Detailed information for compound 50702

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 374.459 | Formula: C21H18N4OS
  • H donors: 3 H acceptors: 3 LogP: 2.51 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C(\Sc1ccccc1N)/N)/c1cccc(c1)C(c1cccnc1)O
  • InChi: 1S/C21H18N4OS/c22-12-17(21(24)27-19-9-2-1-8-18(19)23)14-5-3-6-15(11-14)20(26)16-7-4-10-25-13-16/h1-11,13,20,26H,23-24H2/b21-17+
  • InChiKey: VZGYTIMXFWIIJM-HEHNFIMWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase kinase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni protein kinase Get druggable targets OG5_127304 All targets in OG5_127304
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 Get druggable targets OG5_127304 All targets in OG5_127304
Schistosoma japonicum Dual specificity mitogen-activated protein kinase kinase 2, putative Get druggable targets OG5_127304 All targets in OG5_127304
Echinococcus granulosus dual specificity mitogen activated protein Get druggable targets OG5_127304 All targets in OG5_127304
Trichomonas vaginalis STE family protein kinase Get druggable targets OG5_127304 All targets in OG5_127304
Leishmania donovani mitogen-activated protein kinase kinase 5 Get druggable targets OG5_127304 All targets in OG5_127304
Leishmania infantum mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 Get druggable targets OG5_127304 All targets in OG5_127304
Trichomonas vaginalis STE family protein kinase Get druggable targets OG5_127304 All targets in OG5_127304
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 Get druggable targets OG5_127304 All targets in OG5_127304
Candida albicans member of the HOG1 MAPK cascade Get druggable targets OG5_127304 All targets in OG5_127304
Trypanosoma brucei mitogen-activated protein kinase kinase 5 Get druggable targets OG5_127304 All targets in OG5_127304
Candida albicans likely MAP kinase kinase that can functionally substitute for S. cerevisiae STE7 (YDL159W) Get druggable targets OG5_127304 All targets in OG5_127304
Trypanosoma brucei gambiense protein kinase, putative,MAP kinase kinase, putative Get druggable targets OG5_127304 All targets in OG5_127304
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 Get druggable targets OG5_127304 All targets in OG5_127304
Trypanosoma congolense mitogen-activated protein kinase kinase 5 Get druggable targets OG5_127304 All targets in OG5_127304
Candida albicans likely MAP kinase kinase that can functionally substitute for S. cerevisiae STE7 (YDL159W) Get druggable targets OG5_127304 All targets in OG5_127304
Echinococcus multilocularis dual specificity mitogen activated protein Get druggable targets OG5_127304 All targets in OG5_127304
Leishmania braziliensis mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 Get druggable targets OG5_127304 All targets in OG5_127304
Trichomonas vaginalis STE family protein kinase Get druggable targets OG5_127304 All targets in OG5_127304
Schistosoma japonicum Dual specificity mitogen-activated protein kinase kinase 1, putative Get druggable targets OG5_127304 All targets in OG5_127304
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase Get druggable targets OG5_127304 All targets in OG5_127304
Cryptosporidium hominis protein kinase NPK2 (EC 2.7.1.-) Get druggable targets OG5_127304 All targets in OG5_127304
Leishmania mexicana protein kinase, putative,mitogen activated protein kinase, putative Get druggable targets OG5_127304 All targets in OG5_127304
Giardia lamblia Kinase, STE STE20 Get druggable targets OG5_127304 All targets in OG5_127304
Cryptosporidium parvum protein kinase NPK2 Get druggable targets OG5_127304 All targets in OG5_127304
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica tubulin alpha chain, putative 0.041 0.1472 0.7349
Treponema pallidum cell division protein FtsZ 0.014 0.0444 1
Toxoplasma gondii tubulin, putative 0.0028 0.0016 0.0068
Giardia lamblia Delta tubulin 0.014 0.0444 0.2012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0087 0.0241 0.1217
Giardia lamblia Alpha-tubulin 0.041 0.1472 0.7349
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0087 0.0241 0.3982
Echinococcus granulosus thyroid hormone receptor alpha 0.0041 0.0066 0.0333
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0043 0.0216
Loa Loa (eye worm) tubulin alpha 2 0.027 0.0937 0.2152
Leishmania major beta tubulin 0.0545 0.1982 1
Schistosoma mansoni hypothetical protein 0.0132 0.0411 0.2074
Plasmodium falciparum alpha tubulin 2 0.041 0.1472 0.7422
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0146
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0087 0.0241 0.1217
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0043 0.001
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0087 0.0241 0.0549
Brugia malayi steroid hormone receptor 0.0087 0.0241 0.0549
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0144 0.0726
Brugia malayi RNA binding protein 0.0062 0.0144 0.0325
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0033 0.0154
Schistosoma mansoni transcription factor LCR-F1 0.0223 0.0757 0.3821
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0061 0.0309
Loa Loa (eye worm) tubulin alpha 2 0.027 0.0937 0.2152
Brugia malayi Steroid receptor seven-up type 2 0.0087 0.0241 0.0549
Echinococcus multilocularis tubulin gamma 1 chain 0.0335 0.1184 0.5973
Mycobacterium tuberculosis Cell division protein FtsZ 0.014 0.0444 0.0412
Loa Loa (eye worm) hypothetical protein 0.0046 0.0085 0.0189
Brugia malayi tubulin alpha chain - mouse 0.041 0.1472 0.3383
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0087 0.0241 0.1217
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0039 0.0057 0.0273
Plasmodium vivax tubulin epsilon chain, putative 0.0334 0.1182 0.5959
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0092
