Detailed information for compound 507951

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 885.179 | Formula: C53H76N2O9
  • H donors: 5 H acceptors: 7 LogP: 4.96 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@H]1C[C@H]2Cc3nc4C[C@@]5(C)[C@H](Cc4nc3C[C@@]2([C@@H]2[C@@H]1C1=C[C@H]3[C@]([C@@]1(C)[C@@H](C2)O)(O)[C@@H]([C@]1(O3)CC[C@](CO1)(C)O)C)C)CC[C@@H]1[C@@H]5C[C@@H](O)[C@]2([C@@H]1C[C@H]1[C@@H]2C[C@]2(O1)CCC(O2)(C)C)C
  • InChi: 1S/C53H76N2O9/c1-26-52(14-12-46(4,59)25-61-52)63-43-21-33-44-32(20-42(58)50(33,8)53(26,43)60)48(6)24-38-36(16-28(48)17-39(44)56)55-37-23-47(5)27(15-35(37)54-38)9-10-29-30(47)19-41(57)49(7)31(29)18-40-34(49)22-51(62-40)13-11-45(2,3)64-51/h21,26-32,34,39-44,56-60H,9-20,22-25H2,1-8H3/t26-,27+,28-,29-,30+,31-,32+,34+,39+,40+,41-,42-,43+,44-,46+,47+,48+,49+,50-,51+,52-,53-/m1/s1
  • InChiKey: WNJLKEUGNUIKOH-WPJOBVFLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0041 0.015 0.0812
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0212 0.2413
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0154 0.173
Giardia lamblia Proteasome subunit beta type 2 0.0056 0.0236 0.2696
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0033 0.01 0.1093
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0033 0.01 0.1093
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.008 0.0377 0.4359
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0056 0.0236 0.2371
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0017 0.001
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0212 0.2413
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0033 0.01 0.022
Brugia malayi RNA, U transporter 1 0.0088 0.0425 0.2863
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0017 0.001
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0033 0.01 0.1093
Echinococcus granulosus calpain A 0.0116 0.0586 0.3179
Leishmania major trypanothione reductase 0.0048 0.019 0.2157
Leishmania major proteasome alpha 2 subunit, putative 0.0033 0.01 0.1093
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0549 0.0542
Brugia malayi proteasome subunit alpha type 4 0.0033 0.01 0.0673
Echinococcus multilocularis survival motor neuron protein 1 0.027 0.1484 0.3275
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0033 0.01 0.1093
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0154 0.173
Entamoeba histolytica protein kinase, putative 0.003 0.0083 0.0493
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0154 0.173
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0033 0.01 0.022
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0033 0.01 0.0542
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0033 0.01 0.022
Leishmania major proteasome alpha 1 subunit, putative 0.0033 0.01 0.1093
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0033 0.01 0.1093
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0017 0.001
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0033 0.01 0.1093
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0033 0.01 1
Brugia malayi CHE-14 protein 0.0041 0.0151 0.1017
Brugia malayi cytochrome P450 0.0018 0.0017 0.0117
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0033 0.01 0.1093
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0154 0.173
Plasmodium falciparum proteasome subunit beta type-5 0.0162 0.0856 1
Schistosoma mansoni survival motor neuron protein 0.0055 0.0231 0.1255
Brugia malayi Cytochrome P450 family protein 0.0018 0.0017 0.0117
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0033 0.01 0.1093
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0033 0.01 0.0542
Loa Loa (eye worm) hypothetical protein 0.0098 0.0483 0.2622
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0033 0.01 0.0542
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0033 0.01 0.0542
Trypanosoma brucei kinesin, putative 0.0029 0.0081 0.0866
Brugia malayi 20S proteasome alpha5 subunit 0.0033 0.01 0.0673
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0017 0.001
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0017 0.001
Echinococcus granulosus proteasome subunit alpha type 6 0.0033 0.01 0.0542
Loa Loa (eye worm) proteasome subunit beta type 1 0.008 0.0377 0.2046
Echinococcus multilocularis calpain 7 (C02 family) 0.0042 0.0154 0.034
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0043 0.0426
Mycobacterium ulcerans proteasome PrcA 0.1731 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0596 0.3235
Toxoplasma gondii peptidase, T1 family protein 0.0033 0.01 0.1093
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0549 0.0542
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0033 0.01 0.0542
Loa Loa (eye worm) calpain family protein 1 0.0082 0.0386 0.2095
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0162 0.0856 0.4645
Brugia malayi Proteasome subunit alpha type 1 0.0033 0.01 0.0673
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0819
Brugia malayi calpain 7 0.0042 0.0154 0.1037
Toxoplasma gondii prolyl endopeptidase 0.0126 0.0648 0.7547
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0043 0.0235
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0017 0.0121
Giardia lamblia 20S proteasome alpha subunit 5 0.0033 0.01 0.1093
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0033 0.01 0.1093
