Detailed information for compound 510228

Basic information

Technical information
  • TDR Targets ID: 510228
  • Name: (3R)-N-(benzenesulfonyl)-8-cyclopropyl-7-(nap hthalen-1-ylmethyl)-5-oxo-2,3-dihydro-[1,3]th iazolo[3,2-a]pyridine-3-carboxamide
  • MW: 516.631 | Formula: C28H24N2O4S2
  • H donors: 1 H acceptors: 4 LogP: 4.57 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=c1cc(Cc2cccc3c2cccc3)c(c2n1[C@@H](CS2)C(=O)NS(=O)(=O)c1ccccc1)C1CC1
  • InChi: 1S/C28H24N2O4S2/c31-25-16-21(15-20-9-6-8-18-7-4-5-12-23(18)20)26(19-13-14-19)28-30(25)24(17-35-28)27(32)29-36(33,34)22-10-2-1-3-11-22/h1-12,16,19,24H,13-15,17H2,(H,29,32)/t24-/m0/s1
  • InChiKey: BIVRJOXVTORWAX-DEOSSOPVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3R)-N-(benzenesulfonyl)-8-cyclopropyl-7-(1-naphthylmethyl)-5-oxo-2,3-dihydrothiazolo[3,2-a]pyridine-3-carboxamide
  • (3R)-N-(benzenesulfonyl)-8-cyclopropyl-7-(1-naphthalenylmethyl)-5-oxo-2,3-dihydrothiazolo[3,2-a]pyridine-3-carboxamide
  • (3R)-8-cyclopropyl-7-(naphthalen-1-ylmethyl)-5-oxo-N-(phenylsulfonyl)-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-3-carboxamide
  • (3R)-N-besyl-8-cyclopropyl-5-keto-7-(1-naphthylmethyl)-2,3-dihydrothiazolo[3,2-a]pyridine-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.5329 1
Onchocerca volvulus 0.0005 0.0038 0.0224
Plasmodium falciparum lysophospholipase, putative 0.0159 0.3472 1
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0009 0.0139 0.0363
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0011 0.0181 0.0181
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0006 0.0062 0.009
Trichomonas vaginalis ferritin, putative 0.0008 0.0114 0.027
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0009 0.0139 0.0363
Brugia malayi hypothetical protein 0.0005 0.0038 0.0038
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0797 0.1155
Plasmodium falciparum lysophospholipase, putative 0.0159 0.3472 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0047 0.0968 0.1403
Brugia malayi ecdysteroid receptor 0.0006 0.0062 0.0062
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0159 0.3472 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0159 0.3472 1
Schistosoma mansoni ferritin 0.0008 0.0114 0.0166
Schistosoma mansoni hypothetical protein 0.0004 0.0013 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0139 0.0342
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0775 0.1433
Brugia malayi hypothetical protein 0.0005 0.0038 0.0038
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0005 0.0052 0.0075
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0041 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0006 0.0062 0.0062
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0114 0.019
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0006 0.0062 0.009
Loa Loa (eye worm) hypothetical protein 0.0004 0.0021 0.0021
Echinococcus multilocularis muscleblind protein 0.0157 0.3436 0.4981
Brugia malayi hypothetical protein 0.0005 0.0038 0.0038
Schistosoma mansoni cytochrome P450 0.0004 0.0013 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0006 0.0062 0.0062
Loa Loa (eye worm) cytochrome P450 family protein 0.0004 0.0013 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0003 0 0.0001
Brugia malayi Pao retrotransposon peptidase family protein 0.0005 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0038 0.0775 0.0775
Echinococcus granulosus abhydrolase domain containing 3 0.0009 0.0139 0.0201
Loa Loa (eye worm) histone methyltransferase 0.0007 0.0082 0.0082
Loa Loa (eye worm) beta-lactamase 0.0038 0.0775 0.0775
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0775 0.1433
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0006 0.0062 0.009
Mycobacterium ulcerans hypothetical protein 0.0038 0.0775 0.2203
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0009 0.0139 0.0342
Mycobacterium ulcerans hypothetical protein 0.0159 0.3472 1
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0041 0.0058
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0005 0.0038 0.0224
Echinococcus granulosus netrin receptor unc 5 0.0011 0.0181 0.0262
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0004 0.0021 0.0023
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0062 0.009
Schistosoma mansoni hypothetical protein 0.0178 0.3907 0.5663
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0082 0.0118
Schistosoma mansoni hypothetical protein 0.0004 0.0021 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0923 0.1338
