Detailed information for compound 509697

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 394.528 | Formula: C20H30N2O4S
  • H donors: 1 H acceptors: 3 LogP: 3.02 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCCC(C1NC(=O)c1ccc(c(c1)S(=O)(=O)N1CCOCC1)C)C
  • InChi: 1S/C20H30N2O4S/c1-14-7-8-17(20(23)21-19-15(2)5-4-6-16(19)3)13-18(14)27(24,25)22-9-11-26-12-10-22/h7-8,13,15-16,19H,4-6,9-12H2,1-3H3,(H,21,23)
  • InChiKey: DLOPBVUKEBCWFJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cannabinoid receptor 2 (macrophage) Starlite/ChEMBL References
Homo sapiens cannabinoid receptor 1 (brain) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor NHR-88 0.0025 0.0164 0.0322
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0016 0.0056 0.0712
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Schistosoma mansoni atypical protein kinase C 0.0383 0.4302 0.6542
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.003 0.0046
Entamoeba histolytica hypothetical protein 0.0021 0.0111 0.0686
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0111 0.0412
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.013 0.1383 0.2104
Brugia malayi C2 domain containing protein 0.0016 0.0056 0.011
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0111 0.0111
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0111 0.0169
Echinococcus multilocularis neuropeptide receptor A26 0.0014 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0285 0.1725
Entamoeba histolytica C2 domain containing protein 0.0016 0.0056 0.0348
Schistosoma mansoni peptidase 0.0012 0.0011 0.0017
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0014 0.003 0.0046
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Trypanosoma brucei predicted C2 domain protein 0.0016 0.0056 0.0407
Brugia malayi G-protein coupled receptor 0.0014 0.003 0.006
Schistosoma mansoni hypothetical protein 0.0016 0.0056 0.0086
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0079 0.079 0.155
Schistosoma mansoni biogenic amine receptor 0.0014 0.003 0.0046
Loa Loa (eye worm) hypothetical protein 0.0028 0.0199 0.0408
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0053 0.049 0.0745
Echinococcus granulosus alpha 1A adrenergic receptor 0.0014 0.003 0.0046
Echinococcus granulosus dro:myosuppressin receptor 0.0014 0.003 0.0046
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0092 0.0941 0.1927
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0056 0.0712
Trypanosoma brucei cAMP binding protein, putative 0.0016 0.0056 0.0407
Brugia malayi nuclear receptor RXR 0.0025 0.0164 0.0322
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Schistosoma mansoni tyrosinase precursor 0.0091 0.0926 0.1408
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0056 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Loa Loa (eye worm) hypothetical protein 0.0053 0.049 0.1004
Onchocerca volvulus 0.0036 0.0285 0.0866
Leishmania major hypothetical protein, conserved 0.0016 0.0056 0.0712
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0056 0.0407
Brugia malayi Common central domain of tyrosinase family protein 0.0091 0.0926 0.1816
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0016 0.0056 0.0115
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.0584
Brugia malayi Synaptotagmin I 0.0016 0.0056 0.011
Echinococcus granulosus g protein coupled receptor 0.0014 0.003 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.003 0.0046
Schistosoma mansoni glut4 vesicle protein-related 0.0016 0.0056 0.0086
Echinococcus multilocularis copine 9 0.0016 0.0056 0.0056
Echinococcus granulosus cpg binding protein 0.003 0.0221 0.0335
Onchocerca volvulus 0.0014 0.003 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.013 0.1383 0.2104
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0227
Brugia malayi hypothetical protein 0.0025 0.0164 0.0322
Onchocerca volvulus 0.0016 0.0056 0.0171
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0053 0.049 0.0745
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0016 0.0056 0.0115
Loa Loa (eye worm) hypothetical protein 0.0426 0.4803 0.9838
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Echinococcus granulosus Ankyrin 0.0014 0.0039 0.006
Loa Loa (eye worm) nuclear receptor NHR-67 0.0025 0.0164 0.0336
Entamoeba histolytica protein kinase, putative 0.013 0.1383 0.8561
Echinococcus multilocularis G protein coupled receptor 139 0.0014 0.003 0.003
Schistosoma mansoni synaptotagmin 0.0016 0.0056 0.0086
Entamoeba histolytica protein kinase, putative 0.0019 0.0089 0.055
Onchocerca volvulus 0.0014 0.0033 0.0099
Leishmania major hypothetical protein, conserved 0.0016 0.0056 0.0712
Loa Loa (eye worm) hypothetical protein 0.0028 0.0199 0.0408
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0579 0.6575 0.6575
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0016 0.0056 0.0086
Echinococcus multilocularis copine 9 0.0016 0.0056 0.0056
Loa Loa (eye worm) C2 domain-containing protein 0.0016 0.0056 0.0115
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0111 0.0169
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.013 0.1383 0.2104
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0016 0.0056 0.0056
Echinococcus multilocularis FTZ F1 alpha 0.0053 0.049 0.049
Onchocerca volvulus 0.0016 0.0056 0.0171
Brugia malayi conserved hypotetical protein 0.0025 0.0164 0.0322
Loa Loa (eye worm) hypothetical protein 0.0341 0.3815 0.7813
Echinococcus granulosus neuropeptide receptor A26 0.0014 0.003 0.0046
Leishmania major phospholipase c-like protein 0.0016 0.0056 0.0712
Echinococcus granulosus synaptotagmin 2 0.0016 0.0056 0.0086
Onchocerca volvulus Neuropeptide F receptor homolog 0.0014 0.003 0.0092
Onchocerca volvulus 0.0014 0.003 0.0092
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0056 0.000000071837
Echinococcus multilocularis g protein coupled receptor 0.0014 0.003 0.003
Entamoeba histolytica hypothetical protein 0.0016 0.0056 0.0348
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0111 0.0111
Echinococcus multilocularis active breakpoint cluster region 0.0016 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Loa Loa (eye worm) hypothetical protein 0.0092 0.0941 0.1927
Onchocerca volvulus 0.0091 0.0926 0.2811
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0111 0.0169
Echinococcus multilocularis synaptotagmin 0.0016 0.0056 0.0056
Brugia malayi hypothetical protein 0.0021 0.0111 0.0218
Loa Loa (eye worm) hypothetical protein 0.0091 0.0926 0.1896
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.003 0.0046
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0053 0.049 0.0745
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0111 0.0169
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0188 0.0188
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0926 0.1816
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0056 0.0407
Entamoeba histolytica C2 domain containing protein 0.0016 0.0056 0.0348
Loa Loa (eye worm) hypothetical protein 0.0295 0.3293 0.6745
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0.0199 0.0303
Loa Loa (eye worm) hypothetical protein 0.0092 0.0941 0.1927
Schistosoma mansoni thyroid hormone receptor 0.0053 0.049 0.0745
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.2504 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0111 0.0412
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0025 0.0164 0.0336
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0038 0.0058
Brugia malayi putative neuropeptide receptor 0.0014 0.003 0.006
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0053 0.049 0.0745
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0285 0.0434
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0111 0.0111
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0095 0.0974 0.191
Entamoeba histolytica hypothetical protein 0.0016 0.0056 0.0348
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0336
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0014 0.0033 0.0067
Echinococcus multilocularis geminin 0.0353 0.3964 0.3964