Schistosoma mansoni hypothetical protein 0.0365 0.1299 0.6553
Echinococcus multilocularis tubulin alpha chain 0.041 0.1472 0.7425
Brugia malayi Bromodomain containing protein 0.0083 0.0225 0.0511
Brugia malayi Tubulin alpha chain 0.041 0.1472 0.3383
Echinococcus granulosus tubulin alpha chain 0.041 0.1472 0.7425
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.005 0.0099 0.0488
Toxoplasma gondii alpha tubulin TUBA1 0.041 0.1472 0.7422
Leishmania major beta tubulin 0.0545 0.1982 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0231 0.0788 0.0757
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0087 0.0241 0.1217
Plasmodium vivax thioredoxin reductase, putative 0.0144 0.0457 0.2296
Loa Loa (eye worm) BEN-1 protein 0.0545 0.1982 0.4558
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0089 0.045
Echinococcus granulosus GPCR family 2 0.0047 0.0089 0.045
Schistosoma mansoni nuclear receptor 0.0041 0.0066 0.0333
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0043 0.0202
Trypanosoma brucei trypanothione reductase 0.0144 0.0457 0.2296
Plasmodium vivax tubulin alpha chain, putative 0.041 0.1472 0.7422
Trichomonas vaginalis tubulin beta chain, putative 0.041 0.1472 0.7368
Brugia malayi hypothetical protein 0.0041 0.0066 0.0146
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0194 0.0649 0.0618
Trichomonas vaginalis tubulin epsilon chain, putative 0.041 0.1472 0.7368
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0087 0.0241 0.0549
Trypanosoma brucei alpha tubulin 0.041 0.1472 0.7422
Loa Loa (eye worm) hypothetical protein 0.0087 0.0241 0.0549
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0087 0.0241 0.1217
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0223 0.0757 0.3821
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0078 0.0207 0.047
Schistosoma mansoni steroid hormone receptor ad4bp 0.0087 0.0241 0.1217
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0033 0.0154
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0041 0.0066 0.0146
Leishmania major beta tubulin 0.0545 0.1982 1
Trypanosoma brucei beta tubulin 0.0545 0.1982 1
Entamoeba histolytica hypothetical protein 0.0223 0.0757 0.3638
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0087 0.0241 0.0549
Entamoeba histolytica hypothetical protein 0.0223 0.0757 0.3638
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0087 0.0241 0.1217
Leishmania major gamma-tubulin 0.0335 0.1184 0.5967
Leishmania major alpha tubulin 0.041 0.1472 0.7422
Leishmania major alpha tubulin 0.041 0.1472 0.7422
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0061 0.0019
Trichomonas vaginalis tubulin gamma chain, putative 0.0334 0.1182 0.5876
Echinococcus granulosus tubulin subunit beta 0.0545 0.1982 1
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0039 0.0057 0.0287
Plasmodium falciparum tubulin epsilon chain, putative 0.0334 0.1182 0.5959
Schistosoma mansoni zinc finger protein 0.0041 0.0066 0.0333
Echinococcus multilocularis tubulin delta chain 0.014 0.0444 0.2241
Schistosoma mansoni hypothetical protein 0.0047 0.0089 0.045
Brugia malayi beta-lactamase 0.0035 0.0043 0.0092
Trichomonas vaginalis STE family protein kinase 0.009 0.0251 0.1073
Echinococcus granulosus zinc finger protein 0.0024 0.0003 0.0014
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.0477 0.1091
Brugia malayi Tubulin beta chain 0.0166 0.0541 0.1239
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.005 0.0099 0.0488
Entamoeba histolytica tubulin family protein 0.0545 0.1982 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0144 0.0726
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0099 0.0488
Brugia malayi alpha-tubulin 0.041 0.1472 0.3383
Toxoplasma gondii beta tubulin 0.0545 0.1982 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0087 0.0241 0.0549
Toxoplasma gondii beta-1 tubulin, putative 0.0545 0.1982 1
Echinococcus multilocularis beta tubulin 0.0545 0.1982 1
Echinococcus granulosus dual specificity mitogen activated protein 0.009 0.0251 0.1266
Leishmania major beta tubulin 0.0545 0.1982 1
Schistosoma mansoni thyroid hormone receptor 0.0219 0.0743 0.3747
Loa Loa (eye worm) hypothetical protein 0.0046 0.0085 0.0189
Loa Loa (eye worm) tubulin alpha chain 0.041 0.1472 0.3383
Mycobacterium ulcerans cell division protein FtsZ 0.014 0.0444 0.0403
Echinococcus multilocularis thyroid hormone receptor alpha 0.0219 0.0743 0.3747
Leishmania major beta tubulin 0.0545 0.1982 1
Treponema pallidum NADH oxidase 0.005 0.0099 0.1101
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0306 0.1076 0.542
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.005 0.0099 0.0488
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0066 0.0333
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0071 0.0073
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0087 0.0241 0.0549
Entamoeba histolytica hypothetical protein 0.0223 0.0757 0.3638
Giardia lamblia Gamma tubulin 0.0335 0.1184 0.5854
Plasmodium vivax glutathione reductase, putative 0.0144 0.0457 0.2296
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0041 0.0066 0.0333
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0043 0.0216
Entamoeba histolytica tubulin alpha-1 chain 0.041 0.1472 0.7349
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0231 0.0788 0.0749
Trypanosoma brucei alpha tubulin, putative 0.0166 0.0541 0.2719
Onchocerca volvulus Bile acid receptor homolog 0.0087 0.0241 0.3982
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0146
Trypanosoma brucei beta tubulin 0.0306 0.1076 0.542
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.005 0.0099 0.0488
Leishmania major alpha tubulin 0.041 0.1472 0.7422
Echinococcus multilocularis tubulin subunit beta 0.0545 0.1982 1
Brugia malayi Tubulin beta-1 chain 0.0545 0.1982 0.4558
Echinococcus granulosus beta tubulin 0.0545 0.1982 1