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0005 0.0041 0.0058
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0797 0.1155
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0797 0.2266
Echinococcus granulosus dnaJ subfamily B 0.0313 0.6899 1
Leishmania major myo-inositol-1 phosphatase, putative 0.0004 0.0021 0.0023
Brugia malayi reverse transcriptase 0.0005 0.0038 0.0038
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0775 0.1433
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0005 0.0038 0.0055
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0005 0.0038 0.0055
Brugia malayi beta-lactamase family protein 0.0038 0.0775 0.0775
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0775 0.2185
Schistosoma mansoni coup transcription factor 0.0006 0.0062 0.009
Chlamydia trachomatis hydrolase 0.0009 0.0139 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0011 0.0183 0.0265
Schistosoma mansoni steroid hormone receptor ad4bp 0.0006 0.0062 0.009
Mycobacterium tuberculosis Possible maturase 0.0005 0.0038 0.0046
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0006 0.0062 0.009
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0005 0.0038 0.0055
Leishmania major hypothetical protein, conserved 0.0038 0.0775 0.2203
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0005 0.0038 0.1435
Schistosoma mansoni ferritin light chain 0.0008 0.0114 0.0166
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1417 0.2054
Plasmodium falciparum esterase, putative 0.0159 0.3472 1
Entamoeba histolytica ;Alias 0.0009 0.0139 0.0342
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0006 0.0062 0.009
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0004 0.0021 0.0023
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0005 0.0038 0.0055
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0775 0.1124
Brugia malayi Zinc knuckle family protein 0.0005 0.0038 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0006 0.0062 0.0062
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0006 0.0062 0.009
Loa Loa (eye worm) CYP4Cod1 0.0004 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.3472 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0923 0.1338
Brugia malayi Pao retrotransposon peptidase family protein 0.0005 0.0038 0.0038
Echinococcus granulosus tar DNA binding protein 0.0067 0.1417 0.2054
Leishmania major hypothetical protein, conserved 0.0009 0.0139 0.0363
Echinococcus multilocularis netrin receptor unc 5 0.0011 0.0181 0.0262
Mycobacterium tuberculosis Conserved protein 0.0038 0.0775 0.1433
Loa Loa (eye worm) RNA binding protein 0.0067 0.1417 0.1417
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0009 0.0139 0.0342
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0797 0.2266
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0005 0.0038 0.0055
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0006 0.0062 0.0062
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0009 0.0139 1
Schistosoma mansoni cpg binding protein 0.0023 0.0447 0.0648
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0009 0.0139 0.0342
Schistosoma mansoni hypothetical protein 0.0213 0.4688 0.6795
Loa Loa (eye worm) cytochrome P450 family protein 0.0004 0.0013 0.0013
Brugia malayi nuclear receptor NHR-88 0.0006 0.0062 0.0062
Schistosoma mansoni ferritin light chain 0.0008 0.0114 0.0166
Schistosoma mansoni hypothetical protein 0.0178 0.3907 0.5663
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0159 0.3472 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0021 0.0021
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0009 0.0139 0.0201
Loa Loa (eye worm) hypothetical protein 0.0038 0.0775 0.0775
Mycobacterium leprae Probable monophosphatase 0.0004 0.0021 0.0023
Mycobacterium ulcerans hydrolase 0.0009 0.0139 0.0363
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0005 0.0038 0.1435
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.3472 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0005 0.0038 0.0055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0041 0.0058
Brugia malayi Zinc knuckle family protein 0.0005 0.0038 0.0038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0923 0.1338
Brugia malayi Pao retrotransposon peptidase family protein 0.0005 0.0038 0.0038
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.1417 0.1417
Loa Loa (eye worm) hypothetical protein 0.0038 0.0775 0.0775
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0159 0.3472 1
Onchocerca volvulus 0.0006 0.0062 0.0548
