Detailed information for compound 507257

Basic information

Technical information
  • TDR Targets ID: 507257
  • Name: N-[[4-[5-[(4-aminocyclohexylidene)methyl]pyrr olo[2,1-f][1,2,4]triazin-4-yl]oxy-3-fluorophe nyl]carbamoyl]-2-(4-fluorophenyl)acetamide
  • MW: 532.541 | Formula: C28H26F2N6O3
  • H donors: 3 H acceptors: 4 LogP: 3.81 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC1CC/C(=C/c2ccn3c2c(ncn3)Oc2ccc(cc2F)NC(=O)NC(=O)Cc2ccc(cc2)F)/CC1
  • InChi: 1S/C28H26F2N6O3/c29-20-5-1-18(2-6-20)14-25(37)35-28(38)34-22-9-10-24(23(30)15-22)39-27-26-19(11-12-36(26)33-16-32-27)13-17-3-7-21(31)8-4-17/h1-2,5-6,9-13,15-16,21H,3-4,7-8,14,31H2,(H2,34,35,37,38)/b17-13-
  • InChiKey: RZBUEYNQBUDJSK-LGMDPLHJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[4-[5-[(4-aminocyclohexylidene)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]oxy-3-fluoro-phenyl]carbamoyl]-2-(4-fluorophenyl)acetamide
  • N-[[4-[[5-[(4-aminocyclohexylidene)methyl]-4-pyrrolo[2,1-f][1,2,4]triazinyl]oxy]-3-fluoroanilino]-oxomethyl]-2-(4-fluorophenyl)acetamide
  • N-[[4-[5-[(4-azanylcyclohexylidene)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]oxy-3-fluoro-phenyl]carbamoyl]-2-(4-fluorophenyl)ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens MET proto-oncogene, receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0089 0.0089
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0.0052 0.0878
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0134 0.0198
Loa Loa (eye worm) glutathione reductase 0.0114 0.3232 0.3232
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0279 0.0473
Loa Loa (eye worm) Smad1 0.0009 0.0089 0.0089
Schistosoma mansoni smad 0.0009 0.0089 0.0089
Leishmania major short chain dehydrogenase-like protein 0.0008 0.0052 0.0107
Entamoeba histolytica short chain dehydrogenase family protein 0.0008 0.0052 0.0878
Mycobacterium tuberculosis Probable reductase 0.0118 0.3335 0.7908
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0773 0.0773
Brugia malayi hypothetical protein 0.0009 0.0079 0.0135
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.0052
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0011 0.0134 0.0196
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.0052
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0052 0.0077
Schistosoma mansoni Smad4 0.0009 0.0089 0.0089
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.1002 0.1636
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.004 0.1002 1
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0052 0.0052
Brugia malayi oxidoreductase 0.0008 0.0052 0.0088
Entamoeba histolytica disulphide oxidoreductase, putative 0.0011 0.0134 0.2252
Plasmodium vivax steroid dehydrogenase, putative 0.0008 0.0052 0.0161
Toxoplasma gondii carbonyl reductase 1, putative 0.0008 0.0052 0.0113
Trichomonas vaginalis glutamate synthase, putative 0.0011 0.0134 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1332 0.1332
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0008 0.0052 0.0052
Mycobacterium ulcerans ferredoxin reductase 0.0011 0.0134 0.0857
Brugia malayi CXXC zinc finger family protein 0.0028 0.0656 0.1112
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0773 0.1262
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0052 0.0085
Leishmania major hypothetical protein, conserved 0.0028 0.0653 0.1349
Leishmania major quinonoid dihydropteridine reductase 0.0169 0.4844 1
Echinococcus multilocularis NAD(P) binding domain 0.0161 0.4612 0.4612
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0014
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0011 0.0134 0.0134
Schistosoma mansoni smad1 5 8 and 0.0009 0.0089 0.0089
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0052 0.0052
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0008 0.0052 0.0085
Leishmania major acetoin dehydrogenase e3 component-like protein 0.004 0.1002 0.2069
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0011 0.0134 0.2252
Leishmania major importin beta-1 subunit, putative 0.0026 0.0593 0.1224
Trichomonas vaginalis mercuric reductase, putative 0.004 0.1002 0.1487
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0052 0.0052
Brugia malayi Thioredoxin reductase 0.0114 0.3232 0.5477
Loa Loa (eye worm) hypothetical protein 0.0021 0.0441 0.0441
Leishmania major quinonoid dihydropteridine reductase 0.0169 0.4844 1
Echinococcus granulosus semaphorin 1A 0.0009 0.0079 0.0079
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0107 0.0182
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0052 0.0052
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.004 0.1002 0.1002
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0011 0.0134 0.0857
Loa Loa (eye worm) hypothetical protein 0.0009 0.0079 0.0079
Mycobacterium ulcerans hypothetical protein 0.0011 0.0134 0.0857
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0052 0.0052
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0011 0.0134 0.029
Trichomonas vaginalis helicase, putative 0.0006 0.0009 0.0014
Trypanosoma cruzi NADH dehydrogenase, putative 0.0011 0.0134 0.017
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0773 0.0773
