Detailed information for compound 507782

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 363.493 | Formula: C24H29NO2
  • H donors: 0 H acceptors: 1 LogP: 5.5 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC(=O)Oc1cccc2c1c1cccc3c1[C@@H](C2)N(CCC)CC3
  • InChi: 1S/C24H29NO2/c1-3-5-12-22(26)27-21-11-7-9-18-16-20-23-17(13-15-25(20)14-4-2)8-6-10-19(23)24(18)21/h6-11,20H,3-5,12-16H2,1-2H3/t20-/m1/s1
  • InChiKey: JGCVBGVDWQJTDF-HXUWFJFHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References
Homo sapiens dopamine receptor D1 Starlite/ChEMBL References
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Starlite/ChEMBL References
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_132667 All targets in OG5_132667
Schistosoma japonicum 5-hydroxytryptamine receptor 1, putative Get druggable targets OG5_132667 All targets in OG5_132667
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D2 receptor   444 aa 456 aa 29.4 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Schistosoma mansoni biogenic amine receptor Dopamine D2 receptor   444 aa 452 aa 30.1 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D2 receptor   444 aa 474 aa 23.4 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 428 aa 31.3 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 429 aa 31.7 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RecQ helicase 0.0024 0.018 0.019
Plasmodium falciparum metacaspase-like protein 0.0028 0.0261 0.0389
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0104 0.0173
Loa Loa (eye worm) hypothetical protein 0.007 0.0942 0.1037
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.025 0.0268
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.035 0.5529 0.5
Plasmodium falciparum DNA repair protein RAD2, putative 0.0016 0.0059 0.002
Schistosoma mansoni neuropeptide receptor 0.0014 0.0029 0.0022
Brugia malayi hypothetical protein 0.0027 0.0237 0.0254
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0237 0.0346
Trypanosoma cruzi metacaspase, putative 0.0028 0.0261 0.0472
Schistosoma mansoni hypothetical protein 0.0032 0.0325 0.0352
Echinococcus multilocularis caspase 8 0.0028 0.0261 0.0457
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.025 0.0332
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0345 0.0345
Leishmania major DNA damage repair protein, putative 0.0067 0.0898 0.1624
Loa Loa (eye worm) hypothetical protein 0.0028 0.025 0.0268
Echinococcus multilocularis Protein lozenge 0.0057 0.073 0.1307
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0029 0.0037
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0133 0.0155
Schistosoma mansoni myosin xvIII 0.0014 0.0029 0.0022
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0111 0.1614 0.2858
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.025 0.0268
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0761 0.1362
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.1329 0.1467
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.025 0.0437
Trypanosoma brucei phosphoglycerate kinase 0.035 0.5529 1
Brugia malayi hypothetical protein 0.0014 0.0029 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.025 0.0437
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0898 0.1624
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1329 0.1329
Trypanosoma brucei DNA polymerase kappa, putative 0.0176 0.2681 0.4848
Onchocerca volvulus 0.0014 0.0029 0.0028
Echinococcus granulosus neuropeptide s receptor 0.0014 0.0029 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0261 0.0261
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0325 0.0573
Trypanosoma brucei DNA damage repair protein, putative 0.0067 0.0898 0.1624
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.025 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.025 0.0268
Mycobacterium ulcerans glutaminase 0.0562 0.9006 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.1329 0.2403
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0261 0.0389
Loa Loa (eye worm) hypothetical protein 0.0028 0.025 0.0268
Plasmodium falciparum phd finger protein, putative 0.0059 0.0756 0.1292
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0028 0.0261 0.028
Onchocerca volvulus 0.0014 0.0029 0.0028
Schistosoma mansoni caspase-7 (C14 family) 0.0028 0.0261 0.028
Schistosoma mansoni rotamase 0.0034 0.0359 0.0389
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0128 0.1899 0.3435
Brugia malayi nuclear receptor RXR 0.0015 0.0035 0.0029
Brugia malayi hypothetical protein 0.0014 0.0029 0.0022
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.008 0.1099 0.1918
Schistosoma mansoni protein kinase 0.0111 0.1614 0.1784
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0359 0.0389
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0108 0.011
Trypanosoma cruzi metacaspase 5, putative 0.0028 0.0261 0.0472
Schistosoma mansoni amine GPCR 0.0014 0.0029 0.0022
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0756 0.1292
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0756 0.0831
Schistosoma mansoni hypothetical protein 0.0032 0.0325 0.0352
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0028 0.0261 0.028
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0622 1 1
Brugia malayi Dopamine receptor protein 1 0.0014 0.0029 0.0022
Echinococcus multilocularis serotonin receptor 0.0161 0.2441 0.4406
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0599 0.0656
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0035 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0108 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0029 0.0022
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0104 0.0173
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0048 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0029 0.0037
Brugia malayi ImpB/MucB/SamB family protein 0.0321 0.506 0.5614
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.269 0.4865
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0127 0.1875 0.3381
Loa Loa (eye worm) hypothetical protein 0.0101 0.1444 0.1595
Giardia lamblia DINP protein human, muc B family 0.0244 0.3794 0.6828
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.025 0.0268
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0345 0.0625
Schistosoma mansoni hypothetical protein 0.0039 0.0427 0.0465
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0108 0.0196
Echinococcus multilocularis sex peptide receptor 0.0014 0.0029 0.0037
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0014 0.0029 0.0037
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0016 0.0059 0.002
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0014 0.0029 0.0037
Onchocerca volvulus 0.0014 0.0029 0.0028
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0029 0.0037
Echinococcus granulosus chromobox protein 1 0.0068 0.0915 0.1641
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Brugia malayi GnHR receptor homolog 0.0014 0.0029 0.0022
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0029 0.0022
Mycobacterium ulcerans hypothetical protein 0.0067 0.0898 0.0166
