A receptor 0.0035 0.0306 0.0461
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0517 0.1225
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0049 0.0546 0.0594
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0039 0.037 0.037
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0306 0.0461
Schistosoma mansoni tyrosine kinase 0.0078 0.1035 0.1032
Loa Loa (eye worm) hypothetical protein 0.004 0.0394 0.0429
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0101 0.142 0.6834
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0306 0.0306
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0122 0.1772 0.1928
Schistosoma mansoni glutaminase 0.0266 0.4202 0.42
Echinococcus multilocularis dro:myosuppressin receptor 0.0035 0.0306 0.0306
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0803 0.3859
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0059 0.0722 0.2042
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0517 0.1225
Onchocerca volvulus 0.0288 0.4577 0.5484
Echinococcus granulosus intermediate filament protein 0.008 0.1063 0.1601
Echinococcus granulosus acetylcholinesterase 0.0066 0.0833 0.1255
Mycobacterium ulcerans aldehyde dehydrogenase 0.0029 0.021 0.0474
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0306 0.0461
Onchocerca volvulus 0.0058 0.0691 0.0828
Schistosoma mansoni amine GPCR 0.0035 0.0306 0.0303
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0394 0.0391
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0312 0.0716
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0205 0.3178 0.3459
Onchocerca volvulus 0.0035 0.0306 0.0367
Toxoplasma gondii thioredoxin reductase 0.0023 0.0116 0.0546
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0081 0.1089 0.1086
Schistosoma mansoni Smad4 0.0025 0.0144 0.0141
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0803 0.1211
Schistosoma mansoni growth hormone secretagogue receptor 0.0035 0.0306 0.0303
Onchocerca volvulus Peroxidasin homolog 0.0051 0.0583 0.0699
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0046 0.0503 0.0757
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0833 0.0833
Brugia malayi Steroid receptor seven-up type 2 0.0205 0.3178 0.3459
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0044 0.047 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0205 0.3178 0.3459
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Brugia malayi follicle stimulating hormone receptor 0.0035 0.0306 0.0333
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0306 0.0306
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.0394 0.0594
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.1525 0.1523
Plasmodium falciparum phd finger protein, putative 0.0029 0.0208 0.0989
Echinococcus multilocularis serotonin transporter 0.0235 0.3684 0.3684
Plasmodium falciparum transporter, putative 0.004 0.0394 0.1886
Brugia malayi conserved hypotetical protein 0.0097 0.1352 0.1472
Loa Loa (eye worm) hypothetical protein 0.0058 0.0691 0.0752
Loa Loa (eye worm) hypothetical protein 0.0051 0.0583 0.0635
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0306 0.0461
Loa Loa (eye worm) hypothetical protein 0.0108 0.1548 0.1684
Schistosoma mansoni tyrosine kinase 0.0145 0.2166 0.2163
Schistosoma mansoni opsin-like receptor 0.0035 0.0306 0.0303
Loa Loa (eye worm) steroid hormone receptor 0.0205 0.3178 0.3459
Brugia malayi Uncoordinated protein 44 0.0044 0.0464 0.0505
Loa Loa (eye worm) hypothetical protein 0.0051 0.0583 0.0635
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0155 0.0734
Echinococcus multilocularis muscleblind protein 1 0.0183 0.2803 0.2803
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0312 0.0862
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0144 0.0141
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0306 0.0303
Onchocerca volvulus 0.0035 0.0306 0.0367
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0803 0.3859
Echinococcus granulosus smad 0.0025 0.0144 0.0217
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0583 0.0635
Echinococcus multilocularis nuclear factor of activated T cells 5 0.041 0.6636 0.6636
Schistosoma mansoni sodium/chloride dependent transporter 0.0041 0.0404 0.0402
Loa Loa (eye worm) MH2 domain-containing protein 0.0368 0.5923 0.6447
Schistosoma mansoni tar DNA-binding protein 0.0107 0.153 0.1527
Brugia malayi nuclear receptor RXR 0.0097 0.1352 0.1472
Loa Loa (eye worm) hypothetical protein 0.0038 0.0369 0.0401
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0312 0.0862
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0035 0.0306 0.0306
Toxoplasma gondii RNA-directed DNA polymerase 0.014 0.2077 1