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0033 0.01 0.1093
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0231 0.1558
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0033 0.01 0.1093
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0017 0.0121
Toxoplasma gondii heat shock protein hslv, putative 0.0033 0.01 0.1093
Echinococcus multilocularis prolyl endopeptidase 0.0126 0.0648 0.1429
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0033 0.01 0.1093
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0017 0.001
Plasmodium vivax proteasome subunit beta type-4, putative 0.0033 0.01 0.1093
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0471 0.5267
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0017 0.001
Plasmodium vivax proteasome subunit beta type-1, putative 0.008 0.0377 0.4359
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0033 0.01 0.1093
Schistosoma mansoni ran 0.0023 0.0043 0.0235
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0033 0.01 0.1093
Plasmodium vivax calpain, putative 0.0042 0.0154 0.173
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0056 0.0236 0.2696
Leishmania major oligopeptidase b 0.005 0.0203 0.2312
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0017 0.001
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0154 0.173
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0007 0.0039
Loa Loa (eye worm) calpain family protein 1 0.0111 0.0556 0.302
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0123 0.0666
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0033 0.01 0.1093
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0057 0.0586
Plasmodium vivax proteasome subunit beta type-6, putative 0.0033 0.01 0.1093
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0033 0.01 0.0542
Toxoplasma gondii proteasome subunit beta type, putative 0.0162 0.0856 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0007 0.0016
Mycobacterium ulcerans proteasome PrcB 0.0162 0.0856 0.0849
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0154 0.173
Schistosoma mansoni importin beta-1 0.0031 0.0091 0.0495
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.005 0.0203 0.0196
Leishmania major proteasome beta 5 subunit, putative 0.0162 0.0856 1
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.019 0.2157
Echinococcus granulosus subfamily T1A non peptidase ue 0.0033 0.01 0.0542
Onchocerca volvulus Prolyl endopeptidase homolog 0.0126 0.0648 1
Mycobacterium tuberculosis Probable peptidase 0.005 0.0203 0.0196
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0123 0.0666
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.048 0.2605
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0017 0.001
Trypanosoma cruzi 20S proteasome subunit 0.0056 0.0236 0.2696
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0033 0.01 0.0542
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0123 0.1362
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0033 0.01 0.1093
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.008 0.0377 0.0832
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0033 0.01 0.1093
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0033 0.01 0.1093
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0033 0.01 0.1093
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0033 0.01 0.1093
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0033 0.01 0.0696
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0033 0.01 0.0696
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0033 0.01 0.1093
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0017 0.001
Brugia malayi Proteasome A-type and B-type family protein 0.0033 0.01 0.0673
Echinococcus multilocularis expressed conserved protein 0.009 0.0437 0.0965
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0033 0.01 0.1093
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0549 0.0542
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0017 0.001
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0033 0.01 0.0542
Trypanosoma brucei proteasome beta 6 subunit 0.008 0.0377 0.4359
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0566
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0017 0.001
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0017 0.001
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.015 0.0812
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0033 0.01 0.1093
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0154 0.173
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.005 0.0203 0.2312
Toxoplasma gondii proteasome subunit beta type 1, putative 0.008 0.0377 0.4359
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.008 0.0377 0.4359
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0033 0.01 0.1093
Brugia malayi proteasome subunit alpha type 1 0.0033 0.01 0.0673
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.062 0.0613
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0549 0.0532
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0033 0.01 0.0696
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.008 0.0377 0.2046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.015 0.0812
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0772