Toxoplasma gondii 5'-nucleotidase, C-terminal domain-containing protein 0.0119 0.1753 0.3111
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0052 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0029 0.0037
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.025 0.0268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.025 0.0268
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0127 0.1875 0.3381
Loa Loa (eye worm) glutaminase 0.0562 0.9006 1
Brugia malayi hypothetical protein 0.0017 0.008 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0029 0.0037
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0104 0.0106
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.1474 0.1628
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0029 0.0037
Schistosoma mansoni biogenic amine (5HT) receptor 0.0161 0.2441 0.2703
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0014 0.0029 0.0037
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0016 0.0059 0.002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0127 0.1875 0.2074
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0898 0.1624
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0048 0.0087
Brugia malayi hypothetical protein 0.0071 0.0955 0.1051
Brugia malayi XPG I-region family protein 0.0016 0.0059 0.0056
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0422 0.057
Schistosoma mansoni amine GPCR 0.0014 0.0029 0.0022
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0345 0.0543
Echinococcus granulosus tachykinin peptides receptor 99D 0.0014 0.0029 0.0037
Trypanosoma brucei hypothetical protein, conserved 0.0067 0.0898 0.1624
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.025 0.0437
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.025 0.0268
Brugia malayi isocitrate dehydrogenase 0.0016 0.0048 0.0043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0029 0.0022
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0127 0.1875 0.3381
Echinococcus multilocularis peregrin 0.0069 0.0924 0.1657
Trypanosoma brucei DNA polymerase kappa, putative 0.0326 0.5134 0.9286
Brugia malayi bZIP transcription factor family protein 0.009 0.1272 0.1404
Brugia malayi chromobox protein homolog 3 0.0038 0.0422 0.0459
Trypanosoma brucei phosphoglycerate kinase 0.0128 0.1899 0.3435
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0029 0.0022
Schistosoma mansoni hypothetical protein 0.0032 0.0325 0.0352
Plasmodium falciparum phosphoglycerate kinase 0.035 0.5529 1
Trichomonas vaginalis phosphoglycerate kinase, putative 0.035 0.5529 0.5529
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0029 0.0022
Onchocerca volvulus 0.0014 0.0029 0.0028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.025 0.0437
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0104 0.0189
Trypanosoma brucei hypothetical protein, conserved 0.0067 0.0898 0.1624
Leishmania major hypothetical protein, conserved 0.0016 0.0059 0.0107
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0104 0.0173
Trypanosoma cruzi phosphoglycerate kinase, putative 0.035 0.5529 1
Schistosoma mansoni tsg101-related 0.0057 0.0726 0.0797
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0325 0.0352
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0048 0.0087
Brugia malayi hypothetical protein 0.0014 0.0029 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0287 0.0287
Echinococcus multilocularis serotonin receptor 0.0161 0.2441 0.4406
Echinococcus granulosus FTZ F1 alpha 0.0028 0.025 0.0437
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.1474 0.1628
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.025 0.0268
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0104 0.0173
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0915 0.0915
Brugia malayi neuropeptide F receptor 0.0014 0.0029 0.0022
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.025 0.0437
Toxoplasma gondii phosphoglycerate kinase PGKII 0.035 0.5529 1
Plasmodium falciparum flap endonuclease 1 0.008 0.1099 0.1918
Onchocerca volvulus 0.0014 0.0029 0.0028
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.025 0.0437
Schistosoma mansoni adenoreceptor 0.0014 0.0029 0.0022
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0046 0.0555 0.0555
Brugia malayi Serotonin receptor 0.0014 0.0029 0.0022
Echinococcus multilocularis flap endonuclease GEN 1 0.0016 0.0059 0.0091
Brugia malayi Fli-1 protein 0.0236 0.3664 0.4063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0599 0.1069
Brugia malayi nuclear hormone receptor 0.0028 0.025 0.0268
Onchocerca volvulus 0.0071 0.0955 0.1304
Onchocerca volvulus 0.0028 0.025 0.0332
Echinococcus multilocularis flap endonuclease 1 0.008 0.1099 0.1975
Echinococcus granulosus g protein coupled receptor 0.0014 0.0029 0.0037
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0029 0.0037
Echinococcus granulosus jun protein 0.009 0.1272 0.2288
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0029
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0127 0.1875 0.2074
Brugia malayi Ets-domain containing protein 0.0078 0.1069 0.1178
Schistosoma mansoni kinase 0.0048 0.0581 0.0636
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0104 0.0103
Echinococcus granulosus G protein coupled receptor 139 0.0014 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.003 0.0286 0.0308
Onchocerca volvulus Neuropeptide F receptor homolog 0.0014 0.0029 0.0028
Brugia malayi G protein-coupled receptor F59B2.13 0.0014 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0325 0.0352
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0959 0.172
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0029 0.0037
Echinococcus granulosus alpha 1A adrenergic receptor 0.0014 0.0029 0.0037
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0014 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.025 0.0268
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0014 0.0029 0.0022
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0035 0.0371 0.0655
Echinococcus granulosus serotonin receptor 0.0014 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.025 0.0268
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0111 0.1614 0.2908
Brugia malayi hypothetical protein 0.0455 0.726 0.806
Loa Loa (eye worm) SMO-1 protein 0.003 0.0287 0.031
Schistosoma mansoni chromobox protein 0.0068 0.0915 0.1007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0239 0.0239
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0014 0.0029 0.0022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0427 0.0758
Brugia malayi Dopamine receptor protein 2 0.0014 0.0029 0.0022
Loa Loa (eye worm) AUR protein kinase 0.0111 0.1614 0.1784
Brugia malayi Phosphoglycerate kinase 0.0128 0.1899 0.2101
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.025 0.0437
Leishmania major hypothetical protein, conserved 0.0022 0.0152 0.0274
Schistosoma mansoni hypothetical protein 0.0348 0.5504 0.6108
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0029 0.0037
Onchocerca volvulus 0.0014 0.0029 0.0028
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.1781 0.197