Echinococcus multilocularis Ankyrin 0.0011 0.0183 0.0265
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0797 0.2249
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0139 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0006 0.0062 0.0062
Mycobacterium ulcerans lysophospholipase 0.0159 0.3472 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0058 0.1214 0.176
Echinococcus multilocularis Phospholipase carboxylesterase 0.0009 0.0139 0.0201
Trypanosoma brucei RNA helicase, putative 0.0213 0.4688 1
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.0038 0.0071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0006 0.0062 0.009
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.0114 0.0292
Echinococcus granulosus geminin 0.0178 0.3907 0.5663
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0797 0.2266
Loa Loa (eye worm) CXXC zinc finger family protein 0.0022 0.0419 0.0419
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0775 0.1124
Loa Loa (eye worm) hypothetical protein 0.0006 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0157 0.3436 0.3436
Toxoplasma gondii histone lysine methyltransferase SET1 0.0042 0.0857 1
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0005 0.0038 0.0049
Trypanosoma brucei ingi protein (ORF1) 0.0005 0.0038 0.0053
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0775 0.2203
Brugia malayi MGC79044 protein 0.0009 0.0139 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0006 0.0062 0.0062
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0159 0.3472 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0005 0.0038 0.0038
Mycobacterium leprae Probable lipase LipE 0.0038 0.0775 0.2203
Brugia malayi beta-lactamase 0.0038 0.0775 0.0775
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0041 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0006 0.0062 0.0062
Echinococcus granulosus KRAB A domain containing protein 0.0005 0.0038 0.0055
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0114 0.019
Brugia malayi Pao retrotransposon peptidase family protein 0.0005 0.0038 0.0038
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0009 0.0139 0.0363
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0009 0.0139 0.0363
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0159 0.3472 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0797 0.2249
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0006 0.0062 0.0548
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0005 0.0038 0.0055
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0009 0.0139 0.0342
Echinococcus granulosus abhydrolase domain containing protein 13 0.0009 0.0139 0.0201
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0005 0.0038 0.0055
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0797 0.2266
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0139
Brugia malayi Steroid receptor seven-up type 2 0.0006 0.0062 0.0062
Schistosoma mansoni peptidase 0.0009 0.0139 0.0201
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0009 0.0139 0.0269
Onchocerca volvulus 0.0005 0.0038 0.0224
Loa Loa (eye worm) hypothetical protein 0.0157 0.3436 0.3436
Brugia malayi Pao retrotransposon peptidase family protein 0.0005 0.0038 0.0038
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0009 0.0139 0.149
Brugia malayi Uncoordinated protein 44 0.0011 0.0181 0.0181
Mycobacterium tuberculosis Conserved hypothetical protein 0.0009 0.0139 0.0237
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0139 0.0342
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0923 0.1338
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0009 0.0139 0.149
Brugia malayi cytochrome P450 0.0004 0.0013 0.0013
Echinococcus granulosus ecdysone induced protein 78C 0.0006 0.0062 0.009
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0009 0.0139 0.0201
Trypanosoma brucei monoglyceride lipase, putative 0.0159 0.3472 0.74
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0775 0.163
Loa Loa (eye worm) cytochrome P450 family protein 0.0004 0.0013 0.0013
Mycobacterium tuberculosis Possible lysophospholipase 0.0159 0.3472 0.6507
Loa Loa (eye worm) hypothetical protein 0.0038 0.0775 0.0775
Trypanosoma brucei unspecified product 0.0005 0.0038 0.0053
Schistosoma mansoni hypothetical protein 0.0005 0.0038 0.0055
Schistosoma mansoni inositol monophosphatase 0.0039 0.0797 0.1155
Brugia malayi Pao retrotransposon peptidase family protein 0.0005 0.0038 0.0038
Echinococcus granulosus FTZ F1 alpha 0.0006 0.0062 0.009