Brugia malayi ecdysteroid receptor 0.0205 0.3178 0.3459
Brugia malayi putative neuropeptide receptor 0.0035 0.0306 0.0333
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Onchocerca volvulus Serine\/threonine kinase homolog 0.0047 0.0517 0.062
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0039 0.037 0.0367
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0637 0.0693
Echinococcus granulosus FTZ F1 alpha 0.0205 0.3178 0.4789
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0306 0.0306
Onchocerca volvulus 0.0035 0.0306 0.0367
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0312 0.0862
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0144 0.0144
Schistosoma mansoni amine GPCR 0.0035 0.0306 0.0303
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0123 0.1788 0.8606
Brugia malayi Telomerase reverse transcriptase 0.0372 0.599 0.6519
Echinococcus granulosus uncharacterized sodium dependent transporter 0.004 0.0394 0.0594
Plasmodium vivax aspartyl proteinase, putative 0.0056 0.0661 0.3175
Echinococcus multilocularis g-protein coupled receptor 0.0035 0.0306 0.0306
Loa Loa (eye worm) glutaminase 2 0.0266 0.4202 0.4573
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Schistosoma mansoni lozenge 0.0036 0.0331 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0205 0.3178 0.3459
Brugia malayi hypothetical protein 0.0097 0.1352 0.1472
Plasmodium vivax plasmepsin V, putative 0.0056 0.0661 0.3175
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0312 0.1488
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0306 0.0303
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0803 0.3859
Schistosoma mansoni amine GPCR 0.0035 0.0306 0.0303
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0078 0.0084
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0306 0.0303
Echinococcus granulosus lamin 0.008 0.1063 0.1601
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0988 0.0985
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0101 0.142 0.142
Brugia malayi Dopamine receptor protein 2 0.0035 0.0306 0.0333
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Plasmodium vivax thioredoxin reductase, putative 0.0023 0.0116 0.0546
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0803 0.0803
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.004 0.0394 0.0391
Echinococcus granulosus Ankyrin 0.0044 0.047 0.0708
Plasmodium vivax amine transporter, putative 0.004 0.0394 0.1886
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0097 0.1352 0.2037
Echinococcus multilocularis neuropeptide receptor A26 0.0035 0.0306 0.0306
Schistosoma mansoni nuclear receptor 0.0097 0.1352 0.1349
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0306 0.0303
Loa Loa (eye worm) hypothetical protein 0.0097 0.1352 0.1472
Brugia malayi Tachykinin-like peptides receptor 99D 0.0035 0.0306 0.0333
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0053 0.0622 0.8586
Schistosoma mansoni amine GPCR 0.0035 0.0306 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0205 0.3178 0.3459
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0306 0.0303
Loa Loa (eye worm) hypothetical protein 0.0205 0.3178 0.3459
Echinococcus multilocularis neuropeptide s receptor 0.0035 0.0306 0.0306
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0394 0.0429
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0107 0.153 0.1665
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0035 0.0306 0.0306
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0312 0.0312
Echinococcus multilocularis GPCR, family 2 0.0039 0.037 0.037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0205 0.3178 0.3459
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0205 0.3178 0.4789
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0394 0.0391
Echinococcus granulosus tar DNA binding protein 0.0107 0.153 0.2305
Echinococcus granulosus serotonin transporter 0.0235 0.3684 0.5552
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0035 0.0306 0.0333
Echinococcus granulosus mitogen activated protein kinase 14 0.0123 0.1788 0.2694
Schistosoma mansoni cytochrome P450 0.0017 0.0012 0.0009
Brugia malayi Smad1 0.0025 0.0144 0.0157
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0208 0.0227
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0035 0.0306 0.0461
Schistosoma mansoni hypothetical protein 0.0044 0.0464 0.0461
Echinococcus multilocularis ecdysone induced protein 78C 0.0205 0.3178 0.3178
Echinococcus granulosus peroxidasin 0.0051 0.0583 0.0879
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0205 0.3178 0.3459
