Detailed information for compound 508438

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 899.162 | Formula: C53H74N2O10
  • H donors: 5 H acceptors: 8 LogP: 3.41 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@H]1C[C@H]2Cc3nc4C[C@@]5(C)[C@H](Cc4nc3C[C@@]2([C@@H]2[C@@H]1C1=C[C@H]3[C@]([C@@]1(C)[C@@H](C2)O)(O)[C@@H]([C@]1(O3)CC[C@](CO1)(C)O)C)C)CC[C@@H]1[C@@H]5CC(=O)[C@]2([C@]1(O)C[C@H]1[C@@H]2C[C@]2(O1)CCC(O2)(C)C)C
  • InChi: 1S/C53H74N2O10/c1-26-52(14-12-45(4,59)25-62-52)64-42-20-32-43-31(19-41(58)49(32,8)53(26,42)61)47(6)23-37-35(16-28(47)17-38(43)56)55-36-22-46(5)27(15-34(36)54-37)9-10-29-30(46)18-40(57)48(7)33-21-50(13-11-44(2,3)65-50)63-39(33)24-51(29,48)60/h20,26-31,33,38-39,41-43,56,58-61H,9-19,21-25H2,1-8H3/t26-,27+,28-,29-,30+,31+,33+,38+,39+,41-,42+,43-,45+,46+,47+,48+,49-,50+,51+,52-,53-/m1/s1
  • InChiKey: CLRDJZUPAQTIMO-FAAUWCJHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans bacterioferritin BfrB 0.0013 0.0063 0.0073
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0076 0.0076
Leishmania major adenylate cyclase-like protein 0.0007 0.0014 0.0088
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0055 0.0065
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0026 0.0178 0.024
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0078 0.0093
Schistosoma mansoni hypothetical protein 0.0991 0.8361 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0646 0.5433 0.5433
Schistosoma mansoni dishevelled 0.0007 0.0012 0.0015
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0026 0.0178 0.1274
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0169 0.1387 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0016 0.0089 0.0107
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0009 0.0035 0.0049
Onchocerca volvulus 0.0007 0.0014 0.0018
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0031 0.0222 0.0305
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0045 0.0065
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0035 0.005
Schistosoma mansoni zinc finger protein 0.0014 0.0078 0.0093
Mycobacterium tuberculosis Probable dehydrogenase 0.0093 0.0744 0.1083
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0007 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0014 0.0078 0.0144
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0009 0.0035 0.0031
Trichomonas vaginalis penicillin-binding protein, putative 0.0125 0.1017 0.148
Brugia malayi Thioredoxin reductase 0.0041 0.0302 0.044
Schistosoma mansoni hypothetical protein 0.0005 0.0001 0.0002
Mycobacterium ulcerans acetyl-CoA synthetase 0.0009 0.0035 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0171
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0026 0.0178 0.1274
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0009 0.0033 0.0033
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0108 0.0871 0.0871
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0093 0.0744 0.1083
Mycobacterium tuberculosis Probable monooxygenase 0.0007 0.0014 0.0018
Trypanosoma cruzi importin beta-1 subunit, putative 0.0017 0.0103 0.0732
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0016 0.0089 0.0634
Brugia malayi exodeoxyribonuclease III family protein 0.0026 0.0178 0.0259
Mycobacterium tuberculosis Hypothetical protein 0.0169 0.1387 0.2019
Plasmodium falciparum glutathione reductase 0.0041 0.0302 0.217
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0125 0.1017 0.1465
Echinococcus granulosus snurportin 1 0.0227 0.1879 0.2248
Loa Loa (eye worm) hypothetical protein 0.0014 0.0078 0.0144
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0009 0.0035 0.0035
Onchocerca volvulus 0.0125 0.1017 0.148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0214 0.0394
Echinococcus granulosus histone lysine methyltransferase setb 0.0023 0.0153 0.0183
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0016 0.0089 0.0634
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0302 0.217
Echinococcus granulosus segment polarity protein dishevelled 0.0007 0.0012 0.0015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0021 0.0138 0.0165
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0078 0.0078
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0016 0.0089 0.0634
Echinococcus granulosus uridine phosphorylase 1 0.0169 0.1387 0.1659
Brugia malayi hypothetical protein 0.0016 0.0093 0.0135
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0078 0.0114
Treponema pallidum exodeoxyribonuclease (exoA) 0.0026 0.0178 0.1274
Treponema pallidum NADH oxidase 0.0014 0.0076 0.0541
Entamoeba histolytica Ran family GTPase 0.0016 0.0089 0.0634
Echinococcus multilocularis purine nucleoside phosphorylase 0.0814 0.6863 0.6863
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0214 0.0394
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0026 0.0178 0.1274
Brugia malayi CXXC zinc finger family protein 0.0043 0.0323 0.0471
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0005 0.0001 0.0002
Mycobacterium tuberculosis Probable hydrolase 0.0125 0.1017 0.148
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0055 0.0065
Echinococcus granulosus neutral sphingomyelinase 0.0005 0.0001 0.0002
Trichomonas vaginalis antibiotic synthetase, putative 0.0009 0.0035 0.0049
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0009 0.0035 0.0064
Schistosoma mansoni ferritin light chain 0.0013 0.0063 0.0076
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0089 0.0709 0.1033
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0103 0.0832 0.1211
Entamoeba histolytica hypothetical protein 0.0024 0.0161 0.1155
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0014 0.0076 0.0541
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0078 0.0144
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0076 0.0541
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0103 0.0832 0.1211
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0077 0.0077
Schistosoma mansoni nuclear receptor 0.0014 0.0078 0.0093
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0009 0.0033 0.0039
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0394
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0032 0.0226 0.1619
Echinococcus multilocularis segment polarity protein dishevelled 0.0007 0.0012 0.0012
Schistosoma mansoni ferritin 0.0013 0.0063 0.0076
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0214 0.0256
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0169 0.1387 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0009 0.0035 0.0064
Brugia malayi nuclear hormone receptor 0.003 0.0214 0.0312
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0076 0.0541
Brugia malayi glutathione reductase 0.0041 0.0302 0.044
Schistosoma mansoni globin X 0.0007 0.0014 0.0016
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0009 0.0035 0.024