Plasmodium falciparum lysophospholipase, putative 0.0159 0.3472 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0006 0.0062 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0006 0.0062 0.0062
Trypanosoma cruzi monoglyceride lipase, putative 0.0159 0.3472 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0062 0.0062
Echinococcus granulosus cpg binding protein 0.0023 0.0447 0.0648
Schistosoma mansoni cpg binding protein 0.0022 0.0419 0.0608
Schistosoma mansoni ferritin 0.0008 0.0114 0.0166
Brugia malayi reverse transcriptase 0.0005 0.0038 0.0038
Toxoplasma gondii hypothetical protein 0.0009 0.0139 0.149
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0005 0.0038 0.0055
Brugia malayi Inositol monophosphatase family protein 0.0004 0.0021 0.0021
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0923 0.0923
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0004 0.0021 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0041 0.0058
Toxoplasma gondii hypothetical protein 0.0009 0.0139 0.149
Brugia malayi Pao retrotransposon peptidase family protein 0.0005 0.0038 0.0038
Toxoplasma gondii protein c14orf29, putative 0.0009 0.0139 0.149
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0775 0.2185
Toxoplasma gondii phospholipase 0.0009 0.0139 0.149
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0041 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0006 0.0062 0.0062
Brugia malayi MGC83647 protein 0.0009 0.0139 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0006 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0038 0.0775 0.0775
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0005 0.0038 0.0055
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0006 0.0062 0.0062
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0004 0.0021 0.0017
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0009 0.0139 0.0342
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0005 0.0052 0.0075
Mycobacterium ulcerans hypothetical protein 0.0009 0.0139 0.0363
Echinococcus multilocularis RNA directed DNA polymerase 0.0005 0.0038 0.0055
Toxoplasma gondii peptidase S15, putative 0.0009 0.0139 0.149
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0139 0.0342
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0775 0.1433
Plasmodium vivax PST-A protein 0.0159 0.3472 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0041 0.0058
Onchocerca volvulus 0.0038 0.0775 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0775 0.2185
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0775 0.1433
Echinococcus granulosus inositol monophosphatase 0.0004 0.0021 0.003
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0005 0.0038 0.0055
Loa Loa (eye worm) hypothetical protein 0.0011 0.0181 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0006 0.0062 0.0062
Mycobacterium tuberculosis Conserved protein 0.0038 0.0775 0.1433
Echinococcus granulosus cytochrome P450 2K1 0.0004 0.0013 0.0019
Onchocerca volvulus 0.0022 0.0419 0.5283
Chlamydia trachomatis acyltransferase family protein 0.0009 0.0139 1
Schistosoma mansoni retinoic acid receptor RXR 0.0006 0.0062 0.009
Echinococcus multilocularis inositol monophosphatase 0.0004 0.0021 0.003
Schistosoma mansoni thyroid hormone receptor 0.0006 0.0062 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0139 0.0342
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0005 0.0052 0.0075
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0009 0.0139 0.149
Schistosoma mansoni hypothetical protein 0.0004 0.0021 0.003
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0009 0.0139 0.0269
Mycobacterium ulcerans monophosphatase 0.0004 0.0021 0.0023
Brugia malayi Pao retrotransposon peptidase family protein 0.0005 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0139 0.0342
Echinococcus multilocularis thyroid hormone receptor alpha 0.0006 0.0062 0.009
Brugia malayi Muscleblind-like protein 0.0157 0.3436 0.3436
Loa Loa (eye worm) steroid hormone receptor 0.0006 0.0062 0.0062
Onchocerca volvulus Protein ultraspiracle homolog 0.0006 0.0062 0.0548
Loa Loa (eye worm) TAR-binding protein 0.0067 0.1417 0.1417
Toxoplasma gondii ABC1 family protein 0.0038 0.0775 0.9028
Loa Loa (eye worm) cytochrome P450 0.0004 0.0013 0.0013
Toxoplasma gondii phospholipase/carboxylesterase 0.0009 0.0139 0.149
Schistosoma mansoni hypothetical protein 0.0011 0.0181 0.0262
Loa Loa (eye worm) inositol-1 0.0039 0.0797 0.0797
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0005 0.0041 0.0058
