Detailed information for compound 510675

Basic information

Technical information
  • TDR Targets ID: 510675
  • Name: Glucagon-like Peptide-1 (7-37)
  • MW: 3355.67 | Formula: C151H228N40O47
  • H donors: 49 H acceptors: 48 LogP: -14.6 Rotable bonds: 140
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)O)CCCN=C(N)N)CCCCN)C(C)C)CC(C)C)Cc1c[nH]c2c1cccc2)C)[C@H](CC)C)Cc1ccccc1)CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1nc[nH]c1)N)C)CCC(=O)O)Cc1ccccc1)CO)CC(=O)O)CO)CO)Cc1ccc(cc1)O)CC(C)C)CCC(=O)O)CCC(=O)N)C)C
  • InChi: 1S/C151H228N40O47/c1-17-77(10)121(148(236)169-81(14)127(215)177-105(60-87-63-160-92-36-25-24-35-90(87)92)138(226)179-101(56-74(4)5)139(227)188-119(75(6)7)146(234)176-94(37-26-28-52-152)130(218)161-65-111(199)170-93(39-30-54-159-151(156)157)129(217)164-68-118(210)211)190-140(228)103(57-84-31-20-18-21-32-84)180-135(223)99(47-51-116(206)207)175-134(222)95(38-27-29-53-153)172-125(213)79(12)166-124(212)78(11)168-133(221)98(44-48-110(155)198)171-112(200)66-162-132(220)97(46-50-115(204)205)174-136(224)100(55-73(2)3)178-137(225)102(59-86-40-42-89(197)43-41-86)181-143(231)107(69-192)184-145(233)109(71-194)185-147(235)120(76(8)9)189-142(230)106(62-117(208)209)182-144(232)108(70-193)186-150(238)123(83(16)196)191-141(229)104(58-85-33-22-19-23-34-85)183-149(237)122(82(15)195)187-113(201)67-163-131(219)96(45-49-114(202)203)173-126(214)80(13)167-128(216)91(154)61-88-64-158-72-165-88/h18-25,31-36,40-43,63-64,72-83,91,93-109,119-123,160,192-197H,17,26-30,37-39,44-62,65-71,152-154H2,1-16H3,(H2,155,198)(H,158,165)(H,161,218)(H,162,220)(H,163,219)(H,164,217)(H,166,212)(H,167,216)(H,168,221)(H,169,236)(H,170,199)(H,171,200)(H,172,213)(H,173,214)(H,174,224)(H,175,222)(H,176,234)(H,177,215)(H,178,225)(H,179,226)(H,180,223)(H,181,231)(H,182,232)(H,183,237)(H,184,233)(H,185,235)(H,186,238)(H,187,201)(H,188,227)(H,189,230)(H,190,228)(H,191,229)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H,210,211)(H4,156,157,159)/t77-,78-,79-,80-,81-,82+,83+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,119-,120-,121-,122-,123-/m0/s1
  • InChiKey: GCYXWQUSHADNBF-AAEALURTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia DINP protein human, muc B family 0.0021 0.1111 0.5
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.037 0.0833
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.037 0.0833
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0737 0.0967
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0737 0.0737
Schistosoma mansoni hypothetical protein 0.0019 0.0737 0.1661
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0708 0.1596
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.3529 0.4354
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.3529 0.4628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.3529 0.4628
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.3529 0.4354
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.3529 0.7953
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4492 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.3529 0.7953
Echinococcus multilocularis GPCR, family 2 0.0019 0.0737 0.0737
Loa Loa (eye worm) hypothetical protein 0.0017 0.037 0.0485
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.3529 0.3529
Brugia malayi hypothetical protein 0.0019 0.0708 0.0466
Schistosoma mansoni hypothetical protein 0.0019 0.0737 0.1661
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.1111 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.3529 0.3529
Loa Loa (eye worm) hypothetical protein 0.0019 0.0708 0.0928
Loa Loa (eye worm) hypothetical protein 0.0019 0.0708 0.0928
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0708 0.0466
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0708 0.0708
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.3529 0.7953
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.4492 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.3529 0.3529
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0708 0.1596
Schistosoma mansoni nuclear hormone receptor 0.0017 0.037 0.0833
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.3529 0.4628
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.1111 0.1835
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0737 0.0737
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.4492 1
Leishmania major DNA polymerase kappa, putative 0.0021 0.1111 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.3529 0.4354
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.3529 0.4354
Loa Loa (eye worm) hypothetical protein 0.0017 0.037 0.0485
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0017 0.037 0.0485
Loa Loa (eye worm) hypothetical protein 0.0036 0.3529 0.4628
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4492 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.037 0.0485
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4492 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4492 1
Schistosoma mansoni hypothetical protein 0.0041 0.4438 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.3529 0.4354
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.037 0.0485
