Detailed information for compound 508345

Basic information

Technical information
  • TDR Targets ID: 508345
  • Name: 6-N-[2-[5-(diethylamino)pentan-2-ylamino]-6-m ethylpyrimidin-4-yl]-2-methylquinoline-4,6-di amine
  • MW: 421.582 | Formula: C24H35N7
  • H donors: 3 H acceptors: 3 LogP: 4.7 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCCC(Nc1nc(Nc2ccc3c(c2)c(N)cc(n3)C)cc(n1)C)C)CC
  • InChi: 1S/C24H35N7/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30)
  • InChiKey: DEFBCZWQLILOJF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N6-[2-[[4-(diethylamino)-1-methyl-butyl]amino]-6-methyl-pyrimidin-4-yl]-2-methyl-quinoline-4,6-diamine
  • N6-[2-[[4-(diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methylquinoline-4,6-diamine
  • N6-[2-[5-(diethylamino)pentan-2-ylamino]-6-methyl-pyrimidin-4-yl]-2-methyl-quinoline-4,6-diamine
  • 4-[[4-[(4-amino-2-methyl-6-quinolyl)amino]-6-methyl-pyrimidin-2-yl]amino]pentyl-diethyl-amine
  • NSC 23766
  • N'-[2-(5-diethylaminopentan-2-ylamino)-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine
  • N'-[2-[(4-diethylamino-1-methyl-butyl)amino]-6-methyl-pyrimidin-4-yl]-2-methyl-quinoline-4,6-diamine
  • N'-[2-[(4-diethylamino-1-methylbutyl)amino]-6-methyl-4-pyrimidinyl]-2-methylquinoline-4,6-diamine
  • N'-[2-(5-diethylaminopentan-2-ylamino)-6-methyl-pyrimidin-4-yl]-2-methyl-quinoline-4,6-diamine
  • SMP2_000232

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0059 0.0161 0.0471
Loa Loa (eye worm) hypothetical protein 0.0504 0.1777 0.519
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0188 0.0631 0.2329
Trichomonas vaginalis steroid dehydrogenase, putative 0.002 0.0019 0.0052
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0122 0.1569
Brugia malayi G protein-coupled receptor 0.0056 0.0151 0.0441
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0019 0.0052
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0019 0.0015 0.0043
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0056 0.0151 0.0441
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0202 0.0679 0.1982
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.076 0.2708 0.5212
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2324 0.8396 0.8396
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0019 0.0069
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.076 0.2708 0.5212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0086 0.03
Treponema pallidum oxidoreductase 0.0202 0.0679 0.2455
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0078 0.0216
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.002 0.0019 0.0036
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0018 0.0035
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0028 0.0046 0.0089
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0135
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0202 0.0679 0.2506
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0356 0.5116
Schistosoma mansoni short chain dehydrogenase 0.002 0.0019 0.0036
Loa Loa (eye worm) hypothetical protein 0.0123 0.0394 0.1149
Brugia malayi Carboxylesterase family protein 0.0059 0.0161 0.0471
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0168 0.0323
Echinococcus granulosus g protein coupled receptor 0.0056 0.0151 0.029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0151 0.029
Loa Loa (eye worm) carboxylesterase 0.0351 0.1223 0.3572
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0028 0.0054
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0104 0.0368
Brugia malayi Serotonin receptor 0.0056 0.0151 0.0441
Brugia malayi oxidoreductase 0.002 0.0019 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0051 0.0171
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.002 0.0019 0.0036
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0056 0.0151 0.0441
Echinococcus multilocularis neuropeptide receptor A26 0.0056 0.0151 0.029
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0167 0.0321
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0202 0.0679 0.1306
Brugia malayi hypothetical protein 0.0028 0.0046 0.0135
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.002 0.0019 0.0053
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Echinococcus granulosus Ankyrin 0.0031 0.0059 0.0113
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0056 0.0151 0.029
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0175 0.0511
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0151 0.0441
Echinococcus multilocularis sodium and chloride dependent glycine 0.0028 0.0046 0.0089
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.002 0.0019 0.0054
Trypanosoma cruzi short chain dehydrogenase, putative 0.002 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Onchocerca volvulus 0.0075 0.0219 0.1141
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0156 0.0455
Loa Loa (eye worm) hypothetical protein 0.0163 0.0539 0.1574
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0151 0.0441
Plasmodium vivax JmjC domain containing protein 0.0016 0.0005 0.001
Plasmodium vivax steroid dehydrogenase, putative 0.002 0.0019 0.005
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0135
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0471
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.002 0.0019 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0611 0.2243
Schistosoma mansoni sodium/chloride dependent transporter 0.0029 0.005 0.0096
Mycobacterium ulcerans oxidoreductase 0.002 0.0019 0.0069
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0028 0.0046 0.0089
Echinococcus granulosus serotonin receptor 0.0056 0.0151 0.029
Schistosoma mansoni steroid dehydrogenase 0.002 0.0019 0.0036
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0107 0.0333 0.0333
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.002 0.0019 0.0036
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0005 0.0005
Plasmodium falciparum LCCL domain-containing protein 0.0123 0.0394 0.1137
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0333 0.0641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0041 0.0133
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0044 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0041 0.0134
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0202 0.0679 0.1982
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0151 0.029
Leishmania major short chain dehydrogenase, putative 0.002 0.0019 0.0019
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0056 0.0161
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Schistosoma mansoni hypothetical protein 0.0101 0.0312 0.0601
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0028 0.0087
Schistosoma mansoni myosin xvIII 0.0056 0.0151 0.029
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.0356 0.1315
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.002 0.0019 0.0053
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0151 0.029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0122 0.0356
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Onchocerca volvulus 0.0058 0.0156 0.0783
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0019 0.0019
Schistosoma mansoni steroid dehydrogenase 0.002 0.0019 0.0036
Schistosoma mansoni hypothetical protein 0.0181 0.0602 0.1159
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0151 0.029
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0056 0.0151 0.0441
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.002 0.0019 0.0054
Onchocerca volvulus 0.0056 0.0151 0.0754
Echinococcus granulosus geminin 0.0181 0.0602 0.1159
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Trypanosoma cruzi trypanothione reductase, putative 0.076 0.2708 0.2708
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.002 0.0019 0.0019
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0202 0.0679 0.1982
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0135
Echinococcus granulosus carbonyl reductase 1 0.002 0.0019 0.0036
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0951 0.3404 0.655
Mycobacterium ulcerans putative regulatory protein 0.0076 0.0221 0.0816
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.002 0.0019 0.0019
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0191 0.0558
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0059 0.0161 0.031
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Schistosoma mansoni growth hormone secretagogue receptor 0.0056 0.0151 0.029
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0175 0.0646
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0122 0.0122
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0044 0.0044
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0019 0.0019
Treponema pallidum NADH oxidase 0.076 0.2708 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0019 0.0015 0.0029
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.002 0.0019 0.0069
Loa Loa (eye worm) oxidoreductase 0.002 0.0019 0.0054
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0356 0.0356
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0151 0.029
Echinococcus granulosus inositol monophosphatase 1 0.0079 0.0234 0.045
Echinococcus multilocularis allatostatin A receptor 0.0056 0.0151 0.029
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0018 0.0018
Onchocerca volvulus 0.0056 0.0151 0.0754
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0202 0.0679 0.0679
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0356 0.0686
Schistosoma mansoni neuropeptide receptor 0.0056 0.0151 0.029
Plasmodium vivax thioredoxin reductase, putative 0.0957 0.3424 1
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.002 0.0019 0.0036
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0398 0.1392 0.4065
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0086 0.0086
Echinococcus multilocularis carbonyl reductase 1 0.002 0.0019 0.0036
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0018 0.0018
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0005 0.0009
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0005 0.0009
Giardia lamblia Short-chain dehydrogenase, putative 0.002 0.0019 0.0001
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0202 0.0679 0.1306
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0019 0.0019
Schistosoma mansoni short chain dehydrogenase 0.002 0.0019 0.0036
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0192 0.0192
Leishmania major short chain dehydrogenase, putative 0.002 0.0019 0.0019
Echinococcus granulosus lipoxygenase domain containing protein 0.0123 0.0394 0.0757
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0611 0.2243
Schistosoma mansoni inositol monophosphatase 0.0079 0.0234 0.045
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0202 0.0679 0.1306
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0279 0.096 0.2803
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.002 0.0019 0.0019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0018 0.0018