Echinococcus granulosus synaptotagmin 0.0016 0.0056 0.0086
Schistosoma mansoni synaptotagmin 12 0.0016 0.0056 0.0086
Echinococcus multilocularis ubiquitin specific protease 41 0.0079 0.079 0.079
Brugia malayi orphan nuclear receptor NR2E1 0.0025 0.0164 0.0322
Echinococcus multilocularis myoferlin 0.0016 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0053 0.049 0.0961
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Loa Loa (eye worm) nuclear hormone receptor 0.0025 0.0164 0.0336
Brugia malayi Uncoordinated protein 44 0.0014 0.0038 0.0074
Brugia malayi ORL1-like opioid receptor 0.0014 0.003 0.006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.003 0.003
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0524 0.1029
Brugia malayi nuclear hormone receptor 0.0053 0.049 0.0961
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.003 0.0046
Loa Loa (eye worm) hypothetical protein 0.0092 0.0941 0.1927
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0027 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.031 0.1912
Brugia malayi nuclear hormone receptor 0.0025 0.0164 0.0322
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.003 0.0046
Schistosoma mansoni synaptotagmin-like protein 0.0016 0.0056 0.0086
Echinococcus multilocularis transcription factor btf3 0.0038 0.031 0.031
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0053 0.049 0.049
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0025 0.0164 0.0164
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0111 0.0218
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0016 0.0056 0.0086
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Brugia malayi follicle stimulating hormone receptor 0.0014 0.003 0.006
Brugia malayi beta-lactamase family protein 0.0036 0.0285 0.0559
Brugia malayi Ras association domain family 1 isoform A 0.0092 0.0941 0.1846
Schistosoma mansoni unc-13 (munc13) 0.0108 0.1124 0.1709
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Brugia malayi Serotonin receptor 0.0014 0.003 0.006
Onchocerca volvulus 0.0016 0.0056 0.0171
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0027 0.0342
Loa Loa (eye worm) hypothetical protein 0.0092 0.0941 0.1927
Loa Loa (eye worm) hypothetical protein 0.0053 0.049 0.1004
Loa Loa (eye worm) hypothetical protein 0.0053 0.049 0.1004
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0285 1
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.013 0.1383 0.2833
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0285 0.1725
Brugia malayi RhoGEF domain containing protein 0.0092 0.0941 0.1846
Brugia malayi Steroid receptor seven-up type 2 0.0053 0.049 0.0961
Onchocerca volvulus 0.0295 0.3293 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.3293 0.6745
Schistosoma mansoni vav2 0.0092 0.0941 0.1431
Echinococcus granulosus protein kinase c eta type 0.0092 0.0941 0.1431
Brugia malayi C2 domain containing protein 0.0016 0.0056 0.011
Entamoeba histolytica C2 domain containing protein 0.0016 0.0056 0.0348
Schistosoma mansoni diacylglycerol kinase theta 0.0092 0.0941 0.1431
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.0584
Echinococcus granulosus RNA directed DNA polymerase 0.0341 0.3815 0.5802
Brugia malayi hypothetical protein 0.0014 0.003 0.006
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Leishmania major basic transcription factor 3a, putative 0.0038 0.031 0.3924
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0053 0.049 0.049
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0079 0.079 0.5712
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0926 0.1816
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0079 0.079 0.489
Echinococcus granulosus Rac GTPase activating protein 1 0.0092 0.0941 0.1431
Trichomonas vaginalis AGC family protein kinase 0.013 0.1383 1
Echinococcus multilocularis synaptotagmin 0.0016 0.0056 0.0056
Onchocerca volvulus 0.0091 0.0926 0.2811
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0028 0.0199 0.0303
Onchocerca volvulus 0.0025 0.0164 0.0499
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Brugia malayi PXA domain containing protein 0.0021 0.0111 0.0218
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.003 0.003
Onchocerca volvulus 0.0014 0.003 0.0092
Echinococcus granulosus ubiquitin specific protease 41 0.0079 0.079 0.1202
Brugia malayi hypothetical protein 0.0021 0.0111 0.0218
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0111 0.0111
Entamoeba histolytica hypothetical protein 0.0038 0.031 0.1919
Onchocerca volvulus 0.0014 0.003 0.0092
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Brugia malayi G protein-coupled receptor F59B2.13 0.0014 0.003 0.006
Trypanosoma brucei C2 domain containing protein, putative 0.0016 0.0056 0.0407
Loa Loa (eye worm) tyrosinase 1 0.0091 0.0926 0.1896
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.031 0.3924
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0143 0.0218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.003 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.049 0.0745
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0143 0.0218
Schistosoma mansoni neuropeptide receptor 0.0014 0.003 0.0046
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.003 0.003
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0016 0.0056 0.0056
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.003 0.003
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0014 0.003 0.006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Entamoeba histolytica hypothetical protein 0.0039 0.0331 0.2046
Trichomonas vaginalis AGC family protein kinase 0.013 0.1383 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0111 0.0111
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.003 0.0046
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0016 0.0056 0.0115
Leishmania major hypothetical protein, conserved 0.0016 0.0056 0.0712
Echinococcus granulosus extended synaptotagmin 2 0.0016 0.0056 0.0086
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0014 0.003 0.003
Trypanosoma brucei C2 domain containing protein, putative 0.0016 0.0056 0.0407
Echinococcus multilocularis protein kinase c epsilon type 0.0386 0.4344 0.4344
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0079 0.079 0.079
Brugia malayi nuclear hormone receptor family member nhr-6 0.0025 0.0164 0.0322
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0111 0.0169
Echinococcus granulosus nuclear receptor nhr 48 0.0025 0.0164 0.025
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0143 0.0294
Schistosoma mansoni synaptotagmin 12 0.0016 0.0056 0.0086
Brugia malayi C2 domain containing protein 0.0016 0.0056 0.011
Echinococcus granulosus raf serine:threonine protein kinase 0.0092 0.0941 0.1431
Echinococcus multilocularis synaptotagmin 15 0.0016 0.0056 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0056 0.0712
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0038 0.0115
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0227
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0053 0.049 0.049
Schistosoma mansoni amine GPCR 0.0014 0.003 0.0046
Onchocerca volvulus 0.0056 0.0524 0.1593
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0016 0.0056 0.0056
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.003 0.0046
Brugia malayi PXA domain containing protein 0.0021 0.0111 0.0218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.003 0.0046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.003 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0111 0.0412
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0111 0.0218
Echinococcus granulosus Diacylglycerol kinase theta 0.0092 0.0941 0.1431
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0095 0.0974 0.1994
Echinococcus granulosus NEDD4 E3 ubiquitin protein ligase WWP1 0.0016 0.0056 0.0086
Echinococcus multilocularis serotonin receptor 0.0014 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0386 0.4344 0.8897
Loa Loa (eye worm) hypothetical protein 0.0028 0.0199 0.0408