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0014 0.0076 0.0092
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0024 0.0161 0.0193
Onchocerca volvulus 0.0023 0.0153 0.0221
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0169 0.1387 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0814 0.6863 0.8209
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0009 0.0035 0.0049
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0214 0.0256
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0078 0.0144
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0089 0.0709 0.0709
Leishmania major importin beta-1 subunit, putative 0.0017 0.0103 0.0732
Echinococcus granulosus regulator of G protein signaling 7 0.0007 0.0012 0.0015
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0001 0.0002
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0126 0.0899
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0302 0.0302
Echinococcus granulosus regulator of G protein signaling 7 0.0007 0.0012 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0222 0.0305
Loa Loa (eye worm) hypothetical protein 0.0014 0.0078 0.0144
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0093 0.0742 0.0887
Echinococcus multilocularis mothers against decapentaplegic 5 0.0006 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.0126 0.0232
Plasmodium vivax acetyl-CoA synthetase, putative 0.0009 0.0035 0.024
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0078 0.0093
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0078 0.0078
Onchocerca volvulus 0.0009 0.0035 0.0049
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0025
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0169 0.1387 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0031 0.0222 0.1594
Echinococcus multilocularis beta LACTamase domain containing family member 0.0125 0.1017 0.1017
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0076 0.0111
Loa Loa (eye worm) oxidoreductase 0.0009 0.0035 0.0064
Loa Loa (eye worm) hypothetical protein 0.0014 0.0078 0.0144
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0076 0.0541
Onchocerca volvulus Globin homolog 0.0007 0.0014 0.0018
Echinococcus multilocularis purine nucleoside phosphorylase 0.0814 0.6863 0.6863
Echinococcus granulosus Niemann Pick C1 protein 0.0076 0.06 0.0717
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0009 0.0035 0.024
Trichomonas vaginalis conserved hypothetical protein 0.001 0.004 0.0056
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0016 0.0089 0.0164
Entamoeba histolytica hypothetical protein 0.0024 0.0161 0.1155
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0153 0.0183
Brugia malayi hypothetical protein 0.002 0.0126 0.0183
Schistosoma mansoni ferritin 0.0013 0.0063 0.0076
Echinococcus multilocularis segment polarity protein dishevelled 0.0007 0.0012 0.0012
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0433 0.3117
Echinococcus granulosus mothers against decapentaplegic 5 0.0006 0.0008 0.001
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0031 0.0222 0.0305
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0016 0.0089 0.0634
Loa Loa (eye worm) hypothetical protein 0.0125 0.1017 0.1872
Loa Loa (eye worm) hypothetical protein 0.0125 0.1017 0.1872
Trichomonas vaginalis importin beta-1, putative 0.0017 0.0103 0.0148
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0002
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0078 0.0112
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0026 0.0178 0.0327
Toxoplasma gondii thioredoxin reductase 0.0041 0.0302 0.217
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0007 0.0012 0.0018
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0076 0.0541
Loa Loa (eye worm) MH1 domain-containing protein 0.0006 0.0008 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.001 0.004 0.0056
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0814 0.6863 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0009 0.0035 0.0041
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0024 0.0161 0.0161
Onchocerca volvulus 0.0007 0.0014 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0153 0.0183
Brugia malayi Hypothetical 22.2 kDa protein C28F5.2 in chromosome II, putative 0.0007 0.0014 0.002
Brugia malayi RNA binding protein 0.0049 0.037 0.054
Trichomonas vaginalis conserved hypothetical protein 0.001 0.004 0.0056
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0013 0.0063 0.0042
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0799 0.6732 0.9808
Echinococcus multilocularis expressed conserved protein 0.0071 0.0561 0.0561
Schistosoma mansoni thyroid hormone receptor 0.003 0.0214 0.0256
Brugia malayi hypothetical protein 0.0024 0.0161 0.0235
Echinococcus multilocularis ferritin 0.0013 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0214 0.0312
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0433 0.3117
Schistosoma mansoni regulator of G protein signaling 0.0007 0.0012 0.0015
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0125 0.1017 0.148
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0049 0.037 0.0682
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0001 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0214 0.0214
Brugia malayi regulator of G-protein signaling egl-10 0.0007 0.0012 0.0018
Plasmodium falciparum purine nucleoside phosphorylase 0.0169 0.1387 1
Onchocerca volvulus 0.0125 0.1017 0.148
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0031 0.0222 0.0305
Echinococcus multilocularis importin subunit beta 1 0.0021 0.0137 0.0137
Treponema pallidum bacterioferrin (TpF1) 0.0013 0.0063 0.0448
Trichomonas vaginalis ran, putative 0.0016 0.0089 0.0128
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0233 0.0337
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0114 0.0923 0.1104
Brugia malayi MH1 domain containing protein 0.0006 0.0008 0.0012
Onchocerca volvulus 0.0043 0.0323 0.0469
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0125 0.1017 0.148
Mycobacterium tuberculosis Conserved protein 0.0125 0.1017 0.148
Echinococcus granulosus FTZ F1 alpha 0.0305 0.2544 0.3042
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0227 0.1879 0.3459
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0214 0.0394
Entamoeba histolytica acyl-CoA synthetase, putative 0.0031 0.0222 0.1594
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0214 0.0312
Trypanosoma brucei uridine phosphorylase 0.0169 0.1387 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0031 0.0222 0.1594
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0009 0.0035 0.024
Mycobacterium ulcerans beta-lactamase 0.0125 0.1017 0.1465
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0014 0.0076 0.0541
