Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ImpB/MucB/SamB family protein | 0.0093 | 0.4436 | 0.6614 |
Trypanosoma brucei | unspecified product | 0.0064 | 0.2631 | 0.2304 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0182 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0093 | 0.4436 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0182 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0182 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.1402 | 0.0742 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0093 | 0.4436 | 0.3528 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0051 | 0.1805 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0182 | 1 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0093 | 0.4436 | 0.3528 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0182 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0182 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0182 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0182 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1658 | 0.3075 |
Echinococcus multilocularis | dna polymerase kappa | 0.0182 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0182 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.5989 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0182 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.4436 | 0.6865 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0093 | 0.4436 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0182 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0093 | 0.4436 | 0.7627 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1658 | 0.3075 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0093 | 0.4436 | 0.4189 |
Echinococcus granulosus | dna polymerase eta | 0.0093 | 0.4436 | 0.3528 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0182 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0182 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0115 | 0.5816 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0086 | 0.4011 | 0.3745 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0182 | 1 | 1 |
Brugia malayi | polk-prov protein | 0.0118 | 0.5989 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0115 | 0.5816 | 1 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0029 | 0.0425 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0093 | 0.4436 | 0.6865 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0182 | 1 | 1 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0029 | 0.0425 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0064 | 0.2631 | 0.2304 |
Trypanosoma brucei | unspecified product | 0.016 | 0.862 | 0.8558 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0182 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.016 | 0.862 | 0.8558 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0093 | 0.4436 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0093 | 0.4436 | 0.3528 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0115 | 0.5816 | 0.5631 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0093 | 0.4436 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0093 | 0.4436 | 0.744 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0182 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0182 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0115 | 0.5816 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0115 | 0.5816 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0118 | 0.5989 | 0.5811 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0093 | 0.4436 | 0.4189 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0182 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0093 | 0.4436 | 0.6614 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0086 | 0.4011 | 0.3745 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0118 | 0.5989 | 0.5811 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0086 | 0.4011 | 0.3745 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6 nM | Displacement of [125I]MCP1 from CCR2 receptor in human monocytes | ChEMBL. | 18164199 |
IC50 (binding) | = 6 nM | Displacement of [125I]MCP1 from CCR2 receptor in human monocytes | ChEMBL. | 18164199 |
IC50 (binding) | = 11 nM | Selectivity for human CCR2 over human ERG | ChEMBL. | 18164199 |
IC50 (binding) | = 67 nM | Displacement of [33S]MK499 from human ERG expressed in HEK cells | ChEMBL. | 18164199 |
IC50 (binding) | = 67 nM | Displacement of [33S]MK499 from human ERG expressed in HEK cells | ChEMBL. | 18164199 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.