TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 364.362 | Formula: C19H19F3N2O2
H donors: 1 H acceptors: 1 LogP: 4.59 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(cc1)OC(F)(F)F)NCCN1CCCc2c1cccc2
InChi: 1S/C19H19F3N2O2/c20-19(21,22)26-16-9-7-15(8-10-16)18(25)23-11-13-24-12-3-5-14-4-1-2-6-17(14)24/h1-2,4,6-10H,3,5,11-13H2,(H,23,25)
InChiKey: HDFPRHCUOKOHIS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	transient receptor potential cation channel, subfamily V, member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	amine GPCR	0.0014	0.0995	0.0933
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0727	0.0595
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0995	0.0933
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.1353	0.1329
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0995	0.0933
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.135	0.1326
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0727	0.0702
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0727	0.0595
Echinococcus granulosus	neuropeptide receptor A26	0.0014	0.0995	0.097
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0995	0.097
Trichomonas vaginalis	CAMK family protein kinase	0.0107	1	1
Schistosoma mansoni	hypothetical protein	0.0018	0.135	0.129
Brugia malayi	larval opioid receptor	0.0014	0.0995	0.0867
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.04	0.0374
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0014	0.0995	0.0867
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0014	0.0995	0.097
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0005	0.014	0.0113
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0014	0.0995	0.097
Onchocerca volvulus		0.0014	0.0995	0.0867
Onchocerca volvulus		0.0014	0.0995	0.0867
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0727	0.0702
Echinococcus granulosus	neuropeptide FF receptor 2	0.0014	0.0995	0.097
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0727	0.0702
Schistosoma mansoni	serine/threonine protein kinase	0.0107	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0995	0.097
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0995	0.097
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0995	0.0933
Brugia malayi	Dopamine receptor protein 1	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Echinococcus granulosus	7tm_1 domain containing protein	0.0014	0.0995	0.097
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0203	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0331	0.0331
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0995	0.097
Schistosoma mansoni	hypothetical protein	0.0014	0.0995	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Echinococcus multilocularis	neuropeptide s receptor	0.0014	0.0995	0.097
Schistosoma mansoni	myosin xvIII	0.0014	0.0995	0.0933
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0727	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0727	0.0595
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0203	0.0135
Brugia malayi	Serotonin receptor	0.0014	0.0995	0.0867
Schistosoma mansoni	amine GPCR	0.0014	0.0995	0.0933
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Brugia malayi	hypothetical protein	0.0014	0.0995	0.0867
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0995	0.097
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0203	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0331	0.0331
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0014	0.0995	0.0867
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.1353	0.1329
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.1353	0.1329
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0331	0.0331
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0203	0.0064
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0727	0.0663
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0727	0.0595
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0727	0.0595
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0005	0.014	0.0113
Echinococcus multilocularis	fmrfamide receptor	0.0014	0.0995	0.097
Echinococcus granulosus	somatostatin receptor	0.0014	0.0995	0.097
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0018	0.1353	0.1293
Schistosoma mansoni	hypothetical protein	0.0014	0.0995	0.0933
Trichomonas vaginalis	CAMK family protein kinase	0.0107	1	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Echinococcus multilocularis	serotonin receptor	0.0014	0.0995	0.097
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0995	0.097
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.135	0.1227
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.04	0.0374
Brugia malayi	isocitrate dehydrogenase	0.0018	0.1353	0.123
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0727	0.0663
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0727	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Echinococcus granulosus	serotonin receptor	0.0014	0.0995	0.097
Trypanosoma brucei	polo-like protein kinase	0.0107	1	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0727	0.0702
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0995	0.0933
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0727	0.0663
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.5096	0.5026
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0727	0.0595
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0014	0.0995	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0727	0.0595
Schistosoma mansoni	coup transcription factor	0.0011	0.0727	0.0663