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0191 0.0368
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0202 0.0679 0.2506
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0151 0.029
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Echinococcus granulosus RUN 0.0123 0.0394 0.0757
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0202 0.0679 0.0679
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0056 0.0151 0.029
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0046 0.0135
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0079 0.0234 0.0863
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0014
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0128 0.0409 0.0788
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.096 0.3534
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0028 0.0046 0.0089
Brugia malayi hypothetical protein 0.0056 0.0151 0.0441
Schistosoma mansoni BC026374 protein (S09 family) 0.0059 0.0161 0.031
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0202 0.0679 0.193
Brugia malayi putative neuropeptide receptor 0.0056 0.0151 0.0441
Echinococcus multilocularis jun protein 0.0266 0.0914 0.176
Echinococcus multilocularis Ankyrin 0.0031 0.0059 0.0113
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0188 0.0631 0.1214
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0202 0.0679 0.193
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0005 0.0009
Schistosoma mansoni short chain dehydrogenase 0.002 0.0019 0.0036
Giardia lamblia Thioredoxin reductase 0.0202 0.0679 0.2455
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0202 0.0679 0.0679
Trichomonas vaginalis inositol monophosphatase, putative 0.0079 0.0234 0.0847
Echinococcus multilocularis retinol dehydrogenase 11 0.002 0.0019 0.0036
Brugia malayi Pre-SET motif family protein 0.0063 0.0176 0.0513
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0056 0.0151 0.029
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0356 0.13
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.002 0.0019 0.0001
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0019 0.0019
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0059 0.0161 0.058
Schistosoma mansoni steroid dehydrogenase 0.002 0.0019 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2029 0.7322 0.7322
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0176 0.0338
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0202 0.0679 0.0679
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.0058 0.0111
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0028 0.0046 0.0135
Loa Loa (eye worm) RNA binding protein 0.0068 0.0191 0.0558
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0019 0.0019
Mycobacterium ulcerans short-chain type oxidoreductase 0.002 0.0019 0.0069
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0044 0.0116
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0351 0.1223 0.2354
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.0126
Echinococcus granulosus single minded 2 0.0079 0.0234 0.0451
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0093 0.0424
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0019 0.0019
Trypanosoma cruzi short chain dehydrogenase, putative 0.002 0.0019 0.0019
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0018 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0176 0.0338
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0151 0.029
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0078 0.0078
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0015 0.0029
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.076 0.2708 0.7908
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0151 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.006 0.0205
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Brugia malayi hypothetical protein 0.0056 0.0151 0.0441
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0471
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.002 0.0019 0.0053
Schistosoma mansoni ap endonuclease 0.002 0.0018 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0086 0.03
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0019 0.0019
Schistosoma mansoni biogenic amine receptor 0.0056 0.0151 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.005 0.0167
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0151 0.029
Mycobacterium ulcerans short-chain dehydrogenase 0.002 0.0019 0.0069
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0151 0.029
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0058 0.0168
Echinococcus granulosus neuroligin 0.0059 0.0161 0.031
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.002 0.0019 0.0053
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.002 0.0019 0.0019
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0135
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.002 0.0019 0.0053
Trichomonas vaginalis glutamate synthase, putative 0.0202 0.0679 0.2493
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0001 0.0002
Schistosoma mansoni rab6-interacting 0.0123 0.0394 0.0757
Trichomonas vaginalis glutathione reductase, putative 0.076 0.2708 1
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0042 0.0139
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0056 0.0151 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0014
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0234 0.0234
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0151 0.029
Leishmania major pteridine reductase 1 0.002 0.0019 0.0019
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0059 0.0161 0.0459
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0056 0.0192
Schistosoma mansoni neuropeptide receptor 0.0056 0.0151 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.0202 0.0679 0.0679
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0209 0.061
Schistosoma mansoni opsin-like receptor 0.0056 0.0151 0.029
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0156 0.0455
Echinococcus multilocularis G-protein coupled receptor, putative 0.0056 0.0151 0.029
Loa Loa (eye worm) hepatopoietin HPO2 0.0037 0.0078 0.0229
Schistosoma mansoni carbonyl reductase 0.002 0.0019 0.0036
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.2766 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0151 0.029
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0046 0.0135
Echinococcus granulosus 7tm_1 domain containing protein 0.0056 0.0151 0.029
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0019 0.0019
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Echinococcus granulosus g-protein coupled receptor 0.0056 0.0151 0.029
Toxoplasma gondii oxidoreductase, putative 0.002 0.0019 0.0054
Echinococcus multilocularis steroid dehydrogenase 0.002 0.0019 0.0036
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.076 0.2708 1
Schistosoma mansoni hypothetical protein 0.0123 0.0394 0.0757
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.076 0.2708 0.2708
Echinococcus multilocularis serotonin receptor 0.0188 0.0629 0.1211
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0163 0.0539 0.1037
Echinococcus multilocularis para nitrobenzyl esterase 0.0059 0.0161 0.031
Schistosoma mansoni lipoxygenase 0.0253 0.0865 0.1664
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0042 0.0139
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0424 0.1487 0.4228
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0202 0.0679 0.1306
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.0058 0.0111
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0107 0.0333 0.0333
Brugia malayi glutamate synthase 0.0202 0.0679 0.1982
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0611 0.2243
Brugia malayi Carboxylesterase family protein 0.0351 0.1223 0.3572
Echinococcus granulosus serotonin transporter 0.0163 0.0539 0.1037
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0079 0.0234 0.0683
Leishmania major hypothetical protein, conserved 0.002 0.0019 0.0019
Brugia malayi larval opioid receptor 0.0056 0.0151 0.0441
Leishmania major hypothetical protein, conserved 0.002 0.0019 0.0019
Schistosoma mansoni carbonyl reductase 0.002 0.0019 0.0036
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0122 0.0356
Echinococcus multilocularis microtubule associated protein 2 0.1444 0.5196 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0202 0.0679 0.0679
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0175 0.0337
Echinococcus granulosus bloom syndrome protein 0.0023 0.0028 0.0054
Brugia malayi RNA binding protein 0.0068 0.0191 0.0558
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0046 0.0089
Onchocerca volvulus 0.0123 0.0394 0.2138
Echinococcus multilocularis conserved hypothetical protein 0.002 0.0019 0.0036
Brugia malayi dehydrogenases, short chain protein 2 0.002 0.0019 0.0054
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0028 0.0046 0.0135
Mycobacterium ulcerans dehydrogenase/reductase 0.002 0.0019 0.0069
Brugia malayi G-protein coupled receptor 0.0056 0.0151 0.0441
Mycobacterium ulcerans NADH dehydrogenase 0.0202 0.0679 0.2506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0041 0.0134
Schistosoma mansoni chromobox protein 0.0072 0.0209 0.0402
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0056 0.0151 0.029
Echinococcus multilocularis sex peptide receptor 0.0056 0.0151 0.029
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0202 0.0679 0.0679
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0054
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0333 0.1215
Leishmania major short chain dehydrogenase-like protein 0.002 0.0019 0.0019
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0151 0.029
Schistosoma mansoni short chain dehydrogenase 0.002 0.0019 0.0036
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0188 0.0631 0.2329
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.0161 0.031
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0044 0.013
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Echinococcus granulosus Polycystic kidney disease protein 0.0123 0.0394 0.0757
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0019 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2324 0.8396 0.8396
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0259 0.0888 0.2592
Loa Loa (eye worm) phosphofructokinase 0.0113 0.0356 0.104
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0168 0.0557 0.1628
Schistosoma mansoni opsin-like receptor 0.0056 0.0151 0.029
Schistosoma mansoni short chain dehydrogenase 0.002 0.0019 0.0036
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0982 0.3516 1
Echinococcus multilocularis carboxylesterase 5A 0.0351 0.1223 0.2354
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Brugia malayi G-protein coupled receptor 0.0056 0.0151 0.0441
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0151 0.029
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2766 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0082
