Detailed information for compound 508184

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 296.445 | Formula: C18H32O3
  • H donors: 1 H acceptors: 3 LogP: 5.05 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCC(=O)CC/C=C/CCCCCCC(=O)O
  • InChi: 1S/C18H32O3/c1-2-3-4-11-14-17(19)15-12-9-7-5-6-8-10-13-16-18(20)21/h7,9H,2-6,8,10-16H2,1H3,(H,20,21)/b9-7+
  • InChiKey: QAWDFAKVVKKSPM-VQHVLOKHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus para nitrobenzyl esterase 0.0039 0.0289 0.1129
Mycobacterium ulcerans hypothetical protein 0.0019 0.0049 0.0605
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0039 0.0289 0.0848
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0457 0.5063
Echinococcus granulosus GPCR family 2 0.0033 0.0209 0.0817
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0628 0.6962
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0039 0.0289 0.1129
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0526 0.2059
Loa Loa (eye worm) hypothetical protein 0.0234 0.2556 0.9781
Mycobacterium ulcerans membrane protein ComEA 0.0019 0.0048 0.0585
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0111 0.1128 0.2501
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0064 0.0059
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0092 0.0902 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0309 0.1209
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.0085 0.0815 0.3189
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.1032 0.395
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.044 0.1721
Leishmania major cathepsin L-like protease 0.0069 0.0628 0.6962
Echinococcus multilocularis neuroligin 0.0039 0.0289 0.0289
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0565 0.2212
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0189 0.0721
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0024 0.0024
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0189 0.0721
Echinococcus granulosus lamin 0.0031 0.0189 0.0738
Schistosoma mansoni intermediate filament proteins 0.0031 0.0189 0.0738
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0558 0.6192
Brugia malayi CAAX amino terminal protease family protein 0.0092 0.0902 0.3452
Schistosoma mansoni ap endonuclease 0.002 0.0064 0.0249
Brugia malayi Carboxylesterase family protein 0.0039 0.0289 0.1104
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0227 0.0227
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0533 0.0533
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0024 0.0457
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0309 0.0309
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0533 0.6539
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0024 0.027
Brugia malayi NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor 0.0085 0.0815 0.3119
Loa Loa (eye worm) hypothetical protein 0.0122 0.1251 0.4786
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0526 0.6458
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.044 0.1683
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0024 0.027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0628 0.6962
Giardia lamblia Hypothetical protein 0.0092 0.0902 0.1934
Echinococcus granulosus CAAX prenyl protease 2 0.0092 0.0902 0.3529
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.044 0.1721
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0064 1
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0038 0.0417
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0024 0.0024
Chlamydia trachomatis hypothetical protein 0.0019 0.0049 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0209 0.0209
Echinococcus granulosus neuroligin 0.0039 0.0289 0.1129
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0038 0.0038
Brugia malayi Cathepsin L-like precursor 0.0018 0.0038 0.0144
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.044 0.044
Loa Loa (eye worm) ctsf protein 0.0018 0.0038 0.0144
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0092 0.0902 0.3529
Toxoplasma gondii cathepsin CPL 0.0018 0.0038 0.0706
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0227 0.0889
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0039 0.0289 0.3541
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0107 0.0408
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0227 0.4262
Echinococcus multilocularis para nitrobenzyl esterase 0.0039 0.0289 0.0289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0628 0.6962
Onchocerca volvulus 0.0272 0.2998 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0038 0.0144
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0651 0.2491
Onchocerca volvulus 0.0039 0.0289 0.0848
Schistosoma mansoni hypothetical protein 0.0033 0.0209 0.0817
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0092 0.0902 0.3529
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.0085 0.0815 0.9036
Leishmania major hypothetical protein, conserved 0.0017 0.0024 0.027
Brugia malayi Carboxylesterase family protein 0.0039 0.0289 0.1104
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0024 0.0095
Schistosoma mansoni hypothetical protein 0.0033 0.0209 0.0817
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0039 0.0289 0.1129
Brugia malayi Carboxylesterase family protein 0.0234 0.2556 0.9781
Onchocerca volvulus 0.0095 0.0932 0.3023
Entamoeba histolytica hypothetical protein 0.0041 0.0309 0.0623
Entamoeba histolytica hypothetical protein 0.0111 0.1128 0.2501
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0212 0.0831
Echinococcus multilocularis acetylcholinesterase 0.0234 0.2556 0.2556
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0209 0.0799
Brugia malayi intermediate filament protein 0.0031 0.0189 0.0721
