Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0042 | 0.0699 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0053 | 0.0949 | 0.0824 |
Schistosoma mansoni | calpain (C02 family) | 0.0042 | 0.0699 | 0.0603 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.3967 | 0.3905 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.0423 | 0.0691 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.1229 | 1 |
Brugia malayi | calpain 5 | 0.0042 | 0.0699 | 0.114 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0709 | 0.0913 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0019 | 0.0148 | 0.0012 |
Trichomonas vaginalis | set domain proteins, putative | 0.0263 | 0.5943 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0231 | 0.5187 | 0.8465 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.6128 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0197 | 0.4374 | 0.4296 |
Loa Loa (eye worm) | calpain | 0.0042 | 0.0699 | 0.0896 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0053 | 0.0949 | 0.0855 |
Schistosoma mansoni | calpain-7 (C02 family) | 0.0042 | 0.0699 | 0.0603 |
Echinococcus multilocularis | calpain A | 0.0149 | 0.3228 | 0.3134 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0042 | 0.0699 | 1 |
Onchocerca volvulus | 0.0034 | 0.0501 | 0.014 | |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0512 | 0.0381 |
Trypanosoma cruzi | kinesin, putative | 0.0042 | 0.0699 | 1 |
Trypanosoma brucei | calpain-like protein, putative | 0.0042 | 0.0699 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0334 | 0.02 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0018 | 0.0136 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.1229 | 1 |
Brugia malayi | TAR-binding protein | 0.0137 | 0.296 | 0.4831 |
Brugia malayi | calpain family protein 1 | 0.0141 | 0.3056 | 0.4988 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0148 | 0.0047 |
Echinococcus granulosus | cpg binding protein | 0.0034 | 0.0515 | 0.0384 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0149 | 0.3228 | 0.3158 |
Brugia malayi | RNA binding protein | 0.0137 | 0.296 | 0.4831 |
Plasmodium vivax | calpain, putative | 0.0042 | 0.0699 | 1 |
Echinococcus granulosus | calpain | 0.0042 | 0.0699 | 0.057 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0149 | 0.3228 | 0.3134 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0334 | 0.02 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.0501 | 0.0817 |
Schistosoma mansoni | Mername-AA248 (C02 family) | 0.0042 | 0.0699 | 0.0603 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.1229 | 0.1108 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0197 | 0.4374 | 0.4296 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0141 | 0.3056 | 0.485 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0042 | 0.0699 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0271 | 0.6128 | 1 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0396 | 0.0646 |
Trypanosoma brucei | calpain-like protein, putative | 0.0042 | 0.0699 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.1229 | 0.1138 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.296 | 0.2888 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.1229 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.0645 | 0.0515 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0423 | 0.0324 |
Onchocerca volvulus | 0.016 | 0.3505 | 0.5583 | |
Echinococcus granulosus | geminin | 0.018 | 0.3967 | 0.3884 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.0645 | 0.0515 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0042 | 0.0699 | 0.5294 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.3967 | 0.3905 |
Echinococcus granulosus | tar DNA binding protein | 0.0137 | 0.296 | 0.2863 |
Schistosoma mansoni | bromodomain containing protein | 0.0072 | 0.1405 | 0.1316 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1454 | 0.2163 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0148 | 0.0047 |
Onchocerca volvulus | 0.0263 | 0.5943 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.1454 | 0.1366 |
Echinococcus granulosus | calpain A | 0.0042 | 0.0699 | 0.057 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0137 | 0.296 | 0.4689 |
Schistosoma mansoni | ferritin | 0.0018 | 0.0136 | 0.0035 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0099 | 0.2058 | 0.3175 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.0512 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0862 | 0.117 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.0707 | 0.1154 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0018 | 0.0136 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0137 | 0.296 | 0.4689 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0242 | 0.0142 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.0423 | 0.0434 |
Echinococcus granulosus | zinc finger protein | 0.0023 | 0.0256 | 0.0121 |
Echinococcus multilocularis | geminin | 0.018 | 0.3967 | 0.3884 |
Schistosoma mansoni | zinc finger protein | 0.0023 | 0.0256 | 0.0155 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.1229 | 1 |
Schistosoma mansoni | ferritin light chain | 0.0018 | 0.0136 | 0.0035 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0137 | 0.296 | 0.4831 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.3056 | 0.485 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.3056 | 0.485 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0068 | 0.1311 | 0.1191 |
Echinococcus granulosus | calpain 7 C02 family | 0.0042 | 0.0699 | 0.057 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0042 | 0.0699 | 0.5294 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0149 | 0.3228 | 0.3134 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.2058 | 0.3175 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0949 | 0.1316 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0053 | 0.0949 | 0.0855 |
Brugia malayi | calpain 7 | 0.0042 | 0.0699 | 0.114 |
Entamoeba histolytica | protein kinase, putative | 0.0042 | 0.0699 | 0.5 |
Trypanosoma cruzi | kinesin, putative | 0.0042 | 0.0699 | 1 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0099 | 0.2058 | 0.1948 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0512 | 0.0835 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0074 | 0.1454 | 0.2373 |
