Detailed information for compound 510302

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 499.302 | Formula: C19H19NO11P2
  • H donors: 5 H acceptors: 8 LogP: -0.69 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1cc(=O)oc2c1ccc(c2)OP(=O)(O)O)NCCc1ccc(cc1)OP(=O)(O)O
  • InChi: 1S/C19H19NO11P2/c21-18(20-8-7-12-1-3-14(4-2-12)30-32(23,24)25)9-13-10-19(22)29-17-11-15(5-6-16(13)17)31-33(26,27)28/h1-6,10-11H,7-9H2,(H,20,21)(H2,23,24,25)(H2,26,27,28)
  • InChiKey: UQVPEJSVTMGQHL-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0038 0.0136
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0028 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.022
Brugia malayi hypothetical protein 0.0032 0.0095 0.0552
Brugia malayi MH1 domain containing protein 0.0026 0.0069 0.0398
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0173 0.3706
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0037 0.0118 0.2685
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0069 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0093
Brugia malayi MH2 domain containing protein 0.0012 0.0002 0.001
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0239 0.4997
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.2804
Brugia malayi hypothetical protein 0.0111 0.0458 0.2654
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.000000000055478 0.00000000032135
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Schistosoma mansoni cpg binding protein 0.003 0.0084 0.0257
Echinococcus multilocularis Chromo domain 0.0011 0.000000000055478 0.00000000017055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.107
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0075 0.2743
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0151 0.3175
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0063 0.0239 0.0735
Brugia malayi Bloom's syndrome protein homolog 0.0043 0.0147 0.0851
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0127 0.4668
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0271 0.1197 0.0206
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0037 0.0118 0.0363
Echinococcus multilocularis mothers against decapentaplegic 6 0.0012 0.0002 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0148 0.2748
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0028 0.0163
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0028 0.0163
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.0239 0.0202
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0037 0.0118 0.0363
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0082 0.0475
Echinococcus multilocularis GPCR, family 2 0.0017 0.0028 0.0086
Treponema pallidum NADH oxidase 0.0037 0.0118 0.0102
Loa Loa (eye worm) PDE1B protein 0.0044 0.0151 0.0873
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0141 1
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0458 0.1409
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.5524
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.3424
Schistosoma mansoni DNA polymerase eta 0.0092 0.0374 0.115
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0028 0.0163
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0118 0.2409
Plasmodium falciparum phosphodiesterase delta, putative 0.0044 0.0151 0.3424
Brugia malayi MH1 domain containing protein 0.0026 0.0069 0.0398
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0028 0.0086
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0239 0.5256
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0037 0.0118 0.1996
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0044 0.0151 0.2804
Brugia malayi MH2 domain containing protein 0.0026 0.0069 0.0398
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0362 0.1617 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0037 0.0118 0.0685
Schistosoma mansoni hypothetical protein 0.0038 0.0122 0.0374
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0362 0.1617 0.4972
Echinococcus multilocularis chromobox protein 1 0.007 0.0268 0.0825
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0151 0.3175
Loa Loa (eye worm) Smad1 0.0026 0.0069 0.0398
Giardia lamblia Myb 1-like protein 0.007 0.0273 0.1487
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.5524
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0127 0.4668
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0075 0.2743
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0007 0.0023
Schistosoma mansoni blooms syndrome DNA helicase 0.0028 0.0078 0.0241
Brugia malayi hypothetical protein 0.005 0.0177 0.1023
Schistosoma mansoni hypothetical protein 0.0716 0.3253 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0118 0.2409
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.5524
Echinococcus multilocularis tar DNA binding protein 0.007 0.0271 0.0833
Schistosoma mansoni terminal deoxycytidyl transferase 0.0063 0.0239 0.0735
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.107
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0177 0.3446
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0177 0.3784
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0118 0.2409
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Brugia malayi RNA binding protein 0.007 0.0271 0.157
Loa Loa (eye worm) transcription factor SMAD2 0.0385 0.1726 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0362 0.1617 0.4972
Echinococcus granulosus thioredoxin glutathione reductase 0.0107 0.044 0.1353