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0053 0.049 0.0745
Brugia malayi sulfakinin receptor protein 0.0014 0.003 0.006
Brugia malayi C2 domain containing protein 0.0016 0.0056 0.011
Brugia malayi Melatonin receptor type 1A 0.0014 0.003 0.006
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0199 0.0303
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0111 0.0169
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0014 0.003 0.0046
Brugia malayi Synaptotagmin protein 3 0.0016 0.0056 0.011
Echinococcus granulosus G protein coupled receptor 139 0.0014 0.003 0.0046
Schistosoma mansoni amine GPCR 0.0014 0.003 0.0046
Echinococcus multilocularis g-protein coupled receptor 0.0014 0.003 0.003
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.013 0.1383 0.2104
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0053 0.049 0.0961
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0014 0.003 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.003 0.003
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0014 0.003 0.0062
Schistosoma mansoni hypothetical protein 0.0014 0.0038 0.0058
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0079 0.079 0.1202
Brugia malayi Copine VIII 0.0016 0.0056 0.011
Loa Loa (eye worm) copine family protein 0.0016 0.0056 0.0115
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0111 0.0412
Loa Loa (eye worm) hypothetical protein 0.0092 0.0941 0.1927
Schistosoma mansoni lamin 0.0056 0.0524 0.0798
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0025 0.0164 0.025
Brugia malayi beta-NAC-like protein 0.0038 0.031 0.0608
Echinococcus granulosus neuropeptide receptor 0.0014 0.003 0.0046
Onchocerca volvulus 0.0014 0.003 0.0092
Brugia malayi hypothetical protein 0.0014 0.003 0.006
Brugia malayi hypothetical protein 0.0014 0.003 0.006
Schistosoma mansoni nuclear hormone receptor 0.0053 0.049 0.0745
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0359 0.403 0.8255
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0227
Brugia malayi steroid hormone receptor 0.0053 0.049 0.0961
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.0584
Loa Loa (eye worm) hypothetical protein 0.0027 0.0188 0.0384
Echinococcus granulosus g-protein coupled receptor 0.0014 0.003 0.0046
Echinococcus multilocularis lamin 0.0056 0.0524 0.0524
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.003 0.0046
Echinococcus granulosus ecdysone induced protein 78C 0.0053 0.049 0.0745
Loa Loa (eye worm) hypothetical protein 0.0053 0.049 0.1004
Echinococcus multilocularis protein kinase c eta type 0.0092 0.0941 0.0941
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0285 0.1725
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.003 0.003
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0056 0.0348
Onchocerca volvulus 0.0014 0.003 0.0092
Echinococcus granulosus expressed protein 0.04 0.4498 0.6841
Entamoeba histolytica hypothetical protein 0.0092 0.0941 0.5823
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0336
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0095 0.0974 0.1481
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0143 0.0143
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0111 0.0169
Brugia malayi C2 domain containing protein 0.0016 0.0056 0.011
Schistosoma mansoni synaptotagmin 0.0016 0.0056 0.0086
Schistosoma mansoni hypothetical protein 0.0039 0.0331 0.0503
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0014 0.003 0.006
Schistosoma mansoni hypothetical protein 0.0016 0.0056 0.0086
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.031 0.2241
Echinococcus granulosus serotonin receptor 0.0014 0.003 0.0046
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0056 0.0348
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0285 0.5
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0111 0.0169
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0255 0.2824 0.5785
Loa Loa (eye worm) synaptotagmin-1 0.0016 0.0056 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0053 0.049 0.0961
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.003 0.0046
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0053 0.049 0.0745
Brugia malayi Protein kinase domain containing protein 0.013 0.1383 0.2714
Schistosoma mansoni neuropeptide receptor 0.0014 0.003 0.0046
Brugia malayi nuclear receptor NHR-88 0.0053 0.049 0.0961
Brugia malayi hypothetical protein 0.0028 0.0199 0.0391
Echinococcus multilocularis unc 13 (munc13) 0.0108 0.1124 0.1124
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0014 0.003 0.003
Loa Loa (eye worm) AGC/NDR protein kinase 0.013 0.1383 0.2833
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0038 0.0038
Onchocerca volvulus 0.0014 0.003 0.0092
Schistosoma mansoni opsin-like receptor 0.0014 0.003 0.0046
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.003 0.0062
Entamoeba histolytica hypothetical protein 0.0016 0.0056 0.0348
Brugia malayi Protein kinase domain containing protein 0.013 0.1383 0.2714
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0053 0.049 0.1004
Echinococcus granulosus g protein coupled receptor 0.0014 0.003 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0053 0.049 0.1004
Echinococcus multilocularis orexin receptor type 2 0.0014 0.003 0.003
Loa Loa (eye worm) ICD-1 protein 0.0038 0.031 0.0635
Brugia malayi G protein-coupled receptor 0.0014 0.003 0.006
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0111 0.0169
Trypanosoma brucei predicted C2 domain protein 0.0016 0.0056 0.0407
Echinococcus multilocularis Diacylglycerol kinase theta 0.0092 0.0941 0.0941
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0092 0.0941 0.0941
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0285 0.0434
Entamoeba histolytica C2 domain containing protein 0.0016 0.0056 0.0348
Schistosoma mansoni protein kinase C 0.0108 0.1124 0.1709
Trypanosoma cruzi C2 domain/Ankyrin repeats (3 copies), putative 0.0016 0.0056 0.0712
Loa Loa (eye worm) hypothetical protein 0.0433 0.4882 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0285 0.0584
Loa Loa (eye worm) RasGEF domain-containing protein 0.0092 0.0941 0.1927
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.003 0.0062
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.003 0.0046
Brugia malayi hypothetical protein 0.0014 0.003 0.006
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0079 0.079 0.1202
Echinococcus granulosus transcription factor btf3 0.0038 0.031 0.0472
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0336
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0285 0.0559
Brugia malayi Protein kinase domain containing protein 0.0095 0.0974 0.191
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0092 0.0941 0.1927
Echinococcus granulosus synaptotagmin 15 0.0016 0.0056 0.0086
Schistosoma mansoni alpha-1 adrenergic receptor 0.0014 0.003 0.0046
Brugia malayi WW domain containing protein 0.0016 0.0056 0.011
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0038 0.0074
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0222 0.0455
Schistosoma mansoni synaptotagmin 0.0016 0.0056 0.0086
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0027 0.0055
Echinococcus granulosus somatostatin receptor 0.0014 0.003 0.0046
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.003 0.0046
Schistosoma mansoni coup transcription factor 0.0053 0.049 0.0745
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0336
Onchocerca volvulus 0.0014 0.003 0.0092
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0014 0.003 0.0062
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.003 0.0046
Loa Loa (eye worm) C2 domain-containing protein 0.0016 0.0056 0.0115
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Echinococcus multilocularis neuropeptide receptor 0.0014 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0336
Echinococcus granulosus serine:threonine protein kinase N2 0.013 0.1383 0.2104
Echinococcus multilocularis allatostatin A receptor 0.0014 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0336