Loa Loa (eye worm) hypothetical protein 0.0031 0.0189 0.0721
Brugia malayi hypothetical protein 0.0039 0.0289 0.1104
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0526 0.0526
Echinococcus granulosus intermediate filament protein 0.0031 0.0189 0.0738
Entamoeba histolytica hypothetical protein 0.0041 0.0309 0.0623
Echinococcus multilocularis lamin 0.0031 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0039 0.0289 0.1104
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0107 0.1309
Loa Loa (eye worm) carboxylesterase 0.0039 0.0289 0.1104
Plasmodium falciparum protease, putative 0.0019 0.0049 0.6364
Onchocerca volvulus Huntingtin homolog 0.0122 0.1251 0.4098
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0526 0.6458
Brugia malayi jmjC domain containing protein 0.0063 0.0565 0.2164
Giardia lamblia DNA repair protein RAD52 0.0392 0.4398 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.044 0.1721
Trichomonas vaginalis set domain proteins, putative 0.0272 0.2998 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0209 0.0799
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0565 0.2212
Onchocerca volvulus NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog 0.0045 0.0357 0.1078
Onchocerca volvulus 0.0039 0.0289 0.0848
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0565 0.2212
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0024 0.0024
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0526 0.6458
Loa Loa (eye worm) fibroinase 0.0018 0.0038 0.0144
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) 0.0085 0.0815 1
Entamoeba histolytica hypothetical protein 0.0041 0.0309 0.0623
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.0085 0.0815 0.9036
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0024 0.0093
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0565 0.2212
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0024 0.0095
Entamoeba histolytica CAAX amino terminal protease family 0.0019 0.0049 0.0027
Echinococcus granulosus acetylcholinesterase 0.0234 0.2556 1
Echinococcus granulosus acetylcholinesterase 0.0234 0.2556 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0038 0.0144
Trypanosoma brucei CAAX amino terminal protease, putative 0.0092 0.0902 1
Echinococcus granulosus cathepsin l1 0.0018 0.0038 0.0147
Brugia malayi Cytochrome P450 family protein 0.0024 0.0107 0.0408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0628 0.6962
Brugia malayi Cytochrome P450 family protein 0.0024 0.0107 0.0408
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0024 0.027
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0021 0.008
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0209 0.0799
Mycobacterium ulcerans carboxylesterase, LipT 0.0039 0.0289 0.3541
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0533 0.2085
Loa Loa (eye worm) hypothetical protein 0.0039 0.0289 0.1104
Brugia malayi Pre-SET motif family protein 0.0239 0.2613 1
Toxoplasma gondii exonuclease III APE 0.002 0.0064 0.1192
Leishmania major cathepsin L-like protease 0.0018 0.0038 0.0417
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0209 0.0817
Loa Loa (eye worm) hypothetical protein 0.0095 0.0932 0.3569
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0039 0.0289 0.1129
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0565 0.2212
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0064 0.0704
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0019 0.0049 0.0605
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0227 0.0889
Brugia malayi Carboxylesterase family protein 0.0039 0.0289 0.1104
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0024 0.0095
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0526 0.2014
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0526 0.2059
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0064 0.1932
Brugia malayi jmjC domain containing protein 0.0017 0.0024 0.0093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0093
Brugia malayi Cathepsin L-like precursor 0.0018 0.0038 0.0144
Brugia malayi Carboxylesterase family protein 0.0039 0.0289 0.1104
Schistosoma mansoni gliotactin 0.0039 0.0289 0.1129
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.0085 0.0815 1
Echinococcus multilocularis acetylcholinesterase 0.0234 0.2556 0.2556
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0002 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0227 0.0889
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0189 0.0721
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0628 0.6962
Schistosoma mansoni lamin 0.0031 0.0189 0.0738
Schistosoma mansoni lamin 0.0031 0.0189 0.0738
Toxoplasma gondii hypothetical protein 0.0019 0.0049 0.0925
Echinococcus granulosus carboxylesterase 5A 0.0234 0.2556 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0093
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0039 0.0289 0.3541
Loa Loa (eye worm) hypothetical protein 0.0034 0.0227 0.0869
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.044 0.044
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0533 0.6539
Brugia malayi Trypsin family protein 0.0095 0.0932 0.3569
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0234 0.2556 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0064 0.0704
Plasmodium vivax vivapain-2 0.0018 0.0038 0.0656
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.0085 0.0815 0.0815
Echinococcus multilocularis cysteine protease 0.0018 0.0038 0.0038
Echinococcus granulosus BC026374 protein S09 family 0.0039 0.0289 0.1129
Schistosoma mansoni neuroligin 3 (S09 family) 0.0039 0.0289 0.1129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0628 0.6962
