TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 380.361 | Formula: C19H19F3N2O3
H donors: 2 H acceptors: 2 LogP: 4.24 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc2c(c1)N(CCC2)CCNC(=O)c1ccc(cc1)OC(F)(F)F
InChi: 1S/C19H19F3N2O3/c20-19(21,22)27-16-7-4-14(5-8-16)18(26)23-9-11-24-10-1-2-13-3-6-15(25)12-17(13)24/h3-8,12,25H,1-2,9-11H2,(H,23,26)
InChiKey: MKVINKFSJSMUIZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	transient receptor potential cation channel, subfamily V, member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	coup transcription factor	0.0018	0.0231	0.0231
Schistosoma mansoni	RAR-like nuclear receptor	0.0018	0.0231	0.0231
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	0.0374	1	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0018	0.0231	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2155	0.2737
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0258	0.0235
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0018	0.0231	0.0293
Trichomonas vaginalis	thymidine kinase, putative	0.0262	0.6924	0.6842
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0038	0.0795	0.0795
Echinococcus multilocularis	GPCR, family 2	0.0028	0.0505	0.0505
Brugia malayi	follicle stimulating hormone receptor	0.0226	0.5946	0.5946
Echinococcus granulosus	purine nucleoside phosphorylase	0.0374	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0231	0.0293
Schistosoma mansoni	hypothetical protein	0.0028	0.0505	0.0505
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	0.0374	1	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0028	0.0505	0.0505
Brugia malayi	Latrophilin receptor protein 2	0.0028	0.0505	0.0505
Trypanosoma brucei	unspecified product	0.0019	0.0258	0.0235
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0258	0.0258
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0028	0.0505	0.0642
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0018	0.0231	0.0231
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0038	0.0795	0.0795
Loa Loa (eye worm)	uridine phosphorylase	0.0077	0.1866	0.2369
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0018	0.0231	0.0231
Trypanosoma cruzi	thymidine kinase, putative	0.0262	0.6924	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0028	0.0505	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0297	0.7876	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0018	0.0231	0.0231
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0018	0.0231	0.0231
Brugia malayi	latrophilin 2 splice variant baaae	0.006	0.1392	0.1392
Mycobacterium tuberculosis	Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase	0.0077	0.1866	0.165
Treponema pallidum	uridine phosphorylase (udp)	0.0077	0.1866	0.5
Treponema pallidum	pfs protein (pfs)	0.0077	0.1866	0.5
Giardia lamblia	5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase	0.0077	0.1866	0.165
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0077	0.1866	0.2411
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0018	0.0231	0.0231
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0258	0.0235
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0258	0.0235
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0258	0.0235
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0258	0.0258
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0018	0.0231	0.0231
Schistosoma mansoni	hypothetical protein	0.0028	0.0505	0.0505
Schistosoma mansoni	thyroid hormone receptor	0.0018	0.0231	0.0231
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0028	0.0505	0.0505
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0258	0.0328
Schistosoma mansoni	hypothetical protein	0.0028	0.0505	0.0505
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0258	0.0258
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0258	0.0258
Trichomonas vaginalis	thymidine kinase, putative	0.0262	0.6924	0.6842
Toxoplasma gondii	Purine nucleoside phosphorylase	0.0077	0.1866	0.5
Plasmodium vivax	purine nucleoside phosphorylase, putative	0.0077	0.1866	0.5
Giardia lamblia	UPL-1	0.0077	0.1866	0.165
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0258	0.0235
Giardia lamblia	5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase	0.0077	0.1866	0.165
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0018	0.0231	0.0231
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0077	0.1866	0.1866
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0231	0.0293
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0038	0.0795	0.0795
Brugia malayi	ecdysteroid receptor	0.0018	0.0231	0.0231
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0258	0.0235
Trichomonas vaginalis	thymidine kinase, putative	0.0262	0.6924	0.6842
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0088	0.2155	0.2737
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	0.0374	1	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0018	0.0231	0.0231
Schistosoma mansoni	purine nucleoside phosphorylase	0.0374	1	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0374	1	1
Entamoeba histolytica	thymidine kinase, putative	0.0262	0.6924	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.0231	0.0231
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0258	0.0235