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0052 0.0052
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0011 0.0134 0.0196
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.004 0.1002 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0708 0.0708
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.1002 0.2069
Giardia lamblia Glutamate synthase 0.0011 0.0134 0.0857
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0134 0.0198
Brugia malayi RNA, U transporter 1 0.0091 0.2531 0.429
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0279 0.0279
Loa Loa (eye worm) oxidoreductase 0.0008 0.0052 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0708 0.0708
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0008 0.0052 0.0085
Toxoplasma gondii selenide, water dikinase 0.0011 0.0134 0.029
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.1002 0.1983
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0052 0.0052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.0014
Leishmania major quinonoid dihydropteridine reductase 0.0169 0.4844 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0008 0.0052 0.0107
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1272 0.2155
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0052 0.0052
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0008 0.0052 0.0085
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0134 0.0218
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0011 0.0134 0.0196
Schistosoma mansoni hypothetical protein 0.0012 0.0182 0.0182
Plasmodium vivax ferrodoxin reductase, putative 0.0011 0.0134 0.0413
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0052 0.0077
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0011 0.0134 0.2252
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0008 0.0052 0.0052
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0008 0.0052 0.0052
Leishmania major hypothetical protein, conserved 0.0008 0.0052 0.0107
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0014
Schistosoma mansoni carbonyl reductase 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.0052
Loa Loa (eye worm) oxidoreductase 0.0008 0.0052 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.1002 0.1983
Plasmodium falciparum steroid dehydrogenase, putative 0.0008 0.0052 0.0161
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0011 0.0134 0.029
Plasmodium falciparum importin beta, putative 0.0032 0.0773 0.2393
Loa Loa (eye worm) dihydropteridine reductase-PC 0.0161 0.4612 0.4612
Loa Loa (eye worm) oxidoreductase 0.0008 0.0052 0.0052
Schistosoma mansoni sulfide quinone reductase 0.0011 0.0134 0.0134
Echinococcus multilocularis snurportin 1 0.0342 1 1
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0052 0.0052
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.004 0.1002 0.1698
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0011 0.0134 0.0134
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0008 0.0052 0.0088
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0008 0.0052 0.0088
Leishmania major short chain dehydrogenase, putative 0.0008 0.0052 0.0107
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0052 0.0052
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0052 0.0077
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0008 0.0052 0.0052
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0059 0.0059
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0169 0.4844 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0059 0.0059
Plasmodium falciparum glutathione reductase 0.004 0.1002 0.3101
Schistosoma mansoni carbonyl reductase 0.0008 0.0052 0.0052
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0049 0.1272 0.1272
Trypanosoma brucei trypanothione reductase 0.0114 0.3232 0.5276
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0011 0.0134 0.0857
Schistosoma mansoni hypothetical protein 0.0009 0.0079 0.0079
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.004 0.1002 0.1636
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0773 0.1677
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0052 0.0052
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0052 0.0077
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.3335 0.7908
Trypanosoma brucei NADH dehydrogenase 0.0011 0.0134 0.0218
Echinococcus granulosus importin subunit beta 1 0.0032 0.0773 0.0773
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0342 1 1
Onchocerca volvulus 0.0011 0.0134 0.0122
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0089 0.0089
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0011 0.0134 0.2252
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.0014
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0052 0.0052
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0011 0.0134 0.2252
Brugia malayi MH2 domain containing protein 0.0009 0.0089 0.015
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0194 0.0194
Echinococcus multilocularis hypothetical protein 0.0009 0.0079 0.0079
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0011 0.0134 0.0413
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0688 0.1166
Echinococcus granulosus glutamate synthase 0.0011 0.0134 0.0134