Mycobacterium leprae conserved hypothetical protein 0.0125 0.1017 0.1439
Loa Loa (eye worm) hypothetical protein 0.0031 0.0222 0.0409
Loa Loa (eye worm) globin family protein 0.0007 0.0014 0.0025
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0646 0.5433 0.6498
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0214 0.0256
Toxoplasma gondii histone lysine methyltransferase SET1 0.0085 0.0681 0.4905
Loa Loa (eye worm) hypothetical protein 0.0089 0.0709 0.1305
Echinococcus granulosus histone acetyltransferase KAT2B 0.0105 0.0846 0.1011
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0126 0.0899
Schistosoma mansoni ran 0.0016 0.0089 0.0107
Schistosoma mansoni acetyl-CoA synthetase 0.0009 0.0035 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0125 0.1017 0.7331
Plasmodium falciparum histone acetyltransferase GCN5 0.0029 0.0203 0.1457
Onchocerca volvulus 0.0007 0.0014 0.0018
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0093 0.0744 0.1083
Echinococcus multilocularis uridine phosphorylase 1 0.0169 0.1387 0.1387
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0214 0.0312
Schistosoma mansoni tar DNA-binding protein 0.0049 0.037 0.0443
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0169 0.1387 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0169 0.1387 0.2019
Loa Loa (eye worm) hypothetical protein 0.0133 0.1084 0.1996
Brugia malayi RNA recognition motif domain containing protein 0.0049 0.037 0.054
Trypanosoma brucei trypanothione reductase 0.0041 0.0302 0.217
Schistosoma mansoni hypothetical protein 0.0031 0.0223 0.0266
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0226 0.0327
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0005 0.0001 0.0002
Schistosoma mansoni uridine phosphorylase 0.0169 0.1387 0.1659
Onchocerca volvulus 0.0009 0.0035 0.0049
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0214 0.0214
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0114 0.0923 0.1699
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0114 0.0923 0.0923
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0076 0.0541
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0214 0.0312
Echinococcus multilocularis purine nucleoside phosphorylase 0.0814 0.6863 0.6863
Mycobacterium leprae probable uridine phosphorylase 0.0169 0.1387 0.198
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0035 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0171
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0394
Schistosoma mansoni smad 0.0006 0.0008 0.001
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0078 0.0078
Loa Loa (eye worm) DIX domain-containing protein 0.0007 0.0012 0.0022
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0023 0.0153 0.0153
Schistosoma mansoni coup transcription factor 0.003 0.0214 0.0256
Loa Loa (eye worm) MH2 domain-containing protein 0.0089 0.071 0.1307
Trichomonas vaginalis D-aminoacylase, putative 0.0125 0.1017 0.148
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0005 0.0001 0.0002
Toxoplasma gondii exonuclease III APE 0.0026 0.0178 0.1274
Loa Loa (eye worm) MH2 domain-containing protein 0.0006 0.0008 0.0015
Brugia malayi ecdysone receptor 0.0014 0.0078 0.0114
Plasmodium vivax hypothetical protein, conserved 0.0125 0.1017 0.7331
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0214 0.0394
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0005 0.0001 0.0000087894
Trichomonas vaginalis conserved hypothetical protein 0.001 0.004 0.0056
Mycobacterium tuberculosis Conserved protein 0.0125 0.1017 0.148
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0144 0.0208
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0302 0.0556
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0214 0.0256
Mycobacterium ulcerans bacterioferritin BfrA 0.0013 0.0063 0.0073
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0144 0.0208
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0035 0.024
Loa Loa (eye worm) hypothetical protein 0.0014 0.0078 0.0144
Leishmania major GTP-binding protein, putative 0.0016 0.0089 0.0634
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0005 0.0001 0.0000087894
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0076 0.0541
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0144 0.0208
Loa Loa (eye worm) uridine phosphorylase 0.0169 0.1387 0.2553
Giardia lamblia Histone acetyltransferase GCN5 0.0029 0.0203 0.0294
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0016 0.0089 0.0634
Schistosoma mansoni carbon catabolite repressor protein 0.0005 0.0001 0.0002
Brugia malayi TAR-binding protein 0.0049 0.037 0.054
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0169 0.1387 0.2005
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0076 0.0541
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0005 0.0001 0.0002
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0433 0.3117
Mycobacterium tuberculosis Conserved protein 0.0125 0.1017 0.148
Loa Loa (eye worm) hypothetical protein 0.0014 0.0078 0.0144
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0076 0.0541
Onchocerca volvulus 0.0009 0.0035 0.0049
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0089 0.0709 0.0848
Loa Loa (eye worm) hypothetical protein 0.0023 0.0153 0.0282
Schistosoma mansoni neutral sphingomyelinase 0.0005 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0025
Schistosoma mansoni cpg binding protein 0.0043 0.0323 0.0387
Schistosoma mansoni myoglobin 1 0.0007 0.0014 0.0016
Brugia malayi steroid hormone receptor 0.003 0.0214 0.0312
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0026 0.0178 0.1274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0214 0.0394
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0076 0.0109
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0814 0.6863 1
Schistosoma mansoni tar DNA-binding protein 0.0049 0.037 0.0443
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0214 0.0256
Loa Loa (eye worm) hypothetical protein 0.004 0.0295 0.0543
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0114 0.0923 0.1104
Echinococcus granulosus histone acetyltransferase KAT2B 0.0032 0.0226 0.027
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0005 0.0001 0.0000087894
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0433 0.0629
Loa Loa (eye worm) beta-lactamase 0.0125 0.1017 0.1872
Brugia malayi nuclear receptor RXR 0.0014 0.0078 0.0114
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0031 0.0222 0.0275
Echinococcus granulosus expressed protein 0.0013 0.0063 0.0076
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0103 0.0148
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0171
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0009 0.0035 0.0031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0155 0.0285
Brugia malayi beta-lactamase family protein 0.0125 0.1017 0.1482
