Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0018 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0018 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0018 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0018 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0018 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0018 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 1 uM | Agonist activity at glucocorticoid receptor (unknown origin) assessed as glucose repsponse element transcriptional transactivation by luciferase assay | ChEMBL. | 18513967 |
EC50 (functional) | > 1 uM | Agonist activity at glucocorticoid receptor (unknown origin) assessed as glucose repsponse element transcriptional transactivation by luciferase assay | ChEMBL. | 18513967 |
Efficacy (functional) | < 20 % | Agonist activity at glucocorticoid receptor (unknown origin) assessed as glucose repsponse element transcriptional transactivation by luciferase assay relative to dexamethasone | ChEMBL. | 18513967 |
Efficacy (functional) | < 20 % | Antagonist activity at glucocorticoid receptor (unknown origin) assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivation by luciferase assay relative to control | ChEMBL. | 18513967 |
Efficacy (binding) | < 20 % | Activity at glucocorticoid receptor (unknown origin) assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression relative to prednislone | ChEMBL. | 18513967 |
Efficacy (functional) | < 20 % | Agonist activity at glucocorticoid receptor (unknown origin) assessed as glucose repsponse element transcriptional transactivation by luciferase assay relative to dexamethasone | ChEMBL. | 18513967 |
Efficacy (functional) | < 20 % | Antagonist activity at glucocorticoid receptor (unknown origin) assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivation by luciferase assay relative to control | ChEMBL. | 18513967 |
Efficacy (binding) | < 20 % | Activity at glucocorticoid receptor (unknown origin) assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression relative to prednislone | ChEMBL. | 18513967 |
IC50 (functional) | > 1 uM | Antagonist activity at glucocorticoid receptor (unknown origin) assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivation by luciferase assay | ChEMBL. | 18513967 |
IC50 (binding) | > 1 uM | Activity at glucocorticoid receptor (unknown origin) assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression | ChEMBL. | 18513967 |
IC50 (functional) | > 1 uM | Antagonist activity at glucocorticoid receptor (unknown origin) assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivation by luciferase assay | ChEMBL. | 18513967 |
IC50 (binding) | > 1 uM | Activity at glucocorticoid receptor (unknown origin) assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression | ChEMBL. | 18513967 |
Ki (binding) | = 460 nM | Displacement of radiolabeled dexamethasone from glucocorticoid receptor (unknown origin) | ChEMBL. | 18513967 |
Ki (binding) | = 460 nM | Displacement of radiolabeled dexamethasone from glucocorticoid receptor (unknown origin) | ChEMBL. | 18513967 |
Ki (binding) | = 2300 nM | Binding affinity at progesterone receptor (unknown origin) | ChEMBL. | 18513967 |
Ki (binding) | = 2300 nM | Binding affinity at progesterone receptor (unknown origin) | ChEMBL. | 18513967 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.