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.003 0.003
Schistosoma mansoni biogenic amine receptor 0.0014 0.003 0.0046
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0111 0.0169
Trypanosoma brucei C2 domain/Ankyrin repeats (3 copies), putative 0.0016 0.0056 0.0407
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0027 0.0195
Leishmania major hypothetical protein, conserved 0.0016 0.0056 0.0712
Onchocerca volvulus 0.0036 0.0285 0.0866
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0016 0.0056 0.0712
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0974 0.1481
Schistosoma mansoni hypothetical protein 0.0353 0.3964 0.603
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0716 0.1088
Loa Loa (eye worm) DR-78 0.0025 0.0164 0.0336
Echinococcus granulosus g protein coupled receptor 0.0014 0.003 0.0046
Onchocerca volvulus 0.0014 0.003 0.0092
Loa Loa (eye worm) hypothetical protein 0.0055 0.0513 0.105
Brugia malayi C2 domain containing protein 0.0016 0.0056 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Trypanosoma cruzi cAMP binding protein, putative 0.0016 0.0056 0.0712
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Schistosoma mansoni serine/threonine protein kinase 0.013 0.1383 0.2104
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0222 0.0436
Entamoeba histolytica C2 domain protein, putative 0.0016 0.0056 0.0348
Loa Loa (eye worm) raf kinase 0.0092 0.0941 0.1927
Loa Loa (eye worm) steroid hormone receptor 0.0053 0.049 0.1004
Schistosoma mansoni tyrosinase precursor 0.0091 0.0926 0.1408
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0111 0.0169
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0027 0.0342
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.0584
Schistosoma mansoni neuropeptide receptor 0.0014 0.003 0.0046
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0341 0.3815 0.3815
Schistosoma mansoni hypothetical protein 0.0016 0.0056 0.0086
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.003 0.0046
Brugia malayi putative neuropeptide receptor NPR1 0.0014 0.003 0.006
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0014 0.003 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.079 0.553
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.008
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0016 0.0056 0.0086
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0079 0.079 0.553
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0164 0.0322
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.003 0.0046
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0496 0.3311
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.031 0.3924
Brugia malayi C2 domain containing protein 0.0016 0.0056 0.011
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0111 0.0111
Echinococcus granulosus protein kinase C gamma type 0.0487 0.5507 0.8376
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0716 0.0716
Echinococcus granulosus copine 9 0.0016 0.0056 0.0086
Entamoeba histolytica PH domain containing protein kinase, putative 0.0151 0.1616 1
Onchocerca volvulus 0.0092 0.0941 0.2857
Echinococcus granulosus hypothetical protein 0.0014 0.003 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.003 0.0046
Echinococcus granulosus N chimaerin 0.0092 0.0941 0.1431
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0227
Schistosoma mansoni Mername-AA248 (C02 family) 0.0016 0.0056 0.0086
Echinococcus multilocularis extended synaptotagmin 2 0.0016 0.0056 0.0056
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.003 0.0046
Echinococcus multilocularis somatostatin receptor 0.0014 0.003 0.003
Echinococcus granulosus NDR protein kinase 0.013 0.1383 0.2104
Loa Loa (eye worm) hypothetical protein 0.0053 0.049 0.1004
Brugia malayi calpain 5 0.0016 0.0056 0.011
Echinococcus multilocularis ecdysone induced protein 78C 0.0053 0.049 0.049
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0014 0.003 0.0092
Schistosoma mansoni E3 ubiquitin-protein ligase nedd-4 0.0016 0.0056 0.0086
Brugia malayi C2 domain containing protein 0.0016 0.0056 0.011
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0016 0.0056 0.0712
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0053 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Brugia malayi Synapse defective protein 1 0.0016 0.0056 0.011
Echinococcus granulosus active breakpoint cluster region 0.0016 0.0056 0.0086
Onchocerca volvulus Putative cc2d1b protein 0.0016 0.0056 0.0171
Entamoeba histolytica hypothetical protein 0.0039 0.0331 0.2046
Echinococcus multilocularis cpg binding protein 0.003 0.0221 0.0221
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.013 0.1383 0.2104
Loa Loa (eye worm) C2 domain-containing protein 0.0016 0.0056 0.0115
Echinococcus multilocularis protein piccolo 0.0016 0.0056 0.0056
Echinococcus multilocularis synaptotagmin 0.0016 0.0056 0.0056
Brugia malayi hypothetical protein 0.0039 0.0331 0.0648
Echinococcus granulosus otoferlin 0.0016 0.0056 0.0086
Brugia malayi C1-like domain containing protein 0.0095 0.0974 0.191
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.003 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0053 0.049 0.0961
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.031 0.1912
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.003 0.003
Echinococcus granulosus 7TM GPCR rhodopsin 0.0014 0.003 0.0046
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0014 0.003 0.0046
Trichomonas vaginalis esterase, putative 0.0036 0.0285 0.1725
Echinococcus multilocularis g protein coupled receptor 0.0014 0.003 0.003
Entamoeba histolytica Rap/Ran GTPase activating protein, putative 0.0016 0.0056 0.0348
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.003 0.0046
Schistosoma mansoni cpg binding protein 0.003 0.0221 0.0335
Brugia malayi Nuclear hormone receptor-like 1 0.0053 0.049 0.0961
Onchocerca volvulus 0.0028 0.0202 0.0613
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0038 0.0058
Leishmania major hypothetical protein, conserved 0.0036 0.0285 0.3609
Schistosoma mansoni synaptic ras gtpase activating protein syngap 0.0016 0.0056 0.0086
Brugia malayi AKH receptor 0.0014 0.003 0.006
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Onchocerca volvulus 0.0014 0.003 0.0092
Brugia malayi Cytochrome P450 family protein 0.0013 0.0027 0.0053
Trypanosoma brucei predicted C2 domain protein 0.0016 0.0056 0.0407
Entamoeba histolytica diacylglycerol kinase, putative 0.0092 0.0941 0.5823
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0164 0.0164
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0092 0.0941 0.1431
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0016 0.0056 0.0056
Schistosoma mansoni fer-1-related 0.0016 0.0056 0.0086
Schistosoma mansoni hypothetical protein 0.0016 0.0056 0.0086
Echinococcus multilocularis N chimaerin 0.0092 0.0941 0.0941
Schistosoma mansoni unc-13 (munc13) 0.0016 0.0056 0.0086
Leishmania major cytochrome p450-like protein 0.0013 0.0027 0.0342
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Echinococcus multilocularis synaptotagmin protein 4 0.0016 0.0056 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0285 0.3609
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0056 0.0712
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.003 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0053 0.049 0.1004
Brugia malayi RhoGAP domain containing protein 0.0092 0.0941 0.1846
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0038 0.0077
Echinococcus granulosus thyroid hormone receptor alpha 0.0025 0.0164 0.025
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0016 0.0056 0.0086
Brugia malayi Protein kinase domain containing protein 0.013 0.1383 0.2714
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0053 0.049 0.0961
Brugia malayi Tachykinin-like peptides receptor 99D 0.0014 0.003 0.006
Brugia malayi Death domain containing protein 0.0014 0.0038 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0053 0.049 0.0961
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0039 0.006