Loa Loa (eye worm) RecQ helicase 0.0043 0.0147 0.0851
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0014 0.0496
Loa Loa (eye worm) hypothetical protein 0.0044 0.0151 0.0873
Loa Loa (eye worm) thioredoxin reductase 0.0107 0.044 0.255
Mycobacterium tuberculosis Conserved hypothetical protein 0.0063 0.0239 0.0171
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.3424
Echinococcus granulosus mothers against decapentaplegic 2 0.0012 0.0002 0.0005
Entamoeba histolytica hypothetical protein 0.0111 0.0458 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0044 0.0151 0.3424
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0151 0.3175
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0037 0.0118 0.2685
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0049 0.0173 0.0623
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0038 0.0516
Schistosoma mansoni hypothetical protein 0.0017 0.0028 0.0086
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0239 0.1384
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000055478 0.0000000012108
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0082 0.0295
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.5524
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.007 0.0271 0.9943
Loa Loa (eye worm) hypothetical protein 0.0044 0.0151 0.0873
Mycobacterium tuberculosis Probable oxidoreductase 0.0271 0.1197 0.153
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0163
Echinococcus granulosus GPCR family 2 0.0017 0.0028 0.0086
Loa Loa (eye worm) hypothetical protein 0.0038 0.0122 0.0704
Leishmania major cAMP-specific phosphodiesterase, putative 0.0044 0.0151 0.2804
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2178 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0016 0.0574
Schistosoma mansoni Smad4 0.0026 0.0069 0.0211
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Trypanosoma brucei hypothetical protein, conserved 0.0044 0.0151 0.2804
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0244 0.1071 0.1352
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000055478 0.0000000020332
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.000000000055478 0.00000000017055
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.007 0.0271 0.9943
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0044 0.0151 0.2804
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0028 0.0086
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0029 0.107
Brugia malayi polk-prov protein 0.002 0.0038 0.022
Echinococcus multilocularis bloom syndrome protein 0.0043 0.0147 0.0452
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0151 0.3175
Leishmania major DNA polymerase eta, putative 0.0049 0.0173 0.3363
Schistosoma mansoni tar DNA-binding protein 0.007 0.0271 0.0833
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.000000000055478 0.00000000019946
Plasmodium vivax glutathione reductase, putative 0.0107 0.044 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.007 0.0271 0.9943
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.007 0.0271 0.9943
Schistosoma mansoni Smad4 0.0012 0.0002 0.0005
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0118 0.1996
Schistosoma mansoni smad1 5 8 and 0.0026 0.0069 0.0211
Brugia malayi TAR-binding protein 0.007 0.0271 0.157
Entamoeba histolytica hypothetical protein 0.0111 0.0458 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.3424
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0073 0.0422
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0063 0.0239 0.0735
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Trypanosoma brucei unspecified product 0.0044 0.0148 0.2748
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0151 0.5524
Schistosoma mansoni smad1 5 8 and 0.0026 0.0069 0.0211
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.1782 0.5479
Trichomonas vaginalis C-MYB, putative 0.007 0.0271 0.9943
Plasmodium vivax thioredoxin reductase, putative 0.0107 0.044 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.3424
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0202 0.1171
Schistosoma mansoni tar DNA-binding protein 0.007 0.0271 0.0833
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.000000000055478 0.00000000017055
Schistosoma mansoni hypothetical protein 0.0398 0.1782 0.5479
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0362 0.1617 0.5815
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0177 0.3784
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.001
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0013 0.0293
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0151 0.5524
Leishmania major trypanothione reductase 0.0107 0.044 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Entamoeba histolytica recQ family DNA helicase 0.0015 0.0016 0.035
Brugia malayi MH2 domain containing protein 0.0385 0.1726 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0177 0.1023
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.000000000055478 0.00000000017055
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0069 0.0211
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0239 0.4997
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0614 0.2781 0.2806
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0151 0.0873
Giardia lamblia DINP protein human, muc B family 0.0063 0.0239 0.1273
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.007 0.0273 0.0981
Loa Loa (eye worm) hypothetical protein 0.0029 0.0082 0.0475