Trypanosoma brucei proteasome alpha 7 subunit 0.0033 0.01 0.1093
Echinococcus granulosus proteasome prosome macropain subunit beta 0.008 0.0377 0.2046
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0033 0.01 0.1093
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0033 0.01 0.0542
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0033 0.01 0.1093
Echinococcus multilocularis proteasome subunit alpha type 2 0.0033 0.01 0.022
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0033 0.01 0.1093
Echinococcus multilocularis proteasome subunit beta type 6 0.0033 0.01 0.022
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0212 0.2413
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0017 0.001
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0033 0.01 0.1093
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0033 0.01 0.0696
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0162 0.0856 1
Brugia malayi proteasome subunit alpha type 2 0.0033 0.01 0.0673
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0033 0.01 0.1093
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0056 0.0236 0.2696
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.062 0.0613
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0042 0.0154 0.173
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0057 0.0586
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0151 0.0333
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.005 0.0203 0.2312
Brugia malayi proteasome subunit beta type 1 0.008 0.0377 0.2541
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0033 0.01 0.1093
Schistosoma mansoni Mername-AA248 (C02 family) 0.0042 0.0154 0.0835
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0017 0.001
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0471 0.2557
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0033 0.01 0.0542
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0154 0.173
Echinococcus granulosus snurportin 1 0.0331 0.1842 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0033 0.01 0.1093
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0033 0.01 0.0696
Brugia malayi MH2 domain containing protein 0.0118 0.0596 0.4016
Trypanosoma brucei prolyl oligopeptidase, putative 0.005 0.0203 0.2312
Brugia malayi glutathione reductase 0.0048 0.019 0.1281
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0033 0.01 0.022
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0154 0.173
Onchocerca volvulus 0.0069 0.0313 0.3885
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0162 0.0856 0.4645
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0057 0.0586
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0212 0.115
Brugia malayi proteasome subunit alpha type 6 0.0033 0.01 0.0673
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0017 0.001
Echinococcus granulosus proteasome subunit alpha type 2 0.0033 0.01 0.0542
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.008 0.0377 0.4359
Plasmodium falciparum importin beta, putative 0.0031 0.0091 0.0989
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0033 0.01 0.1093
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0154 0.173
Loa Loa (eye worm) PAS-3 protein 0.0033 0.01 0.0542
Schistosoma mansoni hypothetical protein 0.0055 0.0231 0.1255
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0056 0.0236 0.1281
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0712 0.1571
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0033 0.01 0.0542
Schistosoma mansoni ran 0.0023 0.0043 0.0235
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0033 0.01 0.1093
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0123 0.0116
Trypanosoma brucei protein kinase, putative 0.0052 0.0212 0.2413
Trypanosoma brucei proteasome beta 7 subunit 0.0033 0.01 0.1093
Giardia lamblia Proteasome subunit beta type 3 0.0033 0.01 0.1093
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0033 0.01 0.1093
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0154 0.173
Echinococcus multilocularis proteasome subunit beta type 7 0.0033 0.01 0.022
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0033 0.01 0.022
Brugia malayi Cytochrome P450 family protein 0.0036 0.0123 0.0827
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0033 0.01 0.1093
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0123 0.0666
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.1731 1 1
Echinococcus multilocularis calpain 5 0.0042 0.0154 0.034
Leishmania major proteasome beta 2 subunit, putative 0.0056 0.0236 0.2696
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0033 0.01 0.0542
Schistosoma mansoni calpain C (C02 family) 0.0042 0.0154 0.0835
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0043 0.0235
Leishmania major cytochrome p450-like protein 0.0018 0.0017 0.0121
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0162 0.0856 1
Brugia malayi proteasome subunit beta type 3 0.0033 0.01 0.0673
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0033 0.0103 0.073
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0151 0.0819
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0033 0.01 0.0696
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0043 0.0426
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0126 0.0648 0.3515