Onchocerca volvulus 0.0129 0.04 0.7172
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0194 0.0649 0.0618
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0095 0.0269
Schistosoma mansoni tubulin subunit beta 0.014 0.0444 0.2241
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0087 0.0241 0.0549
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0078 0.0207 0.1044
Echinococcus multilocularis nuclear receptor nhr 48 0.0041 0.0066 0.0333
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0089 0.045
Schistosoma mansoni retinoic acid receptor RXR 0.0183 0.0606 0.3055
Loa Loa (eye worm) beta-lactamase 0.0035 0.0043 0.0092
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0061 0.0295
Giardia lamblia Kinase, STE STE20 0.009 0.0251 0.1008
Mycobacterium ulcerans flavoprotein disulfide reductase 0.005 0.0099 0.0057
Trichomonas vaginalis tubulin gamma chain, putative 0.014 0.0444 0.207
Echinococcus granulosus tubulin alpha 1C chain 0.041 0.1472 0.7425
Echinococcus multilocularis Tubulin alpha 1 chain 0.041 0.1472 0.7425
Brugia malayi MH2 domain containing protein 0.0116 0.0351 0.0802
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0146
Trichomonas vaginalis tubulin beta chain, putative 0.0166 0.0541 0.2569
Echinococcus granulosus tubulin beta 1 chain 0.0545 0.1982 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0164 0.0825
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0033 0.0154
Schistosoma mansoni nuclear receptor 0.0041 0.0066 0.0333
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.2651 1 1
Echinococcus granulosus tar DNA binding protein 0.0062 0.0144 0.0726
Echinococcus granulosus tubulin alpha 3 chain 0.041 0.1472 0.7425
Toxoplasma gondii exonuclease III APE 0.004 0.0061 0.0295
Trypanosoma cruzi alpha tubulin, putative 0.041 0.1472 0.7422
Trichomonas vaginalis tubulin epsilon chain, putative 0.0545 0.1982 1
Echinococcus granulosus FTZ F1 alpha 0.0087 0.0241 0.1217
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.0491 0.2476
Echinococcus granulosus tubulin alpha 1C chain 0.041 0.1472 0.7425
Trichomonas vaginalis tubulin beta chain, putative 0.041 0.1472 0.7368
Schistosoma mansoni ap endonuclease 0.004 0.0061 0.0309
Trypanosoma cruzi zeta tubulin, putative 0.0434 0.1562 0.7877
Plasmodium vivax tubulin gamma chain, putative 0.0335 0.1184 0.5967
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0316 0.1113 0.5608
Echinococcus granulosus tubulin alpha chain 0.041 0.1472 0.7425
Loa Loa (eye worm) tubulin alpha chain 0.041 0.1472 0.3383
Echinococcus granulosus ecdysone induced protein 78C 0.0087 0.0241 0.1217
Trichomonas vaginalis tubulin beta chain, putative 0.041 0.1472 0.7368
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.041 0.1472 0.7368
Trypanosoma cruzi trypanothione reductase, putative 0.0144 0.0457 0.2296
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0089 0.0199
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0046 0.0085 0.0428
Schistosoma mansoni hypothetical protein 0.0102 0.0297 0.15
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0139
Brugia malayi follicle stimulating hormone receptor 0.0224 0.0761 0.1746
Schistosoma mansoni nuclear receptor nhr-48 0.0041 0.0066 0.0333
Loa Loa (eye worm) hypothetical protein 0.0068 0.0168 0.0379
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.0517 0.1184
Trichomonas vaginalis tubulin beta chain, putative 0.041 0.1472 0.7368
Trypanosoma brucei alpha tubulin 0.041 0.1472 0.7422
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0078 0.0207 0.1044
Trichomonas vaginalis STE family protein kinase 0.009 0.0251 0.1073
Echinococcus granulosus cysteinyl tRNA synthetase 0.0039 0.0057 0.0287
Plasmodium falciparum tubulin delta chain, putative 0.014 0.0444 0.223
Brugia malayi Tubulin beta chain 0.014 0.0444 0.1016
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0168 0.0551 0.2769
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0183 0.0606 0.3055
Loa Loa (eye worm) hypothetical protein 0.041 0.1472 0.3383
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0043 0.001
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0087 0.0241 0.1217
Schistosoma mansoni tubulin subunit alpha 0.041 0.1472 0.7425
Echinococcus multilocularis tubulin alpha chain 0.041 0.1472 0.7425
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0099 0.0488
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.005 0.0099 0.0488
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0071 0.0073
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0033 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0444 0.207
Plasmodium falciparum thioredoxin reductase 0.0144 0.0457 0.2296
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0039 0.0057 0.0287
Plasmodium falciparum glutathione reductase 0.0144 0.0457 0.2296
Onchocerca volvulus 0.0166 0.0541 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0043 0.001
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0033 0.0168
Schistosoma mansoni alpha tubulin 0.041 0.1472 0.7425
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0099 0.0488
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0033 0.007
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0033 0.0154
Echinococcus granulosus Tubulin alpha 1 chain 0.041 0.1472 0.7425
Leishmania major beta tubulin 0.0545 0.1982 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.0517 0.2608
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.005 0.0099 0.0066
Leishmania major alpha tubulin 0.041 0.1472 0.7422
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0066 0.0333
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0095 0.0479
Echinococcus multilocularis thioredoxin glutathione reductase 0.0144 0.0459 0.2317
Giardia lamblia Beta tubulin 0.0545 0.1982 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0193 0.0438