Schistosoma mansoni short chain dehydrogenase 0.002 0.0019 0.0036
Onchocerca volvulus 0.0056 0.0151 0.0754
Schistosoma mansoni biogenic amine receptor 0.0056 0.0151 0.029
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.096 0.3534
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0957 0.3424 0.974
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0056 0.0151 0.029
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0202 0.0679 0.2455
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0019 0.0052
Echinococcus granulosus alpha 1A adrenergic receptor 0.0056 0.0151 0.029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0151 0.029
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0056 0.0151 0.029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0042 0.0123
Schistosoma mansoni sulfide quinone reductase 0.0202 0.0679 0.1306
Echinococcus multilocularis neuropeptide FF receptor 2 0.0056 0.0151 0.029
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0086 0.0086
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0151 0.029
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0054
Echinococcus multilocularis mitogen activated protein kinase 3 0.0107 0.0333 0.0641
Schistosoma mansoni intermediate filament proteins 0.0058 0.0156 0.03
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0168 0.0323
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.002 0.0019 0.0019
Echinococcus multilocularis dro:myosuppressin receptor 0.0056 0.0151 0.029
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0202 0.0679 0.1306
Echinococcus multilocularis lamin dm0 0.0058 0.0156 0.03
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0044 0.0116
Echinococcus multilocularis serotonin receptor 0.0188 0.0629 0.1211
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0151 0.029
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0086 0.0086
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0202 0.0679 0.2493
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0046 0.0131
Brugia malayi 6-phosphofructokinase 0.0113 0.0356 0.104
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0202 0.0679 0.1306
Mycobacterium ulcerans flavoprotein disulfide reductase 0.076 0.2708 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.0059 0.0113
Brugia malayi Augmenter of liver regeneration 0.0037 0.0078 0.0229
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0056 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0042 0.0139
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Brugia malayi Pre-SET motif family protein 0.0441 0.1549 0.4525
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.002 0.0019 0.0069
Echinococcus granulosus acetylcholinesterase 0.0351 0.1223 0.2354
Mycobacterium tuberculosis Carboxylesterase LipT 0.0059 0.0161 0.0459
Loa Loa (eye worm) hypothetical protein 0.0188 0.0629 0.1837
Trichomonas vaginalis glutamate synthase, putative 0.0202 0.0679 0.2493
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0005 0.0014
Plasmodium falciparum thioredoxin reductase 0.0957 0.3424 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0019 0.0015 0.0029
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0019 0.0036
Onchocerca volvulus 0.0056 0.0151 0.0754
Brugia malayi Carboxylesterase family protein 0.0351 0.1223 0.3572
Entamoeba histolytica hypothetical protein, conserved 0.002 0.0019 0.0004
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.002 0.0019 0.0053
Brugia malayi Retinol dehydrogenase 12 0.002 0.0019 0.0054
Echinococcus multilocularis sodium channel protein 0.0128 0.0409 0.0788
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0175 0.0337
Leishmania major dehydrogenase-like protein 0.002 0.0019 0.0019
Onchocerca volvulus 0.0028 0.0046 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0077 0.0267
Echinococcus granulosus WW domain containing oxidoreductase 0.002 0.0019 0.0036
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0333 0.1215
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0202 0.0679 0.0679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0086 0.03
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0027 0.0042 0.0081
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0046 0.0089
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0356 0.104
Mycobacterium ulcerans ketoacyl reductase 0.002 0.0019 0.0069
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0028 0.0046 0.0089
Plasmodium vivax glutathione reductase, putative 0.0957 0.3424 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0158 0.052 0.1001
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0014
Onchocerca volvulus 0.0056 0.0151 0.0754
Plasmodium falciparum glutathione reductase 0.0957 0.3424 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0018 0.0051
Schistosoma mansoni sodium-dependent amino acid transporter 0.0028 0.0046 0.0089
Entamoeba histolytica hypothetical protein 0.002 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0019 0.0019
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0005 0.0009
Trichomonas vaginalis set domain proteins, putative 0.0502 0.1771 0.6534
Echinococcus granulosus retinol dehydrogenase 11 0.002 0.0019 0.0036
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0028 0.0046 0.0089
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0019 0.0019
Entamoeba histolytica disulphide oxidoreductase, putative 0.0202 0.0679 1
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0202 0.0679 0.1979
Echinococcus granulosus voltage gated potassium channel 0.0023 0.0028 0.0054
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0137
Echinococcus multilocularis voltage gated potassium channel 0.0023 0.0028 0.0054
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0192 0.0369
Entamoeba histolytica hypothetical protein 0.0038 0.0085 0.1008
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0202 0.0679 0.0679
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Schistosoma mansoni short chain dehydrogenase 0.002 0.0019 0.0036
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0019 0.0053
Trypanosoma cruzi oxidoreductase-like protein, putative 0.002 0.0019 0.0019
Chlamydia trachomatis thioredoxin reductase 0.0202 0.0679 0.2388
Brugia malayi bHLH-PAS transcription factor 0.0076 0.0221 0.0646
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0107 0.0333 0.0333
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.002 0.0019 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0151 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0041 0.0133
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0266 0.0914 0.176
Echinococcus granulosus peptide allatostatin:somatostatin 0.0056 0.0151 0.029
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0202 0.0679 0.1306
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.0161 0.031
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0005 0.0009
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.002 0.0019 0.0041
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Loa Loa (eye worm) oxidoreductase 0.002 0.0019 0.0054
Echinococcus multilocularis sodium and chloride dependent glycine 0.0028 0.0046 0.0089
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0176 0.0338
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0056 0.0576
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0056 0.0151 0.029
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0078 0.0225
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0151 0.029
Brugia malayi Carboxylesterase family protein 0.0059 0.0161 0.0471
Echinococcus granulosus death domain containing protein 0.0031 0.0058 0.0111
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0014
Plasmodium vivax hypothetical protein, conserved 0.002 0.0019 0.005
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Leishmania major short chain dehydrogenase/reductase, putative 0.002 0.0019 0.0019
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.002 0.0019 0.0019
Schistosoma mansoni biogenic amine (5HT) receptor 0.0188 0.0629 0.1211
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0356 0.13
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0056 0.0165
Echinococcus multilocularis steroid dehydrogenase 0.002 0.0019 0.0036
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.076 0.2708 0.7908
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0151 0.029
Brugia malayi Melatonin receptor type 1A 0.0056 0.0151 0.0441
Leishmania major hypothetical protein, conserved 0.0202 0.0679 0.0679
Brugia malayi hypothetical protein 0.0056 0.0151 0.0441
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0079 0.0234 0.0801
Echinococcus multilocularis lipoxygenase domain containing protein 0.0123 0.0394 0.0757
Echinococcus granulosus tachykinin peptides receptor 99D 0.0056 0.0151 0.029
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0424 0.1487 0.4228
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0056 0.0151 0.0754
Echinococcus multilocularis carbonyl reductase 1 0.002 0.0019 0.0036
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0234 0.0847
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0085 0.0163
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0202 0.0679 0.0679
Mycobacterium ulcerans carveol-like dehydrogenase 0.002 0.0019 0.0069
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0168 0.0323
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0202 0.0679 0.1979
Schistosoma mansoni amine GPCR 0.0593 0.2103 0.4046
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0019 0.0019
Onchocerca volvulus 0.0202 0.0679 0.3765
Brugia malayi sulfakinin receptor protein 0.0056 0.0151 0.0441
Plasmodium falciparum steroid dehydrogenase, putative 0.002 0.0019 0.0041
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0202 0.0679 0.1982
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Leishmania major hypothetical protein, conserved 0.002 0.0019 0.0019
Onchocerca volvulus 0.0056 0.0151 0.0754
Echinococcus granulosus aryl hydrocarbon receptor 0.0027 0.0042 0.0081
Schistosoma mansoni neuropeptide f receptor 76f 0.0056 0.0151 0.029
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0475 0.1671 0.3217
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Trypanosoma cruzi NADH dehydrogenase, putative 0.0202 0.0679 0.0679
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0176 0.0513
Schistosoma mansoni steroid dehydrogenase 0.002 0.0019 0.0036
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0202 0.0679 0.2493
Schistosoma mansoni adenoreceptor 0.0056 0.0151 0.029
Leishmania major short chain dehydrogenase/reductase, putative 0.002 0.0019 0.0019
Echinococcus multilocularis transfer RNA-Lys 0.0076 0.0221 0.0426
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.0356 0.1013
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0202 0.0679 0.1971
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0046 0.0089
Schistosoma mansoni glutamate synthase 0.0202 0.0679 0.1306
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0023 0.0028 0.0054