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0014 0.0029 0.0028
Echinococcus multilocularis dna polymerase kappa 0.0326 0.5134 0.9285
Echinococcus multilocularis aurora kinase A 0.0111 0.1614 0.2908
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0048 0.0071
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0104 0.0106
Trichomonas vaginalis rotamase, putative 0.0034 0.0359 0.0359
Trypanosoma brucei phosphoglycerate kinase, putative 0.0128 0.1899 0.3435
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0059 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.025 0.0268
Leishmania major protein kinase, putative 0.0111 0.1614 0.292
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0756 0.0831
Loa Loa (eye worm) melatonin receptor type 1A 0.0014 0.0029 0.0022
Echinococcus multilocularis dro:myosuppressin receptor 0.0014 0.0029 0.0037
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0014 0.0029 0.0037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0599 0.1069
Loa Loa (eye worm) XPG I-region family protein 0.0016 0.0059 0.0056
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0029
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0104 0.0106
Trichomonas vaginalis flap endonuclease-1, putative 0.008 0.1099 0.1099
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0237 0.0346
Loa Loa (eye worm) hypothetical protein 0.0028 0.025 0.0268
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0261 0.0261
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.2946 0.532
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.1329 0.182
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0239 0.0239
Entamoeba histolytica hypothetical protein 0.0039 0.0427 0.0427
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0016 0.0059 0.0107
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0261 0.0261
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.025 0.0437
Plasmodium falciparum metacaspase 1 0.0028 0.0261 0.0389
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0014 0.0029 0.0037
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0325 0.0573
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1329 0.2403
Schistosoma mansoni hypothetical protein 0.007 0.0942 0.1037
Trypanosoma cruzi metacaspase, putative 0.0028 0.0261 0.0472
Schistosoma mansoni coup transcription factor 0.0028 0.025 0.0268
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0029 0.0037
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.035 0.5529 0.5
Entamoeba histolytica DNA-repair protein, putative 0.0016 0.0059 0.0059
Onchocerca volvulus 0.0014 0.0029 0.0028
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1329 0.1329
Schistosoma mansoni lozenge 0.0057 0.073 0.0802
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0029 0.0037
Brugia malayi hypothetical protein 0.0014 0.0029 0.0022
Schistosoma mansoni glutaminase 0.0562 0.9006 1
Schistosoma mansoni DNA polymerase eta 0.0321 0.506 0.5614
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Onchocerca volvulus 0.0014 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Schistosoma mansoni biogenic amine receptor 0.0014 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Brugia malayi ORL1-like opioid receptor 0.0014 0.0029 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.025 0.0268
Trichomonas vaginalis AGC family protein kinase 0.0111 0.1614 0.1614
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0029 0.0037
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.1329 0.1467
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0152 0.0274
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0104 0.0103
Loa Loa (eye worm) AUR protein kinase 0.0111 0.1614 0.1784
Trypanosoma cruzi phosphoglycerate kinase, putative 0.035 0.5529 1
Brugia malayi jmjC domain containing protein 0.0019 0.0104 0.0106
Trypanosoma brucei metacaspase MCA2 0.0028 0.0261 0.0472
Echinococcus granulosus neuropeptide receptor 0.0014 0.0029 0.0037
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0104 0.0189
Leishmania major DNA polymerase eta, putative 0.0171 0.2606 0.4713
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0068 0.0913 0.1005
Trypanosoma brucei metacaspase 0.0028 0.0261 0.0472
Trypanosoma brucei DNA polymerase kappa, putative 0.0176 0.2681 0.4848
Onchocerca volvulus Alhambra homolog 0.0059 0.0756 0.103
Leishmania major phosphoglycerate kinase C, glycosomal 0.035 0.5529 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0029 0.0037
Echinococcus granulosus caspase 2 0.0028 0.0261 0.0457
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0561 0.0561
Echinococcus granulosus flap endonuclease GEN 1 0.0016 0.0059 0.0091
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.008 0.1099 0.1988
Echinococcus granulosus orexin receptor type 2 0.0014 0.0029 0.0037
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0345 0.0625
Brugia malayi glutaminase DH11.1 0.0562 0.9006 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0345 0.0625
Echinococcus multilocularis expressed protein 0.0034 0.0359 0.0634
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.035 0.5529 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.047 0.047
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0422 0.0422
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0029 0.0022
Schistosoma mansoni jun-related protein 0.0073 0.0995 0.1096
Echinococcus granulosus jumonji domain containing protein 0.0082 0.1133 0.2036
Loa Loa (eye worm) hypothetical protein 0.0028 0.025 0.0268
Brugia malayi Phosphoglycerate kinase 0.035 0.5529 0.6136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0599 0.0656
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.025 0.0437
Brugia malayi AKH receptor 0.0014 0.0029 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0029 0.0022
Brugia malayi serine/threonine protein kinase 6 0.0111 0.1614 0.1784
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0016 0.0059 0.0091
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0029 0.0037
Loa Loa (eye worm) flap endonuclease-1 0.008 0.1099 0.1212
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1329 0.1467
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0599 0.0656
Onchocerca volvulus 0.0455 0.726 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.008 0.1099 0.1988
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0016 0.0059 0.002
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0171 0.2606 0.4667
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0029 0.0037
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0014 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Trypanosoma cruzi metacaspase 5, putative 0.0028 0.0261 0.0472
Trypanosoma brucei exonuclease, putative 0.0016 0.0059 0.0107
Giardia lamblia Flap structure-specific endonuclease 0.008 0.1099 0.1901
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Brugia malayi follicle stimulating hormone receptor 0.0014 0.0029 0.0022
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.1329 0.1329
Loa Loa (eye worm) hypothetical protein 0.0028 0.0261 0.028