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0995	0.097
Schistosoma mansoni	neuropeptide f receptor 76f	0.0014	0.0995	0.0933
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0593	0.0459
Brugia malayi	follicle stimulating hormone receptor	0.0014	0.0995	0.0867
Brugia malayi	hypothetical protein	0.0014	0.0995	0.0867
Onchocerca volvulus		0.0014	0.0995	0.0867
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.04	0.0334
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0727	0.0595
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0014	0.0995	0.0933
Echinococcus multilocularis	neuropeptide Y receptor	0.0014	0.0995	0.097
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0107	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0014	0.0995	0.097
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0331	0.0331
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0014	0.0995	0.0867
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.014	0.0072
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.5096	0.5026
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0014	0.0995	0.097
Brugia malayi	G protein-coupled receptor	0.0014	0.0995	0.0867
Schistosoma mansoni	hypothetical protein	0.0014	0.0995	0.0933
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0331	0.0331
Schistosoma mansoni	histamine h1 receptor	0.0014	0.0995	0.0933
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0018	0.1353	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0014	0.0995	0.097
Echinococcus granulosus	cpg binding protein	0.0035	0.2953	0.2934
Brugia malayi	GnHR receptor homolog	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0995	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0995	0.097
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0995	0.097
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0727	0.0702
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0727	0.0595
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0727	0.0595
Echinococcus granulosus	g-protein coupled receptor	0.0014	0.0995	0.097
Echinococcus granulosus	neuropeptide Y receptor	0.0014	0.0995	0.097
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0014	0.0995	0.097
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0014	0.0995	0.097
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0727	0.0595
Schistosoma mansoni	hypothetical protein	0.0014	0.0995	0.0933
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0727	0.0702
Echinococcus granulosus	biogenic amine 5HT receptor	0.0014	0.0995	0.097
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.135	0.1326
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0014	0.0995	0.097
Schistosoma mansoni	nuclear receptor	0.0005	0.014	0.0072
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0014	0.0995	0.097
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0203	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0727	0.0595
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0014	0.0995	0.097
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0995	0.0933
Onchocerca volvulus		0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Schistosoma mansoni	cpg binding protein	0.0035	0.2953	0.2904
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0014	0.0995	0.0933
Echinococcus granulosus	neuropeptide Y receptor	0.0014	0.0995	0.097
Echinococcus granulosus	orexin receptor type 2	0.0014	0.0995	0.097
Brugia malayi	hypothetical protein	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0727	0.0595
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0995	0.097
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0727	0.0595
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0331	0.0331
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0995	0.097
Echinococcus multilocularis	GPCR, family 2	0.0018	0.135	0.1326
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0995	0.0933
Echinococcus multilocularis	cpg binding protein	0.0035	0.2953	0.2934
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0014	0.0995	0.0933
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0727	0.0595
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0727	0.0595
Echinococcus granulosus	fmrfamide receptor	0.0014	0.0995	0.097
Echinococcus granulosus	G protein coupled receptor 139	0.0014	0.0995	0.097
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0727	0.0595
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0014	0.0995	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0014	0.0995	0.097
Schistosoma mansoni	kinase	0.0055	0.4894	0.4858
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0014	0.0995	0.097
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0203	0.0064
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0014	0.0995	0.0933
Schistosoma mansoni	hypothetical protein	0.0018	0.135	0.129
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0593	0.0567
Echinococcus granulosus	allatostatin A receptor	0.0014	0.0995	0.097
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0995	0.0933
Brugia malayi	nuclear hormone receptor	0.0011	0.0727	0.0595
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0995	0.097
Onchocerca volvulus		0.0011	0.0727	0.0595
Onchocerca volvulus		0.0014	0.0995	0.0867
Brugia malayi	G-protein coupled receptor	0.0014	0.0995	0.0867
Brugia malayi	hypothetical protein	0.0014	0.0995	0.0867
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0014	0.0995	0.0867
Brugia malayi	RE15519p	0.0014	0.0995	0.0867
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0727	0.0702