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0069 0.0211
Plasmodium vivax hypothetical protein, conserved 0.0011 0.000000000055478 0.0000000012604
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0362 0.1617 0.4972
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0037 0.0118 0.0081
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0095 0.2083
Echinococcus multilocularis mothers against decapentaplegic 2 0.0012 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0111 0.0458 0.1409
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0151 0.0873
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0044 0.0151 0.0463
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0044 0.0151 0.3175
Echinococcus multilocularis cpg binding protein 0.003 0.0084 0.0257
Schistosoma mansoni hypothetical protein 0.0017 0.0028 0.0086
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.0038 0.0862
Echinococcus granulosus dna polymerase kappa 0.0063 0.0239 0.0735
Brugia malayi MH1 domain containing protein 0.0015 0.0015 0.0084
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0271 0.1197 0.153
Brugia malayi chromobox protein homolog 3 0.0039 0.0127 0.0738
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Leishmania major DNA polymerase kappa, putative 0.0063 0.0239 0.4997
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0244 0.1071 0.1352
Trichomonas vaginalis C-MYB, putative 0.007 0.0271 0.9943
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0082 0.0252
Trypanosoma cruzi trypanothione reductase, putative 0.0107 0.044 1
Schistosoma mansoni smad 0.0026 0.0069 0.0211
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0202 0.1171
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0037 0.0118 0.0425
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0069 0.0398
Trypanosoma brucei trypanothione reductase 0.0107 0.044 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.5524
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1564 0.7166 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0037 0.0118 0.1996
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0151 0.0463
Trichomonas vaginalis MYB3r3, putative 0.007 0.0271 0.9943
Giardia lamblia NADH oxidase lateral transfer candidate 0.0037 0.0118 0.0508
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0614 0.2781 0.2695
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.005 0.0154
Echinococcus multilocularis thioredoxin glutathione reductase 0.0107 0.044 0.1353
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0458 0.1409
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0037 0.0118 0.0363
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0026 0.0068 0.1535
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0118 0.2409
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0221 0.0679
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0202 0.1171
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0029 0.107
Plasmodium falciparum glutathione reductase 0.0107 0.044 1
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0318 0.1414 0.8191
Plasmodium falciparum DNA repair protein REV1, putative 0.002 0.0038 0.0862
Schistosoma mansoni cpg binding protein 0.0028 0.0076 0.0235
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0037 0.0118 0.0081
Trichomonas vaginalis DNA polymerase eta, putative 0.0063 0.0239 0.8757
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0095 0.143
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0069 0.0211
Schistosoma mansoni hypothetical protein 0.0017 0.0028 0.0086
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.000000000055478 0.00000000032135
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0239 0.4997
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0044 0.0151 0.0873
Trichomonas vaginalis pc-MYB2, putative 0.007 0.0271 0.9943
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0044 0.0151 0.0873
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.3424
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0148 0.2748
Echinococcus granulosus chromobox protein 1 0.007 0.0268 0.0825
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0271 0.1197 0.153
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.007 0.0271 0.5921
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.5524
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0239 0.4997
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000055478 0.0000000020332
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0239 0.4997
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.2804
Echinococcus multilocularis dna polymerase eta 0.0092 0.0374 0.115
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.007 0.0271 0.9943
Brugia malayi CHD4 protein 0.0013 0.0007 0.0043
Echinococcus multilocularis geminin 0.0716 0.3253 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.007 0.0271 0.9943
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0044 0.0151 0.0463
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0063 0.0239 0.4997
Toxoplasma gondii NADPH-glutathione reductase 0.0037 0.0118 0.0425
Giardia lamblia Hypothetical protein 0.0044 0.0151 0.0714
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0095 0.1872
Echinococcus multilocularis dna polymerase kappa 0.0063 0.0239 0.0735
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Plasmodium falciparum glutathione reductase 0.0037 0.0118 0.2685
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0028 0.0086