Echinococcus granulosus purine nucleoside phosphorylase 0.0814 0.6863 0.8209
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0214 0.0214
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0035 0.0031
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0009 0.0035 0.024
Onchocerca volvulus 0.0177 0.1459 0.2125
Schistosoma mansoni ran 0.0016 0.0089 0.0107
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0222 0.0305
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0025
Giardia lamblia NADH oxidase lateral transfer candidate 0.0014 0.0076 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0214 0.0394
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0035 0.0049
Leishmania major 4-coumarate:coa ligase-like protein 0.0031 0.0222 0.1594
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0007 0.0012 0.0016
Echinococcus granulosus cpg binding protein 0.0046 0.0344 0.0412
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0133 0.1084 0.1578
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0214 0.0256
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0026 0.0178 0.0213
Schistosoma mansoni cpg binding protein 0.0046 0.0344 0.0412
Schistosoma mansoni thyroid hormone receptor 0.003 0.0214 0.0256
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0214 0.0256
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0078 0.0114
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0006 0.0008 0.001
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0005 0.0001 0.0001
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0009 0.0035 0.005
Echinococcus granulosus mixed lineage leukemia protein mll 0.0012 0.0055 0.0065
Plasmodium vivax importin-beta 2, putative 0.0021 0.0137 0.0978
Leishmania major hypothetical protein, conserved 0.0125 0.1017 0.7331
Mycobacterium ulcerans esterase/lipase LipP 0.0125 0.1017 0.1465
Brugia malayi hypothetical protein 0.0007 0.0014 0.002
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0035 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0114 0.0923 0.1104
Trichomonas vaginalis ferritin, putative 0.0013 0.0063 0.0091
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0214 0.0256
Brugia malayi nuclear receptor NHR-88 0.0014 0.0078 0.0114
Echinococcus multilocularis regulator of G protein signaling 7 0.0007 0.0012 0.0012
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0078 0.0114
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0005 0.0001 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0078 0.0093
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0032 0.0226 0.1619
Schistosoma mansoni apoferritin-2 0.0013 0.0063 0.0076
Loa Loa (eye worm) TAR-binding protein 0.0049 0.037 0.0682
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0169 0.1387 1
Mycobacterium ulcerans hypothetical protein 0.0125 0.1017 0.1465
Plasmodium vivax acyl-CoA synthetase, putative 0.0023 0.0155 0.111
Loa Loa (eye worm) hypothetical protein 0.0125 0.1017 0.1872
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0005 0.0001 0.0002
Echinococcus granulosus Smad4 0.0006 0.0008 0.001
Brugia malayi Smad1 0.0006 0.0008 0.0012
Schistosoma mansoni nocturnin 0.0005 0.0001 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0049 0.037 0.0443
Echinococcus granulosus importin subunit beta 1 0.0021 0.0137 0.0164
Brugia malayi RNA, U transporter 1 0.006 0.0469 0.0683
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0814 0.6863 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0076 0.0091
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0214 0.031
Trichomonas vaginalis D-aminoacylase, putative 0.0125 0.1017 0.148
Trichomonas vaginalis antibiotic synthetase, putative 0.0009 0.0035 0.0049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0114 0.0923 0.0923
Brugia malayi uridine phosphorylase family protein 0.0169 0.1387 0.2021
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0009 0.0035 0.0049
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0078 0.0093
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0076 0.1129
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0433 0.0629
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0214 0.0312
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0214 0.0394
Echinococcus multilocularis sterol regulatory element binding protein 0.0033 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0171
Mycobacterium tuberculosis Probable oxidoreductase 0.0103 0.0832 0.1211
Brugia malayi Niemann-Pick C1 protein precursor 0.0076 0.06 0.0874
Echinococcus granulosus smad 0.0006 0.0008 0.001
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0001 0.0002
Echinococcus multilocularis Niemann Pick C1 protein 0.0076 0.06 0.06
Trichomonas vaginalis conserved hypothetical protein 0.001 0.004 0.0056
Echinococcus multilocularis purine nucleoside phosphorylase 0.0646 0.5433 0.5433
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0005 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0002
Schistosoma mansoni ferritin 0.0013 0.0063 0.0076
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0078 0.0078
Loa Loa (eye worm) acetyltransferase 0.0108 0.0871 0.1604
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.001 0.004 0.0056
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0169 0.1387 1
Schistosoma mansoni hypothetical protein 0.0058 0.0451 0.054
Echinococcus granulosus purine nucleoside phosphorylase 0.0814 0.6863 0.8209
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0433 0.0433
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0026 0.0178 0.0178
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0076 0.0541
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0214 0.0312
Brugia malayi hypothetical protein 0.0007 0.0014 0.002
Echinococcus granulosus Protein patched homolog 1 0.0033 0.0233 0.0278
Brugia malayi MTAP 0.0169 0.1387 0.2021
Mycobacterium tuberculosis Probable esterase LipL 0.0125 0.1017 0.148
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0005 0.0001 0.0000087894
Onchocerca volvulus 0.0014 0.0078 0.0112
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0076 0.0109
Leishmania major acetyl-CoA synthetase, putative 0.0009 0.0035 0.024
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0078 0.0114
Echinococcus granulosus ferritin 0.0013 0.0063 0.0076
Schistosoma mansoni hypothetical protein 0.0031 0.0223 0.0266
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0076 0.0541
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0076 0.1129
Entamoeba histolytica acyl-coA synthetase, putative 0.0031 0.0222 0.1594
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0076 0.0541
Schistosoma mansoni methylthioadenosine phosphorylase 0.0169 0.1387 0.1659
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0214 0.0256
