Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Huntingtin homolog | 0.0131 | 0.9926 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2635 | 0.5782 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.2635 | 0.2635 |
Echinococcus granulosus | dna polymerase eta | 0.007 | 0.4558 | 0.4802 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.2635 | 0.2777 |
Leishmania major | DNA polymerase eta, putative | 0.0022 | 0.0237 | 0.0409 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.007 | 0.4558 | 0.4802 |
Brugia malayi | polk-prov protein | 0.0077 | 0.517 | 0.517 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0022 | 0.0237 | 0.1437 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0126 | 0.9492 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0126 | 0.9492 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.007 | 0.4558 | 0.4558 |
Echinococcus multilocularis | dna polymerase eta | 0.007 | 0.4558 | 0.4802 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.007 | 0.4558 | 0.7883 |
Giardia lamblia | DNA damage repair protein | 0.0022 | 0.0237 | 0.0409 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0022 | 0.0237 | 0.0249 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0022 | 0.0237 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1647 | 0.1735 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.1647 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.007 | 0.4558 | 0.4802 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.3837 | 0.4043 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0126 | 0.9492 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.007 | 0.4558 | 0.4558 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0022 | 0.0237 | 0.1437 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0126 | 0.9492 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.1647 | 0.1735 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0126 | 0.9492 | 1 |
Trypanosoma brucei | unspecified product | 0.0049 | 0.2613 | 0.2753 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1647 | 0.1735 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0126 | 0.9492 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0112 | 0.8268 | 0.871 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.9926 | 0.9926 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.007 | 0.4558 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2635 | 0.5782 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0126 | 0.9492 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.007 | 0.4558 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.517 | 0.517 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.2635 | 0.2635 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.2635 | 0.2777 |
Leishmania major | DNA damage repair protein, putative | 0.0022 | 0.0237 | 0.0409 |
Trypanosoma cruzi | DNA damage repair protein, putative | 0.0022 | 0.0237 | 0.0249 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0126 | 0.9492 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0126 | 0.9492 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.1295 | 0.224 |
Giardia lamblia | DINP protein human, muc B family | 0.0084 | 0.5782 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1647 | 0.3613 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0077 | 0.517 | 0.5447 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.4558 | 0.4558 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.1647 | 0.1647 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0126 | 0.9492 | 1 |
Trypanosoma cruzi | DNA damage repair protein, putative | 0.0022 | 0.0237 | 0.0249 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0126 | 0.9492 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.2635 | 0.2777 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0084 | 0.5782 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0126 | 0.9492 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0126 | 0.9492 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.3837 | 0.4043 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1647 | 0.1735 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0126 | 0.9492 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0126 | 0.9492 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0084 | 0.5782 | 1 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0036 | 0.1461 | 0.887 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0022 | 0.0237 | 0.0249 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.007 | 0.4558 | 0.4802 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1647 | 0.3613 |
Leishmania major | DNA polymerase eta, putative | 0.007 | 0.4558 | 0.7883 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.3837 | 0.4043 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0126 | 0.9492 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.1647 | 0.1735 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.9926 | 0.9926 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1647 | 0.1735 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.1647 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.007 | 0.4558 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0022 | 0.0237 | 0.0409 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0084 | 0.5782 | 0.6092 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0022 | 0.0237 | 0.0249 |
Trypanosoma brucei | DNA damage repair protein, putative | 0.0022 | 0.0237 | 0.0249 |
Schistosoma mansoni | DNA polymerase IV / kappa | 0.0022 | 0.0237 | 0.0519 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1647 | 0.2848 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.007 | 0.4558 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.1647 | 0.3613 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0022 | 0.0237 | 0.0249 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.1647 | 0.1735 |
Trypanosoma brucei | unspecified product | 0.0112 | 0.8268 | 0.871 |
Brugia malayi | Inositol-1 | 0.0038 | 0.1647 | 0.1647 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.007 | 0.4558 | 0.4558 |