Echinococcus granulosus tubulin delta chain 0.014 0.0444 0.2241
Schistosoma mansoni tubulin subunit alpha 0.041 0.1472 0.7425
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0066 0.0467
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0164 0.0825
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0087 0.0241 0.0549
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0071 0.0343
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0066 0.0333
Brugia malayi tailless protein 0.0041 0.0066 0.0146
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0146
Brugia malayi Bromodomain containing protein 0.0044 0.0078 0.0173
Loa Loa (eye worm) hypothetical protein 0.0046 0.0085 0.0189
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0043 0.0092
Schistosoma mansoni bromodomain containing protein 0.007 0.0178 0.0897
Mycobacterium tuberculosis Probable oxidoreductase 0.0231 0.0788 0.0757
Echinococcus multilocularis Tubulin beta 2C chain 0.0545 0.1982 1
Brugia malayi isocitrate dehydrogenase 0.0032 0.0033 0.007
Trypanosoma brucei epsilon tubulin 0.0334 0.1182 0.5959
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.0187 0.0745
Echinococcus granulosus Tubulin beta 2C chain 0.0545 0.1982 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0545 0.1982 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.005 0.0099 0.0488
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0066 0.0333
Leishmania major zeta tubulin, putative 0.0434 0.1562 0.7877
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0087 0.0241 0.0549
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0099 0.0488
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0041 0.0066 0.0333
Mycobacterium leprae cell division protein FtsZ 0.014 0.0444 0.0403
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0087 0.0241 0.1217
Trypanosoma cruzi zeta tubulin, putative 0.0434 0.1562 0.7877
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0137 0.043 0.2172
Echinococcus multilocularis beta tubulin 0.0545 0.1982 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0166 0.0541 0.2569
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0033 0.0168
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0092
Echinococcus granulosus tubulin beta 4A class IVa 0.0545 0.1982 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.014 0.0444 0.207
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0099 0.0488
Brugia malayi tubulin alpha-2 chain 0.041 0.1472 0.3383
Brugia malayi Tubulin alpha-2 chain 0.041 0.1472 0.3383
Plasmodium vivax delta tubulin, putative 0.014 0.0444 0.223
Mycobacterium tuberculosis Probable reductase 0.0194 0.0649 0.0618
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0144 0.0325
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0087 0.0241 0.0549
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0041 0.0066 0.0333
Leishmania major epsilon tubulin, putative 0.0334 0.1182 0.5959
Leishmania major beta tubulin 0.0545 0.1982 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0144 0.0459 0.2317
Echinococcus multilocularis tubulin alpha 1C chain 0.041 0.1472 0.7425
Toxoplasma gondii alpha-tubulin I, putative 0.041 0.1472 0.7422
Trypanosoma brucei alpha tubulin 0.041 0.1472 0.7422
Brugia malayi Tubulin alpha-2 chain 0.041 0.1472 0.3383
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0066 0.0333
Schistosoma mansoni tubulin subunit delta 0.014 0.0444 0.2241
Plasmodium vivax tubulin alpha chain, putative 0.041 0.1472 0.7422
Schistosoma mansoni hypothetical protein 0.0365 0.1299 0.6553
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0092
Leishmania major delta tubulin, putative 0.0316 0.1113 0.5608
Schistosoma mansoni hypothetical protein 0.0047 0.0089 0.045
Echinococcus granulosus tubulin alpha chain 0.041 0.1472 0.7425
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.005 0.0099 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0146
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0545 0.1982 1
Echinococcus multilocularis jun protein 0.0164 0.0534 0.2695
Echinococcus granulosus peroxisome assembly protein 26 0.041 0.1472 0.7425
Echinococcus granulosus jun protein 0.0164 0.0534 0.2695
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.005 0.0099 0.0488
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0164 0.0534 0.2695
Trichomonas vaginalis tubulin epsilon chain, putative 0.041 0.1472 0.7368
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0223 0.0757 0.3821
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.005 0.0099 0.0488
Schistosoma mansoni coup transcription factor 0.0087 0.0241 0.1217
Brugia malayi small heat shock protein 0.1166 0.4345 1
Loa Loa (eye worm) hypothetical protein 0.1166 0.4345 1
Trichomonas vaginalis tubulin beta chain, putative 0.041 0.1472 0.7368
Schistosoma mansoni hypothetical protein 0.0223 0.0757 0.3821
Loa Loa (eye worm) tubulin beta-4 chain 0.0545 0.1982 0.4558
Echinococcus multilocularis tubulin alpha chain 0.041 0.1472 0.7425
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0066 0.0146
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0087 0.0241 0.1217
Trypanosoma brucei beta tubulin 0.0545 0.1982 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0043 0.001
Onchocerca volvulus 0.0039 0.0057 0.0282
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0043 0.0216
Plasmodium falciparum alpha tubulin 1 0.041 0.1472 0.7422
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0046 0.0085 0.0189
Leishmania major beta tubulin 0.0545 0.1982 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0041 0.0066 0.0146
Echinococcus granulosus tubulin subunit TubB 0.041 0.1472 0.7425
Loa Loa (eye worm) hypothetical protein 0.0087 0.0241 0.0549
Brugia malayi ecdysteroid receptor 0.0087 0.0241 0.0549
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0146
