TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 338.525 | Formula: C21H38O3
H donors: 0 H acceptors: 1 LogP: 6.22 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CC(CCCC(OC(C)C)(C)C)C/C=C/C(=C/C(=O)OC(C)C)/C
InChi: 1S/C21H38O3/c1-16(2)23-20(22)15-19(6)12-9-11-18(5)13-10-14-21(7,8)24-17(3)4/h9,12,15-18H,10-11,13-14H2,1-8H3/b12-9+,19-15+
InChiKey: KZRBDLDITSYOPL-NSMFRCMUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0388	0.3584	0.3584
Echinococcus granulosus	sex peptide receptor	0.0388	0.3584	0.3584
Echinococcus granulosus	g protein coupled receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0388	0.3584	0.3584
Brugia malayi	G-protein coupled receptor	0.0388	0.3584	0.3584
Brugia malayi	ORL1-like opioid receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0388	0.3584	0.3584
Brugia malayi	sulfakinin receptor protein	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Onchocerca volvulus		0.0388	0.3584	0.3584
Echinococcus granulosus	neuropeptides capa receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0388	0.3584	0.3584
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	amine GPCR	0.0388	0.3584	0.3584
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Trichomonas vaginalis	conserved hypothetical protein	0.0453	0.4327	1
Echinococcus granulosus	activin receptor type	0.0073	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0388	0.3584	0.3584
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0073	0.0003	0.0003
Onchocerca volvulus		0.0388	0.3584	0.3584
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0388	0.3584	0.3584
Echinococcus granulosus	neuropeptide Y receptor	0.0388	0.3584	0.3584
Brugia malayi	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus granulosus	thymidylate synthase	0.0953	1	1
Mycobacterium tuberculosis	Hypothetical protein	0.0453	0.4327	0.4327
Brugia malayi	AKH receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Brugia malayi	Serotonin receptor	0.0388	0.3584	0.3584
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0953	1	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0388	0.3584	0.3584
Echinococcus granulosus	G protein coupled receptor 139	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0388	0.3584	0.3584
Echinococcus granulosus	g protein coupled receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	dro:myosuppressin receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0388	0.3584	0.3584
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0388	0.3584	0.3584
Echinococcus multilocularis	neuropeptide s receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0388	0.3584	0.3584
Echinococcus granulosus	biogenic amine 5HT receptor	0.0388	0.3584	0.3584
Echinococcus granulosus	rhodopsin orphan GPCR	0.0388	0.3584	0.3584
Brugia malayi	hypothetical protein	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus multilocularis	orexin receptor type 2	0.0388	0.3584	0.3584
Onchocerca volvulus		0.0388	0.3584	0.3584
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0388	0.3584	0.3584
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus granulosus	biogenic amine 5HT receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	neuropeptides capa receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	serotonin receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus granulosus	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	amine GPCR	0.0388	0.3584	0.3584
Brugia malayi	follicle stimulating hormone receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus granulosus	rhodopsin orphan GPCR	0.0388	0.3584	0.3584
Echinococcus granulosus	g-protein coupled receptor	0.0388	0.3584	0.3584
Brugia malayi	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0388	0.3584	0.3584
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Brugia malayi	hypothetical protein	0.0453	0.4327	0.4327
Echinococcus granulosus	neuropeptide FF receptor 2	0.0388	0.3584	0.3584
Echinococcus multilocularis	fmrfamide receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	thymidylate synthase	0.0953	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0388	0.3584	0.3584
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0388	0.3584	0.3584
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0388	0.3584	0.3584
Brugia malayi	Dopamine receptor protein 2	0.0388	0.3584	0.3584
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0388	0.3584	0.3584
Brugia malayi	G protein-coupled receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0953	1	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus granulosus	rhodopsin orphan GPCR	0.0388	0.3584	0.3584
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	neuropeptide F-like receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	amine GPCR	0.0388	0.3584	0.3584
Echinococcus granulosus	neuropeptide receptor	0.0388	0.3584	0.3584
Brugia malayi	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	growth hormone secretagogue receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	opsin-like receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0388	0.3584	0.3584