Brugia malayi phosphofructokinase 0.0113 0.0356 0.104
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0151 0.029
Brugia malayi glutathione reductase 0.0957 0.3424 1
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.0356 0.0356
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0046 0.0135
Brugia malayi hypothetical protein 0.0018 0.0009 0.0027
Schistosoma mansoni carbonyl reductase 0.002 0.0019 0.0036
Toxoplasma gondii thioredoxin reductase 0.0957 0.3424 1
Trichomonas vaginalis apoptosis inducing factor, putative 0.0202 0.0679 0.2493
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0056 0.0192
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0202 0.0679 0.193
Onchocerca volvulus 0.0028 0.0046 0.0157
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0279 0.096 0.2803
Trypanosoma cruzi oxidoreductase-like protein, putative 0.002 0.0019 0.0019
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0056 0.0151 0.0441
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Schistosoma mansoni hypothetical protein 0.0056 0.0151 0.029
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0151 0.029
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.002 0.0019 0.0019
Mycobacterium tuberculosis Probable oxidoreductase 0.0982 0.3516 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0056 0.0053
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0028 0.0046 0.0135
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0202 0.0679 0.1971
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0188 0.0631 0.1794
Onchocerca volvulus 0.0056 0.0151 0.0754
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0075 0.0219 0.0421
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0202 0.0679 0.2506
Giardia lamblia Hypothetical protein 0.002 0.0019 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0054
Brugia malayi Uncoordinated protein 44 0.0031 0.0058 0.0168
Schistosoma mansoni glutamate synthase 0.0202 0.0679 0.1306
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0046 0.0135
Brugia malayi Dopamine receptor protein 1 0.0056 0.0151 0.0441
Echinococcus granulosus allatostatin A receptor 0.0056 0.0151 0.029
Echinococcus granulosus tm gpcr rhodopsin 0.0951 0.3404 0.655
Loa Loa (eye worm) oxidoreductase 0.002 0.0019 0.0054
Schistosoma mansoni aryl hydrocarbon receptor 0.0102 0.0318 0.0612
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0079 0.0275
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0056 0.0151 0.029
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0982 0.3516 1
Plasmodium falciparum glutathione reductase 0.076 0.2708 0.7905
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0266 0.0914 0.176
Toxoplasma gondii NADPH-glutathione reductase 0.076 0.2708 0.7908
Schistosoma mansoni short chain dehydrogenase 0.002 0.0019 0.0036
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Loa Loa (eye worm) hypothetical protein 0.0163 0.0539 0.1574
Schistosoma mansoni polycystin 1-related 0.0123 0.0394 0.0757
Brugia malayi GnHR receptor homolog 0.0056 0.0151 0.0441
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.002 0.0019 0.0054
Echinococcus multilocularis hyperpolarization activated cyclic 0.0019 0.0015 0.0029
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0019 0.0015 0.0029
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0077 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0077 0.0267
Schistosoma mansoni survival motor neuron protein 0.0101 0.0312 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0051 0.0171
Schistosoma mansoni sodium/chloride dependent transporter 0.0163 0.0539 0.1037
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0046 0.0089
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0028 0.0046 0.0089
Loa Loa (eye worm) hypothetical protein 0.0057 0.0152 0.0444
Brugia malayi jmjC domain containing protein 0.0061 0.0168 0.049
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0151 0.029
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0079 0.0275
Mycobacterium tuberculosis Possible ketoacyl reductase 0.002 0.0019 0.0053
Echinococcus granulosus g protein coupled receptor 0.0056 0.0151 0.029
Echinococcus multilocularis lipoxygenase domain containing protein 0.0123 0.0394 0.0757
Brugia malayi 6-phosphofructokinase 0.0113 0.0356 0.1041
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0019 0.0052
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.002 0.0019 0.0019
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0151 0.029
Mycobacterium leprae Possible regulatory protein 0.0027 0.0042 0.012
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0151 0.029
Schistosoma mansoni steroid dehydrogenase 0.002 0.0019 0.0036
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0151 0.029
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0234 0.0234
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0019 0.0069
Schistosoma mansoni loxhd1 0.0123 0.0394 0.0757
Mycobacterium ulcerans monoxygenase 0.0202 0.0679 0.2506
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0151 0.029
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0019 0.0053
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0019 0.0015 0.0029
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0202 0.0679 0.2493
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0056 0.0151 0.0441
Schistosoma mansoni steroid dehydrogenase 0.002 0.0019 0.0036
Echinococcus granulosus neuropeptide receptor A26 0.0056 0.0151 0.029
Echinococcus granulosus intermediate filament protein 0.0058 0.0156 0.03
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.002 0.0019 0.0004
Loa Loa (eye worm) carboxylesterase 0.0059 0.0161 0.0471
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0019 0.0053
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0151 0.029
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0005 0.0005
Leishmania major protein kinase, putative 0.0033 0.0065 0.0065
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0028 0.0087
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.002 0.0019 0.0004
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0018 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0096 0.0339
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0085 0.0163
Loa Loa (eye worm) inositol-1 0.0079 0.0234 0.0683
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0059 0.0161 0.0459
Loa Loa (eye worm) programmed cell death 8 0.0202 0.0679 0.1982
Loa Loa (eye worm) hypothetical protein 0.0351 0.1223 0.3572
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0005 0.0009
Schistosoma mansoni inositol monophosphatase 0.0079 0.0234 0.045
Loa Loa (eye worm) hypothetical protein 0.0058 0.0156 0.0455
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0122 0.1569
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0019 0.0019
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0151 0.029
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0046 0.0089
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0356 0.5116
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0398 0.1392 0.4065
Schistosoma mansoni steroid dehydrogenase 0.002 0.0019 0.0036
Schistosoma mansoni alpha-1 adrenergic receptor 0.0056 0.0151 0.029
Trypanosoma cruzi short-chain dehydrogenase, putative 0.002 0.0019 0.0019
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0128 0.0409 0.0409
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0019 0.0052
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0056 0.0151 0.0441
Brugia malayi hypoxia-induced factor 1 0.0317 0.1098 0.3207
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0027 0.0042 0.0139
Leishmania major hypothetical protein, conserved 0.002 0.0019 0.0019
Loa Loa (eye worm) oxidoreductase 0.002 0.0019 0.0054
Onchocerca volvulus 0.0059 0.0161 0.0814
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0077 0.0267
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Echinococcus multilocularis orexin receptor type 2 0.0056 0.0151 0.029
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0054
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0027 0.0042 0.0123
Loa Loa (eye worm) hypothetical protein 0.0188 0.0629 0.1837
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Schistosoma mansoni glutamate synthase 0.0202 0.0679 0.1306
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0333 0.1215
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0047 0.0091
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0202 0.0679 0.2493
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0202 0.0679 0.1306
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0107 0.0333 0.0973
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0078 0.0229
Onchocerca volvulus 0.0076 0.0221 0.1155
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0078 0.0229
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.002 0.0019 0.0019
Plasmodium falciparum amino acid transporter, putative 0.0028 0.0046 0.0121
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.2324 0.8396 0.8396
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0191 0.0558
Brugia malayi jmjC domain containing protein 0.0061 0.0168 0.049
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0056 0.0151 0.0441
Echinococcus multilocularis acetylcholinesterase 0.0351 0.1223 0.2354
Leishmania major hypothetical protein, conserved 0.0037 0.0078 0.0078
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0424 0.1487 0.4228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0064 0.0219
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.096 0.3534
Brugia malayi putative neuropeptide receptor NPR1 0.0056 0.0151 0.0441
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.002 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0504 0.1777 0.519
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0042 0.0139
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Loa Loa (eye worm) hypothetical protein 0.0163 0.0539 0.1574
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0188 0.0631 0.0631
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0005 0.0005
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0071 0.0204 0.0579
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0202 0.0679 0.1982
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0356 0.0686
Schistosoma mansoni lipoxygenase 0.0475 0.1671 0.3217
Loa Loa (eye worm) hypothetical protein 0.0063 0.0176 0.0513
Onchocerca volvulus 0.0056 0.0151 0.0754
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0046 0.0135
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0151 0.029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0168 0.0323
Mycobacterium ulcerans dehydrogenase 0.002 0.0019 0.0069
Echinococcus multilocularis neuropeptide s receptor 0.0056 0.0151 0.029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0151 0.029
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0078 0.0078
Echinococcus granulosus glutamate synthase 0.0202 0.0679 0.1306
