Detailed information for compound 510779

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 432.911 | Formula: C16H27ClF2N2O5S
  • H donors: 5 H acceptors: 4 LogP: 1.07 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CS[C@H]1O[C@H]([C@@H]([C@@H](Cl)C)NC(=O)[C@H]2NC[C@@H]2CCC(F)F)[C@@H]([C@@H]([C@H]1O)O)O
  • InChi: 1S/C16H27ClF2N2O5S/c1-6(17)9(14-12(23)11(22)13(24)16(26-14)27-2)21-15(25)10-7(5-20-10)3-4-8(18)19/h6-14,16,20,22-24H,3-5H2,1-2H3,(H,21,25)/t6-,7-,9+,10-,11-,12+,13+,14+,16+/m0/s1
  • InChiKey: ZRFLECCTJLQRPR-ARTRGHOGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1602 0.1114
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.4534 0.4923
Brugia malayi jmjC domain containing protein 0.0049 0.1097 0.1191
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0088 0.2565 0.2375
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0752 0.0871
Wolbachia endosymbiont of Brugia malayi delta-aminolevulinic acid dehydratase 0.0227 0.7826 0.5
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0055 0.134 0.0923
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0809 0.0709
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0076 0.2113 0.2435
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0055 0.134 0.0781
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0055 0.134 0.0781
Schistosoma mansoni porphobilinogen synthase 0.0227 0.7826 0.8498
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.068 0.0657
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0567 0.0725
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0389 0.0436
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1602 0.1888
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.4505 0.4438
Trypanosoma brucei unspecified product 0.0033 0.0512 0.0584
Giardia lamblia Rab geranylgeranyltransferase 0.0062 0.1579 0.1558
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.1602 0.1114
Onchocerca volvulus 0.0053 0.127 0.6043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1602 0.1888
Trypanosoma cruzi protein farnesyltransferase, putative 0.0055 0.134 0.077
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0179 0.6001 0.6516
Loa Loa (eye worm) hypothetical protein 0.0269 0.9383 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 1 1
Schistosoma mansoni glutaminase 0.0264 0.9209 1
Brugia malayi jmjC domain containing protein 0.0049 0.1097 0.1191
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.4534 0.4923
Loa Loa (eye worm) hypothetical protein 0.0079 0.2231 0.2377
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0088 0.2565 0.3277
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0752 0.0871
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1602 0.1888
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0179 0.6001 0.7412
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1602 0.1888
Trichomonas vaginalis glutaminase, putative 0.0264 0.9209 0.9158
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0088 0.2565 0.3277
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0088 0.2565 0.3277
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0809 0.0216
Brugia malayi bZIP transcription factor family protein 0.0081 0.2315 0.2513
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0062 0.1579 0.1683
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0752 0.0871
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1602 0.1888
Schistosoma mansoni jumonji/arid domain-containing protein 0.0129 0.4125 0.4479
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.1097 0.1169
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0809 0.0709
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0062 0.1579 0.186
Echinococcus granulosus Squalene phytoene synthase 0.0075 0.2101 0.2685
Trypanosoma cruzi protein farnesyltransferase, putative 0.0055 0.134 0.077
Loa Loa (eye worm) hypothetical protein 0.003 0.0389 0.0415
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0179 0.6001 0.5761
Schistosoma mansoni cpg binding protein 0.0059 0.1489 0.1616
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0062 0.1579 0.2018
Schistosoma mansoni phosphatidylserine receptor 0.0049 0.1097 0.1191
Schistosoma mansoni hypothetical protein 0.0066 0.1742 0.1891
Giardia lamblia Rab geranylgeranyltransferase 0.0179 0.6001 0.5991
Leishmania major lanosterol synthase, putative 0.0046 0.0977 0.114
Brugia malayi jmjC domain containing protein 0.0068 0.1837 0.1995
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.1097 0.1169
Brugia malayi jmjC domain containing protein 0.0175 0.5869 0.6373
Echinococcus multilocularis Squalene phytoene synthase 0.0075 0.2101 0.2685
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.4505 0.7949
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.11 0.0456
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 1 1
Schistosoma mansoni cpg binding protein 0.0053 0.127 0.1379
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0088 0.2565 0.2375
