Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0769 | 0.2803 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0142 | 0.0203 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0271 | 0.0271 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0017 | 0.0769 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0769 | 0.2803 |
Echinococcus multilocularis | pyridine nucleotide disulfide oxidoreductase | 0.0004 | 0.0043 | 0.0043 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0017 | 0.0769 | 0.8051 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0017 | 0.0769 | 0.1102 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0017 | 0.0769 | 0.8051 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0017 | 0.0769 | 0.2803 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0017 | 0.0769 | 0.2803 |
Brugia malayi | glutathione reductase | 0.0048 | 0.2632 | 0.3771 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0945 | 0.3482 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.6286 | 0.8958 |
Echinococcus granulosus | glutamate synthase | 0.0004 | 0.0043 | 0.0043 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0006 | 0.0142 | 0.0382 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.002 | 0.0945 | 0.3482 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0017 | 0.0769 | 0.2803 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0271 | 0.0271 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0945 | 0.3482 |
Schistosoma mansoni | glutamate synthase | 0.0004 | 0.0043 | 0.0043 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.0945 | 1 |
Giardia lamblia | DNA damage repair protein | 0.0006 | 0.0142 | 0.1097 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0271 | 0.0389 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.0945 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.2632 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0.0769 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0017 | 0.0769 | 0.8051 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0271 | 0.0271 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0271 | 0.0271 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0006 | 0.0142 | 0.0382 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0769 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0769 | 0.2803 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0017 | 0.0769 | 0.2803 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0004 | 0.0043 | 0.0043 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.0945 | 0.0945 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0271 | 0.0389 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.0945 | 1 |
Schistosoma mansoni | sulfide quinone reductase | 0.0004 | 0.0043 | 0.0043 |
Loa Loa (eye worm) | pyridine nucleotide-disufhide oxidoreductase | 0.0004 | 0.0043 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0052 | 0.0075 |
Mycobacterium ulcerans | hypothetical protein | 0.0006 | 0.0142 | 0.1097 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0004 | 0.0043 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0945 | 0.1353 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0271 | 0.0271 |
Schistosoma mansoni | DNA polymerase IV / kappa | 0.0006 | 0.0142 | 0.0142 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.6981 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0769 | 0.2803 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.0945 | 0.3482 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0006 | 0.0142 | 0.0382 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0945 | 0.3482 |
Trypanosoma cruzi | DNA damage repair protein, putative | 0.0006 | 0.0142 | 0.0382 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.0945 | 0.0945 |
Loa Loa (eye worm) | programmed cell death 8 | 0.0004 | 0.0043 | 0.0062 |
Echinococcus granulosus | smad | 0.0008 | 0.0271 | 0.0271 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.2632 | 1 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0271 | 0.0271 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0006 | 0.0142 | 0.0382 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0271 | 0.0271 |
Leishmania major | trypanothione reductase | 0.0048 | 0.2632 | 1 |
Schistosoma mansoni | smad | 0.0008 | 0.0271 | 0.0271 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.0945 | 0.0945 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0945 | 0.0945 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0945 | 0.3482 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.2632 | 1 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0583 | 0.2087 |
Schistosoma mansoni | glutamate synthase | 0.0004 | 0.0043 | 0.0043 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0769 | 1 |
Brugia malayi | NADPH:adrenodoxin oxidoreductase, mitochondrial precursor | 0.0004 | 0.0043 | 0.0062 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.6286 | 0.8958 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.0945 | 0.0945 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0271 | 0.0271 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0583 | 0.2087 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0271 | 0.0389 |
Leishmania major | DNA polymerase kappa, putative | 0.0006 | 0.0142 | 0.0382 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0271 | 0.0389 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0017 | 0.0769 | 0.2803 |
Schistosoma mansoni | hypothetical protein | 0.0004 | 0.0043 | 0.0043 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0017 | 0.0769 | 0.0769 |
Loa Loa (eye worm) | nuclear factor I | 0.0005 | 0.0052 | 0.0075 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0048 | 0.2632 | 0.3716 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0945 | 0.3482 |
Brugia malayi | Smad1 | 0.0008 | 0.0271 | 0.0389 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0769 | 0.2803 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0017 | 0.0769 | 0.2803 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.0945 | 0.0945 |
Trypanosoma brucei | unspecified product | 0.002 | 0.0945 | 0.3482 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0017 | 0.0769 | 0.0769 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0945 | 0.3482 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0004 | 0.0043 | 0.0043 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0017 | 0.0769 | 0.0769 |
Echinococcus multilocularis | glutamate synthase | 0.0004 | 0.0043 | 0.0043 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0004 | 0.0043 | 0.0043 |
Brugia malayi | MH1 domain containing protein | 0.0005 | 0.0052 | 0.0075 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0945 | 0.3482 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.0945 | 0.3482 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0271 | 0.0389 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0769 | 0.2803 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0769 | 1 |
Echinococcus multilocularis | geminin | 0.0172 | 1 | 1 |
Echinococcus granulosus | sulfide:quinone oxidoreductase | 0.0004 | 0.0043 | 0.0043 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0945 | 0.3482 |