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.003 0.0046
Schistosoma mansoni diacylglycerol kinase theta 0.0092 0.0941 0.1431
Onchocerca volvulus 0.0014 0.003 0.0092
Brugia malayi Protein kinase c protein 2 0.0451 0.5098 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0025 0.0164 0.0164
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0027 0.0055
Brugia malayi Serotonin receptor 0.0014 0.003 0.006
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0016 0.0056 0.0086
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0016 0.0056 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0053 0.049 0.1004
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0926 0.1816
Onchocerca volvulus 0.0053 0.049 0.1488
Toxoplasma gondii AGC kinase 0.013 0.1383 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0941 0.1927
Echinococcus granulosus intermediate filament protein 0.0056 0.0524 0.0798
Echinococcus granulosus synaptotagmin 0.0016 0.0056 0.0086
Echinococcus granulosus copine 9 0.0016 0.0056 0.0086
Echinococcus granulosus calpain 5 0.0016 0.0056 0.0086
Loa Loa (eye worm) hypothetical protein 0.0092 0.0941 0.1927
Loa Loa (eye worm) hypothetical protein 0.0388 0.4361 0.8932
Onchocerca volvulus 0.0108 0.1124 0.3413
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0111 0.0169
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0.0199 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0111 0.0412
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0164 0.025
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0014 0.003 0.0062
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.003 0.003
Schistosoma mansoni unc-13 (munc13) 0.0108 0.1124 0.1709
Onchocerca volvulus 0.0025 0.0164 0.0499
Loa Loa (eye worm) hypothetical protein 0.0053 0.049 0.1004
Loa Loa (eye worm) hypothetical protein 0.0056 0.0524 0.1074
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.003 0.003
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0014 0.003 0.0046
Schistosoma mansoni myosin xvIII 0.0014 0.003 0.0046
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Entamoeba histolytica hypothetical protein 0.0016 0.0056 0.0348
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Schistosoma mansoni hypothetical protein 0.0353 0.3964 0.603
Loa Loa (eye worm) C2 domain-containing protein 0.0016 0.0056 0.0115
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0014 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.0584
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0524 0.1074
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0111 0.0169
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0053 0.049 0.1004
Brugia malayi Hr1 repeat family protein 0.013 0.1383 0.2714
Schistosoma mansoni growth hormone secretagogue receptor 0.0014 0.003 0.0046
Toxoplasma gondii diacylglycerol kinase, putative 0.0092 0.0941 0.6667
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0014 0.003 0.003
Brugia malayi Variant SH3 domain containing protein 0.0016 0.0056 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Brugia malayi ecdysteroid receptor 0.0053 0.049 0.0961
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0016 0.0056 0.011
Echinococcus multilocularis raf serine:threonine protein kinase 0.0092 0.0941 0.0941
Echinococcus granulosus neuropeptide FF receptor 2 0.0014 0.003 0.0046
Echinococcus multilocularis neuropeptide receptor 0.0014 0.003 0.003
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0285 0.1725
Echinococcus granulosus 7tm_1 domain containing protein 0.0014 0.003 0.0046
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.013 0.1383 0.1383
Echinococcus granulosus synaptotagmin protein 4 0.0016 0.0056 0.0086
Leishmania major copine i-like protein 0.0016 0.0056 0.0712
Trichomonas vaginalis AGC family protein kinase 0.013 0.1383 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0079 0.079 0.1202
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0056 0.0712
Echinococcus multilocularis lamin dm0 0.0056 0.0524 0.0524
Schistosoma mansoni nedd-4-like E3 ubiquitin-protein ligase 0.0016 0.0056 0.0086
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.003 0.0046
Brugia malayi nuclear receptor NHR-67 0.0025 0.0164 0.0322
Loa Loa (eye worm) hypothetical protein 0.0028 0.0199 0.0408
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0014 0.003 0.0046
Trypanosoma brucei rac serine-threonine kinase, putative 0.013 0.1383 1
Trichomonas vaginalis AGC family protein kinase 0.013 0.1383 1
Echinococcus granulosus allatostatin A receptor 0.0014 0.003 0.0046
Loa Loa (eye worm) hypothetical protein 0.0108 0.1124 0.2302
Loa Loa (eye worm) hypothetical protein 0.0053 0.049 0.1004
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Schistosoma mansoni hypothetical protein 0.0014 0.003 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.049 0.0745
Echinococcus multilocularis serine:threonine protein kinase 38 0.013 0.1383 0.1383
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0014 0.003 0.006
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0053 0.049 0.0961
Echinococcus granulosus myoferlin 0.0016 0.0056 0.0086
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.031 0.1919
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1239 0.2537
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.003 0.0062
Brugia malayi Dopamine receptor 0.0014 0.003 0.006
Onchocerca volvulus 0.0056 0.0524 0.1593
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0164 0.025
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0336
Echinococcus multilocularis G-protein coupled receptor, putative 0.0014 0.003 0.003
Brugia malayi beta-lactamase 0.0036 0.0285 0.0559
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0025 0.0164 0.025
Echinococcus granulosus Immunoglobulin E set 0.0016 0.0056 0.0086
Schistosoma mansoni synaptotagmin 0.0016 0.0056 0.0086
Schistosoma mansoni rac gtpase activating protein 0.0092 0.0941 0.1431
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0199 0.0391
Toxoplasma gondii ABC1 family protein 0.0036 0.0285 0.1725
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0014 0.003 0.0046
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0164 0.0499
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0053 0.049 0.0745
Schistosoma mansoni copine 0.0016 0.0056 0.0086
Trypanosoma brucei C2 domain containing protein, putative 0.0016 0.0056 0.0407
Loa Loa (eye worm) AGC/AKT protein kinase 0.013 0.1383 0.2833
Echinococcus granulosus death domain containing protein 0.0014 0.0038 0.0058
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0014 0.003 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0056 0.0712
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0188 0.0285
Trichomonas vaginalis ion channel nompc, putative 0.0016 0.0056 0.000000071837
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0014 0.003 0.0046
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0111 0.0111
Brugia malayi beta-lactamase family protein 0.0036 0.0285 0.0559
Entamoeba histolytica protein kinase, putative 0.013 0.1383 0.8561
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0111 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0053 0.049 0.0961
Brugia malayi G-protein coupled receptor 0.0014 0.003 0.006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0164 0.025
Entamoeba histolytica hypothetical protein 0.0039 0.0331 0.2046
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0108 0.1124 0.1709
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0227
Echinococcus granulosus neuropeptide receptor 0.0014 0.003 0.0046
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0016 0.0056 0.0086
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.003 0.003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.057 0.0867
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.013 0.1383 0.1383
Echinococcus multilocularis myotubularin protein 13 0.0092 0.0941 0.0941
Schistosoma mansoni amine GPCR 0.0014 0.003 0.0046