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0046 0.0503 0.0503
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0097 0.1352 0.1352
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0155 0.0169
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0394 0.0429
Loa Loa (eye worm) hypothetical protein 0.0437 0.7092 0.7719
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0661 0.0659
Echinococcus granulosus peptide allatostatin:somatostatin 0.0035 0.0306 0.0461
Onchocerca volvulus 0.0058 0.0691 0.0828
Echinococcus granulosus fmrfamide receptor 0.0035 0.0306 0.0461
Echinococcus granulosus neuropeptide receptor A26 0.0035 0.0306 0.0461
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0227
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0394 0.0391
Brugia malayi hypothetical protein 0.0058 0.0691 0.0752
Schistosoma mansoni cathepsin D (A01 family) 0.0216 0.3357 0.3355
Loa Loa (eye worm) TYRA-2 protein 0.0035 0.0306 0.0333
Loa Loa (eye worm) hypothetical protein 0.0097 0.1352 0.1472
Brugia malayi Nuclear hormone receptor-like 1 0.0108 0.1548 0.1684
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0035 0.0306 0.0303
Schistosoma mansoni peroxidasin 0.0051 0.0583 0.058
Brugia malayi G protein-coupled receptor F59B2.13 0.0035 0.0306 0.0333
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0306 0.0303
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0035 0.0306 0.0306
Onchocerca volvulus 0.0097 0.1352 0.162
Brugia malayi RNA recognition motif domain containing protein 0.0107 0.153 0.1665
Loa Loa (eye worm) hypothetical protein 0.0051 0.0583 0.0635
Leishmania major hypothetical protein, conserved 0.0035 0.0312 0.1488
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Echinococcus granulosus lamin dm0 0.008 0.1063 0.1601
Toxoplasma gondii aspartyl protease ASP1 0.0101 0.142 0.6834
Loa Loa (eye worm) melatonin receptor type 1A 0.0035 0.0306 0.0333
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0312 0.0735
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0661 0.0659
Brugia malayi neuropeptide F receptor 0.0035 0.0306 0.0333
Plasmodium vivax aspartyl protease, putative 0.0056 0.0661 0.3175
Loa Loa (eye worm) hypothetical protein 0.0044 0.047 0.0512
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0035 0.0306 0.0303
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Schistosoma mansoni neuropeptide receptor 0.0035 0.0306 0.0303
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0803 0.0874
Schistosoma mansoni netrin receptor unc5 0.0044 0.0464 0.0461
Schistosoma mansoni sodium-dependent amino acid transporter 0.004 0.0394 0.0391
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0035 0.0306 0.0303
Schistosoma mansoni smad 0.0025 0.0144 0.0141
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0035 0.0306 0.0333
Brugia malayi hypothetical protein 0.0056 0.0661 0.072
Echinococcus granulosus 7TM GPCR rhodopsin 0.0035 0.0306 0.0461
Toxoplasma gondii hypothetical protein 0.004 0.0394 0.1886
Loa Loa (eye worm) hypothetical protein 0.0083 0.1123 0.1222
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0661 0.0659
Onchocerca volvulus Alhambra homolog 0.0029 0.0208 0.025
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0205 0.3178 0.3459
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0035 0.0306 0.0333
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0108 0.1548 0.1548
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0306 0.0461
Loa Loa (eye worm) hypothetical protein 0.0205 0.3178 0.3459
Brugia malayi Serotonin receptor 0.0035 0.0306 0.0333
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0344 0.5513 0.8308
Brugia malayi Dopamine receptor protein 1 0.0035 0.0306 0.0333
Echinococcus granulosus death domain containing protein 0.0044 0.0464 0.0699
Brugia malayi Cytochrome P450 family protein 0.0026 0.0155 0.0169
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0306 0.0306
Echinococcus granulosus pikachurin 0.0049 0.0546 0.0822
Schistosoma mansoni tar DNA-binding protein 0.0107 0.153 0.1527
Schistosoma mansoni steroid hormone receptor ad4bp 0.0205 0.3178 0.3176
Schistosoma mansoni thyroid hormone receptor 0.061 1 1
Echinococcus multilocularis 0.0017 0.0012 0.0012
Mycobacterium tuberculosis Probable dehydrogenase 0.0053 0.0622 0.1753
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0035 0.0306 0.0303
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0053 0.0622 0.1753
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0044 0.0464 0.0505
Loa Loa (eye worm) hypothetical protein 0.0051 0.0583 0.0635
Brugia malayi hypothetical protein 0.0058 0.0691 0.0752
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0039 0.037 0.0403