Plasmodium falciparum thioredoxin reductase 0.0048 0.019 0.2157
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0007 0.0048
Plasmodium vivax proteasome subunit beta type-2, putative 0.0056 0.0236 0.2696
Brugia malayi Importin beta-1 subunit 0.0031 0.0091 0.0614
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0056 0.0236 0.2696
Brugia malayi proteasome subunit alpha type 3 0.0033 0.01 0.0673
Echinococcus granulosus proteasome subunit beta type 6 0.0033 0.01 0.0542
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0471 0.3175
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0212 0.2413
Schistosoma mansoni patched 1 0.0041 0.0151 0.0819
Leishmania major proteasome beta-1 subunit, putative 0.0033 0.01 0.1093
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0212 0.0468
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0033 0.01 0.1093
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0549 0.0542
Loa Loa (eye worm) hypothetical protein 0.0082 0.0386 0.2095
Plasmodium falciparum proteasome subunit beta type-1, putative 0.008 0.0377 0.4359
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0154 0.173
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0033 0.01 0.022
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0017 0.001
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0033 0.01 0.1093
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0017 0.0095
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0017 0.001
Brugia malayi Thioredoxin reductase 0.0048 0.019 0.1281
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0017 0.0121
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0033 0.01 0.1093
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.019 0.2157
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.4531 1
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0033 0.01 0.0542
Giardia lamblia Proteasome subunit beta type 1 0.008 0.0377 0.4359
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0194 0.1309
Loa Loa (eye worm) hypothetical protein 0.0096 0.0471 0.2557
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0091 0.0989
Loa Loa (eye worm) hypothetical protein 0.027 0.1484 0.8055
Echinococcus granulosus proteasome prosome macropain 0.0162 0.0856 0.4645
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0194 0.1309
Echinococcus multilocularis 0.0018 0.0017 0.0038
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0043 0.0096
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0331 0.1842 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0471 0.104
Echinococcus granulosus calpain A 0.0042 0.0154 0.0835
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0116 0.0586 0.3179
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0162 0.0856 1
Echinococcus granulosus calpain 7 C02 family 0.0042 0.0154 0.0835
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0033 0.01 0.1093
Loa Loa (eye worm) cytochrome P450 family protein 0.0078 0.0367 0.199
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.019 0.042
Echinococcus granulosus importin subunit beta 1 0.0031 0.0091 0.0495
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0212 0.2413
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0033 0.01 0.1093
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0056 0.0236 0.2696
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0033 0.01 0.1093
Plasmodium vivax proteasome subunit beta type-3, putative 0.0033 0.01 0.1093
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0033 0.01 0.1093
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0033 0.01 0.0542
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0033 0.01 0.1093
Brugia malayi calpain family protein 1 0.0111 0.0556 0.375
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0033 0.01 0.0542
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0017 0.001
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0043 0.0292
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0017 0.001
Leishmania major cytochrome p450-like protein 0.0036 0.0123 0.1362
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0151 0.0819
Brugia malayi Cytochrome P450 family protein 0.0078 0.0367 0.247
Echinococcus granulosus expressed conserved protein 0.009 0.0437 0.2373
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.062 0.0604
Brugia malayi hypothetical protein 0.0041 0.015 0.1008
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0033 0.01 0.1093
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.062 0.0613
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0033 0.01 0.0696
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0033 0.01 0.0696
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0017 0.0121
Giardia lamblia 20S proteasome alpha subunit 4 0.0033 0.01 0.1093
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0043 0.0426
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.008 0.0377 0.4359
Brugia malayi hypothetical protein 0.027 0.1484 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0017 0.001
Toxoplasma gondii proteasome subunit alpha type, putative 0.0033 0.01 0.1093
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.005 0.0203 0.0196
Trypanosoma cruzi oligopeptidase b 0.005 0.0203 0.2312