Brugia malayi hypothetical protein 0.0056 0.0151 0.0441
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0033
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.002 0.0019 0.0052
Treponema pallidum sodium- and chloride- dependent transporter 0.0163 0.0539 0.1936
Brugia malayi Dehydrogenases, short chain protein 2 0.002 0.0019 0.0054
Echinococcus granulosus tar DNA binding protein 0.0068 0.0191 0.0368
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0085 0.0163
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0019 0.0069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0176 0.0338
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.002 0.0019 0.0053
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0019 0.0069
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0054
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0151 0.029
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0071 0.0204 0.0579
Echinococcus granulosus BC026374 protein S09 family 0.0059 0.0161 0.031
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0051 0.013 0.0249
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.002 0.0019 0.0069
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0005 0.0009
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0202 0.0679 0.2455
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0982 0.3516 1
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0202 0.0679 0.0679
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.002 0.0019 0.0054
Schistosoma mansoni netrin receptor unc5 0.0031 0.0058 0.0111
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0156 0.0455
Loa Loa (eye worm) doublecortin family protein 0.0123 0.0394 0.1149
Echinococcus multilocularis serotonin transporter 0.0163 0.0539 0.1037
Brugia malayi hypothetical protein 0.0027 0.0044 0.013
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0471
Schistosoma mansoni amine GPCR 0.0056 0.0151 0.029
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0005 0.0009
Leishmania major hypothetical protein, conserved 0.0027 0.0044 0.0044
Giardia lamblia Reductase, putative 0.002 0.0019 0.0001
Echinococcus granulosus survival motor neuron protein 1 0.0495 0.1745 0.3358
Echinococcus granulosus hypothetical protein 0.0802 0.2861 0.5507
Brugia malayi AKH receptor 0.0056 0.0151 0.0441
Mycobacterium tuberculosis Probable reductase 0.0424 0.1487 0.4228
Trichomonas vaginalis spcc417.12 protein, putative 0.0059 0.0161 0.058
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0151 0.029
Brugia malayi Inositol-1 0.0079 0.0234 0.0683
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0122 0.0122
Echinococcus multilocularis carbonyl reductase 1 0.002 0.0019 0.0036
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0333 0.1215
Entamoeba histolytica hypothetical protein 0.0038 0.0085 0.1008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0151 0.029
Echinococcus multilocularis BC026374 protein (S09 family) 0.0059 0.0161 0.031
Toxoplasma gondii oxidoreductase, putative 0.002 0.0019 0.0054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0151 0.029
Schistosoma mansoni opsin-like receptor 0.0056 0.0151 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0122 0.0434
Schistosoma mansoni hypothetical protein 0.0056 0.0149 0.0286
Toxoplasma gondii hypothetical protein 0.0028 0.0046 0.0135
Loa Loa (eye worm) dehydrogenase 0.002 0.0019 0.0054
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0056 0.0161
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0056 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0611 0.2243
Loa Loa (eye worm) hypothetical protein 0.0123 0.0394 0.1149
Echinococcus granulosus hyperpolarization activated cyclic 0.0019 0.0015 0.0029
Schistosoma mansoni acetylcholinesterase 0.0059 0.0161 0.031
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0202 0.0679 0.1306
Schistosoma mansoni short chain dehydrogenase 0.002 0.0019 0.0036
Loa Loa (eye worm) solute carrier family 6 member 4 0.0163 0.0539 0.1574
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0018 0.0054
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0056 0.0151 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0051 0.0171
Brugia malayi hypothetical protein 0.0056 0.0151 0.0441
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0019 0.0019
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0005 0.0005
Schistosoma mansoni 60S ribosomal protein L21 0.0018 0.0009 0.0018
Plasmodium vivax amine transporter, putative 0.0028 0.0046 0.0131
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0122 0.0235
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0019 0.0069
Echinococcus multilocularis RUN 0.0123 0.0394 0.0757
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0051 0.013 0.0378
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.002 0.0019 0.0019
Mycobacterium ulcerans hypothetical protein 0.0202 0.0679 0.2506
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0056 0.0151 0.029
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0202 0.0679 0.2506
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0188 0.0631 0.1214
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0019 0.0053
Echinococcus granulosus sex peptide receptor 0.0056 0.0151 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0093 0.0327
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0005 0.0009
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0005 0.0014
Echinococcus multilocularis G protein coupled receptor 139 0.0056 0.0151 0.029
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.002 0.0019 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.005 0.0168
Echinococcus granulosus G protein coupled receptor 139 0.0056 0.0151 0.029
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0471
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0151 0.029
Schistosoma mansoni retinal dehydrogenase 0.002 0.0019 0.0036
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0558 0.1975 0.5766
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0202 0.0679 0.1982
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0104 0.0488
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.002 0.0019 0.0019
Brugia malayi hypothetical protein 0.0344 0.1195 0.3489
Schistosoma mansoni voltage-gated potassium channel 0.0054 0.0143 0.0275
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.0161 0.031
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0054
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0027 0.0042 0.0139
Schistosoma mansoni hypothetical protein 0.0056 0.0151 0.029
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Brugia malayi MAP kinase sur-1 0.0107 0.0333 0.0973
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0151 0.029
Brugia malayi Carboxylesterase family protein 0.0059 0.0161 0.0471
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0151 0.029
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0398 0.1392 0.1392
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0122 0.0122
Mycobacterium ulcerans short-chain dehydrogenase 0.002 0.0019 0.0069
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0005 0.0009
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.002 0.0019 0.0052
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0018 0.004
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0054
Echinococcus granulosus orexin receptor type 2 0.0056 0.0151 0.029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0168 0.0323
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0005 0.0005
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0019 0.0015 0.0029
Schistosoma mansoni disulfide oxidoreductase 0.0202 0.0679 0.1306
Onchocerca volvulus 0.0059 0.0161 0.0814
Schistosoma mansoni biogenic amine receptor 0.0056 0.0151 0.029
Brugia malayi Tachykinin-like peptides receptor 99D 0.0056 0.0151 0.0441
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0234 0.0234
Mycobacterium tuberculosis Possible oxidoreductase 0.002 0.0019 0.0053
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0019 0.0053
Mycobacterium ulcerans glutamate synthase subunit beta 0.0202 0.0679 0.2506
Schistosoma mansoni short-chain dehydrogenase/reductase 0.002 0.0019 0.0036
Brugia malayi Dehydrogenases, short chain protein 30 0.002 0.0019 0.0054
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0209 0.0755
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0176 0.0338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0176 0.0338
Echinococcus granulosus mitogen activated protein kinase 3 0.0107 0.0333 0.0641
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.002 0.0019 0.0053
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0005 0.0009
Schistosoma mansoni steroid dehydrogenase 0.002 0.0019 0.0036
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0056 0.0141
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.096 0.3534
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0054
Trypanosoma cruzi NADH dehydrogenase, putative 0.0202 0.0679 0.0679
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0202 0.0679 0.2493
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0019 0.0015 0.0029
Mycobacterium ulcerans ketoacyl reductase 0.002 0.0019 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0077 0.0267
Onchocerca volvulus 0.0502 0.1772 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0168
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0019 0.0019
Echinococcus granulosus carbonyl reductase 1 0.002 0.0019 0.0036
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0056 0.0192
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.002 0.0019 0.0019
Brugia malayi hypothetical protein 0.0056 0.0151 0.0441
Schistosoma mansoni sulfide quinone reductase 0.0202 0.0679 0.1306
Echinococcus multilocularis glutamate synthase 0.0202 0.0679 0.1306
Toxoplasma gondii selenide, water dikinase 0.0202 0.0679 0.1982
Onchocerca volvulus 0.0056 0.0151 0.0754
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0234 0.0234
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0056 0.0151
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0192 0.0369
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.013
Schistosoma mansoni chromobox protein 0.0072 0.0209 0.0402
Schistosoma mansoni hypothetical protein 0.0217 0.0733 0.141
Echinococcus multilocularis geminin 0.0181 0.0602 0.1159
Echinococcus granulosus hypothetical protein 0.002 0.0019 0.0036
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0356 0.0356
Schistosoma mansoni gliotactin 0.0059 0.0161 0.031
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0028 0.0046 0.0046
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0058 0.017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0151 0.029
Echinococcus multilocularis aryl hydrocarbon receptor 0.0027 0.0042 0.0081
Echinococcus granulosus biogenic amine 5HT receptor 0.0188 0.0629 0.1211
Brugia malayi hypothetical protein 0.0056 0.0151 0.0441
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0151 0.0441
