Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0178 | 0.0261 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0229 | 0.155 | 0.4469 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0475 | 0.3468 | 1 |
Loa Loa (eye worm) | orotate phosphoribosyltransferase | 0.013 | 0.0783 | 0.2258 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0226 | 0.1527 | 0.2771 |
Toxoplasma gondii | melibiase subfamily protein | 0.01 | 0.0547 | 0.0984 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0059 | 0.0228 | 0.0408 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.009 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0318 | 0.2249 | 0.3719 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0475 | 0.3468 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0059 | 0.0228 | 0.0658 |
Toxoplasma gondii | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase | 0.013 | 0.0783 | 0.1713 |
Brugia malayi | orotate phosphoribosyltransferase family protein | 0.013 | 0.0783 | 0.2258 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0174 | 0.1124 | 0.3241 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0178 | 0.0261 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.0547 | 0.1351 |
Echinococcus multilocularis | geminin | 0.0196 | 0.1294 | 0.3565 |
Onchocerca volvulus | 0.0059 | 0.0228 | 0.0155 | |
Trypanosoma brucei | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | 0.013 | 0.0783 | 0.0759 |
Echinococcus multilocularis | thymidylate synthase | 0.0475 | 0.3468 | 1 |
Schistosoma mansoni | single-minded | 0.0056 | 0.0205 | 0.0338 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0318 | 0.2249 | 0.639 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.009 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0059 | 0.0228 | 0.0408 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0073 | 0.0335 | 0.0966 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0475 | 0.3468 | 1 |
Schistosoma mansoni | orotidine 5'-phosphate decarboxylase | 0.013 | 0.0783 | 0.2051 |
Brugia malayi | Ets-domain containing protein | 0.0073 | 0.0335 | 0.0966 |
Brugia malayi | Ets-domain containing protein | 0.0073 | 0.0335 | 0.0966 |
Brugia malayi | hypoxia-induced factor 1 | 0.0174 | 0.1124 | 0.3241 |
Trichomonas vaginalis | set domain proteins, putative | 0.047 | 0.3434 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.016 | 0.0207 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0226 | 0.1527 | 0.3942 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0178 | 0.0261 |
Loa Loa (eye worm) | fli-1 protein | 0.0222 | 0.1494 | 0.4307 |
Schistosoma mansoni | gabp alpha | 0.0073 | 0.0335 | 0.0724 |
Echinococcus granulosus | thymidylate synthase | 0.0475 | 0.3468 | 1 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0073 | 0.0335 | 0.0724 |
Echinococcus granulosus | uridine 5' monophosphate synthase | 0.013 | 0.0783 | 0.2051 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.0562 | 0.1398 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.01 | 0.0547 | 0.1351 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0059 | 0.0228 | 0.0408 |
Schistosoma mansoni | ets-related | 0.0222 | 0.1494 | 0.4155 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0287 | 0.0826 |
Brugia malayi | Melibiase family protein | 0.0067 | 0.0287 | 0.0826 |
Brugia malayi | follicle stimulating hormone receptor | 0.0229 | 0.155 | 0.4469 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0228 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.2274 | 0.6558 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0252 | 0.0728 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.0547 | 0.1351 |
Onchocerca volvulus | 0.047 | 0.3434 | 0.376 | |
Brugia malayi | thymidylate synthase | 0.0475 | 0.3468 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0067 | 0.0287 | 0.0581 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0067 | 0.0287 | 0.0581 |
Mycobacterium ulcerans | thymidylate synthase | 0.0475 | 0.3468 | 1 |
Echinococcus granulosus | single minded 2 | 0.0042 | 0.0091 | 0.0001 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0318 | 0.2249 | 0.639 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0413 | 0.2988 | 0.8617 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.0547 | 0.1351 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0178 | 0.0261 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.009 | 1 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0318 | 0.2249 | 0.5 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.01 | 0.0547 | 0.1351 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0073 | 0.0335 | 0.0724 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0475 | 0.3468 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0318 | 0.2249 | 0.5459 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0178 | 0.0515 |
Brugia malayi | hypothetical protein | 0.0042 | 0.009 | 0.0261 |
Plasmodium vivax | orotidine 5'-phosphate decarboxylase, putative | 0.013 | 0.0783 | 0.1713 |
Brugia malayi | Pre-SET motif family protein | 0.0413 | 0.2988 | 0.8617 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0475 | 0.3468 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.1294 | 0.3565 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0056 | 0.0205 | 0.0338 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0059 | 0.0228 | 0.0408 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.009 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0475 | 0.3468 | 1 |
Echinococcus granulosus | geminin | 0.0196 | 0.1294 | 0.3565 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0475 | 0.3468 | 1 |
Brugia malayi | hypothetical protein | 0.0226 | 0.1527 | 0.4403 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0318 | 0.2249 | 0.6237 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0318 | 0.2249 | 0.639 |
Brugia malayi | Protein kinase domain containing protein | 0.0436 | 0.3163 | 0.9121 |
Brugia malayi | bHLH-PAS transcription factor | 0.0042 | 0.0091 | 0.0261 |
Brugia malayi | hypothetical protein | 0.0123 | 0.0728 | 0.21 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0059 | 0.0228 | 0.0408 |
Mycobacterium ulcerans | orotidine 5'-phosphate decarboxylase | 0.013 | 0.0783 | 0.205 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0059 | 0.0228 | 0.0408 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.01 | 0.0547 | 0.1351 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.1294 | 0.3565 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.1238 | 0.357 |
Loa Loa (eye worm) | camk/mapkapk/mnk protein kinase | 0.0436 | 0.3163 | 0.9121 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0178 | 0.0261 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0042 | 0.0091 | 0.0001 |
Onchocerca volvulus | 0.0475 | 0.3468 | 0.3798 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0475 | 0.3468 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0178 | 0.0261 |
Brugia malayi | Fli-1 protein | 0.0222 | 0.1494 | 0.4307 |
Brugia malayi | PAS domain containing protein | 0.0056 | 0.0205 | 0.059 |
Brugia malayi | hypothetical protein | 0.0189 | 0.1238 | 0.357 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.0547 | 0.1351 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0059 | 0.0228 | 0.0408 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0178 | 0.0261 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0057 | 0.0211 | 0.0357 |
Loa Loa (eye worm) | thymidylate synthase | 0.0475 | 0.3468 | 1 |
Echinococcus multilocularis | uridine 5' monophosphate synthase | 0.013 | 0.0783 | 0.2051 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0475 | 0.3468 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0178 | 0.0515 |
Onchocerca volvulus | 0.1182 | 0.8983 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 1.41 mg kg-1 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected iv dosed mouse 1 hr after inoculation | ChEMBL. | 18511280 |
MIC (functional) | = 0.063 ug ml-1 | Antibacterial activity against Streptococcus pyogenes ATCC12344 | ChEMBL. | 18511280 |
MIC (functional) | = 0.125 ug ml-1 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC49619 | ChEMBL. | 18511280 |
MIC (functional) | = 0.25 ug ml-1 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae KT2524 | ChEMBL. | 18511280 |
MIC (functional) | = 0.25 ug ml-1 | Antibacterial activity against Moraxella catarrhalis K1209 | ChEMBL. | 18511280 |
MIC (functional) | = 0.5 ug ml-1 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith | ChEMBL. | 18511280 |
MIC (functional) | = 0.5 ug ml-1 | Antibacterial activity against vancomycin-resistant Enterococcus faecium KU1778 | ChEMBL. | 18511280 |
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus KMP9 | ChEMBL. | 18511280 |
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against Haemophilus influenzae TH13 | ChEMBL. | 18511280 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.