TDR Targets

Basic information

Technical information

TDR Targets ID: 510985
Name: 4-(2,6-difluorophenyl)-1,3-thiazol-2-amine
MW: 212.219 | Formula: C9H6F2N2S
H donors: 1 H acceptors: 1 LogP: 2.47 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Nc1scc(n1)c1c(F)cccc1F
InChi: 1S/C9H6F2N2S/c10-5-2-1-3-6(11)8(5)7-4-14-9(12)13-7/h1-4H,(H2,12,13)
InChiKey: ZRFCBSGOMCOUJG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-(2,6-difluorophenyl)thiazol-2-amine
4-(2,6-difluorophenyl)-2-thiazolamine
[4-(2,6-difluorophenyl)thiazol-2-yl]amine
BAS 05210802
BBV-002816
ZINC00269198
4-(2,6-Difluoro-phenyl)-thiazol-2-ylamine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	MPL proto-oncogene, thrombopoietin receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.1183	1	1
Entamoeba histolytica	protein kinase, putative	0.0069	0.0432	0.0982
Brugia malayi	protein kinase C II.	0.02	0.1554	0.1554
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0259	0.0259
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0106	0.0748	0.0748
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0109	0.0109
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0031	0.0109	0.0109
Echinococcus granulosus	fatty acid amide hydrolase 1	0.1183	1	1
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.0039	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0259	0.0259
Toxoplasma gondii	hypothetical protein	0.0031	0.0109	0.252
Schistosoma mansoni	serine/threonine protein kinase	0.0069	0.0432	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0031	0.0109	0.0109
Brugia malayi	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0069	0.0432	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Plasmodium vivax	unspecified product	0.0031	0.0109	0.0247
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0069	0.0432	0.0432
Echinococcus granulosus	tm gpcr rhodopsin	0.0031	0.0109	0.0109
Schistosoma mansoni	serine/threonine protein kinase	0.0292	0.2349	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Brugia malayi	G-protein coupled receptor	0.0031	0.0109	0.0109
Mycobacterium leprae	PROBABLE AMIDASE AMIC (AMINOHYDROLASE)	0.0143	0.1066	0.2354
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0031	0.0109	0.0247
Echinococcus granulosus	monoacylglycerol lipase abhd12	0.0031	0.0109	0.0109
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0031	0.0109	0.0109
Schistosoma mansoni	unc-13 (munc13)	0.0055	0.0316	0.0316
Schistosoma mansoni	neuropeptide receptor	0.0031	0.0109	0.0109
Trichomonas vaginalis	AGC family protein kinase	0.0069	0.0432	0.0982
Trichomonas vaginalis	AGC family protein kinase	0.0069	0.0432	0.0982
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0031	0.0109	0.0109
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0043	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0259	0.0259
Brugia malayi	Dopamine receptor protein 1	0.0031	0.0109	0.0109
Echinococcus multilocularis	N chimaerin	0.0049	0.0259	0.0259
Brugia malayi	diacylglycerol kinase	0.0049	0.0259	0.0259
Echinococcus granulosus	Protein kinase C brain isozyme	0.0292	0.2349	0.2349
Loa Loa (eye worm)	ShTK domain-containing protein	0.0106	0.0748	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Brugia malayi	ORL1-like opioid receptor	0.0031	0.0109	0.0109
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0031	0.0109	0.0109
Echinococcus granulosus	tm gpcr rhodopsin	0.0031	0.0109	0.0109
Trichomonas vaginalis	AGC family protein kinase	0.0069	0.0432	0.0982
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	G-protein coupled receptor	0.0031	0.0109	0.0109
Brugia malayi	PXA domain containing protein	0.0043	0.0212	0.0212
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0049	0.0259	0.0259
Trichomonas vaginalis	AGC family protein kinase	0.0069	0.0432	0.0982
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0069	0.0432	0.0432
Onchocerca volvulus		0.0082	0.0547	0.1894
Brugia malayi	Protein kinase domain containing protein	0.0069	0.0432	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0547	0.0547
Brugia malayi	small heat shock protein	0.0567	0.4708	0.4708
Schistosoma mansoni	serine/threonine protein kinase	0.0045	0.0224	0.0224
Trypanosoma cruzi	serine peptidase, putative	0.0031	0.0109	0.0247
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0383	0.0869
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0031	0.0109	0.0109
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0039	0.0088
Echinococcus multilocularis	fmrfamide receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	regulator of G protein signaling 3	0.0043	0.0212	0.0212
Plasmodium falciparum	lysophospholipase, putative	0.0031	0.0109	0.0247
Echinococcus multilocularis	dro:myosuppressin receptor	0.0031	0.0109	0.0109
Plasmodium falciparum	esterase, putative	0.0031	0.0109	0.0247
Loa Loa (eye worm)	neuropeptide F receptor	0.0031	0.0109	0.0109
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0143	0.1066	0.2421
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0748	0.0748
Echinococcus granulosus	fmrfamide receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0049	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0369	0.3014	0.3014
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0143	0.1066	0.2421
Schistosoma mansoni	axis inhibition protein axin	0.0043	0.0212	0.0212
Mycobacterium leprae	PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A)	0.0143	0.1066	0.2354