Onchocerca volvulus | Huntingtin homolog | 0.0131 | 0.9926 | 0.5 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.1647 | 0.1735 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.1295 | 0.5 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0022 | 0.0237 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0126 | 0.9492 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1647 | 0.1735 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0022 | 0.0237 | 0.0249 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0022 | 0.0237 | 0.0249 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.007 | 0.4558 | 0.4802 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.2635 | 0.2777 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0077 | 0.517 | 0.5447 |
Trypanosoma brucei | unspecified product | 0.0049 | 0.2613 | 0.2753 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0126 | 0.9492 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0126 | 0.9492 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2635 | 0.5782 |
Echinococcus multilocularis | dna polymerase kappa | 0.0126 | 0.9492 | 1 |
Brugia malayi | hypothetical protein | 0.0131 | 0.9926 | 0.9926 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0126 | 0.9492 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0084 | 0.5782 | 1 |
Trypanosoma brucei | DNA damage repair protein, putative | 0.0022 | 0.0237 | 0.0249 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0022 | 0.0237 | 0.0249 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antifungal activity against Candida albicans ATCC 10231 at 400 ug/disc after 24 hrs by disc diffusion assay | ChEMBL. | 18375122 | |
Activity (functional) | Antibacterial activity against Escherichia coli ATCC 10538 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 | |
Activity (functional) | Antibacterial activity against Escherichia coli ATCC 25922 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 | |
Activity (functional) | Antifungal activity against Candida albicans ATCC 90028 at 400 ug/disc after 24 hrs by disc diffusion assay | ChEMBL. | 18375122 | |
Activity (functional) | Antibacterial activity against Escherichia coli NCTC 8196 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 | |
Activity (functional) | 0 | Antibacterial activity against Escherichia coli ATCC 10538 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 |
Activity (functional) | 0 | Antibacterial activity against Escherichia coli ATCC 25922 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 |
Activity (functional) | 0 | Antibacterial activity against Escherichia coli NCTC 8196 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 |
Activity (functional) | 0 | Antibacterial activity against Proteus vulgaris NCTC 4635 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 |
Activity (functional) | 0 | Antibacterial activity against | ChEMBL. | 18375122 |
Activity (functional) | 0 | Antibacterial activity against Pseudomonas aeruginosa NCTC 6749 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 |
Activity (functional) | 0 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 |
Activity (functional) | 0 | Antibacterial activity against Bordetella bronchiseptica ATCC 4617 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 |
Activity (functional) | 0 | Antifungal activity against Candida albicans ATCC 10231 at 400 ug/disc after 24 hrs by disc diffusion assay | ChEMBL. | 18375122 |
Activity (functional) | 0 | Antifungal activity against Candida albicans ATCC 90028 at 400 ug/disc after 24 hrs by disc diffusion assay | ChEMBL. | 18375122 |
Activity (functional) | 0 | Antifungal activity against Candida parapsilosis ATCC 22019 at 400 ug/disc after 24 hrs by disc diffusion assay | ChEMBL. | 18375122 |
Activity (functional) | 0 | Antibacterial activity against Micrococcus luteus ATCC 9341 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 |
Activity (functional) | 0 | Antibacterial activity against | ChEMBL. | 18375122 |
Activity (functional) | 0 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 |
IZ (functional) | = 11 mm | Antibacterial activity against Micrococcus luteus ATCC 10240 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 |
IZ (functional) | = 11 mm | Antibacterial activity against Staphylococcus aureus ATCC 25923 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 |
IZ (functional) | = 13 mm | Antibacterial activity against Staphylococcus aureus ATCC 29213 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 |
IZ (functional) | = 13 mm | Antibacterial activity against Staphylococcus aureus ATCC 6538 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 |
IZ (functional) | = 13 mm | Antibacterial activity against Staphylococcus aureus NCTC 4163 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 |
IZ (functional) | = 14 mm | Antibacterial activity against Bacillus cereus ATCC 11778 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 |
IZ (functional) | = 15 mm | Antibacterial activity against Bacillus subtilis ATCC 6633 at 400 ug/disc after 18 hrs by disc diffusion assay | ChEMBL. | 18375122 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Bacillus cereus ATCC 11778 after 18 hrs by serial agar dilution method | ChEMBL. | 18375122 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 18 hrs by serial agar dilution method | ChEMBL. | 18375122 |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Micrococcus luteus ATCC 10240 after 18 hrs by serial agar dilution method | ChEMBL. | 18375122 |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against Micrococcus luteus ATCC 9341 after 18 hrs by serial agar dilution method | ChEMBL. | 18375122 |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 after 18 hrs by serial agar dilution method | ChEMBL. | 18375122 |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 18 hrs by serial agar dilution method | ChEMBL. | 18375122 |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 18 hrs by serial agar dilution method | ChEMBL. | 18375122 |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by serial agar dilution method | ChEMBL. | 18375122 |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against Staphylococcus aureus NCTC 4163 after 18 hrs by serial agar dilution method | ChEMBL. | 18375122 |
MIC (functional) | > 400 ug ml-1 | Antibacterial activity against Enterococcus hirae ATCC 10541 after 18 hrs by serial agar dilution method | ChEMBL. | 18375122 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.