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0143 0.0294
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.003 0.0062
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Echinococcus granulosus dnaJ subfamily B 0.0404 0.4551 0.6922
Schistosoma mansoni amine GPCR 0.0014 0.003 0.0046
Echinococcus multilocularis synaptotagmin 0.0016 0.0056 0.0056
Brugia malayi ShTK domain containing protein 0.0091 0.0926 0.1816
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.013 0.1383 0.2833
Entamoeba histolytica hypothetical protein 0.0021 0.0111 0.0686
Echinococcus multilocularis protein kinase c iota type 0.0372 0.4175 0.4175
Onchocerca volvulus 0.0092 0.0941 0.2857
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0111 0.0227
Schistosoma mansoni serine/threonine kinase 0.013 0.1383 0.2104
Echinococcus multilocularis serine threonine protein kinase 0.0487 0.5507 0.5507
Schistosoma mansoni neuropeptide receptor 0.0014 0.003 0.0046
Trichomonas vaginalis AGC family protein kinase 0.013 0.1383 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.079 0.1618
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0014 0.003 0.006
Brugia malayi hypothetical protein 0.0014 0.003 0.006
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0079 0.079 0.5
Echinococcus multilocularis synaptotagmin 0.0016 0.0056 0.0056
Echinococcus multilocularis expressed protein 0.04 0.4498 0.4498
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0016 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0336
Brugia malayi Dopamine receptor protein 2 0.0014 0.003 0.006
Echinococcus granulosus intersectin 2 0.0016 0.0056 0.0086
Onchocerca volvulus 0.0014 0.003 0.0092
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0108 0.1124 0.1124
Brugia malayi hypothetical protein 0.0014 0.003 0.006
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0016 0.0056 0.0056
Echinococcus granulosus synaptotagmin 0.0016 0.0056 0.0086
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0143 0.0218
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0091 0.0926 0.1816
Schistosoma mansoni synaptotagmin 0.0016 0.0056 0.0086
Echinococcus granulosus orexin receptor type 2 0.0014 0.003 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0053 0.049 0.0961
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0336
Trypanosoma cruzi synaptotagmin, putative 0.0016 0.0056 0.0712
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0038 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.003 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0053 0.049 0.1004
Entamoeba histolytica protein kinase, putative 0.013 0.1383 0.8561
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.013 0.1383 0.2833
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.013 0.1383 0.1383
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Echinococcus granulosus neuropeptide s receptor 0.0014 0.003 0.0046
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0077
Echinococcus granulosus myotubularin protein 13 0.0092 0.0941 0.1431
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0014 0.003 0.003
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0025 0.0164 0.0322
Onchocerca volvulus Protein ultraspiracle homolog 0.0053 0.049 0.1488
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0079 0.079 1
Leishmania major hypothetical protein, conserved 0.0016 0.0056 0.0712
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Brugia malayi Cytochrome P450 family protein 0.0013 0.0027 0.0053
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0285 0.0434
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0227
Echinococcus granulosus Protein kinase C brain isozyme 0.0579 0.6575 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0091 0.0926 0.1896
Brugia malayi GnHR receptor homolog 0.0014 0.003 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0111 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0111 0.0412
Loa Loa (eye worm) hypothetical protein 0.0091 0.0926 0.1896
Echinococcus multilocularis fmrfamide receptor 0.0014 0.003 0.003
Echinococcus granulosus unc 13 munc13 0.0108 0.1124 0.1709
Schistosoma mansoni mctp-related 0.0016 0.0056 0.0086
Brugia malayi tailless protein 0.0025 0.0164 0.0322
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0111 0.0169
Entamoeba histolytica hypothetical protein 0.0021 0.0111 0.0686
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0053 0.049 0.0745
Brugia malayi nuclear hormone receptor family member odr-7 0.0025 0.0164 0.0322
Echinococcus granulosus geminin 0.0353 0.3964 0.603
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0079 0.079 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0053 0.049 0.0961
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0014 0.003 0.0062
Loa Loa (eye worm) hypothetical protein 0.0053 0.049 0.1004
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0111 0.0169
Loa Loa (eye worm) hypothetical protein 0.0295 0.3293 0.6745
Onchocerca volvulus 0.0091 0.0926 0.2811
Onchocerca volvulus 0.0014 0.003 0.0092
Onchocerca volvulus 0.0016 0.0056 0.0171
Entamoeba histolytica C2 domain containing protein 0.0016 0.0056 0.0348
Brugia malayi diacylglycerol kinase 0.0092 0.0941 0.1846
Trypanosoma cruzi Coiled-coil and C2 domain-containing protein 0.0016 0.0056 0.0712
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.003 0.003
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0014 0.003 0.003
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0143 0.0281
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0016 0.0056 0.0086
Brugia malayi diacylglycerol kinase 0.0092 0.0941 0.1846
Brugia malayi ecdysone receptor 0.0025 0.0164 0.0322
Trichomonas vaginalis AGC family protein kinase 0.013 0.1383 1
Schistosoma mansoni cpg binding protein 0.0028 0.0202 0.0307
Entamoeba histolytica diacylglycerol kinase, putative 0.0092 0.0941 0.5823
Entamoeba histolytica DENN domain protein 0.0016 0.0056 0.0348
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0016 0.0056 0.0086
Entamoeba histolytica hypothetical protein 0.0039 0.0331 0.2046
Echinococcus multilocularis RNA directed DNA polymerase 0.0341 0.3815 0.3815
Schistosoma mansoni neuropeptide f receptor 76f 0.0014 0.003 0.0046
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0111 0.0169
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0164 0.0164
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0092 0.0941 0.1431
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0095 0.0974 0.0974
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0016 0.0056 0.0086
Brugia malayi hypothetical protein 0.0014 0.003 0.006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.0584
Schistosoma mansoni netrin receptor unc5 0.0014 0.0038 0.0058
Schistosoma mansoni steroid hormone receptor ad4bp 0.0053 0.049 0.0745
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0014 0.003 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.003 0.0046
Echinococcus granulosus UNCoordinated family member unc 13 0.0016 0.0056 0.0086
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0331 0.0503
Echinococcus multilocularis synaptotagmin 2 0.0016 0.0056 0.0056
Schistosoma mansoni retinoic acid receptor RXR 0.0053 0.049 0.0745
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0092 0.0941 0.1927
Echinococcus multilocularis NEDD4 E3 ubiquitin protein ligase WWP1 0.0016 0.0056 0.0056
Onchocerca volvulus Bile acid receptor homolog 0.0053 0.049 0.1488
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.031 0.1912
Brugia malayi hypothetical protein 0.0014 0.003 0.006
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0079 0.079 0.1202
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0285 0.3609
Schistosoma mansoni thyroid hormone receptor 0.0053 0.049 0.0745
Brugia malayi RE15519p 0.0014 0.003 0.006
Onchocerca volvulus 0.0014 0.003 0.0092
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0038 0.0038
Brugia malayi C2 domain containing protein 0.0016 0.0056 0.011
Schistosoma mansoni nuclear receptor 0.0025 0.0164 0.025
