Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cpg binding protein | 0.0034 | 0.0648 | 0.0578 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0253 | 0.5481 | 0.5 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0253 | 0.5481 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0253 | 0.5481 | 0.5447 |
Echinococcus granulosus | cpg binding protein | 0.0034 | 0.0648 | 0.0578 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0608 | 0.0608 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0253 | 0.5481 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0032 | 0.0608 | 0.0918 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0253 | 0.5481 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0253 | 0.5481 | 0.5 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0253 | 0.5481 | 0.5 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0253 | 0.5481 | 0.5 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0253 | 0.5481 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0253 | 0.5481 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0458 | 1 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0032 | 0.0608 | 0.0913 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0068 | 0.1403 | 0.1403 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0253 | 0.5481 | 0.5481 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0157 | 0.3353 | 0.3353 |
Onchocerca volvulus | Huntingtin homolog | 0.0137 | 0.2924 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.2924 | 0.5232 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0458 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0253 | 0.5481 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0118 | 0.0044 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.0648 | 0.0648 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0157 | 0.3353 | 0.3353 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.2924 | 0.5232 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0253 | 0.5481 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0079 | 0.1651 | 0.2936 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0253 | 0.5481 | 0.5 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0253 | 0.5481 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0118 | 0.0044 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0253 | 0.5481 | 0.5447 |
Onchocerca volvulus | Huntingtin homolog | 0.0137 | 0.2924 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0253 | 0.5481 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0074 | 0.0074 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0157 | 0.3353 | 0.3353 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0253 | 0.5481 | 0.5 |
Brugia malayi | Adenosylhomocysteinase | 0.0253 | 0.5481 | 1 |
Brugia malayi | hypothetical protein | 0.0137 | 0.2924 | 0.5235 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0157 | 0.3353 | 0.3353 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.0648 | 0.0648 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | 0 | Toxicity in rabbit erythrocytes assessed as hemolysis at 0.01 uM to 100 uM | ChEMBL. | 18095653 |
IC50 (functional) | > 10 uM | Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay | ChEMBL. | 18095653 |
IC50 (functional) | > 10 uM | Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay | ChEMBL. | 18095653 |
IC50 (functional) | > 10 uM | Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay | ChEMBL. | 18095653 |
IC50 (functional) | > 10 uM | Cytotoxicity against human A549 cells after 96 hrs by MTT assay | ChEMBL. | 18095653 |
IC50 (functional) | > 10 uM | Cytotoxicity against human A2780 cells after 96 hrs by MTT assay | ChEMBL. | 18095653 |
IC50 (functional) | > 10 uM | Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay | ChEMBL. | 18095653 |
IC50 (functional) | > 10 uM | Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay | ChEMBL. | 18095653 |
IC50 (functional) | > 10 uM | Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay | ChEMBL. | 18095653 |
IC50 (functional) | > 10 uM | Cytotoxicity against human A549 cells after 96 hrs by MTT assay | ChEMBL. | 18095653 |
IC50 (functional) | > 10 uM | Cytotoxicity against human A2780 cells after 96 hrs by MTT assay | ChEMBL. | 18095653 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18095653 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.