Leishmania major NADH dehydrogenase, putative 0.0011 0.0134 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0014
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0773 0.1262
Schistosoma mansoni hypothetical protein 0.0015 0.0279 0.0279
Echinococcus granulosus steroid dehydrogenase 0.0008 0.0052 0.0052
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.3335 0.7908
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0011 0.0134 0.0226
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0011 0.0134 0.0198
Schistosoma mansoni hypothetical protein 0.0015 0.0279 0.0279
Mycobacterium tuberculosis Probable oxidoreductase 0.0147 0.4204 1
Leishmania major oxidoreductase-like protein 0.0008 0.0052 0.0107
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0011 0.0134 0.0196
Echinococcus granulosus hypothetical protein 0.0008 0.0052 0.0052
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0059 0.0059
Plasmodium vivax SET domain protein, putative 0.003 0.0708 0.2189
Leishmania major short chain dehydrogenase/reductase, putative 0.0008 0.0052 0.0107
Treponema pallidum NADH oxidase 0.004 0.1002 1
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0033 0.0812 0.0812
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0052 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0708 0.0708
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.004 0.1002 0.3101
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1332 0.1332
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.1002 0.1983
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0011 0.0134 0.0413
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.0014
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0052 0.0052
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0134 0.0198
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0008 0.0052 0.0052
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.004 0.1002 0.1002
Brugia malayi hypothetical protein 0.0018 0.0358 0.0606
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0.0052 0.0878
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0342 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0279 0.0279
Entamoeba histolytica hypothetical protein 0.0008 0.0052 0.0878
Loa Loa (eye worm) hypothetical protein 0.0009 0.0079 0.0079
Toxoplasma gondii oxidoreductase, putative 0.0008 0.0052 0.0113
Schistosoma mansoni hypothetical protein 0.0015 0.0279 0.0279
Schistosoma mansoni glutamate synthase 0.0011 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.0052
Leishmania major quinonoid dihydropteridine reductase 0.0169 0.4844 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0182 0.0182
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0011 0.0134 0.0134
Schistosoma mansoni hypothetical protein 0.0212 0.6126 0.6126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.1002 0.1983
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0114 0.3232 0.766
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0593 0.088
Entamoeba histolytica hypothetical protein, conserved 0.0008 0.0052 0.0878
Brugia malayi dihydropteridine reductase-like 0.0161 0.4612 0.7814
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0008 0.0052 0.0113
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.1002 0.1983
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0593 0.1129
Leishmania major quinonoid dihydropteridine reductase 0.0169 0.4844 1
Brugia malayi dehydrogenases, short chain protein 2 0.0008 0.0052 0.0088
Echinococcus multilocularis plexin a4 0.0025 0.0555 0.0555
Leishmania major hypothetical protein, conserved 0.0008 0.0052 0.0107
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.004 0.1002 0.2069
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0008 0.0052 0.0085
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0011 0.0134 0.0196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1332 0.1332
Brugia malayi Smad1 0.0009 0.0089 0.015
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Loa Loa (eye worm) oxidoreductase 0.0008 0.0052 0.0052
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0009 0.0014
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.1002 0.1983
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0653 0.2021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.1002 0.1983
Schistosoma mansoni glutamate synthase 0.0011 0.0134 0.0134
Brugia malayi Dehydrogenases, short chain protein 30 0.0008 0.0052 0.0088
Schistosoma mansoni hypothetical protein 0.0011 0.0134 0.0134
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.004 0.1002 0.3101
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0008 0.0052 0.0161
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0134 0.0198
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0008 0.0052 0.0052
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0052 0.0052
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0052 0.0052
Loa Loa (eye worm) programmed cell death 8 0.0011 0.0134 0.0134
Toxoplasma gondii NADPH-glutathione reductase 0.004 0.1002 0.2173
Brugia malayi MH2 domain containing protein 0.0009 0.0089 0.015
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0011 0.0134 0.0134