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0004 0.0021 0.003
Echinococcus multilocularis dnaJ subfamily B 0.0313 0.6899 1
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0041 0.0058
Brugia malayi Protein C20orf22 0.0009 0.0139 0.0139
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1417 0.2054
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0009 0.0139 0.0201
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0775 0.2203
Brugia malayi Pao retrotransposon peptidase family protein 0.0005 0.0038 0.0038
Brugia malayi Cytochrome P450 family protein 0.0004 0.0013 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0052 0.0075
Loa Loa (eye worm) hypothetical protein 0.0006 0.0062 0.0062
Brugia malayi Pao retrotransposon peptidase family protein 0.0005 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0313 0.6899 1
Echinococcus multilocularis cpg binding protein 0.0023 0.0447 0.0648
Entamoeba histolytica hypothetical protein 0.0009 0.0139 0.0342
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1417 0.2054
Brugia malayi Cytochrome P450 family protein 0.0004 0.0013 0.0013
Echinococcus multilocularis muscleblind protein 1 0.0157 0.3436 0.4981
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0041 0.0058
Trypanosoma cruzi serine peptidase, putative 0.0009 0.0139 0.0363
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0797 0.9287
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0005 0.0038 0.0053
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0009 0.0139 0.0201
Brugia malayi Pao retrotransposon peptidase family protein 0.0005 0.0038 0.0038
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0775 0.0775
Echinococcus granulosus Ankyrin 0.0011 0.0183 0.0265
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0006 0.0062 0.0062
Mycobacterium ulcerans hypothetical protein 0.0009 0.0139 0.0363
Trichomonas vaginalis reverse transcriptases, putative 0.0005 0.0038 0.0049
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0139 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0041 0.0058
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0005 0.0038 0.0053
Echinococcus multilocularis 0.0004 0.0013 0.0019
Mycobacterium ulcerans monophosphatase CysQ 0.0004 0.0021 0.0023
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0797 1
Trichomonas vaginalis reverse transcriptases, putative 0.0005 0.0038 0.0049
Loa Loa (eye worm) hypothetical protein 0.0006 0.0062 0.0062
Brugia malayi Inositol monophosphatase family protein 0.0004 0.0021 0.0021
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0006 0.0062 0.009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0082 0.0118
Echinococcus granulosus muscleblind protein 0.0157 0.3436 0.4981
Schistosoma mansoni myo inositol monophosphatase 0.0004 0.0021 0.003
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0062 0.0062
Mycobacterium tuberculosis Monophosphatase CysQ 0.0004 0.0021 0.0015
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0009 0.0139 0.0342
Brugia malayi Cytochrome P450 family protein 0.0004 0.0013 0.0013
Schistosoma mansoni pap-inositol-14-phosphatase 0.0004 0.0021 0.003
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0005 0.0038 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0006 0.0062 0.0062
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0797 0.2249
Loa Loa (eye worm) hypothetical protein 0.0452 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0006 0.0062 0.009
Schistosoma mansoni inositol monophosphatase 0.0039 0.0797 0.1155
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.0114 0.0292
Schistosoma mansoni ankyrin 23/unc44 0.0011 0.0181 0.0262
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0775 0.1124
Brugia malayi hypothetical protein 0.0005 0.0038 0.0038
Trypanosoma brucei hypothetical protein, conserved 0.0005 0.0038 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0006 0.0062 0.009
Echinococcus multilocularis tar DNA binding protein 0.0067 0.1417 0.2054
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0009 0.0139 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0006 0.0062 0.0062
Echinococcus multilocularis ferritin 0.0008 0.0114 0.0166
Toxoplasma gondii hypothetical protein 0.0009 0.0139 0.149
Echinococcus granulosus Phospholipase carboxylesterase 0.0009 0.0139 0.0201
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0004 0.0021 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0041 0.0058
Brugia malayi steroid hormone receptor 0.0006 0.0062 0.0062