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0069 0.0398
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0071 0.0273 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000055478 0.0000000020332
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0239 0.5256
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0122 0.0704
Loa Loa (eye worm) hypothetical protein 0.0092 0.0374 0.2168
Loa Loa (eye worm) hypothetical protein 0.0039 0.0127 0.0738
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0151 0.0873
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0118 0.2409
Echinococcus granulosus tar DNA binding protein 0.007 0.0271 0.0833
Loa Loa (eye worm) hypothetical protein 0.0011 0.000000000055478 0.00000000032135
Leishmania major hypothetical protein, conserved 0.005 0.0177 0.3446
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0037 0.0118 0.1996
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0151 0.0463
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0044 0.0151 0.0873
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0063 0.0239 0.1384
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0151 0.5524
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0082 0.0475
Onchocerca volvulus 0.0031 0.0089 0.6276
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.5524
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0118 0.1996
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0177 0.4011
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0239 0.4997
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.5524
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0084
Mycobacterium tuberculosis Probable dehydrogenase 0.0244 0.1071 0.1352
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Trichomonas vaginalis MYB72, putative 0.007 0.0271 0.9943
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0118 0.1996
Trypanosoma brucei unspecified product 0.0063 0.0239 0.4997
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0177 0.0635
Leishmania major DNA polymerase eta, putative 0.0092 0.0374 0.8361
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0118 0.2409
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0151 0.0463
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0044 0.0151 0.0463
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0362 0.1617 0.4972
Trichomonas vaginalis chromobox protein, putative 0.007 0.0268 0.9836
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0151 0.5524
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0044 0.0151 0.0463
Schistosoma mansoni tar DNA-binding protein 0.007 0.0271 0.0833
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0044 0.0151 0.3175
Entamoeba histolytica hypothetical protein 0.0111 0.0458 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0513
Schistosoma mansoni DNA helicase recq5 0.0029 0.0082 0.0252
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.000000000055478 0.0000000012604
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0151 0.3175
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0063 0.0239 0.0735
Schistosoma mansoni smad 0.0012 0.0002 0.0005
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0016 0.0058
Echinococcus multilocularis Smad4 0.0026 0.0069 0.0211
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0151 0.0463
Plasmodium falciparum phosphodiesterase gamma, putative 0.0044 0.0151 0.3424
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0044 0.0151 0.3175
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0118 0.2409
Mycobacterium tuberculosis Probable reductase 0.0244 0.1071 0.1352
Schistosoma mansoni smad1 5 8 and 0.0026 0.0069 0.0211
Brugia malayi ImpB/MucB/SamB family protein 0.0092 0.0374 0.2168
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0118 0.1996
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0239 0.4997
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0044 0.0151 0.2804
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0044 0.0151 0.0463
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Brugia malayi SET domain containing protein 0.0012 0.0003 0.0016
Trichomonas vaginalis DNA helicase recq, putative 0.0043 0.0147 0.5385
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.5524
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0134 0.3034
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0271 0.157
Echinococcus granulosus bloom syndrome protein 0.0043 0.0147 0.0452
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0268 0.1555
Loa Loa (eye worm) MH2 domain-containing protein 0.0385 0.1726 1
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0614 0.2781 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0095 0.143
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0044 0.0151 0.2804
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0151 0.3175
Trypanosoma brucei DNA polymerase eta, putative 0.0092 0.0374 0.8361
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.007 0.0271 0.5921
Brugia malayi Smad1 0.0026 0.0069 0.0398
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1564 0.7166 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.5524
Loa Loa (eye worm) hypothetical protein 0.0044 0.0151 0.0873
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.107
Loa Loa (eye worm) TAR-binding protein 0.007 0.0271 0.157
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0044 0.0151 0.0463
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0063 0.0239 0.0171