Toxoplasma gondii aspartyl protease 0.0056 0.0661 0.3175
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0044 0.0464 0.0464
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0205 0.3178 0.3459
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0803 0.3859
Brugia malayi G-protein coupled receptor 0.0035 0.0306 0.0333
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Onchocerca volvulus 0.0035 0.0312 0.0373
Brugia malayi MH2 domain containing protein 0.0368 0.5923 0.6447
Plasmodium vivax multidomain scavenger receptor, putative 0.0058 0.0691 0.3317
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0035 0.0306 0.0333
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.0394 0.0594
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0222 0.3464 0.3464
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.0691 0.1041
Echinococcus multilocularis jun protein 0.0252 0.3976 0.3976
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Loa Loa (eye worm) hypothetical protein 0.0035 0.0312 0.0339
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0306 0.0333
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0833 0.0833
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0348 0.0348
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0035 0.0306 0.0333
Echinococcus multilocularis somatostatin receptor 0.0035 0.0306 0.0306
Brugia malayi nuclear receptor NHR-88 0.0097 0.1352 0.1472
Toxoplasma gondii aldehyde dehydrogenase 0.0029 0.021 0.1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.1315 0.1315
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0312 0.0862
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0306 0.0461
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0205 0.3178 0.4789
Loa Loa (eye worm) hypothetical protein 0.0037 0.035 0.0381
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0205 0.3178 0.3459
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0583 0.0635
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Loa Loa (eye worm) hypothetical protein 0.005 0.0556 0.0605
Echinococcus multilocularis dnaJ subfamily B 0.0305 0.4866 0.4866
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.004 0.0394 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0306 0.0461
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.1035 0.1559
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0208 0.0205
Brugia malayi nuclear hormone receptor family member nhr-6 0.0097 0.1352 0.1472
Plasmodium vivax glutathione reductase, putative 0.0023 0.0116 0.0546
Schistosoma mansoni thyroid hormone receptor 0.061 1 1
Brugia malayi RNA binding protein 0.0107 0.153 0.1665
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0205 0.3178 0.3459
Brugia malayi ecdysone receptor 0.0097 0.1352 0.1472
Brugia malayi Carboxylesterase family protein 0.0066 0.0833 0.0906
Toxoplasma gondii hypothetical protein 0.004 0.0394 0.1886
Plasmodium vivax aspartyl protease, putative 0.0056 0.0661 0.3175
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0193 0.2968 0.2968
Brugia malayi Nuclear hormone receptor E75 0.0097 0.1352 0.1472
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0306 0.0303
Brugia malayi jmjC domain containing protein 0.0095 0.1315 0.1432
Schistosoma mansoni hypothetical protein 0.0035 0.0306 0.0303
Brugia malayi hypothetical protein 0.0108 0.1548 0.1684
Echinococcus multilocularis lamin 0.008 0.1063 0.1063
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0097 0.1352 0.162
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0306 0.0303
Leishmania major cytochrome p450-like protein 0.0017 0.0012 0.0041
Echinococcus granulosus mitogen activated protein kinase 11 0.0123 0.1788 0.2694
Onchocerca volvulus 0.0051 0.0583 0.0699
Brugia malayi hypothetical protein 0.0288 0.4577 0.4981
Brugia malayi hypothetical protein 0.0035 0.0306 0.0333
Loa Loa (eye worm) hypothetical protein 0.0205 0.3178 0.3459
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.004 0.0394 0.0429
Schistosoma mansoni amine GPCR 0.0035 0.0306 0.0303
Echinococcus multilocularis mitogen activated protein kinase 11 0.0123 0.1788 0.1788
Schistosoma mansoni nuclear hormone receptor 0.0097 0.1352 0.1349
Plasmodium falciparum plasmepsin VII 0.0056 0.0661 0.3175
Echinococcus granulosus geminin 0.0332 0.5319 0.8016
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0049 0.0546 0.0543
Loa Loa (eye worm) abnormal epIthelia family member 0.0049 0.0546 0.0594
Echinococcus granulosus Nuclear hormone receptor HR96 0.0097 0.1352 0.2037
Plasmodium falciparum plasmepsin IV 0.0101 0.142 0.6834
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0306 0.0306