Brugia malayi Globin family protein 0.0007 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0035 0.0064
Schistosoma mansoni hypothetical protein 0.0007 0.0014 0.0016
Toxoplasma gondii propionate-CoA ligase 0.0009 0.0035 0.024
Leishmania major 4-coumarate:coa ligase-like protein 0.0031 0.0222 0.1594
Leishmania major acetyl-CoA synthetase, putative 0.0009 0.0035 0.024
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0169 0.1387 0.2019
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0022
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0005 0.0001 0.0001
Echinococcus granulosus sterol regulatory element binding protein 0.0033 0.0233 0.0278
Treponema pallidum pfs protein (pfs) 0.0169 0.1387 1
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0005 0.0001 0.0000087894
Trichomonas vaginalis ap endonuclease, putative 0.0026 0.0178 0.0257
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0169 0.1387 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0233 0.0428
Brugia malayi Pre-SET motif family protein 0.0156 0.1278 0.1862
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0155 0.0224
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0023 0.0155 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1387 0.2019
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0214 0.0256
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.001 0.004 0.0056
Echinococcus multilocularis cpg binding protein 0.0046 0.0344 0.0344
Brugia malayi MH2 domain containing protein 0.0006 0.0008 0.0012
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0433 0.3117
Trichomonas vaginalis conserved hypothetical protein 0.001 0.004 0.0056
Loa Loa (eye worm) hypothetical protein 0.0125 0.1017 0.1872
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0013 0.0063 0.009
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0394
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0394
Brugia malayi nuclear receptor NHR-88 0.003 0.0214 0.0312
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0023 0.0153 0.0153
Plasmodium falciparum thioredoxin reductase 0.0014 0.0076 0.0541
Brugia malayi CHE-14 protein 0.0033 0.0233 0.0339
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0126 0.0899
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0014 0.0076 0.0092
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0005 0.0001 0.0002
Toxoplasma gondii phosphorylase family protein 0.0169 0.1387 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0035 0.0031
Trichomonas vaginalis ap endonuclease, putative 0.0026 0.0178 0.0257
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0078 0.0093
Loa Loa (eye worm) hypothetical protein 0.0031 0.0222 0.0409
Loa Loa (eye worm) hypothetical protein 0.0014 0.0078 0.0144
Echinococcus granulosus methylthioadenosine phosphorylase 0.0169 0.1387 0.1659
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0394
Trichomonas vaginalis conserved hypothetical protein 0.001 0.004 0.0056
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0155 0.0207
Loa Loa (eye worm) RNA binding protein 0.0049 0.037 0.0682
Schistosoma mansoni dishevelled 0.0007 0.0012 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0078 0.0078
Giardia lamblia UPL-1 0.0169 0.1387 0.2019
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0222 0.0324
Loa Loa (eye worm) hypothetical protein 0.0014 0.0078 0.0144
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0169 0.1387 0.2019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0114 0.0923 0.1104
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0433 0.0797
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.004 0.0056
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.004 0.0056
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0006 0.0008 0.0008
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0032 0.0226 0.1619
Echinococcus granulosus purine nucleoside phosphorylase 0.0814 0.6863 0.8209
Schistosoma mansoni importin beta-1 0.0021 0.0137 0.0164
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0035 0.005
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0433 0.0629
Schistosoma mansoni hypothetical protein 0.0031 0.0223 0.0266
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.0876 0.1048
Trypanosoma brucei hypothetical protein, conserved 0.0125 0.1017 0.7331
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0169 0.1387 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0016 0.0089 0.0634
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0026 0.0178 0.1274
Toxoplasma gondii ABC1 family protein 0.0125 0.1017 0.7331
Trichomonas vaginalis conserved hypothetical protein 0.001 0.004 0.0056
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.004 0.0056
Echinococcus multilocularis purine nucleoside phosphorylase 0.0814 0.6863 0.6863
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0016 0.0089 0.0128
Brugia malayi N-terminal motif family protein 0.0133 0.1084 0.158
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0433 0.0518
Echinococcus multilocularis deoxyribonuclease 1 2 0.0005 0.0001 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0126 0.0899
Loa Loa (eye worm) hypothetical protein 0.0031 0.0222 0.0409
Plasmodium vivax SET domain protein, putative 0.0023 0.0153 0.1095
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0169 0.1387 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0009 0.0035 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0214 0.0312
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0009 0.0035 0.0031
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0035 0.024
Trichomonas vaginalis Phospholipase C precursor, putative 0.0005 0.0001 0.0000087894
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0814 0.6863 1
Brugia malayi hypothetical protein 0.0014 0.0078 0.0114
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0433 0.0629
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0093 0.0111
Trypanosoma brucei protein kinase, putative 0.0056 0.0433 0.3117
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0125 0.1017 0.1482
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0169 0.1387 1
Echinococcus granulosus synaptojanin 1 0.0005 0.0001 0.0002
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0033 0.0233 0.0428
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0214 0.0312
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0169 0.1387 0.2019
Trichomonas vaginalis helicase, putative 0.001 0.004 0.0056
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0114 0.0923 0.1345
Brugia malayi nuclear hormone receptor 0.0014 0.0078 0.0114
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0433 0.0518
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0026 0.0178 0.1274
Brugia malayi hypothetical protein 0.0013 0.0066 0.0096
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0005 0.0001 0.0000087894