Brugia malayi	hypothetical protein	0.0041	0.3571	0.348
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0995	0.097
Echinococcus multilocularis	dro:myosuppressin receptor	0.0014	0.0995	0.097
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0727	0.0595
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0727	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0203	0.0064
Schistosoma mansoni	neuropeptide F-like receptor	0.0014	0.0995	0.0933
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0995	0.097
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0727	0.0595
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0014	0.0995	0.097
Giardia lamblia	Kinase, PLK	0.0107	1	0.5
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0107	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0107	1	1
Onchocerca volvulus		0.0033	0.2773	0.267
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0995	0.097
Echinococcus multilocularis	neuropeptide receptor	0.0014	0.0995	0.097
Echinococcus multilocularis	g-protein coupled receptor	0.0014	0.0995	0.097
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0995	0.097
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0005	0.014	0.0072
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0014	0.0995	0.0867
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0018	0.1353	0.123
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0107	1	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0014	0.0995	0.097
Brugia malayi	Serotonin receptor	0.0014	0.0995	0.0867
Schistosoma mansoni	amine GPCR	0.0014	0.0995	0.0933
Schistosoma mansoni	cpg binding protein	0.0033	0.2773	0.2723
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.058	0.0446
Echinococcus granulosus	GPCR family 2	0.0018	0.135	0.1326
Onchocerca volvulus		0.0014	0.0995	0.0867
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0995	0.0933
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0995	0.097
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0727	0.0702
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0331	0.0331
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.135	0.1326
Brugia malayi	CXXC zinc finger family protein	0.0033	0.2773	0.267
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0727	0.0595
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0018	0.1353	0.1329
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0995	0.097
Brugia malayi	G-protein coupled receptor	0.0014	0.0995	0.0867
Brugia malayi	sulfakinin receptor protein	0.0014	0.0995	0.0867
Echinococcus granulosus	biogenic amine 5HT receptor	0.0014	0.0995	0.097
Schistosoma mansoni	opsin-like receptor	0.0014	0.0995	0.0933
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0727	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Echinococcus granulosus	sex peptide receptor	0.0014	0.0995	0.097
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0995	0.0933
Trichomonas vaginalis	CAMK family protein kinase	0.0107	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0331	0.0331
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0331	0.0331
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0005	0.014	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0018	0.135	0.1227
Echinococcus granulosus	neuropeptide s receptor	0.0014	0.0995	0.097
Brugia malayi	hypothetical protein	0.0014	0.0995	0.0867
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.04	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0727	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Schistosoma mansoni	hypothetical protein	0.0041	0.3571	0.3526
Echinococcus granulosus	neuropeptide receptor	0.0014	0.0995	0.097
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0727	0.0702
Brugia malayi	hypothetical protein	0.0006	0.0203	0.0064
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0727	0.0595
Echinococcus multilocularis	serotonin receptor	0.0014	0.0995	0.097
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0014	0.0995	0.0867
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0005	0.014	0.0113
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0018	0.1353	0.1329
Brugia malayi	hypothetical protein	0.0014	0.0995	0.0867
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0727	0.0663
Onchocerca volvulus		0.0014	0.0995	0.0867
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0995	0.0933
Schistosoma mansoni	hypothetical protein	0.0039	0.3362	0.3316
Schistosoma mansoni	growth hormone secretagogue receptor	0.0014	0.0995	0.0933
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0014	0.0995	0.097
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0727	0.0595
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0014	0.0995	0.0933
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.2773	0.267
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0014	0.0995	0.097
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0995	0.097
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0203	0.0064
Brugia malayi	hypothetical protein	0.0014	0.0995	0.0867
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0727	0.0702
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Loa Loa (eye worm)	melatonin receptor type 1A	0.0014	0.0995	0.0867
Onchocerca volvulus		0.0014	0.0995	0.0867
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0331	0.0331
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0727	0.0663
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.5096	0.5026
Trichomonas vaginalis	CAMK family protein kinase	0.0107	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0203	0.0135