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0031	0.0109	0.0109
Brugia malayi	putative neuropeptide receptor	0.0031	0.0109	0.0109
Plasmodium falciparum	exported lipase 1	0.0031	0.0109	0.0247
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0031	0.0109	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0031	0.0109	0.0109
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0031	0.0109	0.0247
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0212	0.0481
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0069	0.0432	0.0432
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0031	0.0109	0.0109
Echinococcus granulosus	protein kinase C gamma type	0.0243	0.1931	0.1931
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0383	0.0869
Loa Loa (eye worm)	neuropeptide F receptor	0.0031	0.0109	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0531	0.4401	1
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0143	0.1066	0.1066
Echinococcus granulosus	sex peptide receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0031	0.0109	0.0109
Brugia malayi	Amidase family protein	0.0143	0.1066	0.1066
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0049	0.0259	0.0259
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0109	0.0109
Schistosoma mansoni	biogenic amine receptor	0.0031	0.0109	0.0109
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0031	0.0109	0.0109
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0031	0.0109	0.0109
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0106	0.0748	0.0748
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0031	0.0109	0.0109
Schistosoma mansoni	serine/threonine protein kinase	0.0045	0.0224	0.0224
Brugia malayi	Variant SH3 domain containing protein	0.0049	0.0259	0.0259
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0109	0.0109
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0109	0.0109
Schistosoma mansoni	serine/threonine protein kinase	0.0069	0.0432	0.0432
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0031	0.0109	0.0247
Plasmodium vivax	PST-A protein	0.0031	0.0109	0.0247
Schistosoma mansoni	serine/threonine protein kinase	0.0045	0.0224	0.0224
Trichomonas vaginalis	AGC family protein kinase	0.0069	0.0432	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0292	0.2349	0.2349
Echinococcus granulosus	raf serine:threonine protein kinase	0.0049	0.0259	0.0259
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0212	0.0481
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0043	0.0212	0.0212
Schistosoma mansoni	amine GPCR	0.0031	0.0109	0.0109
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0082	0.0547	0.0547
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0069	0.0432	0.0432
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0109	0.0247
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0045	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0212	0.0212
Leishmania major	hypothetical protein, conserved	0.0031	0.0109	0.0247
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0031	0.0109	0.0109
Trichomonas vaginalis	AGC family protein kinase	0.0069	0.0432	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0031	0.0109	0.252
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0069	0.0432	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus granulosus	regulator of G protein signaling 7	0.0043	0.0212	0.0212
Echinococcus multilocularis	myotubularin protein 13	0.0049	0.0259	0.0259
Brugia malayi	RhoGAP domain containing protein	0.0049	0.0259	0.0259
Echinococcus granulosus	protein kinase c iota type	0.0118	0.0851	0.0851
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0031	0.0109	0.0109
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0143	0.1066	1
Onchocerca volvulus		0.0106	0.0748	0.2765
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0143	0.1066	0.2421
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0077	0.0498	0.1132
Schistosoma mansoni	hypothetical protein	0.0067	0.0415	0.0415
Schistosoma mansoni	protein kinase C	0.0055	0.0316	0.0316
Echinococcus granulosus	hypothetical protein	0.0031	0.0109	0.0109
Trypanosoma cruzi	amidase, putative	0.0143	0.1066	0.2421
Echinococcus granulosus	Rac GTPase activating protein 1	0.0049	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0259	0.0259
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0031	0.0109	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0023	0.0039	0.0088
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0212	0.0212
Echinococcus granulosus	regulator of G protein signaling 3	0.0043	0.0212	0.0212
Schistosoma mansoni	neuropeptide receptor	0.0031	0.0109	0.0109
Plasmodium vivax	alpha/beta hydrolase, putative	0.0031	0.0109	0.0247
Echinococcus granulosus	g-protein coupled receptor	0.0031	0.0109	0.0109
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0031	0.0109	0.0109
Brugia malayi	Amidase family protein	0.0143	0.1066	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0031	0.0109	0.0109
Brugia malayi	Pleckstrin Homology Domain	0.0049	0.0259	0.0259
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.0143	0.1066	0.2421
Schistosoma mansoni	tyrosinase precursor	0.0106	0.0748	0.0748
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0043	0.0212	0.0212
Brugia malayi	ShTK domain containing protein	0.0106	0.0748	0.0748