Treponema pallidum thioredoxin reductase (trxB) 0.0202 0.0679 0.2455
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0077 0.0267
Loa Loa (eye worm) oxidoreductase 0.002 0.0019 0.0054
Leishmania major C-8 sterol isomerase-like protein 0.0398 0.1392 0.1392
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.076 0.2708 0.7905
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.2324 0.8396 0.8396
Mycobacterium leprae Probable oxidoreductase 0.002 0.0019 0.0053
Loa Loa (eye worm) hypoxia-induced factor 1 0.0317 0.1098 0.3207
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.002 0.0019 0.0036
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Onchocerca volvulus 0.0163 0.0539 0.2968
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.076 0.2708 1
Schistosoma mansoni hypothetical protein 0.0181 0.0602 0.1159
Echinococcus granulosus neuropeptide FF receptor 2 0.0056 0.0151 0.029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0151 0.029
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0192 0.056
Echinococcus granulosus jun protein 0.0266 0.0914 0.176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0041 0.0134
Echinococcus multilocularis hyperpolarization activated cyclic 0.0019 0.0015 0.0029
Loa Loa (eye worm) serotonin transporter b 0.0163 0.0539 0.1574
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0471
Onchocerca volvulus 0.0056 0.0151 0.0754
Loa Loa (eye worm) hypothetical protein 0.0344 0.1195 0.3489
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0188 0.0631 0.1214
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0202 0.0679 0.193
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0611 0.2243
Brugia malayi ORL1-like opioid receptor 0.0056 0.0151 0.0441
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0475 0.1671 0.3217
Echinococcus granulosus chromobox protein 1 0.0072 0.0209 0.0402
Onchocerca volvulus 0.0056 0.0151 0.0754
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0019 0.0015 0.0043
Brugia malayi hypothetical protein 0.002 0.0019 0.0054
Onchocerca volvulus 0.0059 0.0161 0.0814
Echinococcus granulosus g protein coupled receptor 0.0056 0.0151 0.029
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0005 0.0009
Mycobacterium tuberculosis Possible oxidoreductase 0.002 0.0019 0.0053
Leishmania major acetoin dehydrogenase e3 component-like protein 0.2029 0.7322 0.7322
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0122 0.0235
Plasmodium falciparum thioredoxin reductase 0.076 0.2708 0.7905
Schistosoma mansoni hypothetical protein 0.0031 0.0058 0.0111
Brugia malayi Heterochromatin protein 1 0.0072 0.0209 0.061
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0151 0.029
Schistosoma mansoni short chain dehydrogenase 0.002 0.0019 0.0036
Brugia malayi Dopamine receptor 0.0056 0.0151 0.0441
Mycobacterium ulcerans oxidoreductase 0.002 0.0019 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0019 0.0019
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0424 0.1487 0.4228
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0005 0.0009
Schistosoma mansoni rab6-interacting 0.0123 0.0394 0.0757
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.096 0.3534
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0028 0.0082
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0151 0.029
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0005 0.0005
Trypanosoma cruzi short-chain dehydrogenase, putative 0.002 0.0019 0.0019
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0056 0.0151 0.029
Loa Loa (eye worm) RecQ helicase 0.0023 0.0028 0.0082
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0019 0.0069
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0019 0.0069
Echinococcus granulosus para nitrobenzyl esterase 0.0059 0.0161 0.031
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0005 0.0009
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0005 0.0005
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0202 0.0679 0.2506
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0202 0.0679 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0151 0.029
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0028 0.0046 0.0089
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0101 0.0312 0.0912
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0037 0.0078 0.0151
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0202 0.0679 0.2493
Brugia malayi hypothetical protein 0.0038 0.0085 0.0248
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Echinococcus multilocularis lamin 0.0058 0.0156 0.03
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0151 0.029
Onchocerca volvulus Netrin receptor homolog 0.0031 0.0058 0.0223
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0028 0.0046 0.0015
Brugia malayi hypothetical protein 0.002 0.0019 0.0054
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0005 0.0014
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0175 0.0337
Giardia lamblia Glutamate synthase 0.0202 0.0679 0.2455
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.002 0.0019 0.0036
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0151 0.029
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0647 0.2376
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.076 0.2708 0.2708
Echinococcus granulosus sodium and chloride dependent glycine 0.0028 0.0046 0.0089
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0042 0.0139
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0171
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.002 0.0019 0.0053
Schistosoma mansoni sodium/chloride dependent transporter 0.0028 0.0046 0.0089
Schistosoma mansoni amine GPCR 0.0056 0.0151 0.029
Mycobacterium tuberculosis Probable dehydrogenase 0.002 0.0019 0.0053
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0018 0.005
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0009 0.0018
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0202 0.0679 0.193
Echinococcus multilocularis chromobox protein 1 0.0072 0.0209 0.0402
Schistosoma mansoni neuroligin 3 (S09 family) 0.0059 0.0161 0.031
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0202 0.0679 0.193
Schistosoma mansoni lamin 0.0058 0.0156 0.03
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0471
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0202 0.0679 0.2493
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0202 0.0679 0.2506
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0202 0.0679 0.2493
Leishmania major dihydrolipoamide dehydrogenase, putative 0.076 0.2708 0.2708
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0028 0.0046 0.0046
Plasmodium vivax ferrodoxin reductase, putative 0.0202 0.0679 0.1979
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0005 0.0014
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.002 0.0019 0.0036
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0192 0.0369
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.076 0.2708 1
Onchocerca volvulus 0.0028 0.0046 0.0157
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0019 0.0015 0.0029
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.002 0.0019 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0122 0.0434
Loa Loa (eye worm) hypothetical protein 0.0495 0.1745 0.5095
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0175 0.0646
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0019 0.0053
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.0356 0.0686
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0005 0.0014
Trichomonas vaginalis mercuric reductase, putative 0.076 0.2708 1
Onchocerca volvulus 0.0209 0.0706 0.3922
Loa Loa (eye worm) thioredoxin reductase 0.0957 0.3424 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.002 0.0019 0.0054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0151 0.029
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.002 0.0019 0.0019
Echinococcus granulosus chromobox protein 1 0.0072 0.0209 0.0402
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0019 0.0015 0.0038
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.2029 0.7322 0.7322
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.002 0.0019 0.0004
Trichomonas vaginalis adenylate cyclase, putative 0.0027 0.0042 0.0139
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0191 0.0368
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0192 0.0192
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0019 0.0053
Plasmodium falciparum ferrodoxin reductase-like protein 0.0202 0.0679 0.1971
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.076 0.2708 0.7907
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0192 0.2626
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0056 0.0192
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0168 0.0323
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0151 0.029
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0356 0.13
Mycobacterium ulcerans short-chain dehydrogenase 0.002 0.0019 0.0069
Mycobacterium ulcerans ketoacyl reductase 0.002 0.0019 0.0069
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0015 0.0029
Echinococcus granulosus mitogen activated protein kinase 0.0107 0.0333 0.0641
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0135
Onchocerca volvulus 0.0027 0.0042 0.0135
Giardia lamblia GTOR 0.0049 0.0122 0.0385
Brugia malayi hypothetical protein 0.0127 0.0405 0.1184
Leishmania major hypothetical protein, conserved 0.0202 0.0679 0.0679
Entamoeba histolytica short chain dehydrogenase family protein 0.002 0.0019 0.0004
Echinococcus granulosus hyperpolarization activated cyclic 0.0019 0.0015 0.0029
Schistosoma mansoni neuropeptide receptor 0.0056 0.0151 0.029
Echinococcus granulosus acetylcholinesterase 0.0351 0.1223 0.2354
Echinococcus multilocularis chromobox protein 1 0.0072 0.0209 0.0402
Leishmania major hypothetical protein, conserved 0.0202 0.0679 0.0679
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0202 0.0679 0.1306
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0005 0.0009
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0151 0.029
Schistosoma mansoni steroid dehydrogenase 0.002 0.0019 0.0036
Loa Loa (eye worm) oxidoreductase 0.002 0.0019 0.0054
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0056 0.0151 0.029
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0356 0.104
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0151 0.029
Schistosoma mansoni hypothetical protein 0.0056 0.0151 0.029
Echinococcus granulosus microtubule associated protein 2 0.1444 0.5196 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.002 0.0019 0.0019
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0044 0.0044
Echinococcus granulosus steroid dehydrogenase 0.002 0.0019 0.0036
Echinococcus multilocularis g-protein coupled receptor 0.0056 0.0151 0.029
Echinococcus granulosus thioredoxin glutathione reductase 0.0957 0.3424 0.659
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0086 0.03