Schistosoma mansoni apoferritin-2 0.0008 0.0114 0.0166
Echinococcus multilocularis geminin 0.0178 0.3907 0.5663
Loa Loa (eye worm) hypothetical protein 0.0006 0.0062 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0006 0.0062 0.0062
Mycobacterium tuberculosis Conserved protein 0.0038 0.0775 0.1433
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0139 0.0342
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0706 0.2003
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0775 0.2185
Echinococcus granulosus death domain containing protein 0.0011 0.0181 0.0262
Brugia malayi nuclear hormone receptor 0.0006 0.0062 0.0062
Brugia malayi reverse transcriptase 0.0005 0.0038 0.0038
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0181 0.0181
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0775 0.1433
Onchocerca volvulus Netrin receptor homolog 0.0011 0.0181 0.2119
Echinococcus multilocularis ecdysone induced protein 78C 0.0006 0.0062 0.009
Brugia malayi F/Y-rich N-terminus family protein 0.0007 0.008 0.008
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0005 0.0038 0.1435
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0006 0.0062 0.009
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0706 0.1304
Loa Loa (eye worm) hypothetical protein 0.0038 0.0775 0.0775
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0139 0.0342
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0005 0.0038 0.0055
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0139
Brugia malayi Cytochrome P450 family protein 0.0004 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0139 0.0342
Toxoplasma gondii hypothetical protein 0.0004 0.0021 0.0092
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0797 0.1677
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1417 0.2054
Echinococcus multilocularis FTZ F1 alpha 0.0006 0.0062 0.009
Echinococcus multilocularis expressed protein 0.0008 0.0114 0.0166
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0139 0.0342
Onchocerca volvulus Bile acid receptor homolog 0.0006 0.0062 0.0548
Schistosoma mansoni protein kinase 0.0005 0.0038 0.0055
Schistosoma mansoni netrin receptor unc5 0.0011 0.0181 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0139 0.0342
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0006 0.0062 0.009
Echinococcus granulosus RNA directed DNA polymerase 0.0005 0.0038 0.0055
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0775 0.1433
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0005 0.0038 0.0055
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0775 0.2185
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0062 0.009
Brugia malayi Death domain containing protein 0.0011 0.0181 0.0181
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.1417 0.1417
Schistosoma mansoni hypothetical protein 0.0005 0.0038 0.0055
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0009 0.0139 0.0269
Brugia malayi Pao retrotransposon peptidase family protein 0.0005 0.0038 0.0038
Trichomonas vaginalis helicase, putative 0.0005 0.0041 0.0058
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0005 0.0038 0.0055
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0041 0.0058
Trypanosoma brucei ingi protein (ORF1) 0.0005 0.0038 0.0053
Echinococcus granulosus expressed protein 0.0008 0.0114 0.0166
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0038 0.0055
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0011 0.0181 0.0262
Trypanosoma cruzi serine peptidase, putative 0.0009 0.0139 0.0363
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0923 0.0923
Onchocerca volvulus 0.0038 0.0775 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0923 0.1338
Echinococcus granulosus mixed lineage leukemia protein mll 0.0005 0.0052 0.0075
Entamoeba histolytica hypothetical protein 0.0009 0.0139 0.0342
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0005 0.0038 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0041 0.0058
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0005 0.0038 0.0055
Trichomonas vaginalis esterase, putative 0.0038 0.0775 0.2185
Mycobacterium ulcerans lipase LipD 0.0038 0.0775 0.2203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0923 0.1338
Trypanosoma brucei monoglyceride lipase, putative 0.0159 0.3472 0.74
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0006 0.0062 0.009
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0159 0.3472 1
Leishmania major hypothetical protein, conserved 0.0009 0.0139 0.0363