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0374	1	1
Echinococcus granulosus	methylthioadenosine phosphorylase	0.0077	0.1866	0.1866
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0018	0.0231	0.0231
Entamoeba histolytica	MTA/SAH nucleosidase, putative	0.0077	0.1866	0.2411
Brugia malayi	Steroid receptor seven-up type 2	0.0018	0.0231	0.0231
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0018	0.0231	0.0293
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0077	0.1866	0.2411
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.0077	0.1866	0.2411
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0038	0.0795	0.0795
Schistosoma mansoni	nuclear hormone receptor	0.0018	0.0231	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0231	0.0293
Schistosoma mansoni	purine nucleoside phosphorylase	0.0374	1	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0018	0.0231	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0231	0.0293
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0088	0.2155	0.2155
Brugia malayi	nuclear hormone receptor	0.0018	0.0231	0.0231
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0077	0.1866	0.165
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0018	0.0231	0.0293
Mycobacterium ulcerans	bifunctional Mta/Sah nucleosidase Mtn	0.0077	0.1866	0.165
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0018	0.0231	0.0231
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0018	0.0231	0.0231
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0258	0.0235
Echinococcus granulosus	purine nucleoside phosphorylase	0.0374	1	1
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0077	0.1866	0.2411
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0077	0.1866	0.165
Brugia malayi	nuclear receptor NHR-88	0.0018	0.0231	0.0231
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0258	0.0258
Echinococcus granulosus	purine nucleoside phosphorylase	0.0374	1	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0374	1	1
Giardia lamblia	Thymidine kinase	0.0262	0.6924	0.6842
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0018	0.0231	0.0231
Schistosoma mansoni	uridine phosphorylase	0.0077	0.1866	0.1866
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0018	0.0231	0.0293
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0038	0.0795	0.0795
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0297	0.7876	0.7876
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0018	0.0231	0.0231
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0018	0.0231	0.0293
Giardia lamblia	Deoxynucleoside kinase	0.0369	0.9851	0.9848
Trypanosoma brucei	thymidine kinase	0.0262	0.6924	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0018	0.0231	0.0231
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0018	0.0231	0.0231
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0258	0.0235
Echinococcus multilocularis	FTZ F1 alpha	0.0018	0.0231	0.0231
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0018	0.0231	0.0231
Leishmania major	nucleoside phosphorylase-like protein	0.0077	0.1866	0.2411
Schistosoma mansoni	hypothetical protein	0.0028	0.0505	0.0505
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0077	0.1866	0.1866
Brugia malayi	steroid hormone receptor	0.0018	0.0231	0.0231
Toxoplasma gondii	phosphorylase family protein	0.0077	0.1866	0.5
Entamoeba histolytica	hypothetical protein	0.0077	0.1866	0.2411
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0018	0.0231	0.0231
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0028	0.0505	0.0505
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0018	0.0231	0.0293
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0038	0.0795	0.101
Mycobacterium tuberculosis	Hypothetical protein	0.0077	0.1866	0.165
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0258	0.0258
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0258	0.0235
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0038	0.0795	0.0795
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0018	0.0231	0.0231
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0018	0.0231	0.0231
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0028	0.0505	0.0505
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0018	0.0231	0.0231
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0077	0.1866	0.165
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.1866	0.165
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0018	0.0231	0.0231
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0038	0.0795	0.0795
Toxoplasma gondii	phosphorylase family protein	0.0077	0.1866	0.5
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0258	0.0258
Trypanosoma cruzi	thymidine kinase, putative	0.0262	0.6924	1
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0077	0.1866	0.2411
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0077	0.1866	0.165
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0088	0.2155	0.2155
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0258	0.0235
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0258	0.0258
Trypanosoma brucei	uridine phosphorylase	0.0077	0.1866	0.259
Echinococcus granulosus	uridine phosphorylase 1	0.0077	0.1866	0.1866