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Echinococcus granulosus carbonyl reductase 1 0.002 0.0019 0.0036
Loa Loa (eye worm) hypothetical protein 0.0202 0.0679 0.1982
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.096 0.3534
Loa Loa (eye worm) melatonin receptor type 1A 0.0056 0.0151 0.0441
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.002 0.0019 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0086 0.03
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0056 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0151 0.029
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0023 0.0028 0.0082
Leishmania major protein kinase, putative 0.0028 0.0046 0.0046
Trypanosoma brucei trypanothione reductase 0.0957 0.3424 0.3424
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0019 0.0069
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0054
Onchocerca volvulus 0.0056 0.0151 0.0754
Schistosoma mansoni ap endonuclease 0.002 0.0018 0.0035
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0107 0.0333 0.0333
Brugia malayi Cyclic-nucleotide gated cation channel 0.0019 0.0015 0.0043
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0202 0.0679 0.2455
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0202 0.0679 1
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0202 0.0679 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0441 0.1549 0.4525
Onchocerca volvulus 0.0056 0.0151 0.0754
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0019 0.0052
Trypanosoma cruzi trypanothione reductase, putative 0.0957 0.3424 0.3424
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0019 0.0053
Entamoeba histolytica hypothetical protein 0.0038 0.0085 0.1008
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0056 0.0151 0.0441
Brugia malayi RE15519p 0.0056 0.0151 0.0441
Schistosoma mansoni hypothetical protein 0.0038 0.0085 0.0163
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Leishmania major NADH dehydrogenase, putative 0.0202 0.0679 0.0679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0077 0.0267
Onchocerca volvulus Neuropeptide F receptor homolog 0.0056 0.0151 0.0754
Schistosoma mansoni amine GPCR 0.0056 0.0151 0.029
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0028 0.0054
Onchocerca volvulus 0.0056 0.0151 0.0754
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0135
Brugia malayi Carboxylesterase family protein 0.0059 0.0161 0.0471
Brugia malayi hypothetical protein 0.0056 0.0151 0.0441
Echinococcus granulosus oxidoreductase 0.002 0.0019 0.0036
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0019 0.0052
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0202 0.0679 0.2493
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0011 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0043
Echinococcus multilocularis conserved hypothetical protein 0.0746 0.2656 0.5112
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0023 0.0028 0.0054
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Loa Loa (eye worm) hypothetical protein 0.033 0.1144 0.3342
Brugia malayi bZIP transcription factor family protein 0.0266 0.0914 0.267
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.002 0.0019 0.0053
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0104 0.0368
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0042 0.0042
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0018 0.0018
Mycobacterium ulcerans carboxylesterase, LipT 0.0059 0.0161 0.0596
Loa Loa (eye worm) hypothetical protein 0.0045 0.0111 0.0323
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0107 0.0333 0.0973
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0647 0.2376
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.002 0.0019 0.0004
Echinococcus multilocularis carbonyl reductase 1 0.002 0.0019 0.0036
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0151 0.029
Toxoplasma gondii hypothetical protein 0.0028 0.0046 0.0135
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.002 0.0019 0.0036
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0078 0.0078
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0056 0.0192
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0202 0.0679 0.193
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0028 0.0046 0.0089
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0175 0.0497
Echinococcus multilocularis somatostatin receptor 0.0056 0.0151 0.029
Loa Loa (eye worm) oxidoreductase 0.002 0.0019 0.0054
Onchocerca volvulus 0.0058 0.0156 0.0783
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0234 0.0847
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0005 0.0014
Brugia malayi Protein kinase domain containing protein 0.0032 0.0061 0.0179
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0028 0.0046 0.0089
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0019 0.0053
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Echinococcus granulosus lamin dm0 0.0058 0.0156 0.03
Plasmodium vivax multidomain scavenger receptor, putative 0.0123 0.0394 0.1146
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0056 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0151 0.029
Onchocerca volvulus Glucosylceramidase homolog 0.0183 0.0611 0.3379
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.076 0.2708 1
Onchocerca volvulus 0.0056 0.0151 0.0754
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0471
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0122 0.0122
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0356 0.13
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.076 0.2708 0.2708
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.002 0.0019 0.0036
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0056 0.0151 0.029
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0202 0.0679 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0093 0.0327
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0056 0.0151 0.029
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0151 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0019 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0191 0.0368
Brugia malayi TAR-binding protein 0.0068 0.0191 0.0558
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0202 0.0679 0.2455
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0059 0.0161 0.031
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0611 0.2243
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0168 0.0323
Brugia malayi Doublecortin family protein 0.0123 0.0394 0.1149
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.076 0.2708 0.7905
Echinococcus multilocularis oxidoreductase 0.002 0.0019 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0151 0.029
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Trypanosoma cruzi hypothetical protein, conserved 0.0202 0.0679 0.0679
Echinococcus granulosus neuropeptide receptor 0.0056 0.0151 0.029
Mycobacterium ulcerans dehydrogenase 0.0202 0.0679 0.2506
Onchocerca volvulus 0.0032 0.0061 0.0242
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0018 0.0035
Trypanosoma brucei oxidoreductase-like protein 0.002 0.0019 0.0019
Echinococcus granulosus nuclear factor of activated T cells 5 0.0158 0.052 0.1001
Mycobacterium ulcerans short-chain dehydrogenase 0.002 0.0019 0.0069
Schistosoma mansoni amine GPCR 0.0056 0.0151 0.029
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0056 0.0165
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0202 0.0679 0.1306
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0028 0.0054
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0019 0.0015 0.0038
Loa Loa (eye worm) hypothetical protein 0.0041 0.0093 0.0272
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0088 0.0169
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0019 0.0015 0.0029
Onchocerca volvulus 0.0101 0.0312 0.1676
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.002 0.0019 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2029 0.7322 0.7322
Loa Loa (eye worm) acetylcholinesterase 1 0.0351 0.1223 0.3572
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0056 0.0151 0.0441
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0019 0.0053
Leishmania major hypothetical protein, conserved 0.002 0.0019 0.0019
Mycobacterium ulcerans ferredoxin reductase 0.0202 0.0679 0.2506
Loa Loa (eye worm) carboxylesterase 0.0059 0.0161 0.0471
Echinococcus multilocularis retinol dehydrogenase 13 0.002 0.0019 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0032 0.0061 0.0179
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.002 0.0019 0.0053
Leishmania major hypothetical protein, conserved 0.0016 0.0005 0.0005
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0088 0.0169
Schistosoma mansoni single-minded 0.0102 0.0318 0.0612
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0015 0.0029
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0151 0.029
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0175 0.0175
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0019 0.0015 0.0029
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0107 0.0333 0.0333
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0188 0.0631 0.1842
Loa Loa (eye worm) oxidoreductase 0.002 0.0019 0.0054
Brugia malayi Thioredoxin reductase 0.0957 0.3424 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0056 0.0151 0.029
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0056 0.0151 0.029
Echinococcus granulosus hypothetical protein 0.002 0.0019 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0191 0.0368
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.002 0.0019 0.0004
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0175 0.0337
Brugia malayi Dopamine receptor protein 2 0.0056 0.0151 0.0441
Entamoeba histolytica hypothetical protein, conserved 0.002 0.0019 0.0004
Brugia malayi hypothetical protein 0.0209 0.0706 0.2062
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0058 0.0168
Brugia malayi intermediate filament protein 0.0058 0.0156 0.0455
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0107 0.0333 0.0333
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0202 0.0679 0.193
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0005 0.0014
Brugia malayi neuropeptide F receptor 0.0056 0.0151 0.0441
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0046 0.0135
Giardia lamblia Kinase, CMGC MAPK 0.0107 0.0333 0.117
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0005 0.0009
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0122 0.0235
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0054
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.0058 0.0111
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0018 0.0052
Mycobacterium tuberculosis Probable dehydrogenase 0.0424 0.1487 0.4228
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0077 0.0267
Loa Loa (eye worm) oxidoreductase 0.002 0.0019 0.0054
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0202 0.0679 0.1982
Echinococcus multilocularis musashi 0.0058 0.0156 0.03