Schistosoma mansoni loxhd1 0.0058 0.0691 0.0688
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0205 0.3178 0.3459
Plasmodium falciparum plasmepsin IX 0.0056 0.0661 0.3175
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0205 0.3178 0.3808
Brugia malayi beta-lactamase 0.0035 0.0312 0.0339
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0583 0.0635
Brugia malayi MH1 domain containing protein 0.0025 0.0144 0.0157
Echinococcus multilocularis smad 0.0025 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0205 0.3178 0.3459
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0035 0.0312 0.0339
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0205 0.3178 0.3178
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0306 0.0303
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Onchocerca volvulus 0.0035 0.0306 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0205 0.3178 0.3459
Onchocerca volvulus 0.0035 0.0306 0.0367
Loa Loa (eye worm) hypothetical protein 0.0097 0.1352 0.1472
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0205 0.3178 0.3459
Onchocerca volvulus 0.0235 0.3684 0.4415
Mycobacterium ulcerans hypothetical protein 0.0035 0.0312 0.0716
Brugia malayi Latrophilin receptor protein 2 0.0039 0.037 0.0403
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0394 0.0429
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0056 0.0661 0.072
Loa Loa (eye worm) RNA binding protein 0.0107 0.153 0.1665
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0123 0.1788 0.8606
Schistosoma mansoni aldehyde dehydrogenase 0.0029 0.021 0.0207
Trypanosoma cruzi polo-like protein kinase, putative 0.0047 0.0517 0.248
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0306 0.0461
Echinococcus multilocularis neurogenic locus notch protein 0.0049 0.0546 0.0546
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0605 0.992 0.992
Brugia malayi P38 map kinase family protein 2 0.0123 0.1788 0.1946
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0517 0.0515
Brugia malayi Carboxylesterase family protein 0.0066 0.0833 0.0906
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0056 0.0661 0.3175
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0039 0.037 0.037
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0205 0.3178 0.3176
Echinococcus multilocularis Ankyrin 0.0044 0.047 0.047
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0097 0.1352 0.1352
Echinococcus multilocularis mitogen activated protein kinase 11 0.0123 0.1788 0.1788
Brugia malayi Pepsin A precursor 0.0056 0.0661 0.072
Brugia malayi MH1 domain containing protein 0.0025 0.0144 0.0157
Brugia malayi Cytochrome P450 family protein 0.0017 0.0012 0.0013
Brugia malayi PHD-finger family protein 0.0029 0.0208 0.0227
Echinococcus granulosus neuropeptide FF receptor 2 0.0035 0.0306 0.0461
Echinococcus granulosus tachykinin peptides receptor 99D 0.0035 0.0306 0.0461
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0108 0.1548 0.2332
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0205 0.3178 0.3459
Schistosoma mansoni memapsin-2 (A01 family) 0.0556 0.9085 0.9085
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0312 0.0735
Schistosoma mansoni sodium/chloride dependent transporter 0.0235 0.3684 0.3682
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0405 0.6544 0.9861
Schistosoma mansoni biogenic amine receptor 0.0035 0.0306 0.0303
Brugia malayi nuclear receptor RXR 0.0108 0.1548 0.1684
Brugia malayi nuclear hormone receptor 0.0205 0.3178 0.3459
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0035 0.0306 0.0303
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0132 0.1948 0.1946
Brugia malayi Melatonin receptor type 1A 0.0035 0.0306 0.0333
Echinococcus granulosus nuclear factor of activated T cells 5 0.041 0.6636 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0051 0.0583 0.0635
Onchocerca volvulus 0.0035 0.0306 0.0367
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Giardia lamblia Telomerase catalytic subunit 0.014 0.2077 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0344 0.5513 0.6001
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0517 0.1225
Loa Loa (eye worm) hypothetical protein 0.0049 0.0546 0.0594
Onchocerca volvulus Neurogenic locus notch homolog 0.0017 0.0006 0.0008
Schistosoma mansoni neuropeptide receptor 0.0035 0.0306 0.0303
Loa Loa (eye worm) hypothetical protein 0.0051 0.0583 0.0635
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0132 0.1948 0.1946
Mycobacterium tuberculosis Conserved protein 0.0035 0.0312 0.0862
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0583 0.0635