Leishmania major hypothetical protein, conserved 0.0044 0.0151 0.2804
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.5524
Onchocerca volvulus 0.0012 0.0003 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0151 0.5524
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.007 0.0271 0.5921
Brugia malayi CXXC zinc finger family protein 0.0028 0.0076 0.0442
Echinococcus granulosus Chromo domain 0.0011 0.000000000055478 0.00000000017055
Echinococcus granulosus dna polymerase eta 0.0092 0.0374 0.115
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0362 0.1617 0.4972
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0044 0.0151 0.0463
Trypanosoma brucei unspecified product 0.0044 0.0148 0.2748
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0107 0.044 0.0457
Trichomonas vaginalis DNA helicase recq1, putative 0.0043 0.0147 0.5385
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0151 0.0463
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0118 0.2409
Echinococcus granulosus smad 0.0026 0.0069 0.0211
Echinococcus granulosus dnaJ subfamily B 0.0398 0.1782 0.5479
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0044 0.0151 0.3175
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0016 0.0574
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0118 0.2409
Trichomonas vaginalis chromobox protein, putative 0.007 0.0268 0.9836
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.0038 0.0117
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2178 1 1
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0038 0.0516
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0038 0.0516
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.005 0.0154
Brugia malayi MH2 domain containing protein 0.0026 0.0069 0.0398
Echinococcus granulosus mothers against decapentaplegic 6 0.0012 0.0002 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.107
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0244 0.1071 0.1352
Schistosoma mansoni hypothetical protein 0.0017 0.0028 0.0086
Brugia malayi glutathione reductase 0.0107 0.044 0.255
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0044 0.0151 0.0463
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0141 0.5168
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0069 0.0211
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0127 0.9031
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0073 0.0422
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0151 0.3175
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0239 0.4997
Plasmodium falciparum thioredoxin reductase 0.0107 0.044 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.0271 0.0833
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0063 0.0239 0.8757
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0082 0.0252
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0044 0.0151 0.0463
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0239 0.5256
Echinococcus granulosus Smad4 0.0026 0.0069 0.0211
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0141 0.5168
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.5524
Loa Loa (eye worm) glutathione reductase 0.0107 0.044 0.255
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000055478 0.0000000012108
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.5524
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0148 0.2748
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.0239 0.0202
Echinococcus multilocularis smad 0.0026 0.0069 0.0211
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Echinococcus granulosus chromobox protein 1 0.007 0.0268 0.0825
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0044 0.0151 0.2804
Trichomonas vaginalis glutathione reductase, putative 0.0037 0.0118 0.4332
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.007 0.0271 0.5921
Toxoplasma gondii thioredoxin reductase 0.0107 0.044 0.1582
Plasmodium vivax phosphodiesterase gamma, putative 0.0044 0.0151 0.3424
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0044 0.0151 0.0463
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0192 0.0689
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0014 0.0013 0.0305
Loa Loa (eye worm) hypothetical protein 0.0362 0.1617 0.9368
Loa Loa (eye worm) hypothetical protein 0.0055 0.0202 0.1171
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0044 0.0151 0.3424
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0271 0.157
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0012 0.0002 0.0117
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0016 0.0049
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0177 0.4011
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0044 0.0151 0.0463
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0044 0.0151 0.0463
Trichomonas vaginalis mercuric reductase, putative 0.0037 0.0118 0.4332
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.107
Loa Loa (eye worm) MH1 domain-containing protein 0.0012 0.0002 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Echinococcus multilocularis chromobox protein 1 0.007 0.0268 0.0825
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0082 0.0295
Schistosoma mansoni hypothetical protein 0.0716 0.3253 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0037 0.0118 0.2685
Brugia malayi Heterochromatin protein 1 0.007 0.0268 0.1555
Trichomonas vaginalis MYB, putative 0.0071 0.0273 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0037 0.0118 0.2685