Brugia malayi	Isocitrate dehydrogenase	0.0018	0.1353	0.123
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0014	0.0995	0.0867
Onchocerca volvulus		0.0014	0.0995	0.0867
Brugia malayi	Dopamine receptor protein 2	0.0014	0.0995	0.0867
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0018	0.1353	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0014	0.0995	0.097
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0014	0.0995	0.097
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0727	0.0702
Echinococcus multilocularis	neuropeptides capa receptor	0.0014	0.0995	0.097
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0005	0.014	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Trypanosoma cruzi	polo-like protein kinase, putative	0.0107	1	1
Schistosoma mansoni	adenoreceptor	0.0014	0.0995	0.0933
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0727	0.0595
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0995	0.097
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0727	0.0663
Loa Loa (eye worm)	neuropeptide F receptor	0.0014	0.0995	0.0867
Trichomonas vaginalis	helicase, putative	0.0007	0.0331	0.0331
Brugia malayi	Melatonin receptor type 1A	0.0014	0.0995	0.0867
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0203	0.0176
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0727	0.0702
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0995	0.097
Onchocerca volvulus		0.0014	0.0995	0.0867
Brugia malayi	hypothetical protein	0.0014	0.0995	0.0867
Trichomonas vaginalis	CAMK family protein kinase	0.0053	0.4756	0.4756
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0727	0.0595
Onchocerca volvulus		0.0014	0.0995	0.0867
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0727	0.0595
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0995	0.097
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0005	0.014	0.0113
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0014	0.0995	0.0867
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0727	0.0702
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Schistosoma mansoni	hypothetical protein	0.0018	0.135	0.129
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0727	0.0702
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0995	0.0933
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0018	0.1353	0.5
Onchocerca volvulus		0.0014	0.0995	0.0867
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0593	0.0567
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0727	0.0702
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0014	0.0995	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0014	0.0995	0.0867
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0107	1	1
Loa Loa (eye worm)	TYRA-2 protein	0.0014	0.0995	0.0867
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0331	0.0331
Schistosoma mansoni	neuropeptide F-like receptor	0.0014	0.0995	0.0933
Echinococcus multilocularis	isocitrate dehydrogenase	0.0018	0.1353	0.1329
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0727	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Brugia malayi	G protein-coupled receptor F59B2.13	0.0014	0.0995	0.0867
Trichomonas vaginalis	CAMK family protein kinase	0.0053	0.4756	0.4756
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0727	0.0663
Schistosoma mansoni	nuclear receptor nhr-48	0.0005	0.014	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0995	0.0933
Brugia malayi	ORL1-like opioid receptor	0.0014	0.0995	0.0867
Echinococcus granulosus	neuropeptides capa receptor	0.0014	0.0995	0.097
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.3362	0.3268
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0995	0.0933
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0005	0.014	0.0113
Echinococcus granulosus	nuclear receptor nhr 48	0.0005	0.014	0.0113
Brugia malayi	putative neuropeptide receptor	0.0014	0.0995	0.0867
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0005	0.014	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0727	0.0595
Loa Loa (eye worm)	G-protein coupled receptor	0.0014	0.0995	0.0867
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0995	0.0933
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.135	0.1227
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0727	0.0595
Echinococcus multilocularis	orexin receptor type 2	0.0014	0.0995	0.097
Echinococcus multilocularis	neuropeptides capa receptor	0.0014	0.0995	0.097
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0062	0.5597	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0727	0.0663
Schistosoma mansoni	zinc finger protein	0.0005	0.014	0.0072
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0331	0.0331
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0014	0.0995	0.097
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.3571	0.3553
Echinococcus multilocularis	sex peptide receptor	0.0014	0.0995	0.097
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0203	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Brugia malayi	AKH receptor	0.0014	0.0995	0.0867
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0727	0.0702
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0014	0.0995	0.0933
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0995	0.0933
Schistosoma mansoni	opsin-like receptor	0.0014	0.0995	0.0933
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0005	0.014	0.0113
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0014	0.0995	0.0933
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0014	0.0995	0.097
Brugia malayi	Dopamine receptor	0.0014	0.0995	0.0867
