Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0151 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.3399 | 0.3399 |
Schistosoma mansoni | nuclear hormone receptor | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0104 | 0.3399 | 0.3399 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0151 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0151 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0151 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0104 | 0.3399 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0104 | 0.3399 | 0.3399 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0151 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0151 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0151 | 1 | 1 |
Onchocerca volvulus | 0.0151 | 1 | 1 | |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0151 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0151 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0151 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0151 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0151 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.3399 | 0.3399 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0104 | 0.3399 | 0.3399 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0151 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0151 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0151 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0104 | 0.3399 | 0.3399 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0151 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0151 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0151 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0151 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0151 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0151 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0151 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0151 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0151 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0104 | 0.3399 | 0.3399 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0151 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0151 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0104 | 0.3399 | 0.3399 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0151 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0151 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0151 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0151 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0151 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0104 | 0.3399 | 0.3399 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0104 | 0.3399 | 0.3399 |
Brugia malayi | nuclear receptor NHR-88 | 0.0151 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0151 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0151 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0151 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0151 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0151 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0151 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0151 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0151 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0151 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0151 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.3399 | 0.3399 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0151 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0151 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = -6.64 | Antagonist activity at human CCR2b receptor | ChEMBL. | 18258426 |
IC50 (functional) | = 229 nM | Antagonist activity at human CCR2b receptor | ChEMBL. | 18258426 |
IC50 (functional) | = 229 nM | Antagonist activity at human CCR2b receptor | ChEMBL. | 18258426 |
Log IC50 (functional) | = 6.64 | Antagonist activity at human CCR2b receptor | ChEMBL. | 18258426 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.