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0033 0.01 0.1093
Loa Loa (eye worm) hypothetical protein 0.0051 0.0205 0.1113
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0033 0.01 0.1093
Schistosoma mansoni calpain-7 (C02 family) 0.0042 0.0154 0.0835
Leishmania major proteasome beta 2 subunit, putative 0.0033 0.01 0.1093
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0772
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0162 0.0856 0.084
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0017 0.001
Brugia malayi Proteasome subunit alpha type 7-1 0.0033 0.01 0.0673
Toxoplasma gondii proteasome beta subunit 0.0033 0.01 0.1093
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0154 0.173
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0033 0.01 0.1093
Trypanosoma cruzi oligopeptidase b 0.005 0.0203 0.2312
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0033 0.01 0.0696
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0033 0.01 0.1093
Echinococcus multilocularis proteasome (prosome, macropain) 0.0162 0.0856 0.1888
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0033 0.01 0.1093
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0212 0.115
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0043 0.0426
Plasmodium vivax importin-beta 2, putative 0.0031 0.0091 0.0989
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0033 0.01 0.0542
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0056 0.0236 0.1281
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0033 0.01 0.1093
Brugia malayi prolyl oligopeptidase family protein 0.0126 0.0648 0.4363
Entamoeba histolytica hypothetical protein 0.0025 0.0057 0.0167
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0033 0.01 0.022
Trichomonas vaginalis ran, putative 0.0023 0.0043 0.0426
Brugia malayi Proteasome A-type and B-type family protein 0.0033 0.01 0.0673
Brugia malayi calpain family protein 1 0.0111 0.0556 0.375
Entamoeba histolytica hypothetical protein 0.0041 0.015 0.1308
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0033 0.01 0.1093
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0042 0.0154 0.173
Echinococcus multilocularis hypothetical protein 0.0042 0.0154 0.034
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0017 0.001
Brugia malayi MAP kinase sur-1 0.0052 0.0212 0.1428
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0033 0.01 0.0542
Brugia malayi Cytochrome P450 family protein 0.0036 0.0123 0.0827
Giardia lamblia 20S proteasome alpha subunit 2 0.0033 0.01 0.1093
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0194 0.1054
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0033 0.01 0.0696
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0007 0.5
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0033 0.01 0.0542
Loa Loa (eye worm) proteasome subunit beta type 2 0.0056 0.0236 0.1281
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0596 0.3235
Echinococcus multilocularis protein patched 0.0041 0.0151 0.0333
Entamoeba histolytica hypothetical protein 0.0041 0.015 0.1308
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0212 0.115
Loa Loa (eye worm) hypothetical protein 0.0069 0.0313 0.1697
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0772
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0033 0.01 0.1093
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0033 0.01 0.1093
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0104 0.0703
Giardia lamblia 20S proteasome alpha subunit 3 0.0033 0.01 0.1093
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0033 0.01 0.1093
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0772
Toxoplasma gondii proteasome subunit alpha1, putative 0.0033 0.01 0.1093
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0212 0.2413
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0033 0.01 0.1093
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0212 0.2413
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0033 0.01 0.022
Toxoplasma gondii proteasome subunit 0.0033 0.01 0.1093
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0151 0.1694
Echinococcus multilocularis snurportin 1 0.0331 0.1842 0.4066
Loa Loa (eye worm) hypothetical protein 0.0049 0.0194 0.1054
Trypanosoma cruzi prolyl endopeptidase 0.0126 0.0648 0.7547
Echinococcus multilocularis calpain 0.0042 0.0154 0.034
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0017 0.001
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0017 0.001
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0212 0.2413
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0033 0.01 0.1093
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0111 0.0556 0.302
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0033 0.01 0.0542
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0017 0.001
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0033 0.01 0.1093
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0033 0.01 0.0542
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0113 0.057 0.0563
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0033 0.01 0.1093
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0056 0.0236 0.1281
Plasmodium vivax proteasome subunit beta type-7, putative 0.0033 0.01 0.1093