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0325 0.0352
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0761 0.1376
Brugia malayi serine/threonine-protein kinase 6 0.0111 0.1614 0.1784
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0014 0.0029 0.0022
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.025 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.0244 0.3794 0.6862
Entamoeba histolytica Flap nuclease, putative 0.008 0.1099 0.1099
Brugia malayi Ets-domain containing protein 0.0078 0.1069 0.1178
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0261 0.0261
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1329 0.1329
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0959 0.1056
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.025 0.0437
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0237 0.0346
Loa Loa (eye worm) glutaminase 2 0.0562 0.9006 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0599 0.0656
Brugia malayi putative neuropeptide receptor 0.0014 0.0029 0.0022
Echinococcus granulosus Small ubiquitin modifier 2 0.003 0.0287 0.0504
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0048 0.0043
Onchocerca volvulus 0.0014 0.0029 0.0028
Trypanosoma brucei polo-like protein kinase 0.0094 0.1329 0.2403
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0942 0.1037
Echinococcus granulosus 7tm_1 domain containing protein 0.0014 0.0029 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0035 0.0029
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0104 0.0106
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0761 0.13
Entamoeba histolytica protein kinase, putative 0.0111 0.1614 0.1614
Plasmodium falciparum DNA repair protein REV1, putative 0.0067 0.0898 0.1551
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0014 0.0029 0.0022
Onchocerca volvulus 0.0014 0.0029 0.0028
Echinococcus granulosus exonuclease 1 0.0016 0.0059 0.0091
Loa Loa (eye worm) hypothetical protein 0.0016 0.0059 0.0056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0029 0.0037
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0152 0.0274
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0014 0.0029 0.0022
Schistosoma mansoni caspase-7 (C14 family) 0.0028 0.0261 0.028
Giardia lamblia Sentrin 0.003 0.0287 0.0418
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.025 0.0437
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.0287 0.052
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0217 0.3352 0.3716
Leishmania major metacaspase, putative 0.0028 0.0261 0.0472
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Trichomonas vaginalis flap endonuclease-1, putative 0.0016 0.0059 0.0059
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0028 0.0261 0.0457
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0128 0.1899 0.3435
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0104 0.0173
Schistosoma mansoni histamine h1 receptor 0.0014 0.0029 0.0022
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.018 0.019
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.1329 0.2391
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0029 0.0037
Brugia malayi Tachykinin-like peptides receptor 99D 0.0014 0.0029 0.0022
Trypanosoma brucei phosphoglycerate kinase 0.035 0.5529 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0326 0.5134 0.9286
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0029 0.0037
Echinococcus granulosus dna polymerase kappa 0.0326 0.5134 0.9285
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0029 0.0022
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0128 0.0132
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0068 0.0913 0.1637
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Brugia malayi Heterochromatin protein 1 0.0068 0.0915 0.1007
Onchocerca volvulus 0.0014 0.0029 0.0028
Plasmodium vivax DNA repair protein RAD2, putative 0.0016 0.0059 0.002
Echinococcus granulosus neuropeptide receptor A26 0.0014 0.0029 0.0037
Brugia malayi larval opioid receptor 0.0014 0.0029 0.0022
Echinococcus granulosus dna polymerase eta 0.0321 0.506 0.9149
Trypanosoma cruzi DNA damage repair protein, putative 0.0067 0.0898 0.1624
Brugia malayi Melatonin receptor type 1A 0.0014 0.0029 0.0022
Brugia malayi hypothetical protein 0.0068 0.0913 0.1005
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0029 0.0037
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0217 0.3352 0.3716
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0261 0.0389
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0325 0.0573
Plasmodium vivax phosphoglycerate kinase, putative 0.035 0.5529 1
Plasmodium vivax metacaspase 1, putative 0.0028 0.0261 0.0389
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0104 0.0106
Entamoeba histolytica hypothetical protein 0.0039 0.0427 0.0427
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1329 0.1329
Toxoplasma gondii aurora kinase 0.0111 0.1614 0.2858
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0048 0.0087
Toxoplasma gondii phosphoglycerate kinase PGKI 0.035 0.5529 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0756 0.1354
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0048 0.0071
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0029 0.0037
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.1329 0.2391
Schistosoma mansoni biogenic amine receptor 0.0014 0.0029 0.0022
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0696 0.0763
Plasmodium vivax JmjC domain containing protein 0.0019 0.0104 0.0103
Brugia malayi steroid hormone receptor 0.0028 0.025 0.0268
Onchocerca volvulus Cell death protein 3 homolog 0.0028 0.0261 0.0348
Brugia malayi hypothetical protein 0.0014 0.0029 0.0022
Schistosoma mansoni gabp alpha 0.0078 0.1069 0.1178
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.025 0.0268
Echinococcus multilocularis G-protein coupled receptor, putative 0.0014 0.0029 0.0037
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0959 0.1056
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1329 0.2403
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0029 0.0037
Entamoeba histolytica hypothetical protein 0.0039 0.0427 0.0427
Toxoplasma gondii 5'-nucleotidase, C-terminal domain-containing protein 0.029 0.4553 0.822
Loa Loa (eye worm) hypothetical protein 0.0016 0.0059 0.0056
Schistosoma mansoni growth hormone secretagogue receptor 0.0014 0.0029 0.0022
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0035 0.0029
Echinococcus multilocularis caspase 0.0028 0.0261 0.0457
Schistosoma mansoni DNA polymerase IV / kappa 0.0067 0.0898 0.0988
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.025 0.0268
Echinococcus multilocularis neuropeptide s receptor 0.0014 0.0029 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1329 0.1329
Echinococcus granulosus peregrin 0.0069 0.0924 0.1657
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0029 0.0037
Schistosoma mansoni terminal deoxycytidyl transferase 0.0217 0.3352 0.3716
Schistosoma mansoni hypothetical protein 0.0073 0.0995 0.1096
Echinococcus multilocularis neuropeptide FF receptor 2 0.0014 0.0029 0.0037