Leishmania major methylthioadenosine phosphorylase, putative 0.0169 0.1387 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0076 0.0541
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0076 0.0541
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0089 0.0709 0.0848
Echinococcus multilocularis protein patched 0.0033 0.0233 0.0233
Echinococcus granulosus tar DNA binding protein 0.0049 0.037 0.0443
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0814 0.6863 1
Echinococcus multilocularis protein dispatched 1 0.0037 0.0272 0.0272
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0026 0.0178 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0093 0.0093
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0016 0.0089 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0089 0.0709 0.1033
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0022
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0076 0.0541
Loa Loa (eye worm) hypothetical protein 0.0125 0.1017 0.1872
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0009 0.0035 0.0031
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0093 0.0744 0.1083
Schistosoma mansoni hypothetical protein 0.0227 0.1879 0.2248
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0093 0.0111
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0014 0.0076 0.0541
Loa Loa (eye worm) hypothetical protein 0.0125 0.1017 0.1872
Plasmodium vivax ataxin-2 like protein, putative 0.002 0.0126 0.0899
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0125 0.1017 0.1216
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0035 0.0031
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0169 0.1387 0.2019
Schistosoma mansoni ap endonuclease 0.0026 0.0178 0.0213
Entamoeba histolytica acetyltransferase, GNAT family 0.0029 0.0203 0.1457
Trypanosoma brucei importin beta-1 subunit, putative 0.0021 0.0137 0.0978
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0093 0.0111
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0646 0.5433 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0125 0.1017 0.1872
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.004 0.0056
Echinococcus multilocularis Smad4 0.0006 0.0008 0.0008
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0125 0.1017 0.148
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0035 0.005
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0222 0.0324
Loa Loa (eye worm) CXXC zinc finger family protein 0.0043 0.0323 0.0595
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.004 0.0056
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0005 0.0001 0.0000087894
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0214 0.0312
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0005 0.0001 0.0002
Leishmania major pantothenate kinase subunit, putative 0.0007 0.0012 0.0078
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0222 0.0322
Brugia malayi MH2 domain containing protein 0.0089 0.071 0.1035
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0007 0.0012 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0214 0.0312
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0302 0.217
Brugia malayi Globin family protein 0.0007 0.0014 0.002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0031 0.0222 0.0275
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0125 0.1017 0.1216
Loa Loa (eye worm) hypothetical protein 0.0023 0.0155 0.0285
Trichomonas vaginalis D-aminoacylase, putative 0.0125 0.1017 0.148
Schistosoma mansoni hypothetical protein 0.0991 0.8361 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0433 0.3117
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0014 0.0076 0.0109
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0394
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0302 0.0361
Schistosoma mansoni dep domain containing protein 0.0007 0.0012 0.0015
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0302 0.0438
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0214 0.0214
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0078 0.0093
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0093 0.0135
Loa Loa (eye worm) DR-78 0.0014 0.0078 0.0144
Echinococcus multilocularis purine nucleoside phosphorylase 0.0814 0.6863 0.6863
Brugia malayi acetyltransferase, GNAT family protein 0.0108 0.0871 0.1269
Schistosoma mansoni purine nucleoside phosphorylase 0.0814 0.6863 0.8209
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0005 0.0001 0.0000087894
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0009 0.0035 0.0049
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0103 0.0148
Echinococcus multilocularis synaptojanin 1 0.0005 0.0001 0.0001
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0169 0.1387 0.2019
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.0876 0.0876
Brugia malayi hypothetical protein 0.0007 0.0012 0.0018
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0077 0.061 0.0729
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0007 0.0012 0.0078
Echinococcus granulosus purine nucleoside phosphorylase 0.0814 0.6863 0.8209
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.1387 0.2019
Loa Loa (eye worm) Smad1 0.0006 0.0008 0.0015
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0076 0.06 0.432
Brugia malayi hypothetical protein 0.0007 0.0014 0.002
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0005 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1387 0.2019
Schistosoma mansoni purine nucleoside phosphorylase 0.0814 0.6863 0.8209
Brugia malayi MH1 domain containing protein 0.0006 0.0008 0.0012
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0045 0.0065
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0156 0.1278 0.2352
Echinococcus granulosus segment polarity protein dishevelled 0.0007 0.0012 0.0015
Onchocerca volvulus 0.0007 0.0014 0.0018
Toxoplasma gondii HEAT repeat-containing protein 0.0021 0.0137 0.0978
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0035 0.0031
Toxoplasma gondii LsmAD domain-containing protein 0.002 0.0126 0.0899
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0108 0.0871 0.1042
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0153 0.0183
Schistosoma mansoni tar DNA-binding protein 0.0049 0.037 0.0443
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0078 0.0093
Schistosoma mansoni ferritin light chain 0.0013 0.0063 0.0076
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0169 0.1387 1
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0169 0.1387 0.2553
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0032 0.0226 0.0327
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0169 0.1387 0.2019
Trypanosoma cruzi hypothetical protein, conserved 0.0125 0.1017 0.7331