Echinococcus granulosus	purine nucleoside phosphorylase	0.0374	1	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0018	0.0231	0.0231
Echinococcus granulosus	purine nucleoside phosphorylase	0.0374	1	1
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0077	0.1866	0.2411
Chlamydia trachomatis	AMP nucleosidase	0.0077	0.1866	0.5
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.0077	0.1866	0.2411
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0077	0.1866	0.165
Loa Loa (eye worm)	S-methyl-5'-thioadenosine phosphorylase MTAP	0.0077	0.1866	0.2369
Brugia malayi	uridine phosphorylase family protein	0.0077	0.1866	0.1866
Brugia malayi	MTAP	0.0077	0.1866	0.1866
Loa Loa (eye worm)	hypothetical protein	0.006	0.1392	0.1767
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0018	0.0231	0.0231
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0258	0.0258
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0018	0.0231	0.0231
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0077	0.1866	0.1866
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0018	0.0231	0.0293
Leishmania major	thymidine kinase, putative	0.0262	0.6924	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0018	0.0231	0.0231
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0258	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0231	0.0293
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0374	1	1
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0077	0.1866	0.2411
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0018	0.0231	0.0231
Echinococcus granulosus	GPCR family 2	0.0028	0.0505	0.0505
Echinococcus multilocularis	methylthioadenosine phosphorylase	0.0077	0.1866	0.1866
Schistosoma mansoni	thyroid hormone receptor	0.0018	0.0231	0.0231
Echinococcus granulosus	FTZ F1 alpha	0.0018	0.0231	0.0231
Mycobacterium ulcerans	5'-methylthioadenosine phosphorylase	0.0077	0.1866	0.165
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0018	0.0231	0.0231
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	0.0297	0.7876	0.7876
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0297	0.7876	0.7876
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0018	0.0231	0.0231
Echinococcus granulosus	purine nucleoside phosphorylase	0.0374	1	1
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0077	0.1866	0.165
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0018	0.0231	0.0231
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0018	0.0231	0.0231
Treponema pallidum	purine nucleoside phosphorylase (deoD)	0.0077	0.1866	0.5
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0077	0.1866	0.165
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0226	0.5946	0.755
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0231	0.0293
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0258	0.0235
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0018	0.0231	0.0231
Echinococcus granulosus	purine nucleoside phosphorylase	0.0374	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0038	0.0795	0.0795
Plasmodium falciparum	purine nucleoside phosphorylase	0.0077	0.1866	0.5
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0505	0.0642
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0374	1	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0018	0.0231	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0258	0.0328
Schistosoma mansoni	uridine phosphorylase	0.0077	0.1866	0.1866
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	0.0077	0.1866	0.259
Loa Loa (eye worm)	steroid hormone receptor	0.0018	0.0231	0.0293
Echinococcus granulosus	ecdysone induced protein 78C	0.0018	0.0231	0.0231
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0077	0.1866	0.2411
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	0.0374	1	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0374	1	1
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	0.0374	1	1
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0077	0.1866	0.2411
Echinococcus multilocularis	uridine phosphorylase 1	0.0077	0.1866	0.1866
Leishmania major	methylthioadenosine phosphorylase, putative	0.0077	0.1866	0.2411
Schistosoma mansoni	retinoic acid receptor RXR	0.0018	0.0231	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0231	0.0293
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0374	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0258	0.0235
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0018	0.0231	0.0231
Schistosoma mansoni	hypothetical protein	0.006	0.1392	0.1392
Mycobacterium ulcerans	purine nucleoside phosphorylase	0.0374	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0231	0.0293
Echinococcus granulosus	dna polymerase eta	0.0019	0.0258	0.0258
Brugia malayi	photoreceptor-specific nuclear receptor	0.0018	0.0231	0.0231
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.1866	0.165
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0258	0.0258
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0077	0.1866	0.165

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 960 nM	Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells	ChEMBL.	18155908
IC50 (functional)	= 960 nM	Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells	ChEMBL.	18155908

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 507299