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0082 0.0252
Entamoeba histolytica deoxycytidyl transferase, putative 0.0063 0.0239 0.5215
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0007 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0239 0.4997
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0003 0.0009
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0044 0.0151 0.0463
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0239 0.5256
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0044 0.0151 0.0463
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0151 0.5524
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0151 0.3175
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0037 0.0118 0.0081
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2178 1 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0065 0.0233
Schistosoma mansoni cpg binding protein 0.003 0.0084 0.0257
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0082 0.0252
Entamoeba histolytica hypothetical protein 0.0011 0.000000000055478 0.0000000012108
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0071 0.0273 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0151 0.5524
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0458 0.1409
Schistosoma mansoni chromobox protein 0.007 0.0268 0.0825
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Loa Loa (eye worm) nuclear factor I 0.0015 0.0015 0.0084
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0151 0.0463
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0151 0.3175
Brugia malayi mothers against decapentaplegic homolog 3 0.0012 0.0002 0.001
Trichomonas vaginalis pc-MYB2, putative 0.007 0.0271 0.9943
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.107
Echinococcus granulosus geminin 0.0716 0.3253 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.007 0.0271 0.5921
Schistosoma mansoni Smad4 0.0012 0.0002 0.0005
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0007 0.0043
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0044 0.0151 0.0463
Leishmania major hypothetical protein, conserved 0.0044 0.0151 0.2804
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000055478 0.0000000012108
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0318 0.1414 0.8191
Echinococcus granulosus cpg binding protein 0.003 0.0084 0.0257
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0007 0.0023
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0044 0.0151 0.0873
Brugia malayi Thioredoxin reductase 0.0107 0.044 0.255
Giardia lamblia hypothetical protein 0.0044 0.0151 0.0714
Schistosoma mansoni chromobox protein 0.007 0.0268 0.0825
Trypanosoma cruzi DNA polymerase eta, putative 0.0092 0.0374 0.8445
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0076 0.0442
Loa Loa (eye worm) hypothetical protein 0.013 0.0549 0.3182
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0037 0.0118 0.1996
Onchocerca volvulus 0.0028 0.0076 0.541
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0239 0.4997
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0082 0.1863
Schistosoma mansoni DNA helicase recq1 0.0029 0.0082 0.0252
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0318 0.1414 0.4347
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Schistosoma mansoni hypothetical protein 0.0022 0.005 0.0154
Entamoeba histolytica hypothetical protein 0.0111 0.0458 1
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0614 0.2781 0.2754
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.0082 0.0279
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0318 0.1414 0.4347
Plasmodium falciparum thioredoxin reductase 0.0037 0.0118 0.2685
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.002 0.0038 0.0136
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0044 0.0151 0.5524
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0082 0.0475
Loa Loa (eye worm) MH2 domain-containing protein 0.0012 0.0002 0.001
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0177 0.4011
Schistosoma mansoni tar DNA-binding protein 0.007 0.0271 0.0833
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0095 0.3498
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0044 0.0151 0.0463
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0151 0.0542
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0239 0.4997
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0239 0.4997
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0244 0.1071 0.1352
Schistosoma mansoni hypothetical protein 0.0011 0.000000000055478 0.00000000017055
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0038 0.0516
Loa Loa (eye worm) RNA binding protein 0.007 0.0271 0.157
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0151 0.3175
Brugia malayi MH1 domain containing protein 0.0015 0.0015 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0239 0.4997

Activities

Activity type Activity value Assay description Source Reference
Kcat (binding) = 7.1 /s Activity of PTP1B (unknown origin) ChEMBL. 18442911
Kcat (binding) = 7.1 /s Activity of PTP1B (unknown origin) ChEMBL. 18442911
Km (binding) = 38 uM Activity of PTP1B (unknown origin) ChEMBL. 18442911
Km (binding) = 38 uM Activity of PTP1B (unknown origin) ChEMBL. 18442911
Ratio (binding) = 18.9 Ratio of kcat for PTP1B (unknown origin) to Km for PTP1B (unknown origin) ChEMBL. 18442911

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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