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0009 0.0139 0.0363
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0006 0.0062 0.009
Brugia malayi Inositol-1 0.0039 0.0797 0.0797
Schistosoma mansoni thyroid hormone receptor 0.0006 0.0062 0.009
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0775 0.2203
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0004 0.0021 0.0023
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0011 0.0181 0.0262
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0775 0.1124
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0005 0.0038 0.1435
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0775 0.0775
Mycobacterium ulcerans beta-lactamase 0.0038 0.0775 0.2203
Brugia malayi Pao retrotransposon peptidase family protein 0.0005 0.0038 0.0038
Brugia malayi photoreceptor-specific nuclear receptor 0.0006 0.0062 0.0062
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0058 0.1214 0.176
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0006 0.0062 0.009
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0005 0.0038 0.0053
Brugia malayi TAR-binding protein 0.0067 0.1417 0.1417
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0006 0.0062 0.0062
Brugia malayi beta-lactamase family protein 0.0038 0.0775 0.0775
Loa Loa (eye worm) hypothetical protein 0.0006 0.0062 0.0062
Leishmania major monoglyceride lipase, putative 0.0159 0.3472 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0006 0.0062 0.0062
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0006 0.0062 0.009
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.0114 0.0292
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0159 0.3472 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0006 0.0062 0.0062
Toxoplasma gondii hypothetical protein 0.0009 0.0139 0.149
Schistosoma mansoni ferritin 0.0008 0.0114 0.0166
Giardia lamblia Reverse transcriptase/endonuclease 0.0005 0.0038 0.1435
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1417 0.2054
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0797 0.2249
Onchocerca volvulus 0.0038 0.0775 1
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0041 0.0058
Mycobacterium leprae POSSIBLE MONOPHOSPHATASE CYSQ 0.0004 0.0021 0.0023
Echinococcus multilocularis abhydrolase domain containing 3 0.0009 0.0139 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0139 0.0342
Brugia malayi CXXC zinc finger family protein 0.0022 0.0419 0.0419
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0775 0.1909
Brugia malayi RNA binding protein 0.0067 0.1417 0.1417
Schistosoma mansoni ferritin 0.0008 0.0114 0.0166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0923 0.1338
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0006 0.0062 0.0062
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0159 0.3472 1
Schistosoma mansoni RAR-like nuclear receptor 0.0006 0.0062 0.009
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0775 0.2203
Brugia malayi Protein kinase domain containing protein 0.0011 0.0181 0.0181
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0041 0.0058
Schistosoma mansoni cpg binding protein 0.0023 0.0447 0.0648
Loa Loa (eye worm) hypothetical protein 0.0011 0.0183 0.0183
Mycobacterium ulcerans monophosphatase CysQ 0.0004 0.0021 0.0023
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0006 0.0062 0.009
Schistosoma mansoni apoferritin-2 0.0008 0.0114 0.0166
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0114 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0775 0.2203
Echinococcus granulosus ferritin 0.0008 0.0114 0.0166
Mycobacterium tuberculosis Probable monophosphatase 0.0004 0.0021 0.0015
Loa Loa (eye worm) hypothetical protein 0.0006 0.0062 0.0062
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0006 0.0062 0.009
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.0004 0.0021 0.0023

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 4 Inhibition of P pilus biogenesis in Escherichia coli HB101/pPAP5 assessed as agglutination of erythrocytes at 1.8 mM ChEMBL. 18499455
Activity (functional) = 4 Inhibition of P pilus biogenesis in Escherichia coli HB101/pPAP5 assessed as agglutination of erythrocytes at 1.8 mM ChEMBL. 18499455
Activity (binding) = 100 % Binding affinity to Escherichia coli PapD relative to control ChEMBL. 18499455
Activity (binding) = 100 % Binding affinity to Escherichia coli PapD relative to control ChEMBL. 18499455

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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