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0005	0.014	0.0113
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0014	0.0995	0.097
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0014	0.0995	0.097
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0995	0.0933
Echinococcus granulosus	dro:myosuppressin receptor	0.0014	0.0995	0.097
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0069	0.6313	0.6287
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.04	0.0374
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0727	0.0663
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0995	0.0933
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0727	0.0595
Echinococcus multilocularis	allatostatin A receptor	0.0014	0.0995	0.097
Echinococcus granulosus	neuropeptide receptor	0.0014	0.0995	0.097
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0014	0.0995	0.0933
Trichomonas vaginalis	CAMK family protein kinase	0.0107	1	1
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.3571	0.3526
Echinococcus multilocularis	nuclear receptor nhr 48	0.0005	0.014	0.0113
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0107	1	1
Onchocerca volvulus		0.0014	0.0995	0.0867
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0995	0.097
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0727	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0057	0.5096	0.5026
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0014	0.0995	0.0867
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0014	0.0995	0.0933
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0331	0.0331
Schistosoma mansoni	hypothetical protein	0.0018	0.135	0.129
Echinococcus multilocularis	somatostatin receptor	0.0014	0.0995	0.097
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0995	0.0933
Trichomonas vaginalis	CAMK family protein kinase	0.0107	1	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0014	0.0995	0.097
Echinococcus multilocularis	neuropeptide receptor	0.0014	0.0995	0.097
Echinococcus multilocularis	fmrfamide receptor	0.0014	0.0995	0.097
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0995	0.097
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0727	0.0663
Trypanosoma cruzi	polo-like protein kinase, putative	0.0107	1	1
Schistosoma mansoni	amine GPCR	0.0014	0.0995	0.0933
Brugia malayi	neuropeptide F receptor	0.0014	0.0995	0.0867
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0203	0.0064
Echinococcus granulosus	thyroid hormone receptor alpha	0.0005	0.014	0.0113
Brugia malayi	nuclear receptor RXR	0.0006	0.0203	0.0064
Schistosoma mansoni	opsin-like receptor	0.0014	0.0995	0.0933
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0014	0.0995	0.097
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Onchocerca volvulus		0.0014	0.0995	0.0867
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.014	0.0072
Onchocerca volvulus		0.0014	0.0995	0.0867
Brugia malayi	neuropeptide F receptor	0.0014	0.0995	0.0867
Brugia malayi	hypothetical protein	0.0014	0.0995	0.0867
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0727	0.0595
Echinococcus granulosus	hypothetical protein	0.0014	0.0995	0.097
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0727	0.0702
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0014	0.0995	0.0933
Schistosoma mansoni	amine GPCR	0.0014	0.0995	0.0933
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0331	0.0331
Schistosoma mansoni	cpg binding protein	0.0035	0.2953	0.2904
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3362	0.3268
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0995	0.097
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0727	0.0595
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.3571	0.3553
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0014	0.0995	0.097
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.135	0.1326
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0014	0.0995	0.097
Brugia malayi	hypothetical protein	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Brugia malayi	putative neuropeptide receptor NPR1	0.0014	0.0995	0.0867
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0995	0.097
Loa Loa (eye worm)	neuropeptide F receptor	0.0014	0.0995	0.0867
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0727	0.0595
Loa Loa (eye worm)	G-protein coupled receptor	0.0014	0.0995	0.0867
Onchocerca volvulus		0.0014	0.0995	0.0867
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0014	0.0995	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Brugia malayi	steroid hormone receptor	0.0011	0.0727	0.0595
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0995	0.097
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0107	1	1
Onchocerca volvulus		0.0014	0.0995	0.0867
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.135	0.1227
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Brugia malayi	ecdysteroid receptor	0.0011	0.0727	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0995	0.0867
Brugia malayi	hypothetical protein	0.0006	0.0203	0.0064
Echinococcus granulosus	neuropeptides capa receptor	0.0014	0.0995	0.097
Schistosoma mansoni	nuclear receptor	0.0005	0.014	0.0072
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0727	0.0702

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 4600 nM	Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells	ChEMBL.	18155908
IC50 (functional)	= 4600 nM	Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells	ChEMBL.	18155908

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 507287