Schistosoma mansoni | ferritin | 0.0018 | 0.0136 | 0.0035 |
Trypanosoma brucei | kinesin, putative | 0.0042 | 0.0699 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0512 | 0.0414 |
Schistosoma mansoni | calpain C (C02 family) | 0.0042 | 0.0699 | 0.0603 |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.0042 | 0.0699 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.0512 | 0.0381 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.296 | 0.2888 |
Schistosoma mansoni | ferritin | 0.0018 | 0.0136 | 0.0035 |
Leishmania major | calpain, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0042 | 0.0699 | 0.5294 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0231 | 0.5187 | 0.8423 |
Echinococcus multilocularis | cpg binding protein | 0.0034 | 0.0515 | 0.0384 |
Schistosoma mansoni | apoferritin-2 | 0.0018 | 0.0136 | 0.0035 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0068 | 0.1311 | 0.1191 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.296 | 0.2888 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0334 | 0.0234 |
Schistosoma mansoni | ferritin | 0.0018 | 0.0136 | 0.0035 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0042 | 0.0699 | 1 |
Echinococcus multilocularis | calpain | 0.0042 | 0.0699 | 0.057 |
Leishmania major | kinesin, putative | 0.0042 | 0.0699 | 0.5294 |
Loa Loa (eye worm) | calpain 5 | 0.0042 | 0.0699 | 0.0896 |
Trypanosoma brucei | calpain-like protein, putative | 0.0042 | 0.0699 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0042 | 0.0699 | 1 |
Trypanosoma brucei | antigen, putative | 0.0042 | 0.0699 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0501 | 0.0403 |
Schistosoma mansoni | calpain-7 (C02 family) | 0.0042 | 0.0699 | 0.0603 |
Echinococcus multilocularis | zinc finger protein | 0.0023 | 0.0256 | 0.0121 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0501 | 0.0369 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0053 | 0.0949 | 0.0824 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0042 | 0.0699 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0434 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.2058 | 0.3175 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.0515 | 0.0417 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0456 | 0.0324 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.296 | 0.2888 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.1229 | 1 |
Echinococcus granulosus | calpain A | 0.0149 | 0.3228 | 0.3134 |
Schistosoma mansoni | apoferritin-2 | 0.0018 | 0.0136 | 0.0035 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0062 | 0.1161 | 0.9069 |
Brugia malayi | hypothetical protein | 0.016 | 0.3505 | 0.572 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0042 | 0.0699 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0108 | 0.2266 | 0.3698 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0108 | 0.2266 | 0.3524 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.0042 | 0.0699 | 1 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0042 | 0.0699 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.0501 | 0.0403 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0771 | 0.1017 |
Brugia malayi | calpain family protein 1 | 0.0141 | 0.3056 | 0.4988 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0018 | 0.0136 | 0.5 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0434 | 1 | 1 |
Entamoeba histolytica | calpain large subunit domain III containing protein | 0.0042 | 0.0699 | 0.5 |
Echinococcus multilocularis | hypothetical protein | 0.0042 | 0.0699 | 0.057 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0512 | 0.0381 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.1229 | 0.1138 |
Onchocerca volvulus | 0.0099 | 0.2058 | 0.2961 | |
Echinococcus granulosus | calpain 5 | 0.0042 | 0.0699 | 0.057 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.1229 | 1 |
Trypanosoma brucei | calpain-like protein, putative | 0.0042 | 0.0699 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0512 | 0.0583 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0019 | 0.0148 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0512 | 0.0414 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0149 | 0.3228 | 0.3158 |
Schistosoma mansoni | ferritin light chain | 0.0018 | 0.0136 | 0.0035 |
Brugia malayi | Bromodomain containing protein | 0.0085 | 0.1713 | 0.2795 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.0515 | 0.0417 |
Loa Loa (eye worm) | RNA binding protein | 0.0137 | 0.296 | 0.4689 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0512 | 0.0414 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.296 | 0.2888 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.3505 | 0.5602 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0042 | 0.0699 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0512 | 0.0583 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0242 | 0.0131 |
Echinococcus multilocularis | calpain 5 | 0.0042 | 0.0699 | 0.057 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0512 | 0.0414 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0512 | 0.0835 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.1229 | 0.1108 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0066 | 0.1263 | 0.1173 |
Echinococcus multilocularis | tar DNA binding protein | 0.0137 | 0.296 | 0.2863 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1559 | 0.2339 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0141 | 0.3056 | 0.2985 |
Echinococcus multilocularis | calpain 7 (C02 family) | 0.0042 | 0.0699 | 0.057 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0042 | 0.0699 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 300 nM | Displacement of [3H]raclopride from rat dopamine D2 receptor | ChEMBL. | 17228858 |
IC50 (binding) | = 800 nM | Displacement of [3H]SCH23390 from rat dopamine D1 receptor | ChEMBL. | 17228858 |
IC50 (binding) | = 41000 nM | Displacement of [3H]DA from rat DAT | ChEMBL. | 17228858 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.