Schistosoma mansoni alpha-1 adrenergic receptor 0.0035 0.0306 0.0303
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0306 0.0461
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0205 0.3178 0.3176
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0312 0.0862
Echinococcus multilocularis thioredoxin glutathione reductase 0.0023 0.0116 0.0116
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0312 0.0862
Echinococcus granulosus orexin receptor type 2 0.0035 0.0306 0.0461
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.3491 1
Schistosoma mansoni tyrosine kinase 0.0077 0.1021 0.1018
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0306 0.0306
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0047 0.0517 0.0563
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0097 0.1352 0.1472
Onchocerca volvulus 0.0035 0.0306 0.0367
Brugia malayi hypothetical protein 0.0035 0.0306 0.0333
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.0691 0.0691
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0394 0.0429
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0035 0.0306 0.0306
Loa Loa (eye worm) Smad1 0.0025 0.0144 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0205 0.3178 0.3459
Loa Loa (eye worm) hypothetical protein 0.0108 0.1548 0.1684
Plasmodium falciparum telomerase reverse transcriptase 0.014 0.2077 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0205 0.3178 0.3459
Schistosoma mansoni hypothetical protein 0.0205 0.3179 0.3177
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0517 0.1225
Brugia malayi latrophilin 2 splice variant baaae 0.0083 0.1123 0.1222
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0661 0.0659
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.1525 0.1525
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0306 0.0303
Brugia malayi Protein kinase domain containing protein 0.0046 0.0503 0.0547
Leishmania major cytochrome p450-like protein 0.0026 0.0155 0.0734
Onchocerca volvulus 0.0038 0.0366 0.0439
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0306 0.0306
Onchocerca volvulus 0.0035 0.0312 0.0373
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0306 0.0461
Entamoeba histolytica hypothetical protein 0.0107 0.1525 1
Schistosoma mansoni nuclear hormone receptor 0.0205 0.3178 0.3176
Loa Loa (eye worm) intermediate filament protein 0.008 0.1063 0.1157
Loa Loa (eye worm) hypothetical protein 0.0101 0.142 0.1546
Loa Loa (eye worm) CXXC zinc finger family protein 0.0038 0.0366 0.0399
Brugia malayi Cytochrome P450 family protein 0.0054 0.0637 0.0693
Loa Loa (eye worm) hypothetical protein 0.0056 0.0661 0.072
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0097 0.1352 0.2037
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0035 0.0306 0.0306
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0205 0.3178 0.3176
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0222 0.3464 0.522
Echinococcus granulosus RUN 0.0058 0.0691 0.1041
Mycobacterium ulcerans glutaminase 0.0266 0.4202 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0312 0.0735
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0306 0.0461
Brugia malayi Nuclear hormone receptor-like 1 0.0205 0.3178 0.3459
Schistosoma mansoni zinc finger protein 0.0097 0.1352 0.1349
Loa Loa (eye worm) hypothetical protein 0.0035 0.0312 0.0339
Brugia malayi putative neuropeptide receptor NPR1 0.0035 0.0306 0.0333
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0306 0.0306
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0312 0.0735
Brugia malayi Death domain containing protein 0.0044 0.0464 0.0505
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0394 0.0429
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0097 0.1352 0.1349
Schistosoma mansoni peroxidasin 0.0051 0.0583 0.058
Plasmodium vivax aspartyl protease, putative 0.0056 0.0661 0.3175
Loa Loa (eye worm) hypothetical protein 0.0078 0.1038 0.113
Brugia malayi MH2 domain containing protein 0.0025 0.0144 0.0157
Brugia malayi Doublecortin family protein 0.0058 0.0691 0.0752
Loa Loa (eye worm) cytochrome P450 0.0017 0.0012 0.0013
Toxoplasma gondii histone lysine methyltransferase SET1 0.0072 0.0943 0.4532
Brugia malayi RhoGAP domain containing protein 0.0037 0.035 0.0381
Loa Loa (eye worm) hypothetical protein 0.0205 0.3178 0.3459
Loa Loa (eye worm) latrophilin receptor protein 2 0.0039 0.037 0.0403
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0252 0.3976 0.5991
Echinococcus granulosus G protein coupled receptor 139 0.0035 0.0306 0.0461
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0205 0.3178 0.3459