Echinococcus multilocularis | sulfide:quinone oxidoreductase | 0.0004 | 0.0043 | 0.0043 |
Leishmania major | DNA polymerase eta, putative | 0.0006 | 0.0142 | 0.0382 |
Echinococcus multilocularis | smad | 0.0008 | 0.0271 | 0.0271 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0006 | 0.0142 | 0.0382 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.2632 | 0.2632 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.2632 | 1 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0017 | 0.0769 | 0.2803 |
Onchocerca volvulus | 0.0004 | 0.0043 | 1 | |
Schistosoma mansoni | disulfide oxidoreductase | 0.0004 | 0.0043 | 0.0043 |
Brugia malayi | polk-prov protein | 0.0006 | 0.0142 | 0.0203 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0017 | 0.0769 | 0.2803 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.2632 | 0.3771 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0945 | 0.3482 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0017 | 0.0769 | 0.2803 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0271 | 0.0271 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0006 | 0.0142 | 0.0382 |
Schistosoma mansoni | sulfide quinone reductase | 0.0004 | 0.0043 | 0.0043 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0583 | 0.2087 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0012 | 0.0507 | 0.0726 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.2632 | 0.3771 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.0945 | 0.0945 |
Plasmodium falciparum | thioredoxin reductase | 0.0017 | 0.0769 | 0.2803 |
Trypanosoma brucei | DNA damage repair protein, putative | 0.0006 | 0.0142 | 0.0382 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0017 | 0.0769 | 0.1042 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0043 | 0.0062 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0017 | 0.0769 | 0.2803 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0945 | 0.3482 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0017 | 0.0769 | 0.8051 |
Echinococcus granulosus | pyridine nucleotide disulfide oxidoreductase | 0.0004 | 0.0043 | 0.0043 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0945 | 0.3482 |
Trypanosoma cruzi | DNA damage repair protein, putative | 0.0006 | 0.0142 | 0.0382 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.6286 | 0.8958 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0017 | 0.0769 | 0.2803 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.0945 | 0.1294 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0017 | 0.0769 | 0.8051 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0004 | 0.0043 | 0.0062 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0271 | 0.0271 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0271 | 0.0389 |
Echinococcus granulosus | NADPH:adrenodoxin oxidoreductase | 0.0004 | 0.0043 | 0.0043 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0017 | 0.0769 | 0.2803 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.2632 | 0.3771 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.6981 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0122 | 0.7012 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0122 | 0.7012 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0122 | 0.7012 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0004 | 0.0043 | 0.0062 |
Brugia malayi | glutamate synthase | 0.0004 | 0.0043 | 0.0062 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0006 | 0.0142 | 0.0382 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0006 | 0.0142 | 0.0382 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0945 | 0.1353 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0006 | 0.0142 | 0.0382 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0017 | 0.0769 | 0.2803 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0945 | 0.3482 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0271 | 0.0271 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.6286 | 0.8958 |
Leishmania major | DNA damage repair protein, putative | 0.0006 | 0.0142 | 0.0382 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0945 | 1 |
Echinococcus granulosus | apoptosis inducing factor 1 mitochondrial | 0.0004 | 0.0043 | 0.0043 |
Trypanosoma brucei | DNA damage repair protein, putative | 0.0006 | 0.0142 | 0.0382 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.2632 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0017 | 0.0769 | 0.8051 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.0945 | 0.1294 |
Echinococcus multilocularis | apoptosis inducing factor 1 mitochondrial | 0.0004 | 0.0043 | 0.0043 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0769 | 0.2803 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.2632 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0017 | 0.0769 | 0.2803 |
Schistosoma mansoni | glutamate synthase | 0.0004 | 0.0043 | 0.0043 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.002 | 0.0945 | 0.3482 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0945 | 0.3482 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.0945 | 0.0945 |
Brugia malayi | MH1 domain containing protein | 0.0005 | 0.0052 | 0.0075 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0945 | 0.3482 |
Echinococcus multilocularis | NADPH:adrenodoxin oxidoreductase | 0.0004 | 0.0043 | 0.0043 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0006 | 0.0142 | 0.0382 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0945 | 0.0945 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.2632 | 0.2632 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0006 | 0.0142 | 0.0382 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.6286 | 0.8958 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0271 | 0.0389 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0945 | 0.3482 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.6286 | 0.8958 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0583 | 0.2087 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0012 | 0.0507 | 0.0726 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0109 | 0.6286 | 0.8958 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0006 | 0.0142 | 0.0382 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0.2632 | 1 |
Treponema pallidum | NADH oxidase | 0.0017 | 0.0769 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.6981 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0945 | 0.1353 |
Leishmania major | DNA polymerase eta, putative | 0.002 | 0.0945 | 0.3482 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0017 | 0.0769 | 0.2803 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0122 | 0.7012 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.0945 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0583 | 0.2087 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0945 | 0.1353 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0945 | 0.3482 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0945 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0945 | 0.3482 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0006 | 0.0142 | 0.0382 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.