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0953	1	1
Brugia malayi	Dopamine receptor	0.0388	0.3584	0.3584
Brugia malayi	RE15519p	0.0388	0.3584	0.3584
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0388	0.3584	0.3584
Chlamydia trachomatis	thymidylate kinase	0.0072	0	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus granulosus	rhodopsin orphan GPCR	0.0388	0.3584	0.3584
Loa Loa (eye worm)	G-protein coupled receptor	0.0388	0.3584	0.3584
Onchocerca volvulus		0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus granulosus	orexin receptor type 2	0.0388	0.3584	0.3584
Echinococcus granulosus	7TM GPCR rhodopsin	0.0388	0.3584	0.3584
Schistosoma mansoni	neuropeptide receptor	0.0388	0.3584	0.3584
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0388	0.3584	0.3584
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0953	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0388	0.3584	0.3584
Echinococcus granulosus	neuropeptide Y receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0388	0.3584	0.3584
Onchocerca volvulus		0.0388	0.3584	0.3584
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0388	0.3584	0.3584
Onchocerca volvulus		0.0388	0.3584	0.3584
Echinococcus granulosus	serotonin receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	G protein coupled receptor 139	0.0388	0.3584	0.3584
Schistosoma mansoni	opsin-like receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	neuropeptides capa receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	neuropeptide Y receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	protein kinase	0.0073	0.0003	0.0003
Onchocerca volvulus		0.0388	0.3584	0.3584
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0388	0.3584	0.3584
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0388	0.3584	0.3584
Giardia lamblia	CDC8	0.0072	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	amine GPCR	0.0388	0.3584	0.3584
Echinococcus granulosus	neuropeptide s receptor	0.0388	0.3584	0.3584
Brugia malayi	Serotonin receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	neuropeptide F receptor	0.0388	0.3584	0.3584
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0953	1	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0388	0.3584	0.3584
Brugia malayi	G protein-coupled receptor F59B2.13	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Brugia malayi	hypothetical protein	0.0388	0.3584	0.3584
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0953	1	1
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Brugia malayi	Dopamine receptor protein 1	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Mycobacterium ulcerans	thymidylate synthase	0.0953	1	1
Echinococcus granulosus	g protein coupled receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	g protein coupled receptor	0.0388	0.3584	0.3584
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0388	0.3584	0.3584
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0388	0.3584	0.3584
Brugia malayi	putative neuropeptide receptor NPR1	0.0388	0.3584	0.3584
Brugia malayi	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	neuropeptide receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	g-protein coupled receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	serotonin receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	biogenic amine receptor	0.0388	0.3584	0.3584
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0953	1	1
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	biogenic amine receptor	0.0388	0.3584	0.3584
Onchocerca volvulus		0.0388	0.3584	0.3584
Echinococcus granulosus	tm gpcr rhodopsin	0.0388	0.3584	0.3584
Echinococcus granulosus	neuropeptide receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus multilocularis	allatostatin A receptor	0.0388	0.3584	0.3584
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2222	0.2222
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0388	0.3584	0.3584
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0388	0.3584	0.3584
Loa Loa (eye worm)	melatonin receptor type 1A	0.0388	0.3584	0.3584
Onchocerca volvulus		0.0388	0.3584	0.3584
Onchocerca volvulus		0.0388	0.3584	0.3584
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0073	0.0003	0.0003
Echinococcus multilocularis	g protein coupled receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0388	0.3584	0.3584
Echinococcus multilocularis	fmrfamide receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	adenoreceptor	0.0388	0.3584	0.3584
Onchocerca volvulus		0.0388	0.3584	0.3584
Schistosoma mansoni	neuropeptide F-like receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Loa Loa (eye worm)	G-protein coupled receptor	0.0388	0.3584	0.3584
Echinococcus granulosus	fmrfamide receptor	0.0388	0.3584	0.3584
Echinococcus granulosus	7tm_1 domain containing protein	0.0388	0.3584	0.3584
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Brugia malayi	neuropeptide F receptor	0.0388	0.3584	0.3584
Brugia malayi	Melatonin receptor type 1A	0.0388	0.3584	0.3584