Loa Loa (eye worm) hypothetical protein 0.0031 0.2804 0.3677
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.4492 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.037 0.037
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.3529 0.3529
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.3529 0.3529
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0737 0.0506
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.3529 0.7953
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.4492 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.3529 0.7953
Echinococcus granulosus FTZ F1 alpha 0.0036 0.3529 0.3529
Loa Loa (eye worm) hypothetical protein 0.0017 0.037 0.0485
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0041 0.4438 0.5819
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.037 0.0485
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.3529 0.3529
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.2804 0.5924
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.3529 0.7953
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0708 0.0466
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.7627 1
Schistosoma mansoni nuclear hormone receptor 0.0017 0.037 0.0833
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.3529 0.4628
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.037 0.0833
Loa Loa (eye worm) hypothetical protein 0.0036 0.3529 0.4628
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0017 0.037 0.0485
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.1111 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.3529 0.4628
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.3529 0.3529
Loa Loa (eye worm) hypothetical protein 0.0019 0.0708 0.0928
Echinococcus multilocularis dna polymerase kappa 0.0041 0.4492 0.4492
Loa Loa (eye worm) hypothetical protein 0.0017 0.037 0.0485
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4492 1
Schistosoma mansoni thyroid hormone receptor 0.0036 0.3529 0.7953
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.7627 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.3529 0.4354
Brugia malayi nuclear receptor NHR-88 0.0036 0.3529 0.4354
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.3529 0.4628
Brugia malayi nuclear hormone receptor 0.0036 0.3529 0.4354
Loa Loa (eye worm) hypothetical protein 0.0036 0.3529 0.4628
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0737 0.0737
Loa Loa (eye worm) hypothetical protein 0.0019 0.0708 0.0928
Loa Loa (eye worm) hypothetical protein 0.0017 0.037 0.0485
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0708 0.0708
Schistosoma mansoni hypothetical protein 0.0019 0.0737 0.1661
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.4492 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.3529 0.3529
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0737 0.0967
Schistosoma mansoni nuclear receptor 0.0017 0.037 0.0833
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.4438 0.5606
Schistosoma mansoni thyroid hormone receptor 0.0036 0.3529 0.7953
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.3529 0.3529
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.037 0.037
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.3529 0.3529
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.3529 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.3529 0.4354
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.3529 0.4354
Brugia malayi steroid hormone receptor 0.0036 0.3529 0.4354
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.3529 0.4628
Schistosoma mansoni coup transcription factor 0.0036 0.3529 0.7953
Brugia malayi ecdysteroid receptor 0.0036 0.3529 0.4354
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.3529 0.4354
Loa Loa (eye worm) hypothetical protein 0.006 0.7627 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.3529 0.3529
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.4492 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.3529 0.4354
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.037 0.037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.3529 0.3529
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0708 0.0928
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.3529 0.3529
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.3529 0.7953
Trypanosoma brucei unspecified product 0.0035 0.3376 0.7306
Schistosoma mansoni nuclear hormone receptor 0.0036 0.3529 0.7953
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0017 0.037 0.0485
Onchocerca volvulus 0.0036 0.3529 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.3529 0.3529
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.2804 0.5924
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.037 0.0485
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0737 0.0506
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.3376 0.7306
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.3529 0.7953
Schistosoma mansoni zinc finger protein 0.0017 0.037 0.0833
Schistosoma mansoni hypothetical protein 0.0019 0.0737 0.1661
Loa Loa (eye worm) hypothetical protein 0.0017 0.037 0.0485