Brugia malayi glutaminase DH11.1 0.0264 0.9209 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0809 0.0216
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0088 0.2565 0.2538
Brugia malayi CXXC zinc finger family protein 0.0053 0.127 0.1379
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1602 0.1114
Leishmania major farnesyltransferase beta subunit 0.0055 0.134 0.1574
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0117 0.3679 0.3271
Loa Loa (eye worm) jmjC domain-containing protein 0.0175 0.5869 0.6255
Echinococcus multilocularis jumonji domain containing 1A 0.0049 0.1097 0.1401
Loa Loa (eye worm) hypothetical protein 0.0036 0.0606 0.0646
Toxoplasma gondii hypothetical protein 0.0062 0.1579 0.1729
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0049 0.1097 0.1283
Echinococcus granulosus delta aminolevulinic acid dehydratase 0.0227 0.7826 1
Toxoplasma gondii PLU-1 family protein 0.0046 0.1002 0.0965
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0088 0.2565 0.2733
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0179 0.6001 0.7447
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0076 0.2106 0.2287
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0068 0.1837 0.2347
Trypanosoma cruzi squalene synthase, putative 0.0242 0.8382 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0062 0.1579 0.1035
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0055 0.134 0.1455
Loa Loa (eye worm) glutaminase 2 0.0264 0.9209 0.9815
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0389 0.0436
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0179 0.6001 0.7668
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 1 1
Mycobacterium tuberculosis Probable delta-aminolevulinic acid dehydratase HemB (porphobilinogen synthase) (ALAD) (ALADH) 0.0116 0.3621 0.638
Loa Loa (eye worm) hypothetical protein 0.0179 0.6001 0.6396
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0049 0.1097 0.0451
Brugia malayi fructose-bisphosphate aldolase 1 0.0088 0.2565 0.2785
Echinococcus granulosus lysine specific demethylase 6a 0.0085 0.2446 0.3125
Schistosoma mansoni protein phosphatase 2C 0.0049 0.1097 0.1191
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0752 0.0155
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.1399 0.0847
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0055 0.134 0.1574
Leishmania major cathepsin L-like protease 0.0062 0.1602 0.1888
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1602 0.1888
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1602 0.1888
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 1 1
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0088 0.2565 0.3277
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0055 0.134 0.0781
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0752 0.0871
Loa Loa (eye worm) hypothetical protein 0.0075 0.2101 0.224
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0088 0.2565 0.3277
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.2315 0.2958
Echinococcus multilocularis JmjC domain containing protein 4 0.0049 0.1097 0.1401
Schistosoma mansoni jun-related protein 0.0066 0.1742 0.1891
Brugia malayi jmjC domain containing protein 0.0049 0.1097 0.1191
Echinococcus granulosus jun protein 0.0081 0.2315 0.2958
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0062 0.1579 0.2018
Trypanosoma cruzi lanosterol synthase, putative 0.0061 0.1542 0.1035
Loa Loa (eye worm) acetyltransferase 0.014 0.4534 0.4832
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0151 0.4961 0.634
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0088 0.2565 0.3277
Brugia malayi hypothetical protein 0.0064 0.1658 0.18
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0055 0.134 0.1712
Loa Loa (eye worm) glutaminase 0.0264 0.9209 0.9815
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0055 0.134 0.1455
Mycobacterium ulcerans L-lactate dehydrogenase (cytochrome) LldD2 0.017 0.5661 0.5805
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0055 0.134 0.1412
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0062 0.1579 0.1083
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0088 0.2565 0.3277
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0049 0.1097 0.109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 1 1
Echinococcus multilocularis delta aminolevulinic acid dehydratase 0.0227 0.7826 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1602 0.1888
Schistosoma mansoni jumonji domain containing protein 0.0049 0.1097 0.1191
Treponema pallidum fructose-bisphosphate aldolase 0.0285 1 1
Toxoplasma gondii parasite porphobilinogen synthase PBGS 0.0227 0.7826 1
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0088 0.2565 0.2733
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0055 0.134 0.1712
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0062 0.1579 0.2018
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0567 0.0725
Leishmania major cathepsin L-like protease 0.0062 0.1602 0.1888