Loa Loa (eye worm) steroid hormone receptor 0.0087 0.0241 0.0549
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0089 0.0199
Toxoplasma gondii NADPH-glutathione reductase 0.005 0.0099 0.0488
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0095 0.0465
Echinococcus multilocularis tubulin alpha 0.0306 0.1076 0.5427
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0144 0.0726
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0033 0.0168
Schistosoma mansoni tubulin subunit beta 0.0545 0.1982 1
Loa Loa (eye worm) hypothetical protein 0.027 0.0937 0.2152
Schistosoma mansoni protein kinase 0.009 0.0251 0.1266
Giardia lamblia Beta tubulin 0.0545 0.1982 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.0477 0.1091
Echinococcus multilocularis Tubulin beta 2C chain 0.0545 0.1982 1
Trypanosoma brucei beta tubulin 0.0545 0.1982 1
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0033 0.007
Echinococcus multilocularis Tubulin alpha 1 chain 0.041 0.1472 0.7425
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0194 0.0649 0.0609
Echinococcus multilocularis dual specificity mitogen activated protein 0.009 0.0251 0.1266
Toxoplasma gondii ABC1 family protein 0.0035 0.0043 0.0202
Brugia malayi bZIP transcription factor family protein 0.0164 0.0534 0.1224
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0095 0.0465
Loa Loa (eye worm) alpha-tubulin isotype 2 0.027 0.0937 0.2152
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0033 0.0168
Echinococcus granulosus Tubulin beta 2C chain 0.0545 0.1982 1
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0066 0.0333
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.005 0.0099 0.0502
Echinococcus multilocularis peroxisome assembly protein 26 0.041 0.1472 0.7425
Brugia malayi TAR-binding protein 0.0062 0.0144 0.0325
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.009 0.0251 0.1253
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0087 0.0241 0.0549
Plasmodium falciparum cysteine--tRNA ligase 0.0039 0.0057 0.0273
Onchocerca volvulus 0.0041 0.0066 0.0467
Echinococcus granulosus Tubulin alpha 1 chain 0.041 0.1472 0.7425
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0089 0.045
Schistosoma mansoni hypothetical protein 0.0133 0.0417 0.2105
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0146
Trypanosoma brucei epsilon tubulin 0.0306 0.1076 0.542
Echinococcus multilocularis Tubulin beta 2C chain 0.0545 0.1982 1
Brugia malayi Nuclear hormone receptor-like 1 0.0087 0.0241 0.0549
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0087 0.0241 0.1217
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0043 0.001
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0245 0.084 0.4113
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.005 0.0099 0.1101
Brugia malayi Tubulin alpha chain 0.014 0.0444 0.1016
Echinococcus multilocularis Tubulin alpha 1 chain 0.041 0.1472 0.7425
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0039 0.0057 0.0072
Schistosoma mansoni ap endonuclease 0.004 0.0061 0.0309
Echinococcus granulosus beta tubulin 0.0545 0.1982 1
Leishmania major beta tubulin 0.0545 0.1982 1
Brugia malayi PHD-finger family protein 0.003 0.0024 0.0049
Schistosoma mansoni tubulin subunit beta 0.0545 0.1982 1
Trypanosoma brucei tubulin gamma chain 0.0335 0.1184 0.5967
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0043 0.0202
Loa Loa (eye worm) thioredoxin reductase 0.0144 0.0457 0.1047
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0043 0.001
Leishmania major beta tubulin 0.0545 0.1982 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0124
Entamoeba histolytica tubulin family protein 0.0545 0.1982 1
Schistosoma mansoni tubulin subunit beta 0.0545 0.1982 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0087 0.0241 0.1217
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0037 0.0049 0.0106
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0146
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0061 0.0134
Trichomonas vaginalis tubulin beta chain, putative 0.041 0.1472 0.7368
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0043 0.001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0146
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0033 0.0154
Entamoeba histolytica hypothetical protein 0.0223 0.0757 0.3638
Loa Loa (eye worm) tubulin alpha 2 0.0104 0.0306 0.0698
Echinococcus multilocularis GPCR, family 2 0.0047 0.0089 0.045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0087 0.0241 0.0549
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0194 0.0649 0.0618
Loa Loa (eye worm) hypothetical protein 0.0049 0.0095 0.0213
Trichomonas vaginalis tubulin alpha chain, putative 0.0306 0.1076 0.5326
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0033 0.0168
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0033 0.0168
Trypanosoma brucei zeta tubulin 0.0434 0.1562 0.7877
Leishmania major trypanothione reductase 0.0144 0.0457 0.2296
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0351 0.0802
Schistosoma mansoni hypothetical protein 0.0047 0.0089 0.045
Leishmania major cysteinyl-tRNA synthetase, putative 0.0039 0.0057 0.0273
Schistosoma mansoni tubulin subunit beta 0.0545 0.1982 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0335 0.1184 0.5884
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.009 0.0251 0.1253
Brugia malayi hypothetical protein 0.0223 0.0757 0.1737
Leishmania major dihydrolipoamide dehydrogenase, putative 0.005 0.0099 0.0488
Loa Loa (eye worm) beta-tubulin 0.0545 0.1982 0.4558
Loa Loa (eye worm) BEN-1 protein 0.0545 0.1982 0.4558
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0039 0.0057 0.0124
Schistosoma mansoni hypothetical protein 0.0047 0.0089 0.045
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0087 0.0241 0.1217