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0053 0.049 0.0745
Brugia malayi C2 domain containing protein 0.0016 0.0056 0.011
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0285 0.902
Brugia malayi Variant SH3 domain containing protein 0.0092 0.0941 0.1846
Schistosoma mansoni serine/threonine protein kinase 0.0579 0.6575 1
Schistosoma mansoni intermediate filament proteins 0.0056 0.0524 0.0798
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0336
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0336
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0016 0.0056 0.0056
Leishmania major c2 domain protein, putative 0.0016 0.0056 0.0712
Schistosoma mansoni rabphilin-3a 0.0016 0.0056 0.0086
Brugia malayi hypothetical protein 0.0025 0.0164 0.0322
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0111 0.0218
Brugia malayi nuclear receptor RXR 0.0028 0.0199 0.0391
Leishmania major c2 domain protein, putative 0.0016 0.0056 0.0712
Echinococcus granulosus lamin dm0 0.0056 0.0524 0.0798
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1239 0.2537
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0111 0.0169
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.0579 0.6575 1
Brugia malayi C2 domain containing protein 0.0016 0.0056 0.011
Entamoeba histolytica C2 domain containing protein 0.0016 0.0056 0.0348
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.003 0.0046
Schistosoma mansoni opsin-like receptor 0.0014 0.003 0.0046
Brugia malayi p70 ribosomal S6 kinase beta 0.013 0.1383 0.2714
Loa Loa (eye worm) hypothetical protein 0.0028 0.0199 0.0408
Trichomonas vaginalis AGC family protein kinase 0.013 0.1383 1
Entamoeba histolytica C2 domain containing protein 0.0016 0.0056 0.0348
Mycobacterium ulcerans hypothetical protein 0.0036 0.0285 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.013 0.1383 0.2833
Schistosoma mansoni serine/threonine protein kinase 0.0386 0.4344 0.6606
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0199 0.0391
Schistosoma mansoni amine GPCR 0.0014 0.003 0.0046
Loa Loa (eye worm) TYRA-2 protein 0.0014 0.003 0.0062
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0164 0.0322
Brugia malayi Synapse defective protein 1 0.0016 0.0056 0.011
Echinococcus granulosus tachykinin peptides receptor 99D 0.0014 0.003 0.0046
Onchocerca volvulus 0.0016 0.0056 0.0171
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0014 0.003 0.003
Trypanosoma brucei C2 domain containing protein, putative 0.0016 0.0056 0.0407
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0285 0.0285
Echinococcus multilocularis intersectin 2 0.0016 0.0056 0.0056
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.003 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0056 0.0712
Brugia malayi neuropeptide F receptor 0.0014 0.003 0.006
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.031 1
Schistosoma mansoni biogenic amine receptor 0.0014 0.003 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.003 0.0046
Schistosoma mansoni rho gtpase activating protein 0.0016 0.0056 0.0086
Leishmania major hypothetical protein, conserved 0.0016 0.0056 0.0712
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Schistosoma mansoni nuclear receptor nhr-48 0.0025 0.0164 0.025
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.003 0.0046
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0164 0.025
Schistosoma mansoni hypothetical protein 0.0014 0.003 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0053 0.049 0.0961
Schistosoma mansoni opsin-like receptor 0.0014 0.003 0.0046
Brugia malayi intermediate filament protein 0.0056 0.0524 0.1029
Schistosoma mansoni hypothetical protein 0.0014 0.003 0.0046
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0014 0.003 0.003
Leishmania major hypothetical protein, conserved 0.0016 0.0056 0.0712
Echinococcus granulosus protein kinase c iota type 0.0372 0.4175 0.635
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Loa Loa (eye worm) C2 domain-containing protein 0.0016 0.0056 0.0115
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0941 0.1431
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0025 0.0164 0.025
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0331 0.0331
Trichomonas vaginalis AGC family protein kinase 0.013 0.1383 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0014 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0014 0.003 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.003 0.0046
Loa Loa (eye worm) hypothetical protein 0.0026 0.0176 0.036
Trichomonas vaginalis AGC family protein kinase 0.013 0.1383 1
Brugia malayi hypothetical protein 0.0028 0.0199 0.0391
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.003 0.003
Brugia malayi LD23056p 0.0016 0.0056 0.011
Schistosoma mansoni hypothetical protein 0.0014 0.003 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.003 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0056 0.0712
Schistosoma mansoni hypothetical protein 0.0404 0.4551 0.6922
Brugia malayi neuropeptide F receptor 0.0014 0.003 0.006
Schistosoma mansoni zinc finger protein 0.0025 0.0164 0.025
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0111 0.0218
Schistosoma mansoni lamin 0.0056 0.0524 0.0798
Echinococcus granulosus protein piccolo 0.0016 0.0056 0.0086
Echinococcus multilocularis UNCoordinated family member (unc 13) 0.0016 0.0056 0.0056
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0079 0.079 0.553
Echinococcus multilocularis thyroid hormone receptor alpha 0.0053 0.049 0.049
Echinococcus granulosus sex peptide receptor 0.0014 0.003 0.0046
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0331 0.0503
Loa Loa (eye worm) melatonin receptor type 1A 0.0014 0.003 0.0062
Echinococcus multilocularis calpain 5 0.0016 0.0056 0.0056
Entamoeba histolytica hypothetical protein 0.0016 0.0056 0.0348
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0025 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.003 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0053 0.049 0.0961
Schistosoma mansoni hypothetical protein 0.0016 0.0056 0.0086
Echinococcus multilocularis musashi 0.0056 0.0524 0.0524
Brugia malayi NEDD4.2 0.0016 0.0056 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0974 0.1481
Schistosoma mansoni protein kinase C mu 0.0092 0.0941 0.1431
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0016 0.0056 0.0086
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0128 0.1351 0.9755
Onchocerca volvulus 0.0016 0.0056 0.0171
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0336
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Brugia malayi RhoGAP domain containing protein 0.0092 0.0941 0.1846
Loa Loa (eye worm) Nedd4-PD 0.0016 0.0056 0.0115
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0014 0.003 0.0062
Brugia malayi Protein kinase domain containing protein 0.0014 0.0033 0.0064
Echinococcus multilocularis serotonin receptor 0.0014 0.003 0.003
Brugia malayi Protein kinase domain containing protein 0.0017 0.007 0.0138
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.013 0.1383 0.2833
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0053 0.049 0.1488
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0164 0.0499
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0016 0.0056 0.0407
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0092 0.0941 0.1431
Onchocerca volvulus 0.0091 0.0926 0.2811
Entamoeba histolytica calcium-binding protein, putative 0.0016 0.0056 0.0348
Schistosoma mansoni serine/threonine protein kinase 0.013 0.1383 0.2104
Echinococcus multilocularis neuropeptide s receptor 0.0014 0.003 0.003
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0014 0.003 0.0046
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0053 0.049 0.0961
Mycobacterium leprae Probable lipase LipE 0.0036 0.0285 0.5
Echinococcus granulosus fmrfamide receptor 0.0014 0.003 0.0046
Onchocerca volvulus 0.0014 0.003 0.0092
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0053 0.049 0.0745
Schistosoma mansoni nuclear receptor 0.0025 0.0164 0.025