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0062 0.1579 0.1258
Schistosoma mansoni hypothetical protein 0.0075 0.2101 0.2282
Leishmania major fructose-1,6-bisphosphate aldolase 0.0088 0.2565 0.3039
Brugia malayi jmjC domain containing protein 0.0085 0.2446 0.2656
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0088 0.2565 0.3039
Brugia malayi fructose-bisphosphate aldolase 2 0.0088 0.2565 0.2785
Schistosoma mansoni jumonji/arid domain-containing protein 0.0129 0.4125 0.4479
Onchocerca volvulus 0.0064 0.1658 0.789
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0068 0.1837 0.2347
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0062 0.1579 0.186
Mycobacterium leprae PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH) 0.0227 0.7826 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0809 0.1034
Schistosoma mansoni phd/f-box containing protein 0.0049 0.1097 0.1191
Leishmania major hypothetical protein, conserved 0.0075 0.2101 0.2485
Mycobacterium ulcerans delta-aminolevulinic acid dehydratase 0.0227 0.7826 0.8364
Brugia malayi jmjC domain containing protein 0.0065 0.171 0.1857
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0179 0.6001 0.5743
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0088 0.2565 0.2785
Echinococcus multilocularis lysine specific demethylase 6a 0.0085 0.2446 0.3125
Mycobacterium ulcerans L-lactate dehydrogenase (cytochrome) LldD1 0.0061 0.1553 0.0946
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 1 1
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0062 0.1579 0.1083
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0061 0.1542 0.2692
Loa Loa (eye worm) hypothetical protein 0.0114 0.355 0.3783
Trypanosoma brucei isopentenyl-diphosphate delta-isomerase (type II) 0.0061 0.1553 0.1828
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0055 0.134 0.0781
Trypanosoma cruzi lanosterol synthase, putative 0.0061 0.1542 0.1035
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0062 0.1579 0.1141
Schistosoma mansoni cpg binding protein 0.0059 0.1489 0.1616
Trypanosoma cruzi phytoene synthase, putative 0.0075 0.2101 0.1768
Leishmania major isopentenyl-diphosphate delta-isomerase, putative,isomerase, putative 0.0061 0.1553 0.1828
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0179 0.6001 0.6516
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.0512 0.0584
Leishmania major hypothetical protein, conserved 0.0049 0.1097 0.1283
Loa Loa (eye worm) hypothetical protein 0.0036 0.0606 0.0646
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0055 0.134 0.0781
Plasmodium falciparum porphobilinogen synthase 0.0227 0.7826 1
Echinococcus granulosus cpg binding protein 0.0059 0.1489 0.1902
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0062 0.1579 0.1083
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0088 0.2565 0.3277
Echinococcus multilocularis lysine specific demethylase 5A 0.0123 0.3906 0.4992
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0752 0.0871
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0075 0.2101 0.3685
Mycobacterium ulcerans isopentenyl pyrophosphate isomerase 0.0061 0.1553 0.0946
Echinococcus granulosus JmjC domain containing protein 4 0.0049 0.1097 0.1401
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0752 0.0871
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.1579 0.1083
Plasmodium vivax delta-aminolevulinic acid dehydratase, putative 0.0227 0.7826 1
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0075 0.2101 1
Schistosoma mansoni jumonji domain containing protein 0.0068 0.1837 0.1995
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0055 0.134 0.0819
Trypanosoma brucei squalene synthase, putative 0.0242 0.8382 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0072 0.1982 0.1823
Echinococcus granulosus dna polymerase kappa 0.004 0.0752 0.0961
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0055 0.134 0.0801
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0752 0.0871
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0752 0.0871
Leishmania major squalene synthase, putative 0.0242 0.8382 1
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.1579 0.1083
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0055 0.134 0.1428
Mycobacterium ulcerans phytoene synthase, CrtB 0.0075 0.2101 0.1595
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0752 0.0871
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0062 0.1579 0.186
Loa Loa (eye worm) CXXC zinc finger family protein 0.0053 0.127 0.1354
Onchocerca volvulus 0.0062 0.1579 0.7514
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0062 0.1579 0.2018
Mycobacterium tuberculosis Possible L-lactate dehydrogenase (cytochrome) LldD2 0.017 0.5661 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.4534 0.5794
Brugia malayi polk-prov protein 0.003 0.0389 0.0422
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 1 1
Trypanosoma cruzi squalene synthase, putative 0.0242 0.8382 1
Echinococcus granulosus jumonji domain containing 1A 0.0049 0.1097 0.1401