Trichomonas vaginalis	AGC family protein kinase	0.0069	0.0432	0.0982
Echinococcus multilocularis	neuropeptide s receptor	0.0031	0.0109	0.0109
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.0259	0.0259
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0143	0.1066	0.1066
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.1183	1	1
Echinococcus multilocularis	Phospholipase carboxylesterase	0.0031	0.0109	0.0109
Mycobacterium ulcerans	amidase	0.0143	0.1066	0.2421
Echinococcus granulosus	biogenic amine 5HT receptor	0.0031	0.0109	0.0109
Mycobacterium ulcerans	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0143	0.1066	0.2421
Schistosoma mansoni	axis inhibition protein axin	0.0043	0.0212	0.0212
Mycobacterium ulcerans	amidase	0.0143	0.1066	0.2421
Plasmodium falciparum	lysophospholipase, putative	0.0531	0.4401	1
Loa Loa (eye worm)	hypothetical protein	0.0168	0.1281	0.1281
Onchocerca volvulus		0.0049	0.0259	0.0648
Brugia malayi	hypothetical protein	0.0031	0.0109	0.0109
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0069	0.0432	0.0432
Echinococcus multilocularis	somatostatin receptor	0.0031	0.0109	0.0109
Plasmodium falciparum	epoxide hydrolase 2	0.0031	0.0109	0.0247
Brugia malayi	C1-like domain containing protein	0.005	0.0272	0.0272
Brugia malayi	Protein kinase domain containing protein	0.005	0.0272	0.0272
Brugia malayi	diacylglycerol kinase	0.0049	0.0259	0.0259
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0031	0.0109	0.0109
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0109	0.0109
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0043	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0031	0.0109	0.0247
Loa Loa (eye worm)	melatonin receptor type 1A	0.0031	0.0109	0.0109
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0031	0.0109	0.0109
Echinococcus granulosus	Diacylglycerol kinase theta	0.0049	0.0259	0.0259
Brugia malayi	regulator of G-protein signaling egl-10	0.0043	0.0212	0.0212
Onchocerca volvulus		0.0055	0.0316	0.0897
Mycobacterium ulcerans	hydrolase	0.0031	0.0109	0.0247
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0023	0.0039	0.09
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0049	0.0259	0.0259
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0043	0.0212	0.0212
Echinococcus multilocularis	neuropeptide Y receptor	0.0031	0.0109	0.0109
Plasmodium vivax	PST-A protein	0.0531	0.4401	1
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0023	0.0039	0.0088
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0031	0.0109	0.0109
Plasmodium falciparum	alpha/beta hydrolase fold domain containing protein, putative	0.0031	0.0109	0.0247
Onchocerca volvulus		0.0106	0.0748	0.2765
Schistosoma mansoni	rac gtpase activating protein	0.0049	0.0259	0.0259
Trypanosoma cruzi	cruzipain precursor, putative	0.0063	0.0383	0.0869
Entamoeba histolytica	hypothetical protein	0.0043	0.0212	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Brugia malayi	neuropeptide F receptor	0.0031	0.0109	0.0109
Brugia malayi	hypothetical protein	0.0031	0.0109	0.0109
Leishmania major	hypothetical protein, conserved	0.0031	0.0109	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Toxoplasma gondii	hypothetical protein	0.0031	0.0109	0.252
Echinococcus granulosus	jun protein	0.0082	0.0548	0.0548
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0031	0.0109	0.0109
Echinococcus multilocularis	G protein coupled receptor 139	0.0031	0.0109	0.0109
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0031	0.0109	0.0109
Echinococcus granulosus	protein kinase c eta type	0.0049	0.0259	0.0259
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0049	0.0259	0.0259
Mycobacterium ulcerans	hypothetical protein	0.0031	0.0109	0.0247
Trichomonas vaginalis	conserved hypothetical protein	0.0531	0.4401	1
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0109	0.0247
Schistosoma mansoni	neuropeptide F-like receptor	0.0031	0.0109	0.0109
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0383	0.0869
Trypanosoma cruzi	serine peptidase, putative	0.0031	0.0109	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0259	0.0259
Plasmodium vivax	PST-A protein	0.0031	0.0109	0.0247
Schistosoma mansoni	serine/threonine protein kinase	0.0069	0.0432	0.0432
Mycobacterium ulcerans	amidase	0.0143	0.1066	0.2421
Schistosoma mansoni	regulator of G protein signaling	0.0043	0.0212	0.0212
Brugia malayi	Protein kinase c protein 2	0.0225	0.177	0.177
Echinococcus granulosus	protein kinase c epsilon type	0.02	0.1554	0.1554
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0031	0.0109	0.0109
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0143	0.1066	1
Mycobacterium ulcerans	lysophospholipase	0.0531	0.4401	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0109	0.0109
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0109	0.0109
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0031	0.0109	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0109	0.0109
Echinococcus granulosus	N chimaerin	0.0049	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0301	0.2422	0.2422
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0031	0.0109	0.0247
Trichomonas vaginalis	AGC family protein kinase	0.0069	0.0432	0.0982
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0109	0.0109
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0383	0.0869
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0069	0.0432	0.0432