Brugia malayi nuclear receptor RXR 0.0019 0.0708 0.0466
Loa Loa (eye worm) DR-78 0.0017 0.037 0.0485
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.3529 0.4354
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.3529 0.4628
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0036 0.3529 0.4628
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0036 0.3529 0.4628
Brugia malayi hypothetical protein 0.0019 0.0708 0.0466
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.4492 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.3529 0.4354
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.4492 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.037 0.0485
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.3529 0.4354
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.3529 0.4628
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.3529 1
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.4492 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4492 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.3529 0.4628
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.7627 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.037 0.0485
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.037 0.037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.3529 0.3529
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.3529 0.4354
Brugia malayi polk-prov protein 0.0031 0.2804 0.3355
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.3529 0.4354
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0737 0.0737
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4492 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.037 0.037
Echinococcus granulosus GPCR family 2 0.0019 0.0737 0.0737
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.4492 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.3529 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.3529 0.4628
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.3529 0.3529
Echinococcus granulosus dna polymerase kappa 0.0041 0.4492 0.4492
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.3529 0.4354
Loa Loa (eye worm) hypothetical protein 0.0017 0.037 0.0485
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4492 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4492 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0036 0.3529 0.3529
Schistosoma mansoni nuclear receptor 0.0017 0.037 0.0833
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.3529 0.7953
Loa Loa (eye worm) hypothetical protein 0.0019 0.0708 0.0928

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antagonist activity at human glucagon receptor assessed as forskolin-induced cAMP production ChEMBL. 17213325
Activity (functional) 0 Induction of 10 mM glucose-induced insulin release in CD1 wild type mouse pancreatic islets at 100 nM ChEMBL. 17213325
Activity (functional) 0 Induction of 10 mM glucose-induced insulin release in CD1 GLP1 receptor knockout mouse pancreatic islets at 100 nM ChEMBL. 17213325
Activity (functional) 0 Induction of 10 mM glucose-induced insulin release in CD1 GLP1 receptor knockout mouse pancreatic islets at 1000 nM ChEMBL. 17213325
Activity (functional) 0 Antagonist activity at human glucagon receptor assessed as forskolin-induced cAMP production ChEMBL. 17213325
Activity (functional) 0 Induction of 3 mM glucose-induced insulin release in CD1 wild type mouse pancreatic islets at 100 nM ChEMBL. 17213325
Activity (functional) 0 Induction of 3 mM glucose-induced insulin release in CD1 wild type mouse pancreatic islets at 1000 nM ChEMBL. 17213325
EC50 (functional) = 8 pM Agonist activity at human GLP1 receptor expressed in BHK cells assessed as cAMP accumulation ChEMBL. 17213325
EC50 (functional) = 8 pM Agonist activity at human GLP1 receptor expressed in BHK cells assessed as cAMP accumulation ChEMBL. 17213325
EC50 (binding) = 16.2 pM Agonist activity at human GLP1 receptor expressed in BHK cells after 3 hrs by CRE firefly luciferase reporter gene assay in absence of human serum albumin ChEMBL. 26308095
EC50 (binding) = 55 pM Potency measured using recombinant human GLP-1 receptor expressed in Baby Hamster Kidney (BHK)cells ChEMBL. 10794683
EC50 (binding) = 55 pM Potency measured using recombinant human GLP-1 receptor expressed in Baby Hamster Kidney (BHK)cells ChEMBL. 10794683
IC50 (binding) = 0.1 nM Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albumin ChEMBL. 26308095
IC50 (binding) = 0.19 nM Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin ChEMBL. 26308095
Kd (binding) = 0.51 nM Binding affinity to human GLP1 receptor expressed in BHK cells ChEMBL. 17213325
Kd (binding) = 0.51 nM Binding affinity to human GLP1 receptor expressed in BHK cells ChEMBL. 17213325
Ratio IC50 (binding) = 0.5 Ratio of IC50 for human GLP1 receptor expressed in BHK cells in presence of 2% human serum albumin to IC50 for human GLP1 receptor expressed in BHK cells in absence of human serum albumin ChEMBL. 26308095
T1/2 (ADMET) = 1.2 hr Plasma half life was determined in pigs ChEMBL. 10794683

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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