Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.114 | 0.1767 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0769 | 0.1191 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.01 | 0.3256 | 0.5046 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0769 | 0.1191 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0522 | 0.081 |
Schistosoma mansoni | beta-galactosidase | 0.0091 | 0.2913 | 0.4514 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0039 | 0.0906 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0522 | 0.1604 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.114 | 0.1767 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 0.2148 | 0.5283 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.01 | 0.3256 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0039 | 0.0906 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0522 | 0.0522 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.0906 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.2913 | 0.2913 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1296 | 0.3981 |
Giardia lamblia | Kinase, CMGC MAPK | 0.01 | 0.3256 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.0906 | 0.1404 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0071 | 0.2148 | 0.3328 |
Schistosoma mansoni | serine/threonine protein kinase | 0.01 | 0.3256 | 0.5046 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 0.2148 | 0.5283 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0696 | 0.1079 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.114 | 0.1767 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0522 | 0.0522 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1296 | 0.1296 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.114 | 0.1767 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.01 | 0.3256 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.114 | 0.114 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1296 | 0.3981 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0522 | 0.1604 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.01 | 0.3256 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0039 | 0.0906 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.6453 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0041 | 0.099 | 0.1535 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.0906 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.114 | 0.3501 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0071 | 0.2148 | 0.6595 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0039 | 0.0906 | 0.0906 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.01 | 0.3256 | 0.3256 |
Onchocerca volvulus | 0.0029 | 0.0522 | 0.5 | |
Echinococcus multilocularis | beta galactosidase | 0.0091 | 0.2913 | 0.4514 |
Brugia malayi | MAP kinase sur-1 | 0.01 | 0.3256 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0039 | 0.0906 | 0.0996 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0522 | 0.081 |
Trypanosoma brucei | protein kinase, putative | 0.01 | 0.3256 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0522 | 0.081 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1296 | 0.1296 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.114 | 0.1767 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0039 | 0.0906 | 0.2782 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0071 | 0.2148 | 0.5283 |
Trichomonas vaginalis | CMGC family protein kinase | 0.01 | 0.3256 | 1 |
Echinococcus granulosus | lamin | 0.0029 | 0.0522 | 0.081 |
Echinococcus granulosus | beta galactosidase | 0.0091 | 0.2913 | 0.4514 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.6453 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0769 | 0.1191 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.01 | 0.3256 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0039 | 0.0906 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0039 | 0.0906 | 0.1404 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.01 | 0.3256 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.01 | 0.3256 | 0.5046 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.01 | 0.3256 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.114 | 0.1767 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0071 | 0.2148 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 0.2148 | 0.5283 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0696 | 0.0696 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0522 | 0.081 |
Echinococcus granulosus | geminin | 0.0183 | 0.6453 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0071 | 0.2148 | 0.3328 |
Trichomonas vaginalis | CMGC family protein kinase | 0.01 | 0.3256 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0769 | 0.1191 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.0001 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0502 | 0.0502 |
Schistosoma mansoni | lamin | 0.0029 | 0.0522 | 0.081 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.01 | 0.3256 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0071 | 0.2148 | 0.2148 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0001 | 0.0001 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0696 | 0.2139 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0039 | 0.0906 | 0.1404 |
Echinococcus granulosus | mitogen activated protein kinase | 0.01 | 0.3256 | 0.5046 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.01 | 0.3256 | 0.5046 |
Trichomonas vaginalis | CMGC family protein kinase | 0.01 | 0.3256 | 1 |
Echinococcus multilocularis | geminin | 0.0183 | 0.6453 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.01 | 0.3256 | 1 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0522 | 0.081 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0522 | 0.081 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0522 | 0.0522 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0071 | 0.2148 | 0.3328 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.114 | 0.1767 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.01 | 0.3256 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0041 | 0.099 | 0.1535 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.0906 | 0.1404 |
Onchocerca volvulus | 0.0029 | 0.0522 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0036 | 0.0769 | 0.236 |
Schistosoma mansoni | lamin | 0.0029 | 0.0522 | 0.081 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | ND 0 % | Inhibition of passive cutaneous anaphylaxis in male Sprague-Dawley rats following 3 mg/kg p.o. administration; No data. | ChEMBL. | 6137568 |
Inhibition (functional) | ND 0 % | Antiallergic activity against passive cutaneous anaphylaxis (PCA) in male Sprague-Dawley rats (10 mg/kg oral administration) | ChEMBL. | 6137568 |
Inhibition (functional) | = 14 % | Antiallergic activity against passive cutaneous anaphylaxis(PCA) in male Sprague-Dawley rats after 0.3 mg/kg oral administration;p<0.1 | ChEMBL. | 6137568 |
Inhibition (functional) | = 39 % | Inhibition of passive cutaneous anaphylaxis in male Sprague-Dawley rats following 1 mg/kg p.o. administration; Not significant. | ChEMBL. | 6137568 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.