Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0376 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0376 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0376 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0214 | 0 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0214 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0376 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0376 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0376 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0376 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0376 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0376 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0376 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 33 nM | Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration stopped-flow assay | ChEMBL. | 18513964 |
Ki (binding) | = 33 nM | Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration stopped-flow assay | ChEMBL. | 18513964 |
Ki (binding) | = 41 nM | Inhibition of human cloned carbonic anhydrase 9 by CO2 hydration stopped-flow assay | ChEMBL. | 18513964 |
Ki (binding) | = 41 nM | Inhibition of human cloned carbonic anhydrase 9 by CO2 hydration stopped-flow assay | ChEMBL. | 18513964 |
Ki (binding) | = 170 nM | Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration stopped-flow assay | ChEMBL. | 18513964 |
Ki (binding) | = 170 nM | Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration stopped-flow assay | ChEMBL. | 18513964 |
Ratio Ki (binding) | = 0.8 | Selectivity ratio of Ki for human recombinant carbonic anhydrase 2 to Ki for human cloned carbonic anhydrase 9 | ChEMBL. | 18513964 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.