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0154 0.173
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0162 0.0856 1
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0033 0.01 0.0542
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0033 0.01 0.1093
Treponema pallidum NADH oxidase 0.0017 0.0007 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.015 0.033
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0116 0.0586 0.3179
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.005 0.0203 0.2312
Leishmania major importin beta-1 subunit, putative 0.0025 0.0057 0.0586
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.019 0.1032
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0033 0.01 0.0696
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0033 0.01 0.1093
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0126 0.0648 0.7547
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0154 0.173
Echinococcus granulosus calpain 5 0.0042 0.0154 0.0835
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.005 0.0203 0.0186
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0017 0.001
Plasmodium falciparum glutathione reductase 0.0048 0.019 0.2157
Entamoeba histolytica calpain large subunit domain III containing protein 0.0029 0.0081 0.0459
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0043 0.0426
Plasmodium vivax glutathione reductase, putative 0.0048 0.019 0.2157
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0043 0.0426
Brugia malayi Proteasome A-type and B-type family protein 0.0033 0.01 0.0673
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.019 0.0183
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0033 0.01 0.0696
Loa Loa (eye worm) hypothetical protein 0.0126 0.0648 0.3515
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0126 0.0648 0.3515
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0033 0.01 0.1093
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0212 0.115
Leishmania major proteasome alpha 7 subunit, putative 0.0033 0.01 0.1093
Schistosoma mansoni hypothetical protein 0.0033 0.0104 0.0566
Giardia lamblia 20S proteasome alpha subunit 1 0.0033 0.01 0.1093
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0017 0.001
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0033 0.01 0.1093
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0033 0.01 0.1093
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0017 0.001
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0056 0.0236 0.2696
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0017 0.001
Schistosoma mansoni hypothetical protein 0.0331 0.1842 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0017 0.001
Leishmania major proteasome alpha 3 subunit, putative 0.0033 0.01 0.1093
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0033 0.01 0.0542
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0057 0.0586
Echinococcus multilocularis calpain A 0.0116 0.0586 0.1293
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0033 0.01 0.0542
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0712 0.3864
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0017 0.0121
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0033 0.01 0.0696
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0033 0.01 0.1093
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0017 0.001
Leishmania major cytochrome p450-like protein 0.0018 0.0017 0.0121
Trypanosoma brucei trypanothione reductase 0.0048 0.019 0.2157
Leishmania major proteasome alpha 7 subunit, putative 0.0033 0.01 0.1093
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0116 0.0586 0.3179
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0033 0.01 0.1093
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0033 0.01 0.1093
Schistosoma mansoni hypothetical protein 0.0018 0.0017 0.0095
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0033 0.01 0.1093
Echinococcus granulosus survival motor neuron protein 1 0.027 0.1484 0.8055
Loa Loa (eye worm) hypothetical protein 0.0111 0.0556 0.302
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0033 0.01 0.0542
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0162 0.0856 0.0849
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0017 0.001
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0033 0.01 0.1093
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0017 0.001
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0017 0.0121
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0116 0.0586 0.1293
Leishmania major GTP-binding protein, putative 0.0023 0.0043 0.0426
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0017 0.001
Echinococcus granulosus Proteasome subunit alpha beta 0.0033 0.01 0.0542
Schistosoma mansoni calpain-7 (C02 family) 0.0042 0.0154 0.0835
Trypanosoma brucei oligopeptidase b 0.005 0.0203 0.2312
Leishmania major proteasome beta 7 subunit, putative 0.0033 0.01 0.1093
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0123 0.1362
Loa Loa (eye worm) cytochrome P450 0.0018 0.0017 0.0095
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0017 0.001
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0033 0.01 0.1093
Toxoplasma gondii thioredoxin reductase 0.0048 0.019 0.2157