Giardia lamblia NADH oxidase lateral transfer candidate 0.004 0.1002 1
Leishmania major hypothetical protein, conserved 0.0011 0.0134 0.0276
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0011 0.0134 0.0226
Plasmodium falciparum thioredoxin reductase 0.004 0.1002 0.3101
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1272 0.1272
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.0052
Trypanosoma cruzi trypanothione reductase, putative 0.0114 0.3232 0.6636
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0011 0.0134 0.017
Echinococcus multilocularis oxidoreductase 0.0008 0.0052 0.0052
Leishmania major hypothetical protein, conserved 0.0008 0.0052 0.0107
Loa Loa (eye worm) hypothetical protein 0.0009 0.0079 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0708 0.0708
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0052 0.0052
Loa Loa (eye worm) sema domain-containing protein 0.0009 0.0079 0.0079
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0011 0.0134 0.0134
Echinococcus granulosus thioredoxin glutathione reductase 0.0114 0.3232 0.3232
Plasmodium vivax importin-beta 2, putative 0.0032 0.0773 0.2393
Leishmania major hypothetical protein, conserved 0.0011 0.0134 0.0276
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0008 0.0052 0.0088
Mycobacterium ulcerans dehydrogenase 0.0011 0.0134 0.0857
Echinococcus granulosus semaphorin 5B 0.0009 0.0079 0.0079
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0147 0.4204 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.0052
Trichomonas vaginalis glutamate synthase, putative 0.0011 0.0134 0.0198
Echinococcus multilocularis GPCR, family 2 0.0015 0.0279 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.1002 0.1983
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0052 0.0052
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.1002 0.1983
Echinococcus granulosus smad 0.0009 0.0089 0.0089
Entamoeba histolytica hypothetical protein 0.0026 0.0593 1
Schistosoma mansoni disulfide oxidoreductase 0.0011 0.0134 0.0134
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0653 0.2021
Brugia malayi glutathione reductase 0.0114 0.3232 0.5477
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0011 0.0134 0.0413
Loa Loa (eye worm) plexin A 0.0025 0.0555 0.0555
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0011 0.0134 0.0857
Trypanosoma brucei RNA helicase, putative 0.0212 0.6126 1
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0052 0.0052
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0134 0.0198
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0052 0.0085
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0011 0.0134 0.017
Trichomonas vaginalis glutathione reductase, putative 0.004 0.1002 0.1487
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0052 0.0052
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0113
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.0052
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.004 0.1002 0.3101
Leishmania major quinonoid dihydropteridine reductase 0.0169 0.4844 1
Echinococcus granulosus hypothetical protein 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.003 0.0708 0.0708
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0011 0.0134 0.0857
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0008 0.0052 0.0077
Onchocerca volvulus 0.0009 0.0079 0.0041
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0593 0.088
Schistosoma mansoni cpg binding protein 0.003 0.0704 0.0704
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0011 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0011 0.0134 0.0134
Plasmodium falciparum thioredoxin reductase 0.0114 0.3232 1
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0008 0.0052 0.0161
Schistosoma mansoni importin beta-1 0.0032 0.0773 0.0773
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0009 0.0079 0.0079
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0011 0.0134 0.0134
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.004 0.1002 0.2288
Schistosoma mansoni sulfide quinone reductase 0.0011 0.0134 0.0134
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0008 0.0052 0.0052
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0708 0.0708
Onchocerca volvulus 0.003 0.0708 0.098
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0089 0.0089
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0059 0.0059
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0011 0.0134 0.0857
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0052 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1332 0.1332
Brugia malayi glutamate synthase 0.0011 0.0134 0.0226
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0008 0.0052 0.0878
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0708 0.0708
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0011 0.0134 0.0134
Leishmania major trypanothione reductase 0.0114 0.3232 0.6672
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0593 0.088
Onchocerca volvulus 0.0232 0.6739 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.0014
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0111 0.0111