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0143	0.1066	0.2421
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0259	0.0259
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Onchocerca volvulus		0.0065	0.0396	0.124
Brugia malayi	MGC79044 protein	0.0031	0.0109	0.0109
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0049	0.0259	0.0259
Schistosoma mansoni	hypothetical protein	0.0031	0.0109	0.0109
Brugia malayi	follicle stimulating hormone receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0143	0.1066	0.1066
Entamoeba histolytica	hypothetical protein	0.0043	0.0212	0.0481
Entamoeba histolytica	protein kinase, putative	0.0069	0.0432	0.0982
Trypanosoma brucei	monoglyceride lipase, putative	0.0531	0.4401	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0109	0.0109
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0109	0.0109
Echinococcus granulosus	fatty acid amide hydrolase 1	0.1183	1	1
Brugia malayi	RhoGAP domain containing protein	0.0049	0.0259	0.0259
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0031	0.0109	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0212	0.0481
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0109	0.0109
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0082	0.0547	0.0547
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.008	0.0528	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Schistosoma mansoni	protein kinase C mu	0.005	0.0272	0.0272
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0383	0.0869
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0259	0.0259
Echinococcus granulosus	dro:myosuppressin receptor	0.0031	0.0109	0.0109
Echinococcus granulosus	7tm_1 domain containing protein	0.0031	0.0109	0.0109
Echinococcus multilocularis	jun protein	0.0082	0.0548	0.0548
Loa Loa (eye worm)	ShTK domain-containing protein	0.0106	0.0748	0.0748
Trichomonas vaginalis	AGC family protein kinase	0.0069	0.0432	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0106	0.0748	0.0748
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0109	0.0109
Leishmania major	cathepsin L-like protease	0.0063	0.0383	0.0869
Giardia lamblia	Cgi67 serine protease precursor-like protein	0.0031	0.0109	1
Brugia malayi	Protein kinase domain containing protein	0.0069	0.0432	0.0432
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0109	0.0109
Echinococcus granulosus	L aminoadipate semialdehyde	0.0082	0.0547	0.0547
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0109	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Schistosoma mansoni	atypical protein kinase C	0.0118	0.0851	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0212	0.0481
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0212	0.0481
Echinococcus granulosus	serotonin receptor	0.0031	0.0109	0.0109
Schistosoma mansoni	tyrosinase precursor	0.0106	0.0748	0.0748
Echinococcus multilocularis	neuropeptides capa receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0109	0.0247
Echinococcus multilocularis	neuropeptide receptor	0.0031	0.0109	0.0109
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0531	0.4401	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.0043	0.0212	0.0212
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0069	0.0432	0.0432
Brugia malayi	hypothetical protein	0.0031	0.0109	0.0109
Plasmodium falciparum	prodrug activation and resistance esterase	0.0031	0.0109	0.0247
Schistosoma mansoni	biogenic amine receptor	0.0031	0.0109	0.0109
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.005	0.0272	0.0272
Entamoeba histolytica	;Alias	0.0031	0.0109	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Plasmodium falciparum	esterase, putative	0.0031	0.0109	0.0247
Echinococcus multilocularis	abhydrolase domain containing 3	0.0031	0.0109	0.0109
Toxoplasma gondii	hypothetical protein	0.0031	0.0109	0.252
Brugia malayi	Ras association domain family 1 isoform A	0.0049	0.0259	0.0259
Echinococcus multilocularis	orexin receptor type 2	0.0031	0.0109	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0109	0.0247
Echinococcus granulosus	neuropeptide Y receptor	0.0031	0.0109	0.0109
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0143	0.1066	0.2421
Toxoplasma gondii	phospholipase/carboxylesterase	0.0031	0.0109	0.252
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Brugia malayi	larval opioid receptor	0.0031	0.0109	0.0109
Schistosoma mansoni	peptidase	0.0031	0.0109	0.0109
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0383	0.0869
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0109	0.0109
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0031	0.0109	0.0109
Brugia malayi	Common central domain of tyrosinase family protein	0.0106	0.0748	0.0748
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0043	0.0212	0.0212
Brugia malayi	p70 ribosomal S6 kinase beta	0.0069	0.0432	0.0432
Leishmania major	cathepsin L-like protease	0.0063	0.0383	0.0869
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0383	0.0869
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0031	0.0109	0.0109
Onchocerca volvulus		0.0301	0.2422	1
Echinococcus granulosus	myotubularin protein 13	0.0049	0.0259	0.0259
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0031	0.0109	0.0109
Echinococcus granulosus	neuropeptide s receptor	0.0031	0.0109	0.0109
Mycobacterium ulcerans	hypothetical protein	0.0031	0.0109	0.0247