Echinococcus multilocularis tubulin alpha chain 0.041 0.1472 0.7425
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0087 0.0241 0.0549
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0166 0.0541 0.2569
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0092
Brugia malayi nuclear hormone receptor family member odr-7 0.0041 0.0066 0.0146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0099 0.0488
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0087 0.0241 0.1217
Brugia malayi nuclear receptor RXR 0.0041 0.0066 0.0146
Loa Loa (eye worm) tubulin alpha-2 chain 0.041 0.1472 0.3383
Trypanosoma cruzi tubulin delta chain 0.0316 0.1113 0.5608
Leishmania major alpha tubulin 0.041 0.1472 0.7422
Echinococcus granulosus tubulin alpha 0.0306 0.1076 0.5427
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0039 0.0057 0.0124
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0092
Leishmania major beta tubulin 0.0545 0.1982 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0061 0.0295
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.005 0.0099 0.0488
Loa Loa (eye worm) acetyltransferase 0.016 0.0517 0.1184
Trypanosoma brucei tubulin delta chain 0.0316 0.1113 0.5608
Trypanosoma brucei epsilon tubulin 0.0334 0.1182 0.5959
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0092
Trypanosoma brucei beta tubulin 0.0545 0.1982 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0095 0.0269
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0061 0.0113
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0066 0.0333
Onchocerca volvulus Protein ultraspiracle homolog 0.0087 0.0241 0.3982
Leishmania major beta tubulin 0.0545 0.1982 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0061 0.0028
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0061 0.0095
Echinococcus multilocularis zinc finger protein 0.0024 0.0003 0.0014
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0095 0.0465
Echinococcus granulosus Tubulin alpha 1 chain 0.041 0.1472 0.7425
Echinococcus multilocularis geminin 0.0365 0.1299 0.6553
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.009 0.0251 0.1253
Schistosoma mansoni tubulin subunit beta 0.0545 0.1982 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0089 0.0199
Loa Loa (eye worm) tubulin beta chain 0.0545 0.1982 0.4558
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0043 0.001
Loa Loa (eye worm) hypothetical protein 0.0087 0.0241 0.0549
Loa Loa (eye worm) hypothetical protein 0.0087 0.0241 0.0549
Echinococcus multilocularis hypothetical protein 0.041 0.1472 0.7425
Trypanosoma brucei zeta tubulin, putative 0.0434 0.1562 0.7877
Leishmania major beta tubulin 0.0545 0.1982 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.0477 0.1091
Loa Loa (eye worm) hypothetical protein 0.0046 0.0085 0.0189
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0146
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0054 0.0271
Brugia malayi Thioredoxin reductase 0.0144 0.0457 0.1047
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.005 0.0099 0.0057
Echinococcus granulosus Tubulin beta 2C chain 0.0545 0.1982 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0545 0.1982 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0087 0.0241 0.1217
Leishmania major alpha tubulin 0.041 0.1472 0.7422
Giardia lamblia Alpha-tubulin 0.041 0.1472 0.7349
Leishmania major beta tubulin 0.0545 0.1982 1
Echinococcus multilocularis tubulin beta 1 chain 0.0545 0.1982 1
Brugia malayi ecdysone receptor 0.0041 0.0066 0.0146
Plasmodium falciparum glutathione reductase 0.005 0.0099 0.0488
Schistosoma mansoni zinc finger protein 0.0024 0.0003 0.0014
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0087 0.0241 0.1217
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0297 0.0678
Loa Loa (eye worm) hypothetical protein 0.0047 0.0088 0.0195
Echinococcus granulosus nuclear receptor nhr 48 0.0041 0.0066 0.0333
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0046 0.0085 0.0428
Trichomonas vaginalis STE family protein kinase 0.009 0.0251 0.1073
Leishmania major beta tubulin 0.0545 0.1982 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.005 0.0099 0.0502
Plasmodium falciparum thioredoxin reductase 0.005 0.0099 0.0488
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0099 0.0488
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0061 0.0095
Trichomonas vaginalis tubulin beta chain, putative 0.0545 0.1982 1
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.0234 0.1181
Echinococcus multilocularis tubulin epsilon chain 0.0334 0.1182 0.5965
Echinococcus multilocularis tubulin alpha chain 0.041 0.1472 0.7425
Echinococcus granulosus tubulin alpha chain 0.041 0.1472 0.7425
Leishmania major alpha tubulin 0.041 0.1472 0.7422
Trichomonas vaginalis tubulin alpha chain, putative 0.0166 0.0541 0.2569
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.005 0.0099 0.0488
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0043 0.0092
Trichomonas vaginalis glutathione reductase, putative 0.005 0.0099 0.0292
Trichomonas vaginalis tubulin epsilon chain, putative 0.0545 0.1982 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0041 0.0066 0.0333
Echinococcus multilocularis FTZ F1 alpha 0.0087 0.0241 0.1217
Onchocerca volvulus 0.0041 0.0066 0.0467
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0144 0.0726
Leishmania major alpha tubulin 0.041 0.1472 0.7422
Brugia malayi hypothetical protein 0.0129 0.04 0.0915
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0087 0.0241 0.1217
Loa Loa (eye worm) hypothetical protein 0.0087 0.0241 0.0549
Brugia malayi photoreceptor-specific nuclear receptor 0.0087 0.0241 0.0549
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0061 0.0023
Leishmania major beta tubulin 0.0545 0.1982 1
Brugia malayi orphan nuclear receptor NR2E1 0.0041 0.0066 0.0146