Schistosoma mansoni opsin-like receptor 0.0014 0.0029 0.0022
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0067 0.0898 0.1551
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0119 0.1738 0.1922
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0217 0.3352 0.6056
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0094 0.134 0.2358
Trypanosoma brucei DNA polymerase kappa, putative 0.0326 0.5134 0.9286
Trypanosoma brucei DNA polymerase kappa, putative 0.0326 0.5134 0.9286
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0016 0.0059 0.0056
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0029 0.0037
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0029 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.269 0.4865
Onchocerca volvulus 0.0014 0.0029 0.0028
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0014 0.0029 0.0022
Schistosoma mansoni amine GPCR 0.0014 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.2946 0.532
Onchocerca volvulus 0.0014 0.0029 0.0028
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.003 0.0287 0.031
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0104 0.0173
Brugia malayi hypothetical protein 0.0014 0.0029 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.025 0.0268
Leishmania major DNA polymerase eta, putative 0.0321 0.506 0.9151
Trichomonas vaginalis flap endonuclease-1, putative 0.0016 0.0059 0.0059
Schistosoma mansoni neuropeptide receptor 0.0014 0.0029 0.0022
Schistosoma mansoni biogenic amine receptor 0.0014 0.0029 0.0022
Plasmodium falciparum exonuclease I, putative 0.0016 0.0059 0.002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0128 0.0132
Leishmania major hypothetical protein, conserved 0.0019 0.0104 0.0189
Trypanosoma brucei aurora B kinase 0.0111 0.1614 0.292
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0014 0.0029 0.0037
Plasmodium vivax small ubiquitin-related modifier, putative 0.003 0.0287 0.0437
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0048 0.0071
Echinococcus granulosus aurora kinase A 0.0111 0.1614 0.2908
Mycobacterium ulcerans DNA polymerase IV 0.0326 0.5134 0.5305
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.025 0.0268
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0014 0.0029 0.0022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.025 0.0268
Brugia malayi RE15519p 0.0014 0.0029 0.0022
Mycobacterium ulcerans DNA polymerase IV 0.0326 0.5134 0.5305
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.025 0.0268
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.0287 0.052
Entamoeba histolytica ubiquitin like protein 0.003 0.0287 0.0287
Trypanosoma brucei DNA polymerase kappa, putative 0.0326 0.5134 0.9286
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0029 0.0037
Trichomonas vaginalis hypothetical protein 0.0033 0.0339 0.0339
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0048 0.0071
Plasmodium vivax exonuclease I, putative 0.0016 0.0059 0.002
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.018 0.018
Echinococcus granulosus dro:myosuppressin receptor 0.0014 0.0029 0.0037
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0111 0.1614 0.2908
Trypanosoma brucei DNA polymerase IV, putative 0.0326 0.5134 0.9286
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0029 0.0037
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0325 0.0352
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.025 0.0268
Trypanosoma cruzi DNA polymerase kappa, putative 0.0326 0.5134 0.9286
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0104 0.0189
Trypanosoma cruzi DNA polymerase eta, putative 0.0171 0.2606 0.4713
Schistosoma mansoni thyroid hormone receptor 0.0028 0.025 0.0268
Schistosoma mansoni opsin-like receptor 0.0014 0.0029 0.0022
Giardia lamblia DNA damage repair protein 0.0067 0.0898 0.1534
Giardia lamblia Kinase, PLK 0.0094 0.1329 0.2321
Schistosoma mansoni hypothetical protein 0.0014 0.0029 0.0022
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0756 0.1292
Trichomonas vaginalis AGC family protein kinase 0.0111 0.1614 0.1614
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0014 0.0029 0.0022
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0761 0.0836
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Entamoeba histolytica protein kinase, putative 0.0111 0.1614 0.1614
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Giardia lamblia Hypothetical protein 0.0119 0.1739 0.3072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.025 0.0268
Echinococcus multilocularis g-protein coupled receptor 0.0014 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0104 0.0106
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.047 0.0636
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0029 0.0022
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0068 0.0913 0.1637
Schistosoma mansoni chromobox protein 0.0068 0.0915 0.1007
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0029 0.0037
Echinococcus granulosus biogenic amine 5HT receptor 0.0161 0.2441 0.4406
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0029 0.0037
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0029 0.0037
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0048 0.0071
Brugia malayi neuropeptide F receptor 0.0014 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Brugia malayi PHD-finger family protein 0.0059 0.0756 0.0831
Brugia malayi ImpB/MucB/SamB family protein 0.0217 0.3352 0.3716
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0237 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.025 0.0268
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.025 0.0268
Schistosoma mansoni neuropeptide f receptor 76f 0.0014 0.0029 0.0022
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0261 0.0261
Trypanosoma brucei DNA repair protein RAD2, putative 0.0016 0.0059 0.0107
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0261 0.0261
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0029 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0029 0.0037
Leishmania major flap endonuclease-1 (FEN-1), putative 0.008 0.1099 0.1988
Echinococcus granulosus chromobox protein 1 0.0068 0.0915 0.1641
Brugia malayi G protein-coupled receptor 0.0014 0.0029 0.0022
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0104 0.0106
Trypanosoma brucei small ubiquitin-related modifier 0.003 0.0287 0.052
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0244 0.3794 0.6862
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0055 0.0013
Brugia malayi jmjC domain containing protein 0.0019 0.0104 0.0106
Plasmodium falciparum serine/threonine protein kinase, putative 0.0111 0.1614 0.2858
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0014 0.0029 0.0022
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.025 0.0437
Trypanosoma cruzi DNA polymerase kappa, putative 0.0326 0.5134 0.9286
Schistosoma mansoni hypothetical protein 0.0014 0.0029 0.0022
Loa Loa (eye worm) runx1 0.0057 0.073 0.0802
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Plasmodium falciparum small ubiquitin-related modifier 0.003 0.0287 0.0437