Echinococcus granulosus Nuclear hormone receptor HR96 0.0097 0.1352 0.2037
Onchocerca volvulus 0.0035 0.0306 0.0367
Onchocerca volvulus 0.0051 0.0583 0.0699
Schistosoma mansoni tar DNA-binding protein 0.0107 0.153 0.1527
Onchocerca volvulus 0.0035 0.0306 0.0367
Loa Loa (eye worm) TAR-binding protein 0.0107 0.153 0.1665
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.004 0.0394 0.0594
Echinococcus multilocularis peregrin 0.0029 0.0208 0.0208
Schistosoma mansoni hypothetical protein 0.0332 0.5319 0.5318
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0312 0.4223
Brugia malayi neuropeptide F receptor 0.0035 0.0306 0.0333
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Brugia malayi EGF-like domain containing protein 0.0065 0.0824 0.0897
Brugia malayi beta-lactamase family protein 0.0035 0.0312 0.0339
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0029 0.021 0.0317
Brugia malayi hypothetical protein 0.004 0.0394 0.0429
Loa Loa (eye worm) hypothetical protein 0.0122 0.1772 0.1928
Brugia malayi photoreceptor-specific nuclear receptor 0.0205 0.3178 0.3459
Echinococcus multilocularis netrin receptor unc 5 0.0044 0.0464 0.0464
Onchocerca volvulus 0.004 0.0394 0.0472
Plasmodium falciparum plasmepsin III 0.0056 0.0661 0.3175
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Schistosoma mansoni tar DNA-binding protein 0.0107 0.153 0.1527
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0155 0.0734
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.014 0.2077 1
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0306 0.0306
Schistosoma mansoni cpg binding protein 0.004 0.0403 0.04
Brugia malayi steroid hormone receptor 0.0205 0.3178 0.3459
Loa Loa (eye worm) hypothetical protein 0.0037 0.0344 0.0375
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0833 0.0906
Echinococcus granulosus epidermal growth factor receptor 0.0145 0.2166 0.3264
Loa Loa (eye worm) hypothetical protein 0.0246 0.3859 0.42
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0097 0.1352 0.1352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0132 0.1948 0.1946
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0312 0.1488
Schistosoma mansoni tar DNA-binding protein 0.0107 0.153 0.1527
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0583 0.0635
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0512 0.8345 1
Loa Loa (eye worm) glutathione reductase 0.0023 0.0116 0.0126
Loa Loa (eye worm) hypothetical protein 0.0097 0.1352 0.1472
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0348 0.0524
Echinococcus granulosus hypothetical protein 0.0035 0.0306 0.0461
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0347 0.0523
Schistosoma mansoni notch 0.0017 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0097 0.1352 0.1472
Loa Loa (eye worm) hypothetical protein 0.0051 0.0583 0.0635
Onchocerca volvulus 0.0035 0.0306 0.0367
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0661 0.0659
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0205 0.3178 0.3176
Brugia malayi Cytochrome P450 family protein 0.0026 0.0155 0.0169
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0333
Mycobacterium ulcerans aldehyde dehydrogenase 0.0029 0.021 0.0474
Schistosoma mansoni hypothetical protein 0.0107 0.1525 0.1523
Schistosoma mansoni coup transcription factor 0.0205 0.3178 0.3176
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0405 0.6544 0.6544
Echinococcus multilocularis peroxidasin 0.0051 0.0583 0.0583
Brugia malayi hypothetical protein 0.0198 0.3062 0.3333
Giardia lamblia Rho GAP, putative 0.0037 0.035 0.0756
Echinococcus multilocularis Protein lozenge 0.0036 0.0331 0.0331
Echinococcus granulosus Polycystic kidney disease protein 0.0058 0.0691 0.1041
Echinococcus multilocularis pikachurin 0.0049 0.0546 0.0546

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 280 nM Inhibition of BACE1 (unknown origin) expressed in CHO cells by FRET assay ChEMBL. 18171615
IC50 (binding) = 280 nM Inhibition of BACE1 (unknown origin) expressed in CHO cells by FRET assay ChEMBL. 18171615
IC50 (binding) = 2940 nM Inhibition of Cathepsin D (unknown origin) expressed in CHO cells by FRET assay ChEMBL. 18171615
IC50 (binding) = 2940 nM Inhibition of Cathepsin D (unknown origin) expressed in CHO cells by FRET assay ChEMBL. 18171615
IC50 (binding) = 3080 nM Inhibition of BACE2 (unknown origin) expressed in CHO cells by FRET assay ChEMBL. 18171615
IC50 (binding) = 3080 nM Inhibition of BACE2 (unknown origin) expressed in CHO cells by FRET assay ChEMBL. 18171615

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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