Entamoeba histolytica thioredoxin reductase, putative 0.0011 0.0134 0.2252
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0052 0.0052
Leishmania major short chain dehydrogenase, putative 0.0008 0.0052 0.0107
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1332 0.1332
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0134 0.0218
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0011 0.0134 0.0196
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0011 0.0134 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0028 0.0653 0.0653
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0052 0.0052
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1626 0.1626
Giardia lamblia Thioredoxin reductase 0.0011 0.0134 0.0857
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.0014
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0008 0.0052 0.0085
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0147 0.4204 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0011 0.0134 0.0134
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.004 0.1002 0.2173
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0009 0.0014
Leishmania major hypothetical protein, conserved 0.0008 0.0052 0.0107
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0011 0.0134 0.0134
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0011 0.0134 0.0134
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.3335 0.7908
Schistosoma mansoni smad1 5 8 and 0.0009 0.0089 0.0089
Schistosoma mansoni plexin 0.0021 0.0441 0.0441
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0011 0.0134 0.029
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0052 0.0085
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0011 0.0134 0.0413
Leishmania major 3-keto-dihydrosphingosine reductase 0.0008 0.0052 0.0107
Loa Loa (eye worm) oxidoreductase 0.0008 0.0052 0.0052
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0688 0.1166
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.004 0.1002 1
Loa Loa (eye worm) sema domain-containing protein 0.0009 0.0079 0.0079
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0052 0.0077
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.0052
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0052 0.0052
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0008 0.0052 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1332 0.1332
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0052 0.0052
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0011 0.0134 0.0857
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0134 0.017
Loa Loa (eye worm) thioredoxin reductase 0.0114 0.3232 0.3232
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.004 0.1002 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.004 0.1002 1
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0052 0.0052
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0011 0.0134 0.0198
Toxoplasma gondii thioredoxin reductase 0.0114 0.3232 0.7008
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0011 0.0134 0.0857
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0011 0.0134 0.2252
Schistosoma mansoni carbonyl reductase 0.0008 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0015 0.0279 0.0279
Brugia malayi MH1 domain containing protein 0.0009 0.0089 0.015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0657 0.0657
Schistosoma mansoni hypothetical protein 0.0009 0.0079 0.0079
Brugia malayi Pre-SET motif family protein 0.0204 0.5901 1
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0008 0.0052 0.0077
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.1002 0.2069
Brugia malayi MH1 domain containing protein 0.0009 0.0089 0.015
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0653 0.1255
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0653 0.1417
Loa Loa (eye worm) dehydrogenase 0.0008 0.0052 0.0052
Brugia malayi hypothetical protein 0.0008 0.0052 0.0088
Echinococcus multilocularis semaphorin 5B 0.0009 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0009 0.0079 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0134 0.017
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0134 0.017
Onchocerca volvulus 0.0028 0.0656 0.0904
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0134 0.0198
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0008 0.0052 0.0052
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0089 0.0089
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0011 0.0134 0.0134
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0113
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0147 0.4204 1
Plasmodium vivax thioredoxin reductase, putative 0.0114 0.3232 1
Brugia malayi Retinol dehydrogenase 12 0.0008 0.0052 0.0088
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0089 0.0089
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0011 0.0134 0.029
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0011 0.0134 0.0218
Brugia malayi Dehydrogenases, short chain protein 2 0.0008 0.0052 0.0088
Echinococcus granulosus oxidoreductase 0.0008 0.0052 0.0052
Mycobacterium ulcerans flavoprotein disulfide reductase 0.004 0.1002 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0708 0.0708