Echinococcus multilocularis Small ubiquitin modifier 2 0.003 0.0287 0.0504
Brugia malayi G-protein coupled receptor 0.0014 0.0029 0.0022
Brugia malayi ecdysteroid receptor 0.0028 0.025 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0261 0.0261
Schistosoma mansoni jumonji domain containing protein 0.0153 0.2298 0.2544
Brugia malayi jmjC domain containing protein 0.0019 0.0104 0.0106
Schistosoma mansoni amine GPCR 0.0014 0.0029 0.0022
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.025 0.0268
Brugia malayi hypothetical protein 0.0014 0.0029 0.0022
Echinococcus granulosus sex peptide receptor 0.0014 0.0029 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0561 0.0561
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0014 0.0029 0.0022
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.025 0.0268
Loa Loa (eye worm) hypothetical protein 0.0066 0.0884 0.0972
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0029
Onchocerca volvulus 0.0014 0.0029 0.0028
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0161 0.2441 0.2703
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0029 0.0037
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0111 0.1614 0.1614
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0104 0.0173
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0345 0.0625
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0029 0.0037
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0108 0.011
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0108 0.0196
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0111 0.1614 0.1614
Loa Loa (eye worm) hypothetical protein 0.0455 0.726 0.806
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.035 0.5529 0.6136
Toxoplasma gondii small ubiquitin family modifier, putative 0.003 0.0287 0.0437
Echinococcus granulosus allatostatin A receptor 0.0014 0.0029 0.0037
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0427 0.0465
Echinococcus granulosus caspase 8 0.0028 0.0261 0.0457
Echinococcus multilocularis G protein coupled receptor 139 0.0014 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Echinococcus granulosus geminin 0.0348 0.5504 0.9955
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.025 0.0332
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0261 0.0261
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0029 0.0022
Schistosoma mansoni hypothetical protein 0.0014 0.0029 0.0022
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.025 0.0437
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0029 0.0037
Entamoeba histolytica deoxycytidyl transferase, putative 0.0217 0.3352 0.3352
Schistosoma mansoni ets-related 0.0236 0.3664 0.4063
Loa Loa (eye worm) hypothetical protein 0.0028 0.0261 0.028
Echinococcus multilocularis allatostatin A receptor 0.0014 0.0029 0.0037
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0014 0.0029 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0029 0.0022
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0016 0.0059 0.0091
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0108 0.011
Brugia malayi serine/threonine kinase 12 0.0111 0.1614 0.1784
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.025 0.0268
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0041 0.047 0.047
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.025 0.0268
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0104 0.0106
Echinococcus multilocularis chromobox protein 1 0.0068 0.0915 0.1641
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0014 0.0029 0.0037
Brugia malayi polk-prov protein 0.0176 0.2681 0.297
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0104 0.0173
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0035 0.0047
Echinococcus multilocularis GPCR, family 2 0.0032 0.0325 0.0573
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0761 0.0836
Trypanosoma cruzi metacaspase, putative 0.0028 0.0261 0.0472
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0128 0.1899 0.3435
Trichomonas vaginalis AGC family protein kinase 0.0111 0.1614 0.1614
Loa Loa (eye worm) hypothetical protein 0.0455 0.726 0.806
Mycobacterium ulcerans phosphoglycerate kinase 0.035 0.5529 0.5783
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0359 0.0359
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0029 0.0037
Mycobacterium tuberculosis Conserved hypothetical protein 0.0217 0.3352 0.6028
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0261 0.0261
Brugia malayi jmjC domain containing protein 0.0019 0.0104 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0326 0.5134 0.9286
Echinococcus multilocularis orexin receptor type 2 0.0014 0.0029 0.0037
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0014 0.0029 0.0022
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0016 0.0059 0.002
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0104 0.0173
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0359 0.0389
Echinococcus granulosus caspase 0.0028 0.0261 0.0457
Trypanosoma brucei unspecified product 0.015 0.2247 0.4065
Brugia malayi jmjC domain containing protein 0.0071 0.0959 0.1056
Brugia malayi nuclear receptor NHR-88 0.0028 0.025 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.0326 0.5134 0.9286
Echinococcus multilocularis bloom syndrome protein 0.0024 0.018 0.031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0599 0.1069
Trypanosoma brucei Metacaspase-4 0.0028 0.0261 0.0472
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0108 0.011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0029 0.0037
Treponema pallidum phosphoglycerate kinase 0.035 0.5529 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.025 0.0268
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Brugia malayi hypothetical protein 0.0015 0.0035 0.0029
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0048 0.0043
Trichomonas vaginalis exonuclease%2C+putative 0.0016 0.0059 0.0059
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0244 0.3794 0.6835
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0261 0.0261
Brugia malayi putative neuropeptide receptor NPR1 0.0014 0.0029 0.0022
Echinococcus granulosus GA binding protein alpha chain 0.0078 0.1069 0.192
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.1614 0.1784
Schistosoma mansoni hypothetical protein 0.0348 0.5504 0.6108
Trypanosoma brucei DNA polymerase kappa, putative 0.0326 0.5134 0.9286
Loa Loa (eye worm) hypothetical protein 0.0059 0.0756 0.0831
Loa Loa (eye worm) hypothetical protein 0.0088 0.1232 0.1359
Onchocerca volvulus 0.0014 0.0029 0.0028
Echinococcus multilocularis geminin 0.0348 0.5504 0.9955
Entamoeba histolytica protein kinase , putative 0.0111 0.1614 0.1614
Entamoeba histolytica protein kinase domain containing protein 0.0111 0.1614 0.1614
Loa Loa (eye worm) hypothetical protein 0.0321 0.506 0.5614
Echinococcus granulosus 7TM GPCR rhodopsin 0.0014 0.0029 0.0037
Echinococcus granulosus somatostatin receptor 0.0014 0.0029 0.0037
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0104 0.0103