Loa Loa (eye worm) hypothetical protein 0.0009 0.0035 0.0064
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0024 0.0161 0.1155
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0078 0.0093
Echinococcus multilocularis FTZ F1 alpha 0.0089 0.0709 0.0709
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0222 0.0324
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0169 0.1387 1
Schistosoma mansoni hypothetical protein 0.0024 0.0161 0.0193
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0013 0.0063 0.009
Mycobacterium tuberculosis Probable reductase 0.0093 0.0744 0.1083
Echinococcus multilocularis geminin 0.0991 0.8361 0.8361
Brugia malayi ecdysteroid receptor 0.003 0.0214 0.0312
Loa Loa (eye worm) histone methyltransferase 0.0014 0.0077 0.0142
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0093 0.0744 0.1039
Loa Loa (eye worm) hypothetical protein 0.0014 0.0078 0.0144
Echinococcus granulosus TGF beta signal transducer SmadC 0.0006 0.0008 0.001
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0016 0.0089 0.013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0214 0.0312
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0169 0.1387 1
Echinococcus multilocularis neutral sphingomyelinase 0.0005 0.0001 0.0001
Brugia malayi tailless protein 0.0014 0.0078 0.0114
Schistosoma mansoni smad1 5 8 and 0.0006 0.0008 0.001
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0026 0.0178 0.0257
Brugia malayi hypothetical protein 0.0007 0.0014 0.002
Schistosoma mansoni smad1 5 8 and 0.0006 0.0008 0.001
Brugia malayi Pre-SET motif family protein 0.0023 0.0153 0.0223
Echinococcus granulosus purine nucleoside phosphorylase 0.0814 0.6863 0.8209
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0076 0.0541
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0009 0.0035 0.024
Entamoeba histolytica hypothetical protein 0.0017 0.0103 0.0732
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0433 0.0433
Onchocerca volvulus 0.0031 0.0222 0.0322
Trypanosoma brucei importin beta-1 subunit, putative 0.0021 0.0137 0.0978
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0007 0.0012 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0035 0.0031
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0031 0.0222 0.0305
Loa Loa (eye worm) hypothetical protein 0.0076 0.06 0.1104
Onchocerca volvulus 0.0007 0.0012 0.0016
Onchocerca volvulus 0.0125 0.1017 0.148
Brugia malayi conserved hypotetical protein 0.0014 0.0078 0.0114
Brugia malayi MAP kinase sur-1 0.0056 0.0433 0.0631
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0012 0.0055 0.0055
Mycobacterium leprae Probable lipase LipE 0.0125 0.1017 0.1439
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0433 0.0518
Plasmodium falciparum glutathione reductase 0.0014 0.0076 0.0541
Trichomonas vaginalis penicillin-binding protein, putative 0.0125 0.1017 0.148
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0035 0.005
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0025
Schistosoma mansoni methylthioadenosine phosphorylase 0.0169 0.1387 0.1659
Schistosoma mansoni hypothetical protein 0.0031 0.0223 0.0266
Onchocerca volvulus 0.0009 0.0035 0.0049
Brugia malayi Importin beta-1 subunit 0.0021 0.0137 0.0199
Trypanosoma brucei PAB1-binding protein , putative 0.002 0.0126 0.0899
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0014 0.0076 0.0092
Toxoplasma gondii phosphorylase family protein 0.0169 0.1387 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0031 0.0222 0.0322
Trichomonas vaginalis esterase, putative 0.0125 0.1017 0.148
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0078 0.0144
Schistosoma mansoni Smad4 0.0006 0.0008 0.001
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0093 0.0744 0.1083
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0169 0.1387 0.1387
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0035 0.005
Schistosoma mansoni transcription factor LCR-F1 0.0024 0.0161 0.0193
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0076 0.0091
Echinococcus multilocularis expressed protein 0.0013 0.0063 0.0063
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0076 0.0541
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0171
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0214 0.031
Plasmodium falciparum importin beta, putative 0.0021 0.0137 0.0978
Brugia malayi hypothetical protein 0.0007 0.0012 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0144 0.0208
Echinococcus granulosus geminin 0.0991 0.8361 1
Brugia malayi hypothetical protein 0.0016 0.0093 0.0135
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0433 0.3117
Schistosoma mansoni uridine phosphorylase 0.0169 0.1387 0.1659
Schistosoma mansoni synaptojanin 0.0005 0.0001 0.0002
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0001 0.0002
Schistosoma mansoni ap endonuclease 0.0026 0.0178 0.0213
Treponema pallidum uridine phosphorylase (udp) 0.0169 0.1387 1
Toxoplasma gondii Purine nucleoside phosphorylase 0.0169 0.1387 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0009 0.0035 0.0031
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0076 0.011
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0214 0.031
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0814 0.6863 1
Schistosoma mansoni synaptojanin 0.0005 0.0001 0.0002
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0169 0.1387 0.2019
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0009 0.0035 0.0031
Schistosoma mansoni nuclear hormone receptor 0.003 0.0214 0.0256
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0076 0.0541
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.0014 0.0078 0.0144
Brugia malayi hypothetical protein 0.0014 0.0078 0.0114
Entamoeba histolytica hypothetical protein 0.0024 0.0161 0.1155
Echinococcus granulosus Pleckstrin G protein interacting region 0.0007 0.0012 0.0015
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0214 0.0256
Brugia malayi DIX domain containing protein 0.0007 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0155 0.0285
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0009 0.0035 0.0049
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0009 0.0035 0.0049
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0078 0.0093
Schistosoma mansoni cript-related 0.0005 0.0001 0.0002
Echinococcus multilocularis tar DNA binding protein 0.0049 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0023 0.0155 0.0285
Echinococcus granulosus traf and tnf receptor associated protein 0.0005 0.0001 0.0002
Echinococcus multilocularis traf and tnf receptor associated protein 0.0005 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0214 0.0256
Schistosoma mansoni apoferritin-2 0.0013 0.0063 0.0076
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0077 0.0092
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0035 0.024