Schistosoma mansoni	jun-related protein	0.0067	0.0415	0.0415
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.0266	0.0605
Brugia malayi	AKH receptor	0.0031	0.0109	0.0109
Brugia malayi	Dopamine receptor protein 2	0.0031	0.0109	0.0109
Loa Loa (eye worm)	PXA domain-containing protein	0.0043	0.0212	0.0212
Toxoplasma gondii	peptidase S15, putative	0.0031	0.0109	0.252
Plasmodium vivax	lysophospholipase, putative	0.0031	0.0109	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0349	0.2841	0.2841
Schistosoma mansoni	neuropeptide F-like receptor	0.0031	0.0109	0.0109
Echinococcus granulosus	neuropeptide receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0031	0.0109	0.0109
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0031	0.0109	0.0247
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0031	0.0109	0.0247
Echinococcus granulosus	tm gpcr rhodopsin	0.0031	0.0109	0.0109
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0043	0.0212	0.0481
Schistosoma mansoni	hypothetical protein	0.0049	0.0259	0.0259
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0109	0.0247
Schistosoma mansoni	amine GPCR	0.0031	0.0109	0.0109
Schistosoma mansoni	vav2	0.0049	0.0259	0.0259
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0109	0.0247
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0031	0.0109	0.0247
Schistosoma mansoni	biogenic amine receptor	0.0031	0.0109	0.0109
Trichomonas vaginalis	AGC family protein kinase	0.0069	0.0432	0.0982
Schistosoma mansoni	regulator of G protein signaling	0.0043	0.0212	0.0212
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0031	0.0109	0.0109
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0043	0.0212	0.0212
Echinococcus granulosus	neuropeptide receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0748	0.0748
Brugia malayi	hypothetical protein	0.0031	0.0109	0.0109
Brugia malayi	hypothetical protein	0.0031	0.0109	0.0109
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0049	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Chlamydia trachomatis	hydrolase	0.0031	0.0109	0.0682
Plasmodium falciparum	exported lipase 2	0.0031	0.0109	0.0247
Brugia malayi	RE15519p	0.0031	0.0109	0.0109
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0031	0.0109	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0259	0.0259
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0069	0.0432	0.0432
Schistosoma mansoni	regulator of G protein signaling	0.0043	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus granulosus	axis inhibition protein axin	0.0043	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0216	0.1699	0.1699
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.005	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0383	0.0869
Plasmodium vivax	PST-A protein	0.0031	0.0109	0.0247
Loa Loa (eye worm)	G-protein coupled receptor	0.0031	0.0109	0.0109
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0045	0.0224	0.0224
Echinococcus granulosus	abhydrolase domain containing 3	0.0031	0.0109	0.0109
Schistosoma mansoni	fatty-acid amide hydrolase	0.1183	1	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0031	0.0109	0.0109
Brugia malayi	G-protein coupled receptor	0.0031	0.0109	0.0109
Schistosoma mansoni	opsin-like receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.005	0.0272	0.0272
Plasmodium vivax	alpha/beta hydrolase, putative	0.0031	0.0109	0.0247
Echinococcus multilocularis	g protein coupled receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus granulosus	serine:threonine protein kinase N2	0.0077	0.0498	0.0498
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0043	0.0212	0.0212
Entamoeba histolytica	protein kinase, putative	0.0069	0.0432	0.0982
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0031	0.0109	0.0247
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0067	0.042	0.0953
Echinococcus granulosus	neuropeptide Y receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	g-protein coupled receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	neuropeptide Y receptor	0.0031	0.0109	0.0109
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0069	0.0432	0.0982
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0082	0.0548	0.0548
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0212	0.0481
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0531	0.4401	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0109	0.0109
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus multilocularis	protein kinase c eta type	0.0049	0.0259	0.0259
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0069	0.0432	0.0432
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0082	0.0547	0.0547
Echinococcus multilocularis	RNA directed DNA polymerase	0.0168	0.1281	0.1281
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0031	0.0109	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0109	0.0247
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0031	0.0109	0.0247
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0383	0.0869
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0383	0.0869
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.005	0.0272	0.0272
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0031	0.0109	0.0247
Echinococcus granulosus	NDR protein kinase	0.0069	0.0432	0.0432
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0023	0.0039	0.09