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0127 0.1875 0.3381
Brugia malayi Dopamine receptor 0.0014 0.0029 0.0022
Schistosoma mansoni hypothetical protein 0.0014 0.0029 0.0022
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0016 0.0059 0.0107
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0099 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.269 0.4865
Echinococcus granulosus peptide allatostatin:somatostatin 0.0014 0.0029 0.0037
Echinococcus granulosus neuropeptide FF receptor 2 0.0014 0.0029 0.0037
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0237 0.0429
Trypanosoma brucei DNA damage repair protein, putative 0.0067 0.0898 0.1624
Leishmania major phosphoglycerate kinase B, cytosolic 0.035 0.5529 1
Schistosoma mansoni caspase-3 (C14 family) 0.0028 0.0261 0.028
Brugia malayi AF-10 protein 0.0019 0.0108 0.011
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0326 0.5134 0.5134
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0014 0.0029 0.0022
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0261 0.0389
Echinococcus granulosus bloom syndrome protein 0.0024 0.018 0.031
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0014 0.0029 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0915 0.0915
Echinococcus granulosus g-protein coupled receptor 0.0014 0.0029 0.0037
Echinococcus granulosus flap endonuclease 1 0.008 0.1099 0.1975
Schistosoma mansoni thyroid hormone receptor 0.0028 0.025 0.0268
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Trichomonas vaginalis flap endonuclease-1, putative 0.0016 0.0059 0.0059
Echinococcus multilocularis GA binding protein alpha chain 0.0078 0.1069 0.192
Echinococcus granulosus expressed protein 0.0034 0.0359 0.0634
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0756 0.1354
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0128 0.1899 0.3435
Schistosoma mansoni opsin-like receptor 0.0014 0.0029 0.0022
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0035 0.0029
Entamoeba histolytica exonuclease, putative 0.0016 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0019 0.0108 0.011
Loa Loa (eye worm) TYRA-2 protein 0.0014 0.0029 0.0022
Plasmodium vivax DNA repair protein REV1, putative 0.0067 0.0898 0.1551
Echinococcus multilocularis chromobox protein 1 0.0068 0.0915 0.1641
Trypanosoma cruzi DNA polymerase eta, putative 0.0321 0.506 0.9151
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0029 0.0037
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.025 0.0268
Giardia lamblia PHD finger protein 15 0.0059 0.0756 0.1274
Echinococcus multilocularis phosphoglycerate kinase 1 0.035 0.5529 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0599 0.1069
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0059 0.0107
Brugia malayi sulfakinin receptor protein 0.0014 0.0029 0.0022
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.009 0.1272 0.2288
Brugia malayi hypothetical protein 0.0014 0.0029 0.0022
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0237 0.0346
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0014 0.0029 0.0037
Schistosoma mansoni neuropeptide receptor 0.0014 0.0029 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0261 0.0261
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0029 0.0022
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0014 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.025 0.0268
Echinococcus multilocularis dna polymerase eta 0.0321 0.506 0.9149
Schistosoma mansoni hypothetical protein 0.0032 0.0325 0.0352
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.025 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.025 0.0268
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Trypanosoma brucei metacaspase MCA3 0.0028 0.0261 0.0472
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0427 0.0758
Brugia malayi hypothetical protein 0.0014 0.0029 0.0022
Brugia malayi PHD-finger family protein 0.0019 0.0108 0.011
Schistosoma mansoni flap endonuclease-1 0.0072 0.0974 0.1072
Trypanosoma brucei DNA polymerase IV, putative 0.0299 0.4692 0.8486
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0761 0.1362
Entamoeba histolytica exonuclease, putative 0.0016 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0029
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0029 0.0037
Brugia malayi Cell death protein 3 precursor 0.0028 0.0261 0.028
Trypanosoma brucei DNA polymerase kappa, putative 0.0326 0.5134 0.9286
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.1474 0.1628
Brugia malayi hypothetical protein 0.0039 0.0427 0.0465
Brugia malayi hypothetical protein 0.0014 0.0029 0.0022
Trypanosoma brucei DNA polymerase eta, putative 0.0321 0.506 0.9151
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.025 0.0437
Trichomonas vaginalis rotamase, putative 0.0034 0.0345 0.0345
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0029 0.0022
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0048 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0261 0.0261
Echinococcus multilocularis caspase 2 0.0028 0.0261 0.0457
Trichomonas vaginalis glutaminase, putative 0.0562 0.9006 0.9006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.0254
Brugia malayi Serotonin receptor 0.0014 0.0029 0.0022
Brugia malayi G-protein coupled receptor 0.0014 0.0029 0.0022
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0014 0.0029 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0029 0.0022
Schistosoma mansoni tsg101-related 0.0046 0.0555 0.0607
Trypanosoma brucei metacaspase 5, putative 0.0028 0.0261 0.0472
Schistosoma mansoni amine GPCR 0.0014 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Echinococcus granulosus GPCR family 2 0.0032 0.0325 0.0573
Trypanosoma brucei unspecified product 0.0299 0.4692 0.8486
Loa Loa (eye worm) AUR protein kinase 0.0111 0.1614 0.1784
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0028 0.0261 0.0457
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.025 0.0437
Echinococcus multilocularis neuropeptide receptor A26 0.0014 0.0029 0.0037
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0325 0.0573
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) 0.0027 0.0236 0.0343
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0029 0.0022
Echinococcus granulosus phosphoglycerate kinase 1 0.035 0.5529 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0048 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0029 0.0022
Echinococcus granulosus neuropeptide receptor 0.0014 0.0029 0.0037
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0959 0.172
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0217 0.3352 0.6056
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0127 0.1875 0.2074
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0176 0.2681 0.297
Schistosoma mansoni 23-cyclic-nucleotide 2-phosphodiesterase 0.0289 0.454 0.5036
Loa Loa (eye worm) hypothetical protein 0.0161 0.2441 0.2703
Trichomonas vaginalis flap endonuclease-1, putative 0.0016 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0104 0.0106
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0048 0.0071