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0059 0.0059
Leishmania major quinonoid dihydropteridine reductase 0.0169 0.4844 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1332 0.1332
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0011 0.0134 0.0198
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Leishmania major hypothetical protein, conserved 0.0008 0.0052 0.0107
Mycobacterium ulcerans monoxygenase 0.0011 0.0134 0.0857
Loa Loa (eye worm) histone methyltransferase 0.001 0.0111 0.0111
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0052 0.0052
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0653 0.1255
Echinococcus multilocularis glutamate synthase 0.0011 0.0134 0.0134
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0008 0.0052 0.0878
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0014
Schistosoma mansoni hypothetical protein 0.0013 0.0194 0.0194
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0011 0.0134 0.0857
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0011 0.0134 0.0196
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0.0052 0.0878
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.0014
Brugia malayi Pre-SET motif family protein 0.003 0.0708 0.1199
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0052 0.0052
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0052 0.0077
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0052 0.0052
Plasmodium vivax hypothetical protein, conserved 0.0008 0.0052 0.0161
Mycobacterium ulcerans NADH dehydrogenase 0.0011 0.0134 0.0857
Schistosoma mansoni dihydropteridine reductase 0.0161 0.4612 0.4612
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0134 0.017
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0052 0.0052
Echinococcus granulosus NADP binding domain 0.0161 0.4612 0.4612
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.1002 0.1636
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0008 0.0052 0.0113
Echinococcus multilocularis cpg binding protein 0.003 0.0704 0.0704
Entamoeba histolytica hypothetical protein, conserved 0.0008 0.0052 0.0878
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0052 0.0077
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0008 0.0052 0.0113
Brugia malayi hypothetical protein 0.0009 0.0079 0.0135
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0113
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0194 0.0194
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0113
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.1332 0.2258
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0011 0.0134 0.0196
Echinococcus multilocularis conserved hypothetical protein 0.0008 0.0052 0.0052
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0011 0.0134 0.017
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0052 0.0085
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0011 0.0134 0.0218
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0015 0.0279 0.0279
Leishmania major hypothetical protein, conserved 0.0011 0.0134 0.0276
Brugia malayi MH2 domain containing protein 0.0132 0.3768 0.6385
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.0134 0.0218
Schistosoma mansoni semaphorin 5-related 0.0009 0.0079 0.0079
Brugia malayi Importin beta-1 subunit 0.0032 0.0773 0.131
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0708 0.1534
Schistosoma mansoni cpg binding protein 0.003 0.0704 0.0704
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.3335 0.7908
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.3335 0.7908
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0011 0.0134 0.0857
Loa Loa (eye worm) hypothetical protein 0.0033 0.0812 0.0812
Schistosoma mansoni smad1 5 8 and 0.0009 0.0089 0.0089
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.004 0.1002 0.3101
Echinococcus granulosus Smad4 0.0009 0.0089 0.0089
Plasmodium falciparum ferrodoxin reductase-like protein 0.0011 0.0134 0.0413
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.0052
Leishmania major dehydrogenase-like protein 0.0008 0.0052 0.0107
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0279 0.0473
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1272 0.2155
Echinococcus granulosus cpg binding protein 0.003 0.0704 0.0704
Schistosoma mansoni plexin 0.0012 0.0182 0.0182
Brugia malayi plexin A 0.0025 0.0555 0.0941
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0279 0.0279
Echinococcus multilocularis smad 0.0009 0.0089 0.0089
Echinococcus multilocularis Smad4 0.0009 0.0089 0.0089
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0052 0.0052
Brugia malayi hypothetical protein 0.0028 0.0653 0.1107
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0011 0.0134 0.0198
Schistosoma mansoni glutamate synthase 0.0011 0.0134 0.0134
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0052 0.0052
Trichomonas vaginalis apoptosis inducing factor, putative 0.0011 0.0134 0.0198
Echinococcus multilocularis retinol dehydrogenase 13 0.0008 0.0052 0.0052
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0011 0.0134 0.0134
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.3768 0.3768