Mycobacterium ulcerans lipase LipD 0.0125 0.1017 0.1465
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0009 0.0035 0.024
Echinococcus granulosus purine nucleoside phosphorylase 0.0814 0.6863 0.8209
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0005 0.0001 0.0002
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0433 0.3117
Brugia malayi MH2 domain containing protein 0.0006 0.0008 0.0012
Leishmania major nucleoside phosphorylase-like protein 0.0169 0.1387 1
Mycobacterium ulcerans hypothetical protein 0.0031 0.0222 0.0305
Plasmodium falciparum acyl-CoA synthetase 0.0023 0.0155 0.111
Chlamydia trachomatis AMP nucleosidase 0.0169 0.1387 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0078 0.0078
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0169 0.1387 0.2019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0014 0.0078 0.0144
Schistosoma mansoni hypothetical protein 0.0009 0.0033 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0214 0.0394
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0093 0.0135
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0222 0.0305
Loa Loa (eye worm) hypothetical protein 0.0014 0.0078 0.0144
Mycobacterium tuberculosis Probable lipase LipD 0.0125 0.1017 0.148
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0007 0.0012 0.0015
Echinococcus granulosus beta LACTamase domain containing family member 0.0125 0.1017 0.1216
Echinococcus granulosus expressed conserved protein 0.0071 0.0561 0.0671
Toxoplasma gondii hypothetical protein 0.0007 0.0012 0.0078
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0093 0.0171
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0026 0.0178 0.0257
Loa Loa (eye worm) glutathione reductase 0.0041 0.0302 0.0556
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0076 0.0541
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0169 0.1387 0.2005
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0035 0.0031
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0001 0.0002
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0078 0.0114
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0433 0.0629
Trichomonas vaginalis set domain proteins, putative 0.0177 0.1459 0.2125
Loa Loa (eye worm) transcription factor SMAD2 0.0089 0.071 0.1307
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0014 0.0076 0.0541
Schistosoma mansoni tar DNA-binding protein 0.0049 0.037 0.0443
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0214 0.0256
Echinococcus multilocularis smad 0.0006 0.0008 0.0008
Schistosoma mansoni smad1 5 8 and 0.0006 0.0008 0.001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0055 0.0055
Brugia malayi nuclear receptor RXR 0.0016 0.0093 0.0135
Loa Loa (eye worm) hypothetical protein 0.0014 0.0078 0.0144
Mycobacterium tuberculosis Probable lipase LipE 0.0125 0.1017 0.148
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0008 0.0024 0.0033
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0078 0.0093
Echinococcus multilocularis regulator of G protein signaling 7 0.0007 0.0012 0.0012
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0026 0.0178 0.1274
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0394
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0214 0.0256
Echinococcus multilocularis snurportin 1 0.0227 0.1879 0.1879
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0214 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0214 0.0312
Onchocerca volvulus 0.0014 0.0078 0.0112
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0035 0.0049
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0214 0.0312
Schistosoma mansoni cpg binding protein 0.0046 0.0344 0.0412
Loa Loa (eye worm) globin family protein 0.0007 0.0014 0.0025
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0214 0.0256
Schistosoma mansoni z-protein (S1r protein) 0.0007 0.0012 0.0015
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0035 0.024
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0214 0.0214
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.001 0.004 0.0056
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0009 0.0035 0.024
Loa Loa (eye worm) hypothetical protein 0.0023 0.0155 0.0285
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0169 0.1387 0.2019
Leishmania major trypanothione reductase 0.0041 0.0302 0.217
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0035 0.0049
Plasmodium falciparum thioredoxin reductase 0.0041 0.0302 0.217
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0076 0.0541
Schistosoma mansoni patched 1 0.0033 0.0233 0.0278
Schistosoma mansoni nuclear receptor 0.0014 0.0078 0.0093
Onchocerca volvulus 0.003 0.0214 0.031
Brugia malayi nuclear receptor NHR-67 0.0014 0.0078 0.0114
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0433 0.3117
Echinococcus granulosus purine nucleoside phosphorylase 0.0814 0.6863 0.8209
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0078 0.0093
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0814 0.6863 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0137 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0214 0.0312
Onchocerca volvulus 0.0007 0.0014 0.0018
Brugia malayi beta-lactamase family protein 0.0125 0.1017 0.1482
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0009 0.0035 0.0031
Leishmania major hypothetical protein, conserved 0.002 0.0126 0.0899
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0169 0.1387 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0078 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0023 0.0153 0.0183
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0103 0.0832 0.1168
Brugia malayi Globin family protein 0.0007 0.0014 0.002
Echinococcus multilocularis purine nucleoside phosphorylase 0.0814 0.6863 0.6863
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0009 0.0035 0.0031
Schistosoma mansoni ferritin 0.0013 0.0063 0.0076
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0023 0.0153 0.1095
Brugia malayi beta-lactamase 0.0125 0.1017 0.1482
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0035 0.0031
Brugia malayi CCR4 0.0005 0.0001 0.0002
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0078 0.0112
Schistosoma mansoni methylthioadenosine phosphorylase 0.0169 0.1387 0.1659
Plasmodium vivax glutathione reductase, putative 0.0041 0.0302 0.217
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.004 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0114 0.0923 0.1104

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 15.3 nM Antitumor activity against mouse P388 cells ChEMBL. 18197599
ED50 (functional) = 15.3 nM Antitumor activity against mouse P388 cells ChEMBL. 18197599

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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