Echinococcus multilocularis somatostatin receptor 0.0014 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0029 0.0022
Echinococcus granulosus g protein coupled receptor 0.0014 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Leishmania major DNA polymerase kappa, putative 0.0244 0.3794 0.6862
Echinococcus granulosus fmrfamide receptor 0.0014 0.0029 0.0037
Trypanosoma brucei unspecified product 0.015 0.2247 0.4065
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0422 0.0422
Entamoeba histolytica hypothetical protein 0.0039 0.0427 0.0427
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.025 0.0268
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0029 0.0037
Echinococcus multilocularis exonuclease 1 0.0016 0.0059 0.0091
Loa Loa (eye worm) hypothetical protein 0.0038 0.0422 0.0459
Onchocerca volvulus 0.003 0.0286 0.0383
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Trypanosoma brucei chrX additional, unordered contigs 0.0067 0.0898 0.1624
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0959 0.1056
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0014 0.0029 0.0022
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0261 0.0389
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0237 0.0429
Giardia lamblia Aurora kinase 0.0111 0.1614 0.2843
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.025 0.0268
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0599 0.0656
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Schistosoma mansoni 23-cyclic-nucleotide 2-phosphodiesterase 0.029 0.4553 0.5051
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0016 0.0059 0.0056
Trichomonas vaginalis AGC family protein kinase 0.0111 0.1614 0.1614
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0035 0.0371 0.0655
Leishmania major small ubiquitin protein, putative 0.003 0.0287 0.052
Schistosoma mansoni alpha-1 adrenergic receptor 0.0014 0.0029 0.0022
Schistosoma mansoni SET domain protein 0.0035 0.0371 0.0402
Onchocerca volvulus 0.0014 0.0029 0.0028
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0104 0.0106
Trypanosoma cruzi metacaspase, putative 0.0028 0.0261 0.0472
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0915 0.1007
Leishmania major hypothetical protein, conserved 0.0027 0.0237 0.0429
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Schistosoma mansoni phosphoglycerate kinase 0.035 0.5529 0.6136
Brugia malayi Flap endonuclease-1 0.008 0.1099 0.1212
Brugia malayi hypothetical protein 0.0015 0.0035 0.0029
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.009 0.1272 0.2288
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0128 0.1899 0.3435
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1329 0.1329
Schistosoma mansoni phosphoglycerate kinase 0.035 0.5529 0.6136
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Brugia malayi Ubiquitin-like protein SMT3 0.003 0.0287 0.031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.025 0.0437
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.025 0.0437
Schistosoma mansoni neuropeptide receptor 0.0014 0.0029 0.0022
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0014 0.0029 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.025 0.0268
Loa Loa (eye worm) fli-1 protein 0.0236 0.3664 0.4063
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0756 0.1292
Loa Loa (eye worm) hypothetical protein 0.0028 0.025 0.0268
Schistosoma mansoni exonuclease 0.0016 0.0059 0.0056
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.025 0.0268
Echinococcus granulosus g protein coupled receptor 0.0014 0.0029 0.0037
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0035 0.0047
Schistosoma mansoni nuclear hormone receptor 0.0028 0.025 0.0268
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0128 0.1899 0.3435
Leishmania major DNA polymerase kappa, putative 0.0067 0.0898 0.1624
Echinococcus granulosus hypothetical protein 0.0014 0.0029 0.0037
Schistosoma mansoni tsg101-related 0.0057 0.0726 0.0797
Trichomonas vaginalis DNA polymerase eta, putative 0.0326 0.5134 0.5134
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0111 0.1614 0.1614
Trypanosoma cruzi aurora B kinase, putative 0.0111 0.1614 0.292
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0029 0.0037
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.1133 0.2036
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0261 0.0261
Entamoeba histolytica phosphoglycerate kinase, putative 0.035 0.5529 0.5529
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0022
Echinococcus granulosus phd:f box containing protein 0.0019 0.0104 0.0173
Schistosoma mansoni hypothetical protein 0.0059 0.0756 0.0831
Trichomonas vaginalis phosphoglycerate kinase, putative 0.035 0.5529 0.5529
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1329 0.1329
Trypanosoma cruzi DNA polymerase kappa, putative 0.0326 0.5134 0.9286
Plasmodium vivax flap endonuclease 1, putative 0.008 0.1099 0.1918
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0078 0.1069 0.1178
Trypanosoma cruzi DNA polymerase kappa, putative 0.0326 0.5134 0.9286
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0014 0.0029 0.0022
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0102 0.1474 0.1628
Chlamydia trachomatis phosphoglycerate kinase 0.035 0.5529 0.5
Echinococcus multilocularis jun protein 0.009 0.1272 0.2288
Brugia malayi Bromodomain containing protein 0.0059 0.0756 0.0831
Trypanosoma cruzi DNA damage repair protein, putative 0.0067 0.0898 0.1624
Giardia lamblia Phosphoglycerate kinase 0.035 0.5529 1
Brugia malayi jmjC domain containing protein 0.0192 0.2946 0.3264
Onchocerca volvulus 0.0014 0.0029 0.0028
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0029 0.0022
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0035 0.0029
Trypanosoma brucei DNA polymerase IV, putative 0.0326 0.5134 0.9286

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 23 nM Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells ChEMBL. 18783955
Ki (binding) = 34 nM Displacement of [3H]raclopride from rat dopamine D2 receptor ChEMBL. 17228858
Ki (binding) = 34 nM Displacement of [3H]raclopride from rat dopamine D2 receptor ChEMBL. 17228858
Ki (binding) = 92 nM Displacement of [3H]Spiperone from human 5HT2A receptor expressed in HEK293 cells ChEMBL. 18783955
Ki (binding) = 340 nM Displacement of [3H]nemonapride from dopamine D2 receptor in rat forebrain ChEMBL. 19058967
Ki (binding) > 10000 nM Displacement of [3H]SCH23390 from rat 5HT1A receptor expressed in CHO cells ChEMBL. 18783955
Ki (binding) > 10000 nM Displacement of [3H]ketanserin from human dopamine D2 receptor expressed in HEK293 cells ChEMBL. 18783955
Ki (binding) > 20000 nM Displacement of [3H]SCH23390 from rat dopamine D1 receptor ChEMBL. 17228858
Ki (binding) > 20000 nM Displacement of [3H]SCH23390 from rat dopamine D1 receptor ChEMBL. 17228858
Ki (binding) > 20000 nM Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain ChEMBL. 19058967

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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