Echinococcus multilocularis	regulator of G protein signaling	0.0043	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Brugia malayi	hypothetical protein	0.0065	0.0396	0.0396
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0143	0.1066	0.2421
Schistosoma mansoni	neuropeptide receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0049	0.0259	0.0259
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0383	0.0869
Echinococcus granulosus	g protein coupled receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0049	0.0259	0.0259
Echinococcus granulosus	RNA directed DNA polymerase	0.0168	0.1281	0.1281
Trypanosoma cruzi	monoglyceride lipase, putative	0.0531	0.4401	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0031	0.0109	0.0109
Schistosoma mansoni	fatty-acid amide hydrolase	0.0143	0.1066	0.1066
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0069	0.0432	0.0432
Schistosoma mansoni	unc-13 (munc13)	0.0055	0.0316	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0383	0.0869
Loa Loa (eye worm)	tyrosinase 1	0.0106	0.0748	0.0748
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0031	0.0109	0.0109
Schistosoma mansoni	serine/threonine protein kinase	0.02	0.1554	0.1554
Entamoeba histolytica	diacylglycerol kinase, putative	0.0049	0.0259	0.0588
Echinococcus multilocularis	monoacylglycerol lipase abhd12	0.0031	0.0109	0.0109
Brugia malayi	neuropeptide F receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	allatostatin A receptor	0.0031	0.0109	0.0109
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0109	0.0109
Echinococcus multilocularis	axis inhibition protein axin	0.0043	0.0212	0.0212
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0031	0.0109	0.0247
Brugia malayi	Protein kinase domain containing protein	0.0069	0.0432	0.0432
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0031	0.0109	0.0109
Schistosoma mansoni	hypothetical protein	0.0031	0.0109	0.0109
Entamoeba histolytica	hypothetical protein	0.0031	0.0109	0.0247
Echinococcus granulosus	regulator of G protein signaling 3	0.0043	0.0212	0.0212
Schistosoma mansoni	regulator of G protein signaling	0.0043	0.0212	0.0212
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0531	0.4401	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0531	0.4401	1
Entamoeba histolytica	diacylglycerol kinase, putative	0.0049	0.0259	0.0588
Echinococcus multilocularis	axis inhibition protein axin	0.0043	0.0212	0.0212
Schistosoma mansoni	protein kinase C mu	0.0049	0.0259	0.0259
Trypanosoma cruzi	amidase, putative	0.0143	0.1066	0.2421
Schistosoma mansoni	serine/threonine protein kinase	0.0292	0.2349	0.2349
Echinococcus multilocularis	g protein coupled receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0176	0.1351	0.1351
Entamoeba histolytica	hypothetical protein	0.0043	0.0212	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus multilocularis	protein kinase c epsilon type	0.02	0.1554	0.1554
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0069	0.0432	0.0432
Plasmodium vivax	PST-A protein	0.0031	0.0109	0.0247
Brugia malayi	RhoGEF domain containing protein	0.0049	0.0259	0.0259
Trypanosoma cruzi	hydrolase, alpha/beta fold family, putative	0.0031	0.0109	0.0247
Plasmodium falciparum	lysophospholipase, putative	0.0031	0.0109	0.0247
Brugia malayi	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus multilocularis	neuropeptide receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	fmrfamide receptor	0.0031	0.0109	0.0109
Trichomonas vaginalis	AGC family protein kinase	0.0069	0.0432	0.0982
Schistosoma mansoni	regulator of G protein signaling	0.0043	0.0212	0.0212
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0031	0.0109	0.0109
Echinococcus granulosus	expressed protein	0.0842	0.7076	0.7076
Brugia malayi	GnHR receptor homolog	0.0031	0.0109	0.0109
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0109	0.0109
Entamoeba histolytica	hypothetical protein	0.0049	0.0259	0.0588
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0039	0.0088
Onchocerca volvulus		0.0106	0.0748	0.2765
Echinococcus granulosus	serine:threonine protein kinase N2	0.0069	0.0432	0.0432
Brugia malayi	G protein-coupled receptor	0.0031	0.0109	0.0109
Leishmania major	cathepsin L-like protease	0.0063	0.0383	0.0869
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0531	0.4401	1
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0069	0.0432	0.0432
Echinococcus granulosus	biogenic amine 5HT receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0031	0.0109	0.0109
Brugia malayi	sulfakinin receptor protein	0.0031	0.0109	0.0109
Brugia malayi	hypothetical protein	0.0043	0.0212	0.0212
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0031	0.0109	0.0247
Schistosoma mansoni	serine/threonine protein kinase	0.0069	0.0432	0.0432
Schistosoma mansoni	opsin-like receptor	0.0031	0.0109	0.0109
Brugia malayi	PXA domain containing protein	0.0043	0.0212	0.0212
Entamoeba histolytica	hypothetical protein	0.0023	0.0039	0.0088
Echinococcus granulosus	neuropeptides capa receptor	0.0031	0.0109	0.0109
Brugia malayi	putative amidase	0.0143	0.1066	0.1066
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0109	0.0109
Leishmania major	Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X	0.0031	0.0109	0.0247
Echinococcus granulosus	neuropeptides capa receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0031	0.0109	0.0109
