Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | DNA polymerase I family protein | 0.0101 | 0.0889 | 1 |
Echinococcus granulosus | DNA polymerase subunit gamma | 0.0101 | 0.0889 | 0.4512 |
Giardia lamblia | DNA polymerase alpha subunit A | 0.0094 | 0.0778 | 0.0138 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0112 | 0.107 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0254 | 0.3492 | 0.3492 |
Brugia malayi | RNase H family protein | 0.0092 | 0.0741 | 0.166 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0112 | 0.107 | 0.0355 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0053 | 0.0072 | 0.0163 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0107 | 0.0986 | 0.0986 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0153 | 0.1781 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0107 | 0.0986 | 0.0986 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1781 | 1 |
Leishmania major | ribonuclease H1, putative | 0.0092 | 0.0741 | 0.1672 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0146 | 0.166 | 0.166 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0112 | 0.107 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0146 | 0.166 | 0.3747 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0092 | 0.0741 | 0.1672 |
Toxoplasma gondii | DNA polymerase (pol2) superfamily protein | 0.009 | 0.0711 | 0.959 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0092 | 0.0741 | 0.2121 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0107 | 0.0986 | 0.0986 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0092 | 0.0741 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0163 | 0.1942 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0636 | 1 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0254 | 0.3492 | 0.7882 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0107 | 0.0986 | 0.0986 |
Leishmania major | thymidine kinase, putative | 0.0254 | 0.3492 | 0.7882 |
Schistosoma mansoni | DNA polymerase gamma | 0.0101 | 0.0889 | 0.016 |
Mycobacterium ulcerans | hypothetical protein | 0.0163 | 0.1942 | 0.5 |
Plasmodium vivax | DNA polymerase alpha, putative | 0.009 | 0.0711 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0254 | 0.3492 | 1 |
Toxoplasma gondii | ribonuclease HI protein | 0.0092 | 0.0741 | 1 |
Echinococcus multilocularis | hypothetical protein | 0.0101 | 0.0889 | 0.4512 |
Brugia malayi | RNase H family protein | 0.0092 | 0.0741 | 0.166 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0254 | 0.3492 | 0.7882 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0309 | 0.4431 | 1 |
Trypanosoma brucei | unspecified product | 0.0107 | 0.0986 | 0.0986 |
Trypanosoma brucei | ribonuclease H1 | 0.0092 | 0.0741 | 0.0741 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0146 | 0.166 | 0.3747 |
Brugia malayi | RNase H family protein | 0.0092 | 0.0741 | 0.166 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0309 | 0.4431 | 0.4431 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0309 | 0.4431 | 1 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0092 | 0.0741 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0092 | 0.0741 | 0.1672 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0309 | 0.4431 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.0254 | 0.3492 | 0.5 |
Giardia lamblia | Thymidine kinase | 0.0254 | 0.3492 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0254 | 0.3492 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0254 | 0.3492 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC100 (functional) | = 1 ppm | Anthelmintic activity against benzimidazole-resistant Haemonchus contortus isolate by larva development assay | ChEMBL. | 18400497 |
EC100 (functional) | = 1 ppm | Anthelmintic activity against levamisole-resistant Trichostrongylus colubriformis isolate by larva development assay | ChEMBL. | 18400497 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.