Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0101 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0069 | 0.641 | 0.5 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0069 | 0.641 | 0.5 |
Leishmania major | monoglyceride lipase, putative | 0.0069 | 0.641 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0069 | 0.641 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0069 | 0.641 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0069 | 0.641 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0069 | 0.641 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0069 | 0.641 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0069 | 0.641 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0012 | 0 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0069 | 0.641 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0101 | 1 | 1 |
Schistosoma mansoni | amidase | 0.0101 | 1 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0069 | 0.641 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0069 | 0.641 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0101 | 1 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0069 | 0.641 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0101 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0069 | 0.641 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0101 | 1 | 1 |
Plasmodium falciparum | esterase, putative | 0.0069 | 0.641 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0069 | 0.641 | 0.5 |
Mycobacterium ulcerans | lysophospholipase | 0.0069 | 0.641 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0012 | 0 | 0.5 |
Plasmodium vivax | PST-A protein | 0.0069 | 0.641 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0069 | 0.641 | 0.5 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0069 | 0.641 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0069 | 0.641 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0012 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0069 | 0.641 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0069 | 0.641 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC80 (functional) | = 24 ng/ml | Antifungal activity against Candida albicans CA98001 | ChEMBL. | 18313295 |
MIC80 (functional) | = 24 ng/ml | Antifungal activity against Candida albicans CA98001 | ChEMBL. | 18313295 |
MIC80 (functional) | = 24040 ng/ml | Antifungal activity against Aspergillus fumigatus AF98003 | ChEMBL. | 18313295 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.