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0011 0.0134 0.0276
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0653 0.1066
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0812 0.1377
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.004 0.1002 0.1002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0079 0.0079
Brugia malayi dehydrogenases, short chain protein 9 0.0008 0.0052 0.0088
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0052 0.0085
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0011 0.0134 0.0196
Loa Loa (eye worm) oxidoreductase 0.0008 0.0052 0.0052
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Echinococcus granulosus plexin a4 0.0025 0.0555 0.0555
Trypanosoma cruzi NADH dehydrogenase, putative 0.0011 0.0134 0.017
Echinococcus granulosus GPCR family 2 0.0015 0.0279 0.0279
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Trichomonas vaginalis steroid dehydrogenase, putative 0.0008 0.0052 0.0077
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0279 0.0279
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0653 0.2021
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0008 0.0052 0.0052
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0052 0.0052
Echinococcus granulosus WW domain containing oxidoreductase 0.0008 0.0052 0.0052
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.004 0.1002 0.1636
Brugia malayi Sema domain containing protein 0.0009 0.0079 0.0135
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0011 0.0134 0.029
Trypanosoma brucei oxidoreductase-like protein 0.0008 0.0052 0.0085
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0008 0.0052 0.0052
Plasmodium vivax glutathione reductase, putative 0.0114 0.3232 1
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0011 0.0134 0.0857
Schistosoma mansoni cpg binding protein 0.0028 0.0656 0.0656
Loa Loa (eye worm) dehydrogenase 0.0008 0.0052 0.0052
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.3335 0.7908
Trichomonas vaginalis set domain proteins, putative 0.0232 0.6739 1
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0052 0.0052
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0008 0.0052 0.0077
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0052 0.0052
Loa Loa (eye worm) oxidoreductase 0.0008 0.0052 0.0052
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.3768 0.3768
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0052 0.0052
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0011 0.0134 0.0196
Plasmodium falciparum glutathione reductase 0.0114 0.3232 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Echinococcus multilocularis thioredoxin glutathione reductase 0.0114 0.3232 0.3232
Leishmania major pteridine reductase 1 0.0008 0.0052 0.0107
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0089 0.0089
Brugia malayi Plexin repeat family protein 0.0021 0.0441 0.0748
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0008 0.0052 0.0052
Leishmania major short chain dehydrogenase/reductase, putative 0.0008 0.0052 0.0107
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0011 0.0134 0.0226
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.1332 0.1332
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0052 0.0052
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.5901 0.5901
Mycobacterium ulcerans glutamate synthase subunit beta 0.0011 0.0134 0.0857
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0052 0.0052
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Brugia malayi Sema domain containing protein 0.0009 0.0079 0.0135
Loa Loa (eye worm) oxidoreductase 0.0008 0.0052 0.0052
Brugia malayi hypothetical protein 0.0008 0.0052 0.0088
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1437 0.3116
Entamoeba histolytica short chain dehydrogenase family protein 0.0008 0.0052 0.0878
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0014
Toxoplasma gondii oxidoreductase, putative 0.0008 0.0052 0.0113
Toxoplasma gondii 6,7-dihydropteridine reductase 0.0161 0.4612 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0052 0.0077
Loa Loa (eye worm) oxidoreductase 0.0008 0.0052 0.0052
Onchocerca volvulus 0.0021 0.0441 0.0582
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0052 0.0052
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0113
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0052 0.0088
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0656 0.0656
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0011 0.0134 0.0857
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0052 0.0052
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0279 0.0279

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.5 nM Inhibition of human c-MET ChEMBL. 21641696
IC50 (functional) = 140 nM Antiproliferative activity against human GTL16 cells after 72 hrs by tetrazolium-based colorimetric assay ChEMBL. 18289854
IC50 (binding) = 0.0015 uM Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system ChEMBL. 18289854
IC50 (binding) = 0.0015 uM Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system ChEMBL. 18289854

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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