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0024 0.0457
Leishmania major cathepsin L-like protease 0.0018 0.0038 0.0417
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0064 0.0243
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0533 0.6539
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0085 0.0815 0.9036
Schistosoma mansoni ap endonuclease 0.002 0.0064 0.0249
Loa Loa (eye worm) carboxylesterase 0.0234 0.2556 0.9781
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0565 0.0565
Echinococcus multilocularis lamin dm0 0.0031 0.0189 0.0189
Echinococcus granulosus phd:f box containing protein 0.0017 0.0024 0.0095
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.1032 0.395
Onchocerca volvulus 0.0039 0.0289 0.0848
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0064 0.0249
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0019 0.0049 0.0605
Leishmania major cathepsin L-like protease 0.0018 0.0038 0.0417
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0064 0.0087
Mycobacterium ulcerans integral membrane protein 0.0019 0.0049 0.0605
Echinococcus multilocularis musashi 0.0031 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0007
Mycobacterium tuberculosis Carboxylesterase LipT 0.0039 0.0289 0.3541
Toxoplasma gondii hypothetical protein 0.0019 0.0049 0.0925
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.2613 1
Onchocerca volvulus 0.0031 0.0189 0.051
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0092 0.0902 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0024 0.0093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.044 0.1721
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0038 0.0038
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0092 0.0902 0.292
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0039 0.0289 0.1129
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0565 0.0565
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0085 0.0815 0.2626
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0533 0.2085
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0232 0.0889
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0038 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0227 0.0889
Treponema pallidum hypothetical protein 0.0019 0.0049 0.102
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0533 0.2085
Loa Loa (eye worm) hypothetical protein 0.0039 0.0289 0.1104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0628 0.6962
Schistosoma mansoni hypothetical protein 0.0071 0.0651 0.2547
Mycobacterium tuberculosis Probable integral membrane protein 0.0019 0.0049 0.0605
Loa Loa (eye worm) hypothetical protein 0.0103 0.1032 0.395
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0565 0.2164
Leishmania major cathepsin L-like protease 0.0018 0.0038 0.0417
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0309 0.1209
Loa Loa (eye worm) hypothetical protein 0.003 0.0182 0.0696
Echinococcus multilocularis carboxylesterase 5A 0.0234 0.2556 0.2556
Plasmodium vivax protease, putative 0.0019 0.0049 0.123
Onchocerca volvulus 0.0031 0.0189 0.051
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0038 0.0144
Loa Loa (eye worm) hypothetical protein 0.0039 0.0289 0.1104
Onchocerca volvulus 0.0088 0.086 0.278
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0048 0.0585
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0526 0.5835
Brugia malayi hypothetical protein 0.0122 0.1251 0.4786
Mycobacterium leprae Conserved hypothetical protein 0.0015 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0095 0.0932 0.3569
Loa Loa (eye worm) carboxylesterase 0.0039 0.0289 0.1104
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0628 0.6962
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0227 0.0889
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0628 0.6962
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0024 0.0095
Loa Loa (eye worm) hypothetical protein 0.0039 0.0289 0.1104
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0024 0.0024
Loa Loa (eye worm) acetylcholinesterase 1 0.0234 0.2556 0.9781
Brugia malayi Pre-SET motif family protein 0.0034 0.0227 0.0869
Leishmania major cathepsin L-like protease 0.0069 0.0628 0.6962
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0064 0.0779
Brugia malayi Cathepsin L-like precursor 0.0018 0.0038 0.0144
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0092 0.0902 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0038 0.0147
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0085 0.0815 0.9036
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0107 0.1183
Leishmania major cathepsin L-like protease 0.0018 0.0038 0.0417
Trichomonas vaginalis spcc417.12 protein, putative 0.0039 0.0289 0.0848
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0533 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.1032 0.395
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0024 0.0024
Echinococcus multilocularis cysteine protease 0.0018 0.0038 0.0038
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0039 0.0289 0.1104
Loa Loa (eye worm) hypothetical protein 0.0092 0.0902 0.3452
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0024 0.0093
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0533 0.5909
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0209 0.0799
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0024 0.0095
Leishmania major cytochrome p450-like protein 0.0024 0.0107 0.1183
Schistosoma mansoni BC026374 protein (S09 family) 0.0039 0.0289 0.1129
Echinococcus granulosus lamin dm0 0.0031 0.0189 0.0738
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase I subunit F 0.0085 0.0815 1
