Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0091 | 0.0453 | 0.0409 |
Echinococcus granulosus | geminin | 0.0178 | 0.1429 | 0.1389 |
Echinococcus multilocularis | sodium:potassium transporting ATPase subunit | 0.0206 | 0.1738 | 0.17 |
Echinococcus granulosus | hypothetical protein | 0.079 | 0.831 | 0.8302 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0063 | 0.0132 | 0.0086 |
Onchocerca volvulus | 0.0126 | 0.0847 | 0.1637 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0091 | 0.0453 | 0.0409 |
Brugia malayi | Pre-SET motif family protein | 0.023 | 0.2015 | 0.3668 |
Brugia malayi | mbt repeat family protein | 0.0055 | 0.0046 | 0.0083 |
Brugia malayi | mbt repeat family protein | 0.0055 | 0.0046 | 0.0083 |
Brugia malayi | hypothetical protein | 0.0172 | 0.1355 | 0.2466 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0425 | 0.074 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.051 | 0.5165 | 0.5143 |
Schistosoma mansoni | hypothetical protein | 0.0336 | 0.32 | 0.4145 |
Echinococcus multilocularis | Protein lozenge | 0.0062 | 0.0116 | 0.0071 |
Onchocerca volvulus | 0.0206 | 0.1738 | 0.346 | |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.1352 | 0.2552 |
Brugia malayi | hypothetical protein | 0.0129 | 0.0874 | 0.159 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.1429 | 0.1851 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0158 | 0.1205 | 0.2265 |
Echinococcus granulosus | nervana 2 | 0.0206 | 0.1738 | 0.17 |
Schistosoma mansoni | survival motor neuron protein | 0.0104 | 0.0595 | 0.0771 |
Brugia malayi | hypothetical protein | 0.051 | 0.5165 | 0.9401 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0063 | 0.0132 | 0.024 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0206 | 0.1738 | 0.17 |
Loa Loa (eye worm) | hypothetical protein | 0.049 | 0.4938 | 0.9557 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.0804 | 0.8463 | 0.5 |
Onchocerca volvulus | 0.0104 | 0.0595 | 0.1124 | |
Brugia malayi | hypoxia-induced factor 1 | 0.0158 | 0.1205 | 0.2194 |
Echinococcus granulosus | nervana 2 | 0.0126 | 0.0847 | 0.0805 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0104 | 0.0595 | 0.1084 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0738 | 0.772 | 0.771 |
Schistosoma mansoni | transmemberane protein | 0.0206 | 0.1738 | 0.2252 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.0595 | 0.0771 |
Echinococcus granulosus | nervana 2 | 0.0126 | 0.0847 | 0.0805 |
Echinococcus granulosus | sodium:potassium transporting ATPase subunit | 0.0206 | 0.1738 | 0.17 |
Schistosoma mansoni | sodium / potassium ATPase beta chain | 0.0126 | 0.0847 | 0.1097 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0361 | 0.3482 | 0.6338 |
Brugia malayi | bZIP transcription factor family protein | 0.0091 | 0.0453 | 0.0824 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0055 | 0.0046 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1738 | 0.3306 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0126 | 0.0847 | 0.1097 |
Loa Loa (eye worm) | hypothetical protein | 0.051 | 0.5165 | 1 |
Echinococcus granulosus | nervana 2 | 0.0206 | 0.1738 | 0.17 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0063 | 0.0132 | 0.0171 |
Echinococcus multilocularis | geminin | 0.0178 | 0.1429 | 0.1389 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0126 | 0.0847 | 0.0805 |
Echinococcus multilocularis | serotonin receptor | 0.0171 | 0.1352 | 0.1312 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0874 | 0.1617 |
Brugia malayi | Serotonin receptor | 0.054 | 0.5494 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.1429 | 0.1851 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0126 | 0.0847 | 0.0805 |
Echinococcus multilocularis | nervana 2 | 0.0126 | 0.0847 | 0.0805 |
Onchocerca volvulus | 0.049 | 0.4938 | 1 | |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0206 | 0.1738 | 0.2252 |
Echinococcus multilocularis | serotonin receptor | 0.0171 | 0.1352 | 0.1312 |
Schistosoma mansoni | amine GPCR | 0.0399 | 0.3917 | 0.5073 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0055 | 0.0046 | 0.0059 |
Echinococcus multilocularis | jun protein | 0.0091 | 0.0453 | 0.0409 |
Echinococcus granulosus | jun protein | 0.0091 | 0.0453 | 0.0409 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0171 | 0.1352 | 0.1751 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.051 | 0.5165 | 0.5143 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0206 | 0.1738 | 0.17 |
Brugia malayi | hypothetical protein | 0.049 | 0.4938 | 0.8988 |
Trichomonas vaginalis | set domain proteins, putative | 0.0262 | 0.2373 | 0.5 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0218 | 0.1872 | 0.1835 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0206 | 0.1738 | 0.17 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0218 | 0.1872 | 0.1835 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.023 | 0.2015 | 0.3847 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0063 | 0.0132 | 0.0086 |
Mycobacterium ulcerans | proteasome PrcA | 0.0804 | 0.8463 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0129 | 0.0874 | 0.1692 |
Echinococcus multilocularis | nervana 2 | 0.0126 | 0.0847 | 0.0805 |
Loa Loa (eye worm) | MBCTL1 | 0.0063 | 0.0132 | 0.0168 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0738 | 0.772 | 0.771 |
Echinococcus multilocularis | nervana 2 | 0.0206 | 0.1738 | 0.17 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.1355 | 0.2557 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0361 | 0.3482 | 0.4511 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.026 | 0.0337 |
Onchocerca volvulus | 0.0262 | 0.2373 | 0.4757 | |
Schistosoma mansoni | sex comb on midleg homolog | 0.0055 | 0.0046 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.3482 | 0.6713 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0036 | 0.0047 |
Schistosoma mansoni | lozenge | 0.0062 | 0.0116 | 0.0151 |
Onchocerca volvulus | Huntingtin homolog | 0.0129 | 0.0874 | 0.1692 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0751 | 0.7874 | 0.7864 |
Loa Loa (eye worm) | runx1 | 0.0062 | 0.0116 | 0.0138 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.094 | 1 | 1 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0063 | 0.0132 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.1352 | 0.2552 |
Mycobacterium leprae | probable proteasome (alpha subunit) PrcA | 0.0804 | 0.8463 | 0.5 |
Brugia malayi | hypothetical protein | 0.0072 | 0.0232 | 0.0422 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0132 | 0.0168 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0738 | 0.772 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.049 | 0.4938 | 0.9557 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0206 | 0.1738 | 0.2252 |
Echinococcus multilocularis | nervana 2 | 0.0206 | 0.1738 | 0.17 |
Onchocerca volvulus | 0.0072 | 0.0232 | 0.0381 | |
Schistosoma mansoni | jun-related protein | 0.0074 | 0.026 | 0.0337 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0874 | 0.1617 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0171 | 0.1352 | 0.1312 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1738 | 0.3306 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0206 | 0.1738 | 0.17 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.3482 | 0.6713 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0063 | 0.0132 | 0.0086 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.8 uM | Agonist activity at human sensory neuron-specific G-protein coupled receptor (unknown origin) expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR | ChEMBL. | 18163586 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.