Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0532 | 1 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0532 | 1 | 1 |
Plasmodium vivax | fructose 1,6-bisphosphate aldolase, putative | 0.0532 | 1 | 0.5 |
Leishmania major | fructose-1,6-bisphosphate aldolase | 0.0532 | 1 | 1 |
Echinococcus granulosus | fructose bisphosphate aldolase class I | 0.0532 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0532 | 1 | 1 |
Plasmodium falciparum | fructose-bisphosphate aldolase | 0.0532 | 1 | 0.5 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0474 | 0.8767 | 0.8628 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0532 | 1 | 0.5 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0532 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0532 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0532 | 1 | 1 |
Brugia malayi | fructose-bisphosphate aldolase 1 | 0.0532 | 1 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0077 | 0.0364 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.779 | 0.7707 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0532 | 1 | 1 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 2 | 0.0532 | 1 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0428 | 0.779 | 0.7542 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0077 | 0.0364 | 0.0364 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0532 | 1 | 1 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 1 | 0.0532 | 1 | 1 |
Toxoplasma gondii | fructose-bisphosphate aldolase, putative | 0.0532 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.8154 | 0.8084 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0532 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.8112 | 0.8041 |
Trypanosoma brucei | fructose-bisphosphate aldolase, glycosomal, putative | 0.0532 | 1 | 1 |
Brugia malayi | cation channel family protein | 0.0504 | 0.9414 | 0.9348 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0532 | 1 | 1 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0532 | 1 | 0.5 |
Echinococcus multilocularis | fructose bisphosphate aldolase class I | 0.0532 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0532 | 1 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0532 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | nM | Inhibitory activity against rat neutral endopeptidase(NEP); Not determined | ChEMBL. | 9554884 |
IC50 (binding) | 0 nM | Inhibitory activity against rat neutral endopeptidase(NEP); Not determined | ChEMBL. | 9554884 |
Inhibition (binding) | = 0 % | Inhibitory activity of the compound (1 microM) was assessed on CHO cells expressing in recombinant human Endothelin-converting enzyme 1 (ECE-1) | ChEMBL. | 9554884 |
Inhibition (binding) | = 0 % | Inhibitory activity of the compound (1 microM) was assessed on CHO cells expressing in recombinant human Endothelin-converting enzyme 1 (ECE-1) | ChEMBL. | 9554884 |
Selectivity (binding) | 0 | Ratio of inhibitory activities against endothelin converting enzyme-1(ECE-1) and Neutral Endo Peptidase (NEP); not determined | ChEMBL. | 9554884 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.