Mycobacterium tuberculosis	Possible lysophospholipase	0.0531	0.4401	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0531	0.4401	1
Brugia malayi	hypothetical protein	0.0031	0.0109	0.0109
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0143	0.1066	1
Loa Loa (eye worm)	hypothetical protein	0.1183	1	1
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0109	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Mycobacterium ulcerans	hypothetical protein	0.0531	0.4401	1
Schistosoma mansoni	serine/threonine kinase	0.0069	0.0432	0.0432
Brugia malayi	hypothetical protein	0.0031	0.0109	0.0109
Entamoeba histolytica	hypothetical protein	0.0031	0.0109	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0301	0.2422	0.2422
Toxoplasma gondii	protein c14orf29, putative	0.0031	0.0109	0.252
Plasmodium vivax	lysophospholipase, putative	0.0031	0.0109	0.0247
Trypanosoma brucei	Serine peptidase, Clan SC, Family S09X	0.0031	0.0109	0.0247
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0031	0.0109	0.0109
Schistosoma mansoni	z-protein (S1r protein)	0.0043	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Plasmodium vivax	unspecified product	0.0031	0.0109	0.0247
Echinococcus multilocularis	regulator of G protein signaling 7	0.0043	0.0212	0.0212
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0031	0.0109	0.0109
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0031	0.0109	0.252
Toxoplasma gondii	esterase/lipase/thioesterase domain-containing protein	0.0031	0.0109	0.252
Onchocerca volvulus		0.0106	0.0748	0.2765
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0023	0.0039	0.0365
Toxoplasma gondii	AGC kinase	0.0069	0.0432	1
Loa Loa (eye worm)	TYRA-2 protein	0.0031	0.0109	0.0109
Echinococcus granulosus	orexin receptor type 2	0.0031	0.0109	0.0109
Plasmodium falciparum	lysophospholipase, putative	0.0531	0.4401	1
Echinococcus granulosus	allatostatin A receptor	0.0031	0.0109	0.0109
Schistosoma mansoni	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0109	0.0109
Trypanosoma cruzi	Serine peptidase, Clan SC, Family S09X, putative	0.0031	0.0109	0.0247
Schistosoma mansoni	opsin-like receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	expressed protein	0.0842	0.7076	0.7076
Brugia malayi	Serotonin receptor	0.0031	0.0109	0.0109
Plasmodium falciparum	esterase, putative	0.0531	0.4401	1
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0045	0.0224	0.0224
Plasmodium vivax	lysophospholipase, putative	0.0031	0.0109	0.0247
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0069	0.0432	0.0432
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0143	0.1066	0.1066
Schistosoma mansoni	adenoreceptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0023	0.0039	0.0365
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0109	0.0109
Mycobacterium ulcerans	amidase	0.0143	0.1066	0.2421
Echinococcus multilocularis	neuropeptides capa receptor	0.0031	0.0109	0.0109
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0031	0.0109	0.0109
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.02	0.1554	0.1554
Echinococcus multilocularis	serotonin receptor	0.0031	0.0109	0.0109
Schistosoma mansoni	amine GPCR	0.0031	0.0109	0.0109
Brugia malayi	hypothetical protein	0.0031	0.0109	0.0109
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0031	0.0109	0.0247
Echinococcus multilocularis	g protein coupled receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	amidase	0.0143	0.1066	0.1066
Schistosoma mansoni	neuropeptide f receptor 76f	0.0031	0.0109	0.0109
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0109	0.0109
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0049	0.0259	0.0259
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0031	0.0109	0.0247
Plasmodium falciparum	lysophospholipase, putative	0.0531	0.4401	1
Echinococcus multilocularis	serine threonine protein kinase	0.0243	0.1931	0.1931
Loa Loa (eye worm)	raf kinase	0.0049	0.0259	0.0259
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0055	0.0316	0.0316
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0058	0.0335	0.0762
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0109	0.0247
Schistosoma mansoni	amidase	0.1183	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0109	0.0109
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus multilocularis	unc 13 (munc13)	0.0055	0.0316	0.0316
Entamoeba histolytica	protein kinase, putative	0.0069	0.0432	0.0982
Brugia malayi	G protein-coupled receptor F59B2.13	0.0031	0.0109	0.0109
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0082	0.0548	0.0548
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0316	0.0316
Echinococcus granulosus	7TM GPCR rhodopsin	0.0031	0.0109	0.0109
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0143	0.1066	0.2421
Echinococcus granulosus	g protein coupled receptor	0.0031	0.0109	0.0109
Loa Loa (eye worm)	RGS-3 protein	0.0043	0.0212	0.0212
Brugia malayi	Serotonin receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0055	0.0316	0.0316
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0043	0.0212	0.0212
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0031	0.0109	0.0109
Schistosoma mansoni	diacylglycerol kinase theta	0.0049	0.0259	0.0259
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0031	0.0109	0.0109
Schistosoma mansoni	diacylglycerol kinase theta	0.0049	0.0259	0.0259
Echinococcus multilocularis	regulator of G protein signaling 3	0.0043	0.0212	0.0212