Loa Loa (eye worm) DR-78 0.0041 0.0066 0.0146
Brugia malayi hypothetical protein 0.0046 0.0085 0.0189
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0132 0.0411 0.2074
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0061 0.0134
Toxoplasma gondii thioredoxin reductase 0.0144 0.0457 0.2296
Brugia malayi nuclear receptor NHR-67 0.0041 0.0066 0.0146
Plasmodium vivax cysteine--tRNA ligase, putative 0.0039 0.0057 0.0273
Echinococcus granulosus geminin 0.0365 0.1299 0.6553
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0054 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0444 0.207
Mycobacterium tuberculosis Conserved protein 0.0035 0.0043 0.001
Leishmania major alpha tubulin 0.041 0.1472 0.7422
Brugia malayi beta-lactamase family protein 0.0035 0.0043 0.0092
Loa Loa (eye worm) hypothetical protein 0.0102 0.0297 0.0678
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0144 0.0325
Echinococcus multilocularis tubulin subunit TubB 0.041 0.1472 0.7425
Loa Loa (eye worm) hypothetical protein 0.0046 0.0085 0.0189
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.0517 0.2608
Brugia malayi nuclear receptor NHR-88 0.0041 0.0066 0.0146
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0087 0.0241 0.1217
Echinococcus granulosus Tubulin beta 2C chain 0.0545 0.1982 1
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.014 0.0444 1
Trichomonas vaginalis tubulin, putative 0.0545 0.1982 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0087 0.0241 0.1217
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0194 0.0649 0.0618
Leishmania major beta tubulin 0.0545 0.1982 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0545 0.1982 0.4558
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0132 0.0411 0.2074
Echinococcus multilocularis Tubulin beta 2C chain 0.0545 0.1982 1
Trichomonas vaginalis tubulin, putative 0.0166 0.0541 0.2569
Trypanosoma cruzi beta tubulin, putative 0.0545 0.1982 1
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.009 0.0251 0.0571
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.005 0.0099 0.0488
Trypanosoma cruzi tubulin delta chain 0.0316 0.1113 0.5608
Trypanosoma cruzi epsilon tubulin, putative 0.0334 0.1182 0.5959
Echinococcus granulosus tubulin alpha chain 0.041 0.1472 0.7425
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0066 0.0467
Toxoplasma gondii beta-tubulin, putative 0.0545 0.1982 1
Brugia malayi beta-tubulin, identical 0.0545 0.1982 0.4558
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0085 0.0189
Echinococcus multilocularis tubulin alpha 3 chain 0.041 0.1472 0.7425
Echinococcus multilocularis tubulin alpha 1C chain 0.041 0.1472 0.7425
Schistosoma mansoni thyroid hormone receptor 0.0219 0.0743 0.3747
Schistosoma mansoni tubulin subunit beta 0.0545 0.1982 1
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0039 0.0057 0.0273
Brugia malayi nuclear hormone receptor family member nhr-6 0.0041 0.0066 0.0146
Trichomonas vaginalis mercuric reductase, putative 0.005 0.0099 0.0292
Trichomonas vaginalis tubulin, putative 0.0166 0.0541 0.2569
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0144 0.0325
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0351 0.0802
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0087 0.0241 0.0549
Leishmania major alpha tubulin 0.041 0.1472 0.7422
Schistosoma mansoni RAR-like nuclear receptor 0.0087 0.0241 0.1217
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0039 0.0057 0.0014
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0231 0.0788 0.0757
Entamoeba histolytica tubulin gamma chain 0.0335 0.1184 0.5854
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0039 0.0057 0.0273
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0146
Echinococcus granulosus tubulin epsilon chain 0.0334 0.1182 0.5965
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0043 0.0202
Mycobacterium tuberculosis Probable dehydrogenase 0.0194 0.0649 0.0618
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0061 0.0309
Trypanosoma cruzi epsilon tubulin, putative 0.0334 0.1182 0.5959
Plasmodium falciparum tubulin beta chain 0.0545 0.1982 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0087 0.0241 0.0549
Echinococcus granulosus tubulin gamma 1 chain 0.0335 0.1184 0.5973
Echinococcus multilocularis tubulin alpha 3 chain 0.041 0.1472 0.7425
Schistosoma mansoni jun-related protein 0.0133 0.0417 0.2105
Plasmodium falciparum cysteine--tRNA ligase 0.0039 0.0057 0.0273
Schistosoma mansoni tubulin subunit alpha 0.041 0.1472 0.7425
Brugia malayi Tubulin gamma chain 0.0335 0.1184 0.272
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0087 0.0241 0.0549
Brugia malayi hypothetical protein 0.0046 0.0085 0.0189
Brugia malayi nuclear hormone receptor 0.0087 0.0241 0.0549
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.027 0.0937 0.4612
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0087 0.0241 0.0549
Brugia malayi nuclear hormone receptor 0.0041 0.0066 0.0146
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0033 0.0168
Echinococcus granulosus tubulin alpha 3 chain 0.041 0.1472 0.7425
Echinococcus multilocularis ecdysone induced protein 78C 0.0087 0.0241 0.1217
Plasmodium vivax tubulin beta chain, putative 0.0545 0.1982 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0087 0.0241 0.0549
Brugia malayi beta-lactamase family protein 0.0035 0.0043 0.0092
Leishmania major alpha tubulin 0.041 0.1472 0.7422
Trichomonas vaginalis tubulin alpha chain, putative 0.0166 0.0541 0.2569
Loa Loa (eye worm) hypothetical protein 0.0087 0.0241 0.0549
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0144 0.0457 0.0426
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0061 0.0295
Leishmania major beta tubulin 0.0545 0.1982 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0061 0.0295