Echinococcus multilocularis	neuropeptide receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	myosin xvIII	0.0388	0.3584	0.3584
Echinococcus multilocularis	g protein coupled receptor	0.0388	0.3584	0.3584
Onchocerca volvulus		0.0388	0.3584	0.3584
Brugia malayi	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0388	0.3584	0.3584
Echinococcus granulosus	allatostatin A receptor	0.0388	0.3584	0.3584
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0953	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0388	0.3584	0.3584
Brugia malayi	GnHR receptor homolog	0.0388	0.3584	0.3584
Echinococcus granulosus	dro:myosuppressin receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0388	0.3584	0.3584
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0388	0.3584	0.3584
Onchocerca volvulus		0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Brugia malayi	G-protein coupled receptor	0.0388	0.3584	0.3584
Echinococcus granulosus	somatostatin receptor	0.0388	0.3584	0.3584
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0388	0.3584	0.3584
Treponema pallidum	thymidylate kinase (tmk)	0.0072	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0388	0.3584	0.3584
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0388	0.3584	0.3584
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0453	0.4327	0.4327
Brugia malayi	hypothetical protein	0.0388	0.3584	0.3584
Onchocerca volvulus		0.0388	0.3584	0.3584
Brugia malayi	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0388	0.3584	0.3584
Echinococcus multilocularis	sex peptide receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0268	0.2222	0.2222
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus granulosus	neuropeptides capa receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0953	1	1
Brugia malayi	neuropeptide F receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	hypothetical protein	0.0388	0.3584	0.3584
Wolbachia endosymbiont of Brugia malayi	thymidylate kinase	0.0072	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0388	0.3584	0.3584
Schistosoma mansoni	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus multilocularis	neuropeptide receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0388	0.3584	0.3584
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0388	0.3584	0.3584
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Onchocerca volvulus		0.0953	1	1
Brugia malayi	putative neuropeptide receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	neuropeptide receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	amine GPCR	0.0388	0.3584	0.3584
Echinococcus granulosus	rhodopsin orphan GPCR	0.0388	0.3584	0.3584
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0388	0.3584	0.3584
Brugia malayi	larval opioid receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0388	0.3584	0.3584
Echinococcus multilocularis	somatostatin receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	TYRA-2 protein	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Entamoeba histolytica	Thymidylate kinase, putative	0.0072	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0388	0.3584	0.3584
Echinococcus multilocularis	neuropeptide receptor A26	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0388	0.3584	0.3584
Onchocerca volvulus		0.0388	0.3584	0.3584
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0388	0.3584	0.3584
Echinococcus granulosus	tm gpcr rhodopsin	0.0388	0.3584	0.3584
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0388	0.3584	0.3584
Echinococcus granulosus	tm gpcr rhodopsin	0.0388	0.3584	0.3584
Loa Loa (eye worm)	thymidylate synthase	0.0953	1	1
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	histamine h1 receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0388	0.3584	0.3584
Onchocerca volvulus		0.0388	0.3584	0.3584
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0388	0.3584	0.3584
Onchocerca volvulus		0.0388	0.3584	0.3584
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0388	0.3584	0.3584
Brugia malayi	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	hypothetical protein	0.0388	0.3584	0.3584
Schistosoma mansoni	neuropeptide f receptor 76f	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584
Echinococcus granulosus	neuropeptide receptor A26	0.0388	0.3584	0.3584
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0388	0.3584	0.3584
Schistosoma mansoni	biogenic amine receptor	0.0388	0.3584	0.3584
Echinococcus multilocularis	activin receptor type	0.0073	0.0003	0.0003
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0388	0.3584	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0388	0.3584	0.3584

Activities

Activity type	Activity value	Assay description	Source	Reference
logP (ADMET)	= 6.9	Partition coefficient (logP)	ChEMBL.	6492079
pI50 (functional)	= 5.97 mM	Juvenile hormone mimetic activity in Aedes aegypti (yellow-fever mosquito)	ChEMBL.	6492079
pI50 (functional)	= 3.01 uM pupa-1	Juvenile hormone mimetic activity in Tenebrio molitor (yellow mealworm)	ChEMBL.	6492079

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL37659

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 50681