Entamoeba histolytica C2 domain containing protein 0.0016 0.0056 0.0348
Echinococcus multilocularis serine:threonine protein kinase N2 0.013 0.1383 0.1383
Echinococcus granulosus synaptotagmin 0.0016 0.0056 0.0086
Schistosoma mansoni histamine h1 receptor 0.0014 0.003 0.0046
Toxoplasma gondii NAC domain-containing protein 0.0038 0.031 0.1912
Onchocerca volvulus 0.0016 0.0056 0.0171
Mycobacterium ulcerans beta-lactamase 0.0036 0.0285 1
Onchocerca volvulus 0.0014 0.003 0.0092
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Echinococcus multilocularis 0.0016 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0053 0.049 0.1004
Brugia malayi phospholipase C homolog 0.0016 0.0056 0.011
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Echinococcus granulosus FTZ F1 alpha 0.0053 0.049 0.0745
Leishmania major hypothetical protein, conserved 0.0016 0.0056 0.0712
Brugia malayi C2 domain containing protein 0.0016 0.0056 0.011
Schistosoma mansoni cpg binding protein 0.003 0.0221 0.0335
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0164 0.0164
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.003 0.0046
Echinococcus multilocularis sex peptide receptor 0.0014 0.003 0.003
Mycobacterium ulcerans lipase LipD 0.0036 0.0285 1
Echinococcus granulosus lamin 0.0056 0.0524 0.0798
Echinococcus granulosus protein kinase c epsilon type 0.0386 0.4344 0.6606
Trypanosoma cruzi synaptotagmin, putative 0.0016 0.0056 0.0712
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.4551 0.4551
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0016 0.0056 0.0086
Loa Loa (eye worm) hypothetical protein 0.0092 0.0941 0.1927
Echinococcus multilocularis g protein coupled receptor 0.0014 0.003 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0143 0.0218
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0016 0.0056 0.0056
Echinococcus multilocularis Ankyrin 0.0014 0.0039 0.0039
Brugia malayi protein kinase C II. 0.0386 0.4344 0.8521
Loa Loa (eye worm) ShTK domain-containing protein 0.0091 0.0926 0.1896
Echinococcus multilocularis neural cell expressed, developmentally 0.0016 0.0056 0.0056
Echinococcus multilocularis neuropeptide FF receptor 2 0.0014 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Echinococcus granulosus synaptotagmin 0.0016 0.0056 0.0086
Echinococcus granulosus serine:threonine protein kinase N2 0.0151 0.1616 0.2458
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Brugia malayi C2 domain containing protein 0.0016 0.0056 0.011
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0164 0.025
Trichomonas vaginalis AGC family protein kinase 0.013 0.1383 1
Echinococcus multilocularis Rac GTPase activating protein 1 0.0092 0.0941 0.0941
Echinococcus granulosus neural cell expressed developmentally 0.0016 0.0056 0.0086
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0053 0.049 0.0745
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.003 0.0046
Schistosoma mansoni protein kinase C mu 0.0095 0.0974 0.1481
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0336
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.003 0.003
Schistosoma mansoni synaptotagmin 0.0016 0.0056 0.0086
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0111 0.0111
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0014 0.003 0.0046
Entamoeba histolytica C2 domain containing protein 0.0016 0.0056 0.0348
Entamoeba histolytica protein kinase, putative 0.0019 0.0089 0.055
Trypanosoma brucei Coiled-coil and C2 domain-containing protein 0.0016 0.0056 0.0407
Trichomonas vaginalis AGC family protein kinase 0.013 0.1383 1
Brugia malayi MH2 domain containing protein 0.0118 0.1239 0.243
Loa Loa (eye worm) beta-lactamase 0.0036 0.0285 0.0584
Onchocerca volvulus 0.0014 0.003 0.0092
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Loa Loa (eye worm) C2 domain-containing protein 0.0016 0.0056 0.0115
Onchocerca volvulus 0.0036 0.0285 0.0866
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0111 0.0169
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.003 0.003
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.031 1
Brugia malayi Pleckstrin Homology Domain 0.0092 0.0941 0.1846
Loa Loa (eye worm) hypothetical protein 0.0092 0.0941 0.1927
Onchocerca volvulus Multiple C2 domain and transmembrane region protein homolog 0.0016 0.0056 0.0171
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0079 0.079 0.079
Trypanosoma brucei synaptotagmin, putative 0.0016 0.0056 0.0407
Trypanosoma cruzi C2 domain containing protein, putative 0.0016 0.0056 0.0712
Entamoeba histolytica protein kinase, putative 0.013 0.1383 0.8561
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0524 0.1074
Brugia malayi C2 domain containing protein 0.0016 0.0056 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0062
Schistosoma mansoni adenoreceptor 0.0014 0.003 0.0046
Entamoeba histolytica hypothetical protein 0.0016 0.0056 0.0348
Brugia malayi larval opioid receptor 0.0014 0.003 0.006
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0111 0.0218
Schistosoma mansoni RAR-like nuclear receptor 0.0053 0.049 0.0745
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0202 0.0413
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.003 0.0046
Brugia malayi protein kinase C3,putative 0.0244 0.2698 0.5292
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0079 0.079 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.003 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0053 0.049 0.0961
Schistosoma mansoni otoferlin 0.0016 0.0056 0.0086
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0111 0.0227
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0016 0.0056 0.0086
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0111 0.0169
Brugia malayi Dopamine receptor protein 1 0.0014 0.003 0.006
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0285 0.2061
Brugia malayi hypothetical protein 0.0014 0.003 0.006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0176 0.036
Brugia malayi hypothetical protein 0.0014 0.003 0.006
Echinococcus multilocularis fmrfamide receptor 0.0014 0.003 0.003
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0285 0.1725
Schistosoma mansoni hypothetical protein 0.0092 0.0941 0.1431
Echinococcus granulosus peptide allatostatin:somatostatin 0.0014 0.003 0.0046
Brugia malayi Copine family protein 0.0016 0.0056 0.011
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0115
Echinococcus multilocularis serine:threonine protein kinase N2 0.0278 0.3093 0.3093
Brugia malayi CXXC zinc finger family protein 0.0028 0.0202 0.0396
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0285 1
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0111 0.0227
Schistosoma mansoni transcription factor btf3 0.0038 0.031 0.0472

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 44 nM Agonist activity at human cloned CB2 receptor by [35S]GTPgammaS binding assay ChEMBL. 18430570
EC50 (functional) = 44 nM Agonist activity at human cloned CB2 receptor by [35S]GTPgammaS binding assay ChEMBL. 18430570
EC50 (functional) = 540 nM Agonist activity at human cloned CB1 receptor by [35S]GTPgammaS binding assay ChEMBL. 18430570
EC50 (functional) = 540 nM Agonist activity at human cloned CB1 receptor by [35S]GTPgammaS binding assay ChEMBL. 18430570
Ki (binding) = 92 nM Displacement of [3H]CP55940 from human cloned CB2 receptor ChEMBL. 18430570
Ki (binding) = 92 nM Displacement of [3H]CP55940 from human cloned CB2 receptor ChEMBL. 18430570
Ki (binding) = 470 nM Displacement of [3H]CP55940 from human cloned CB1 receptor ChEMBL. 18430570
Ki (binding) = 470 nM Displacement of [3H]CP55940 from human cloned CB1 receptor ChEMBL. 18430570
Ratio EC50 (binding) = 12 Selectivity ratio of EC50 for human cloned CB1 receptor to EC50 for human cloned CB2 receptor ChEMBL. 18430570
Ratio Ki (binding) = 5 Selectivity ratio of Ki for human cloned CB1 receptor to Ki for human cloned CB2 receptor ChEMBL. 18430570

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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