Onchocerca volvulus 0.0087 0.0241 0.3982
Loa Loa (eye worm) hypothetical protein 0.0087 0.0241 0.0549
Trypanosoma brucei alpha tubulin 0.041 0.1472 0.7422
Schistosoma mansoni alpha tubulin 0.041 0.1472 0.7425
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0066 0.0146
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0078 0.0207 0.047
Giardia lamblia NADH oxidase lateral transfer candidate 0.005 0.0099 0.0221
Loa Loa (eye worm) hypothetical protein 0.016 0.0517 0.1184
Loa Loa (eye worm) nuclear hormone receptor 0.0041 0.0066 0.0146
Loa Loa (eye worm) hypothetical protein 0.0149 0.0477 0.1091
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.005 0.0099 0.0502
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.0187 0.0745
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0061 0.0113
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.2651 1 1
Loa Loa (eye worm) tubulin gamma chain 0.0335 0.1184 0.272
Leishmania major dihydrolipoamide dehydrogenase, putative 0.005 0.0099 0.0488
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0144 0.0726
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.0234 0.1181
Loa Loa (eye worm) glutathione reductase 0.0144 0.0457 0.1047
Trichomonas vaginalis tubulin alpha chain, putative 0.0545 0.1982 1
Loa Loa (eye worm) hypothetical protein 0.0245 0.084 0.1929
Loa Loa (eye worm) nuclear receptor NHR-67 0.0041 0.0066 0.0146
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0039 0.0057 0.0287
Trichomonas vaginalis tubulin, putative 0.0169 0.0553 0.2628
Leishmania major alpha tubulin 0.041 0.1472 0.7422
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.009 0.0251 0.0571
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.0761 0.1746
Trichomonas vaginalis tubulin epsilon chain, putative 0.014 0.0444 0.207
Giardia lamblia Epsilon tubulin 0.0168 0.0551 0.2566
Brugia malayi nuclear receptor RXR 0.0046 0.0085 0.0189
Loa Loa (eye worm) hypothetical protein 0.0047 0.0089 0.0199
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0061 0.0295
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0039 0.0057 0.0273
Mycobacterium tuberculosis Conserved protein 0.0035 0.0043 0.001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0146
Brugia malayi glutathione reductase 0.0144 0.0457 0.1047
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0061 0.0295
Echinococcus granulosus alpha tubulin 0.041 0.1472 0.7425
Schistosoma mansoni tubulin subunit alpha 0.014 0.0444 0.2241
Loa Loa (eye worm) hypothetical protein 0.0087 0.0241 0.0549
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0085 0.0428
Leishmania major hypothetical protein, conserved 0.0035 0.0043 0.0202
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0033 0.0154
Loa Loa (eye worm) alpha-tubulin 0.041 0.1472 0.3383
Brugia malayi Cell division protein ftsZ 0.014 0.0444 0.1016
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.005 0.0099 0.1101
Brugia malayi hypothetical protein 0.0041 0.0066 0.0146
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0033 0.0154
Schistosoma mansoni tubulin subunit gamma 0.0335 0.1184 0.5973
Leishmania major acetoin dehydrogenase e3 component-like protein 0.005 0.0099 0.0488
Loa Loa (eye worm) tubulin alpha-3 chain 0.0245 0.084 0.1929
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.005 0.0099 0.0488
Schistosoma mansoni nuclear hormone receptor 0.0087 0.0241 0.1217
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0033 0.0154
Brugia malayi nuclear receptor NHR-88 0.0087 0.0241 0.0549
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0046 0.0085 0.0428
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0085 0.0189
Loa Loa (eye worm) tubulin beta-1 chain 0.0545 0.1982 0.4558
Echinococcus granulosus Tubulin beta 2C chain 0.0545 0.1982 1
Brugia malayi conserved hypotetical protein 0.0041 0.0066 0.0146
Loa Loa (eye worm) RNA binding protein 0.0062 0.0144 0.0325
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.005 0.0099 0.0222
Echinococcus granulosus leucyl tRNA synthetase 0.0039 0.0057 0.0287
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0061 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0087 0.0241 0.0549
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0164 0.0534 0.2695
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.005 0.0099 0.0057
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0087 0.0241 0.0549
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0037 0.0049 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0087 0.0241 0.0549
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0066 0.0333
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.076 0.0729
Plasmodium falciparum tubulin gamma chain 0.0335 0.1184 0.5967
Giardia lamblia Beta tubulin 0.0545 0.1982 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0144 0.0726
Schistosoma mansoni alpha tubulin 0.041 0.1472 0.7425
Loa Loa (eye worm) tubulin beta chain 0.014 0.0444 0.1016
Schistosoma mansoni tubulin subunit epsilon 0.0334 0.1182 0.5965
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0089 0.045
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0043 0.0216
Trypanosoma cruzi tubulin gamma chain 0.0335 0.1184 0.5967
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0043 0.0202
Loa Loa (eye worm) alpha-tubulin 0.041 0.1472 0.3383

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.025 uM Inhibitory potency against mitogen activated protein kinase kinase kinase 1 ChEMBL. 15006386
IC50 (binding) = 0.025 uM Inhibitory potency against mitogen activated protein kinase kinase kinase 1 ChEMBL. 15006386
IC50 (functional) = 2.72 uM Inhibitory concentration against AP-1 transcription in COS-7 cells ChEMBL. 15006386

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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