Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0138 | 0.0835 | 0.038 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0473 | 0.0473 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0331 | 0.4078 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0269 | 0.3036 | 0.7445 |
Onchocerca volvulus | 0.019 | 0.1706 | 0.3312 | |
Schistosoma mansoni | atypical protein kinase C | 0.0225 | 0.2301 | 0.5642 |
Brugia malayi | protein kinase C II. | 0.028 | 0.3229 | 0.2463 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0089 | 0 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0523 | 0.7327 | 0.7194 |
Toxoplasma gondii | PAN domain-containing protein | 0.0343 | 0.4288 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0343 | 0.4288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.4315 | 0.4315 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.4205 | 0.4205 |
Echinococcus multilocularis | protein kinase c iota type | 0.0219 | 0.22 | 0.1813 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0125 | 0.0612 | 0.0612 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.3098 | 0.3098 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.3358 | 0.3358 |
Giardia lamblia | Cathepsin B precursor | 0.0089 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1637 | 0.1637 |
Schistosoma mansoni | serine/threonine protein kinase | 0.028 | 0.3229 | 0.7919 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0288 | 0.3358 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0089 | 0 | 0.5 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0122 | 0.0565 | 0.0565 |
Loa Loa (eye worm) | hypothetical protein | 0.0682 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0269 | 0.3036 | 0.269 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0269 | 0.3036 | 0.7445 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0288 | 0.3358 | 0.5 |
Onchocerca volvulus | 0.0272 | 0.3098 | 0.7238 | |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0188 | 0.1671 | 0.1671 |
Schistosoma mansoni | hypothetical protein | 0.0288 | 0.3358 | 0.8235 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0288 | 0.3358 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.158 | 0.158 |
Brugia malayi | C1-like domain containing protein | 0.0188 | 0.1671 | 0.0728 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0288 | 0.3358 | 0.3028 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0331 | 0.4078 | 1 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0682 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0288 | 0.3358 | 0.2606 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.3036 | 0.3036 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.028 | 0.3229 | 0.3229 |
Brugia malayi | Protein kinase c protein 2 | 0.0191 | 0.1718 | 0.0781 |
Echinococcus granulosus | cathepsin b | 0.0269 | 0.3036 | 0.269 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0089 | 0 | 0.5 |
Onchocerca volvulus | 0.0186 | 0.1637 | 0.312 | |
Echinococcus granulosus | tissue type plasminogen activator | 0.0288 | 0.3358 | 0.3028 |
Onchocerca volvulus | 0.0331 | 0.4078 | 1 | |
Toxoplasma gondii | kringle domain-containing protein | 0.0288 | 0.3358 | 0.7832 |
Brugia malayi | Trypsin family protein | 0.0331 | 0.4078 | 0.3407 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0531 | 0.0531 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0269 | 0.3036 | 0.9041 |
Echinococcus granulosus | protein kinase c iota type | 0.0219 | 0.22 | 0.1813 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0682 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.1706 | 0.1706 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0269 | 0.3036 | 0.2248 |
Onchocerca volvulus | 0.0258 | 0.2858 | 0.656 | |
Schistosoma mansoni | protein kinase C mu | 0.0188 | 0.1671 | 0.4098 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0523 | 0.7327 | 0.7194 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0261 | 0.2901 | 0.7115 |
Echinococcus multilocularis | cathepsin b | 0.0269 | 0.3036 | 0.269 |
Brugia malayi | Kringle domain containing protein | 0.0288 | 0.3358 | 0.2606 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0261 | 0.2901 | 0.2549 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0531 | 0.0531 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0269 | 0.3036 | 0.7445 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0261 | 0.2901 | 0.7115 |
Echinococcus granulosus | protein kinase c epsilon type | 0.028 | 0.3229 | 0.2893 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.3098 | 0.3098 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.4078 | 0.4078 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0188 | 0.1671 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.4078 | 0.4078 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0269 | 0.3036 | 0.7445 |
Leishmania major | hypothetical protein, conserved | 0.0288 | 0.3358 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0195 | 0.1795 | 0.1387 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.028 | 0.3229 | 0.2893 |
Echinococcus granulosus | protein kinase C gamma type | 0.0195 | 0.1795 | 0.1387 |
Giardia lamblia | Cathepsin B precursor | 0.0089 | 0 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0288 | 0.3358 | 0.3358 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0261 | 0.2901 | 0.2549 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0208 | 0.2018 | 0.1622 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.3098 | 0.3098 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0142 | 0.0904 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0269 | 0.3036 | 0.269 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0155 | 0.1118 | 0.1118 |
Onchocerca volvulus | 0.0288 | 0.3358 | 0.7971 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.5 uM | Antiproliferative activity against PDGF-induced rat aortic VSMC by colorimetric assay | ChEMBL. | 18400498 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.