Brugia malayi Cytochrome P450 family protein 0.0035 0.0232 0.0889
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0064 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0039 0.0289 0.0289
Onchocerca volvulus Huntingtin homolog 0.0122 0.1251 0.4098
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0533 0.6539
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0024 0.0095
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0038 0.3395
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0628 0.6962
Loa Loa (eye worm) hypothetical protein 0.0039 0.0289 0.1104
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0209 0.0209
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0085 0.0815 0.9036
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0064 0.0243
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0085 0.0815 0.2626
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0024 0.0095
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0038 0.0147
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0107 0.1183
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0038 0.0147
Onchocerca volvulus 0.0039 0.0289 0.0848
Brugia malayi jmjC domain containing protein 0.0017 0.0024 0.0093
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0392 0.4398 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0038 0.3395
Mycobacterium ulcerans hypothetical protein 0.0019 0.0049 0.0605
Plasmodium vivax vivapain-2 0.0018 0.0038 0.0656
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0064 0.0779
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.044 0.1683
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0122 0.1251 0.4786
Brugia malayi jmjC domain containing protein 0.0017 0.0024 0.0093
Echinococcus multilocularis GPCR, family 2 0.0033 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0093
Entamoeba histolytica hypothetical protein 0.0041 0.0309 0.0623
Schistosoma mansoni hypothetical protein 0.0033 0.0209 0.0817
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0064 0.0704
Onchocerca volvulus 0.0039 0.0289 0.0848
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0038 0.0144
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0209 0.0817
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0107 0.0408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0628 0.6962
Echinococcus multilocularis BC026374 protein (S09 family) 0.0039 0.0289 0.0289
Entamoeba histolytica CAAX prenyl protease family 0.0092 0.0902 0.1982
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0038 0.0038
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0038 0.3395
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0479 0.1834
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.044 0.1721
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0107 0.1183
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 51 kDa subunit 0.0085 0.0815 0.3119
Loa Loa (eye worm) hypothetical protein 0.0234 0.2556 0.9781
Mycobacterium leprae putative cytochrome p450 0.0015 0 0.5
Toxoplasma gondii CAAX amino terminal protease family protein 0.0019 0.0049 0.0925
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0064 0.0064
Loa Loa (eye worm) cysteine protease 0.0018 0.0038 0.0144
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0024 0.0095
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0064 0.0704
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0107 0.0408
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0021 0.008
Brugia malayi Cathepsin L-like precursor 0.0018 0.0038 0.0144
Onchocerca volvulus 0.0034 0.0227 0.064
Schistosoma mansoni acetylcholinesterase 0.0039 0.0289 0.1129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0628 0.6962
Schistosoma mansoni hypothetical protein 0.0041 0.0309 0.1209
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0085 0.0815 0.3189
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0932 0.3649
Brugia malayi Cathepsin L-like precursor 0.0018 0.0038 0.0144
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0038 0.0147
Leishmania major cathepsin L-like protease 0.0069 0.0628 0.6962
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0628 0.6962
Entamoeba histolytica CAAX amino terminal protease family 0.0019 0.0049 0.0027
Schistosoma mansoni hypothetical protein 0.0033 0.0209 0.0817
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0038 0.0417
Brugia malayi hypothetical protein 0.0041 0.0309 0.1183
Brugia malayi jmjC domain containing protein 0.0017 0.0024 0.0093
Brugia malayi Carboxylesterase family protein 0.0234 0.2556 0.9781
Plasmodium vivax SET domain protein, putative 0.0034 0.0227 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0628 0.6962
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0144
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0024 0.0095
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0049 0.0605
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0064 0.0087
Echinococcus multilocularis CAAX prenyl protease 2 0.0092 0.0902 0.0902
Loa Loa (eye worm) hypothetical protein 0.0071 0.0651 0.2491
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0628 0.6962
Brugia malayi jmjC domain containing protein 0.0063 0.0565 0.2164
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0932 0.3649

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Suppression of iNOS mRNA expression in mouse RAW264.7 cells ChEMBL. 18220352
IC50 (functional) < 33.8 uM Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by ELISA ChEMBL. 18220352
IC50 (functional) < 33.8 uM Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by ELISA ChEMBL. 18220352

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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