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0062 0.1579 0.1715
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0088 0.2565 0.2375
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0752 0.0871
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0062 0.1579 0.1073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1602 0.1888
Echinococcus multilocularis cpg binding protein 0.0059 0.1489 0.1902
Mycobacterium ulcerans glutaminase 0.0264 0.9209 1
Echinococcus multilocularis jun protein 0.0081 0.2315 0.2958
Echinococcus multilocularis phd:f box containing protein 0.0049 0.1097 0.1401
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0151 0.4961 0.634
Echinococcus granulosus phd:f box containing protein 0.0049 0.1097 0.1401
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0179 0.6001 0.6396
Plasmodium vivax JmjC domain containing protein 0.0072 0.1982 0.1712
Schistosoma mansoni hypothetical protein 0.0035 0.0567 0.0616
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0062 0.1579 0.186
Chlamydia trachomatis delta-aminolevulinic acid dehydratase 0.0227 0.7826 0.5
Loa Loa (eye worm) hypothetical protein 0.0049 0.1097 0.1169
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.4386 0.5605
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 1 1
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0088 0.2565 0.3034
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0055 0.134 0.0781
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0752 0.0871
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0088 0.2565 0.3034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1602 0.1888
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0088 0.2565 0.3034
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0809 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.1097 0.1169
Plasmodium falciparum fructose-bisphosphate aldolase 0.0088 0.2565 0.2638
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0567 0.0616
Toxoplasma gondii hypothetical protein 0.0117 0.3679 0.451
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0179 0.6001 0.7668
Brugia malayi hypothetical protein 0.0035 0.0567 0.0616
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0085 0.2446 0.2656
Entamoeba histolytica hypothetical protein, conserved 0.0036 0.0606 0.0042
Schistosoma mansoni porphobilinogen synthase 0.0227 0.7826 0.8498
Brugia malayi jmjC domain containing protein 0.0065 0.171 0.1857
Mycobacterium leprae POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2 0.017 0.5661 0.3482
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.068 0.0119
Trypanosoma brucei hypothetical protein, conserved 0.0062 0.1579 0.186
Trypanosoma brucei lanosterol synthase 0.0061 0.1542 0.1816
Echinococcus granulosus lysine specific demethylase 5A 0.0129 0.4125 0.5271
Entamoeba histolytica isopentenyl-diphosphate delta-isomerase, putative 0.0061 0.1553 0.1045
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0088 0.2565 0.2785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1602 0.1888
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0088 0.2565 0.2375
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.2315 0.2958
Leishmania major cathepsin L-like protease 0.0062 0.1602 0.1888
Echinococcus multilocularis dna polymerase kappa 0.004 0.0752 0.0961
Giardia lamblia Prenyltransferase 0.0055 0.134 0.1318
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1602 0.1114
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0752 0.0155
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0179 0.6001 0.5743
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0049 0.1097 0.0451
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0179 0.6001 0.5743
Loa Loa (eye worm) hypothetical protein 0.0085 0.2446 0.2607

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) Inhibition of protein synthesis in Escherichia coli by transcription/translation inhibition assay ChEMBL. 18359228
IC50 (functional) 0 Inhibition of protein synthesis in Escherichia coli by transcription/translation inhibition assay ChEMBL. 18359228
MIC (functional) = 0.125 ug ml-1 Antibacterial activity against Streptococcus pneumoniae by broth microdilution method ChEMBL. 18359228
MIC (functional) = 0.5 ug ml-1 Antibacterial activity against Enterococcus faecium by broth microdilution method ChEMBL. 18359228
MIC (functional) = 1 ug ml-1 Antibacterial activity against Staphylococcus aureus by broth microdilution method ChEMBL. 18359228
MIC (functional) = 1 ug ml-1 Antibacterial activity against Bacteroides fragilis by broth microdilution method ChEMBL. 18359228
MIC (functional) = 2 ug ml-1 Antibacterial activity against Enterococcus faecalis by broth microdilution method ChEMBL. 18359228
MIC (functional) > 4 ug ml-1 Antibacterial activity against macrolide, licosamide and streptogramin resistant Staphylococcus aureus by broth microdilution method ChEMBL. 18359228

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.