Onchocerca volvulus		0.0049	0.0259	0.0648
Plasmodium vivax	PST-A protein	0.0031	0.0109	0.0247
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0144	0.1078	0.1078
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0383	0.0869
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0109	0.0247
Brugia malayi	hypothetical protein	0.0043	0.0212	0.0212
Schistosoma mansoni	amine GPCR	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0567	0.4708	0.4708
Loa Loa (eye worm)	amidase	0.0143	0.1066	0.1066
Schistosoma mansoni	histamine h1 receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0168	0.1281	0.1281
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0039	0.0088
Echinococcus granulosus	somatostatin receptor	0.0031	0.0109	0.0109
Plasmodium falciparum	BEM46-like protein, putative	0.0031	0.0109	0.0247
Brugia malayi	MGC83647 protein	0.0031	0.0109	0.0109
Echinococcus granulosus	neuropeptide receptor A26	0.0031	0.0109	0.0109
Schistosoma mansoni	myosin xvIII	0.0031	0.0109	0.0109
Brugia malayi	bZIP transcription factor family protein	0.0082	0.0548	0.0548
Echinococcus granulosus	G protein coupled receptor 139	0.0031	0.0109	0.0109
Mycobacterium ulcerans	amidase	0.0143	0.1066	0.2421
Loa Loa (eye worm)	hypothetical protein	0.0301	0.2422	0.2422
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0031	0.0109	0.0247
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0383	0.0869
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0109	0.0247
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0045	0.0224	0.0224
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0531	0.4401	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0031	0.0109	0.0109
Echinococcus granulosus	Phospholipase carboxylesterase	0.0031	0.0109	0.0109
Brugia malayi	A-kinase anchor protein 10, precursor	0.0043	0.0212	0.0212
Schistosoma mansoni	growth hormone secretagogue receptor	0.0031	0.0109	0.0109
Echinococcus multilocularis	protein kinase c iota type	0.0118	0.0851	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Echinococcus granulosus	Regulator of G protein signaling 20	0.0043	0.0212	0.0212
Echinococcus multilocularis	sex peptide receptor	0.0031	0.0109	0.0109
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0023	0.0039	0.0088
Echinococcus granulosus	abhydrolase domain containing protein 13	0.0031	0.0109	0.0109
Toxoplasma gondii	phospholipase	0.0031	0.0109	0.252
Plasmodium falciparum	alpha/beta-hydrolase, putative	0.0031	0.0109	0.0247
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0106	0.0748	0.0748
Leishmania major	hypothetical protein, conserved	0.0143	0.1066	0.2421
Echinococcus granulosus	neuropeptide FF receptor 2	0.0031	0.0109	0.0109
Brugia malayi	Dopamine receptor	0.0031	0.0109	0.0109
Echinococcus granulosus	regulator of G protein signaling 7	0.0043	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0109
Chlamydia trachomatis	acyltransferase family protein	0.0031	0.0109	0.0682
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0031	0.0109	0.0247
Brugia malayi	protein kinase C3,putative	0.005	0.0272	0.0272
Brugia malayi	Protein C20orf22	0.0031	0.0109	0.0109
Echinococcus granulosus	unc 13 munc13	0.0055	0.0316	0.0316
Leishmania major	monoglyceride lipase, putative	0.0531	0.4401	1
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0531	0.4401	1
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0143	0.1066	0.1066
Echinococcus granulosus	g protein coupled receptor	0.0031	0.0109	0.0109
Echinococcus granulosus	axis inhibition protein axin	0.0043	0.0212	0.0212
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0531	0.4401	1
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0045	0.0224	0.0224
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.005	0.0272	0.0272
Echinococcus multilocularis	serotonin receptor	0.0031	0.0109	0.0109
Trypanosoma brucei	monoglyceride lipase, putative	0.0531	0.4401	1
Schistosoma mansoni	amine GPCR	0.0031	0.0109	0.0109
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0272	0.0272
Schistosoma mansoni	hypothetical protein	0.0031	0.0109	0.0109
Toxoplasma gondii	hypothetical protein	0.0031	0.0109	0.252
Brugia malayi	putative neuropeptide receptor NPR1	0.0031	0.0109	0.0109
Schistosoma mansoni	neuropeptide receptor	0.0031	0.0109	0.0109
Mycobacterium ulcerans	peptide amidase, GatA	0.0143	0.1066	0.2421
Brugia malayi	Melatonin receptor type 1A	0.0031	0.0109	0.0109
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0272	0.0272
Toxoplasma gondii	diacylglycerol kinase, putative	0.0049	0.0259	0.5987
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0049	0.0259	0.0259
Brugia malayi	Hr1 repeat family protein	0.0069	0.0432	0.0432
Brugia malayi	regulator of G-protein signaling rgs-7	0.0043	0.0212	0.0212
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0031	0.0109	0.0109

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 0 %	Agonist activity at TPO (unknown origin) receptor at 10 uM	ChEMBL.	18396041
Activity (functional)	= 0 %	Agonist activity at TPO (unknown origin) receptor at 10 uM	ChEMBL.	18396041
EC50 (functional)	> 10 uM	Agonist activity at TPO (unknown origin) receptor	ChEMBL.	18396041
EC50 (functional)	> 10 uM	Agonist activity at TPO (unknown origin) receptor	ChEMBL.	18396041

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL412807
PubChem: 777985

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 510985