Brugia malayi Death domain containing protein 0.0031 0.0058 0.0168
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0042 0.0042
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.076 0.2708 0.5212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0122 0.0434
Echinococcus multilocularis retinol dehydrogenase 11 0.002 0.0019 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0041 0.0134
Schistosoma mansoni histamine h1 receptor 0.0056 0.0151 0.029
Loa Loa (eye worm) hypothetical protein 0.0351 0.1223 0.3572
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2766 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Brugia malayi hypothetical protein 0.0123 0.0394 0.1149
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.002 0.0019 0.0053
Toxoplasma gondii exonuclease III APE 0.002 0.0018 0.0054
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.005 0.0168
Echinococcus granulosus netrin receptor unc 5 0.0031 0.0058 0.0111
Echinococcus multilocularis inositol monophosphatase 1 0.0079 0.0234 0.045
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0191 0.0558
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0047 0.0091
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0037 0.0078 0.0151
Plasmodium falciparum transporter, putative 0.0028 0.0046 0.0121
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0202 0.0679 0.2506
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0192 0.0192
Entamoeba histolytica hypothetical protein 0.0038 0.0085 0.1008
Loa Loa (eye worm) hypothetical protein 0.0203 0.0685 0.2
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.002 0.0019 0.0053
Schistosoma mansoni voltage-gated potassium channel 0.0054 0.0143 0.0275
Entamoeba histolytica thioredoxin reductase, putative 0.0202 0.0679 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0163 0.0539 0.1574
Trypanosoma brucei hypothetical protein, conserved 0.0202 0.0679 0.0679
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0151 0.0441
Entamoeba histolytica short chain dehydrogenase family protein 0.002 0.0019 0.0004
Schistosoma mansoni steroid dehydrogenase 0.002 0.0019 0.0036
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0202 0.0679 0.193
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0042 0.0139
Leishmania major trypanothione reductase 0.0957 0.3424 0.3424
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0051 0.013 0.0378
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0202 0.0679 0.193
Echinococcus granulosus neuropeptide s receptor 0.0056 0.0151 0.029
Brugia malayi G protein-coupled receptor F59B2.13 0.0056 0.0151 0.0441
Trypanosoma brucei NADH dehydrogenase 0.0202 0.0679 0.0679
Schistosoma mansoni short chain dehydrogenase 0.002 0.0019 0.0036
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0424 0.1487 0.4228
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0056 0.0151
Leishmania major oxidoreductase-like protein 0.002 0.0019 0.0019
Brugia malayi hypothetical protein 0.0056 0.0151 0.0441
Schistosoma mansoni lamin 0.0058 0.0156 0.03
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0058 0.017
Leishmania major 3-keto-dihydrosphingosine reductase 0.002 0.0019 0.0019
Schistosoma mansoni short chain dehydrogenase 0.002 0.0019 0.0036
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0054
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0202 0.0679 0.1982
Schistosoma mansoni hypothetical protein 0.0056 0.0151 0.029
Echinococcus granulosus carboxylesterase 5A 0.0351 0.1223 0.2354
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0122 0.0122
Echinococcus granulosus sodium channel protein 0.0128 0.0409 0.0788
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0019 0.0069
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0202 0.0679 0.2493
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0107 0.0333 0.0333
Schistosoma mansoni hypothetical protein 0.0202 0.0679 0.1306
Onchocerca volvulus 0.0056 0.0151 0.0754
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0027 0.0042 0.0081
Schistosoma mansoni microtubule-associated protein tau 0.1444 0.5196 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0123 0.0394 0.0757
Echinococcus granulosus retinol dehydrogenase 11 0.002 0.0019 0.0036
Echinococcus multilocularis thioredoxin glutathione reductase 0.0957 0.3424 0.659
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0046 0.0089
Giardia lamblia NADH oxidase lateral transfer candidate 0.076 0.2708 1
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0611 0.2243
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0042 0.0139
Echinococcus granulosus phd:f box containing protein 0.0016 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0044 0.0044
Schistosoma mansoni short chain dehydrogenase 0.002 0.0019 0.0036
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0051 0.013 0.0249
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0191 0.0368
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0056 0.0141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0151 0.029
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0191 0.0368
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0018 0.0051
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0056 0.0151 0.029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0151 0.029
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0019 0.0053
Plasmodium vivax SET domain protein, putative 0.0063 0.0176 0.0509
Loa Loa (eye worm) norepinephrine transporter 0.0163 0.0539 0.1574
Brugia malayi neuropeptide F receptor 0.0056 0.0151 0.0441
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.076 0.2708 1
Brugia malayi chromobox protein homolog 3 0.0041 0.0093 0.0272
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0028 0.0046 0.0046
Echinococcus granulosus somatostatin receptor 0.0056 0.0151 0.029
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.002 0.0019 0.0052
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.0058 0.0111
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0005 0.0005
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Trypanosoma brucei protein kinase, putative 0.0107 0.0333 0.0333
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0192 0.056
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0014
Brugia malayi hypothetical protein 0.0495 0.1745 0.5095
Schistosoma mansoni jun-related protein 0.0217 0.0733 0.141
Echinococcus granulosus neuropeptide receptor 0.0056 0.0151 0.029
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0019 0.0054
Toxoplasma gondii carbonyl reductase 1, putative 0.002 0.0019 0.0054
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0356 0.5116
Brugia malayi hypothetical protein 0.0123 0.0394 0.1149
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0042 0.0139
Onchocerca volvulus 0.0059 0.0161 0.0814
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0209 0.0755
Echinococcus granulosus fmrfamide receptor 0.0056 0.0151 0.029
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0558 0.1975 0.5766
Onchocerca volvulus 0.0056 0.0151 0.0754
Loa Loa (eye worm) dehydrogenase 0.002 0.0019 0.0054
Echinococcus granulosus lamin 0.0058 0.0156 0.03
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.0356 0.1013
Trypanosoma brucei C-8 sterol isomerase, putative 0.0398 0.1392 0.1392
Loa Loa (eye worm) glutathione reductase 0.0957 0.3424 1
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.0356 0.0686
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0192 0.0192
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0202 0.0679 0.1982
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0015 0.0029
Echinococcus granulosus carbonyl reductase 1 0.002 0.0019 0.0036
Schistosoma mansoni short chain dehydrogenase 0.002 0.0019 0.0036
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.0356 0.1256
Echinococcus granulosus dro:myosuppressin receptor 0.0056 0.0151 0.029
Echinococcus multilocularis survival motor neuron protein 1 0.0495 0.1745 0.3358
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0175 0.0646
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0135
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0168 0.049
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.076 0.2708 0.7702
Loa Loa (eye worm) TYRA-2 protein 0.0056 0.0151 0.0441
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0202 0.0679 0.0679
Echinococcus granulosus lipoxygenase domain containing protein 0.0123 0.0394 0.0757
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0019 0.0053
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0018 0.0068
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0028 0.0046 0.0046
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0202 0.0679 0.1306
Echinococcus granulosus 7TM GPCR rhodopsin 0.0056 0.0151 0.029
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Echinococcus multilocularis neuroligin 0.0059 0.0161 0.031
Echinococcus multilocularis acetylcholinesterase 0.0351 0.1223 0.2354
Brugia malayi PAS domain containing protein 0.0102 0.0318 0.0928
Echinococcus granulosus sodium and chloride dependent glycine 0.0028 0.0046 0.0089
Brugia malayi Serotonin receptor 0.0554 0.1958 0.5718
Schistosoma mansoni short chain dehydrogenase 0.002 0.0019 0.0036
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.002 0.0019 0.0019
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0056 0.0151 0.029
Schistosoma mansoni neuropeptide receptor 0.0056 0.0151 0.029
Brugia malayi hypothetical protein 0.0056 0.0151 0.0441
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0019 0.0069
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.076 0.2708 0.7907
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0041 0.0133
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0079 0.0234 0.3262
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0019 0.0052
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0202 0.0679 1
Brugia malayi follicle stimulating hormone receptor 0.0056 0.0151 0.0441
Onchocerca volvulus 0.0123 0.0394 0.2138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.005 0.0167
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0441
Onchocerca volvulus 0.0059 0.0161 0.0814
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0056 0.0151 0.029
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.002 0.0019 0.0053
Echinococcus multilocularis mitogen activated protein kinase 0.0107 0.0333 0.0641
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0151 0.029
Brugia malayi dehydrogenases, short chain protein 9 0.002 0.0019 0.0054

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 50 uM Binding affinity to Rac (unknown origin) ChEMBL. 18075579
Activity (binding) = 50 uM Binding affinity to Rac (unknown origin) ChEMBL. 18075579
Inhibition (binding) = 88.9 % Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level at 50 uM after 4 hrs by G-LISA relative to control ChEMBL. 19527032

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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