Echinococcus granulosus Proteasome subunit alpha type 7 0.0033 0.01 0.0542
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0043 0.0426
Echinococcus granulosus proteasome subunit beta type 7 0.0033 0.01 0.0542
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0091 0.0989
Plasmodium vivax proteasome subunit beta type-5, putative 0.0162 0.0856 1
Trypanosoma brucei antigen, putative 0.0042 0.0154 0.173
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0007 0.0039
Schistosoma mansoni cytochrome P450 0.0018 0.0017 0.0095
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0212 0.0468
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0033 0.01 0.1093
Entamoeba histolytica hypothetical protein 0.0041 0.015 0.1308
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0017 0.001
Leishmania major kinesin, putative 0.0029 0.0081 0.0866
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0056 0.0236 0.2696
Loa Loa (eye worm) calpain 5 0.0029 0.0081 0.0438
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0212 0.2413
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0162 0.0856 1
Plasmodium falciparum proteasome subunit beta type-4 0.0033 0.01 0.1093
Leishmania major proteasome alpha 1 subunit, putative 0.0033 0.01 0.1093
Trypanosoma cruzi kinesin, putative 0.0029 0.0081 0.0866
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0154 0.173
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0033 0.01 0.1093
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0017 0.001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.0495
Loa Loa (eye worm) glutathione reductase 0.0048 0.019 0.1032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0033 0.01 0.0542
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0091 0.0989
Giardia lamblia 20S proteasome alpha subunit 6 0.0033 0.01 0.1093
Loa Loa (eye worm) proteasome subunit beta type 3 0.0033 0.01 0.0542
Mycobacterium tuberculosis Probable reductase 0.011 0.0549 0.0542
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0017 0.001
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0017 0.001
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0033 0.01 0.1093
Echinococcus multilocularis calpain family protein 1, d 0.0082 0.0386 0.0852
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0033 0.01 0.0696
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0033 0.01 0.1093
Trypanosoma brucei prolyl endopeptidase 0.0126 0.0648 0.7547
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0212 0.2413
Echinococcus granulosus prolyl endopeptidase 0.0126 0.0648 0.3515
Brugia malayi proteasome subunit beta type 2 0.0056 0.0236 0.159
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0123 0.1362
Leishmania major proteasome beta 3 subunit, putative 0.0033 0.01 0.1093
Brugia malayi Proteasome A-type and B-type family protein 0.0162 0.0856 0.5766
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0033 0.01 0.0542
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0212 0.2413
Onchocerca volvulus 0.0055 0.0231 0.2397
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0033 0.01 0.0696
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.019 0.1032
Echinococcus granulosus calpain 0.0042 0.0154 0.0835
Loa Loa (eye worm) calpain 0.0042 0.0154 0.0835
Echinococcus multilocularis protein dispatched 1 0.0047 0.0185 0.0408
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0549 0.0542
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0033 0.01 0.1093
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0212 0.2413
Trypanosoma cruzi kinesin, putative 0.0029 0.0081 0.0866
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0091 0.0201
Schistosoma mansoni calpain (C02 family) 0.0042 0.0154 0.0835
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0162 0.0856 1
Entamoeba histolytica hypothetical protein 0.0041 0.015 0.1308
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0033 0.01 0.0542
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0033 0.01 0.1093
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0151 0.0819
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0212 0.2413
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0154 0.173
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0033 0.01 0.1093
Giardia lamblia 20S proteasome alpha subunit 7 0.0033 0.01 0.1093
Echinococcus granulosus proteasome subunit beta t family 0.0033 0.01 0.0542
Brugia malayi calpain 5 0.0029 0.0081 0.0543
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0033 0.01 0.022
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0033 0.01 0.1093
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0056 0.0236 0.0521
Entamoeba histolytica proteasome subunit beta type 1, putative 0.008 0.0377 0.4108
Echinococcus multilocularis proteasome subunit alpha type 6 0.0033 0.01 0.022
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.005 0.0203 0.2312
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0033 0.01 0.1093

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.81 nM Antitumor activity against mouse P388 cells ChEMBL. 18197599
ED50 (functional) = 0.81 nM Antitumor activity against mouse P388 cells ChEMBL. 18197599

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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