Detailed information for compound 510997

Basic information

Technical information
  • TDR Targets ID: 510997
  • Name: 1-(4-bromophenyl)-3-hydroxyurea
  • MW: 231.047 | Formula: C7H7BrN2O2
  • H donors: 3 H acceptors: 2 LogP: 1.13 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)Nc1ccc(cc1)Br
  • InChi: 1S/C7H7BrN2O2/c8-5-1-3-6(4-2-5)9-7(11)10-12/h1-4,12H,(H2,9,10,11)
  • InChiKey: QFELVVGTIKGYJL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-bromophenyl)-3-hydroxy-urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Agaricus bisporus Tyrosinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.3451 0.322
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.4179 0.8006
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0812 0.0483
Plasmodium falciparum metacaspase-like protein 0.0026 0.0837 0.0655
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.3451 0.322
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.165 0.1355
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0452 0.0146
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.2605 0.2344
Trypanosoma cruzi phosphoglycerate kinase, putative 0.017 0.7906 0.7832
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.1595 0.2017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0837 0.0516
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0111 0.5012 0.6117
Entamoeba histolytica phosphoglycerate kinase, putative 0.017 0.7906 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0053 0.2142 0.2381
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0837 0.0159
Schistosoma mansoni DNA helicase recq1 0.0019 0.0452 0.0146
Toxoplasma gondii phosphoglycerate kinase PGKII 0.017 0.7906 1
Schistosoma mansoni DNA polymerase eta 0.0078 0.3396 0.4038
Schistosoma mansoni tyrosinase precursor 0.0111 0.5012 0.6174
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1782 0.1784
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.4179 0.5
Echinococcus multilocularis phosphoglycerate kinase 1 0.017 0.7906 1
Brugia malayi Cell death protein 3 precursor 0.0026 0.0837 0.0516
Mycobacterium ulcerans DNA polymerase IV 0.0079 0.3451 0.4111
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.1832 0.1544
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0837 0.0655
Loa Loa (eye worm) hypothetical protein 0.0138 0.6315 0.7865
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.2605 0.2344
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4179 0.4812
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.017 0.7906 0.5
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0736 0.0382
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1656 0.1362
Trypanosoma brucei metacaspase MCA3 0.0026 0.0837 0.0513
Chlamydia trachomatis phosphoglycerate kinase 0.017 0.7906 0.5
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0736 0.0382
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.3451 0.322
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0026 0.0837 0.0516
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.2467 0.2201
Trichomonas vaginalis DNA helicase recq1, putative 0.0045 0.1762 0.1447
Loa Loa (eye worm) hypothetical protein 0.0111 0.5012 0.6117
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.2467 0.2201
Brugia malayi polk-prov protein 0.0043 0.165 0.1607
Echinococcus multilocularis dna polymerase eta 0.0078 0.3396 0.395
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0736 0.0409
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0812 0.0623
Trypanosoma cruzi DNA polymerase eta, putative 0.0078 0.3396 0.3163
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0837 0.0159
Loa Loa (eye worm) ShTK domain-containing protein 0.0111 0.5012 0.6117
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.1832 0.1544
Loa Loa (eye worm) ShTK domain-containing protein 0.0111 0.5012 0.6117
Echinococcus granulosus caspase 0.0026 0.0837 0.0516
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0026 0.0837 0.0516
Trypanosoma brucei polo-like protein kinase 0.0094 0.4179 0.3974
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.1021 0.1292
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.3451 0.322
Loa Loa (eye worm) hypothetical protein 0.017 0.7906 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1782 0.1904
Trypanosoma brucei phosphoglycerate kinase 0.0062 0.2605 0.2344
Trypanosoma brucei DNA polymerase eta, putative 0.0078 0.3396 0.3163
Echinococcus granulosus bloom syndrome protein 0.0045 0.1762 0.1758
Loa Loa (eye worm) hypothetical protein 0.0111 0.5012 0.6117
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4179 0.4812
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0736 0.0409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1782 0.1904
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.3451 0.322
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4179 0.4812
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.2605 0.2344
Echinococcus multilocularis caspase 8 0.0026 0.0837 0.0516
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.4179 0.5
Plasmodium falciparum phosphoglycerate kinase 0.017 0.7906 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0837 0.1058
Brugia malayi Phosphoglycerate kinase 0.0062 0.2605 0.2889
Loa Loa (eye worm) hypothetical protein 0.0043 0.165 0.1607
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0837 0.0159
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0723 0.0395
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.1595 0.1298
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.4179 0.3974
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0053 0.2142 0.2268
Treponema pallidum phosphoglycerate kinase 0.017 0.7906 1
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0812 0.0483
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0736 0.0522
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0837 0.0159
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.1039 0.0923
Trypanosoma cruzi metacaspase, putative 0.0026 0.0837 0.0513
Toxoplasma gondii phosphoglycerate kinase PGKI 0.017 0.7906 1
Leishmania major metacaspase, putative 0.0026 0.0837 0.0513
Trypanosoma brucei metacaspase MCA2 0.0026 0.0837 0.0513
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.3451 0.322
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.3451 0.322
Trypanosoma brucei phosphoglycerate kinase 0.017 0.7906 0.7832
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1782 0.1784
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.017 0.7906 0.5
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0111 0.5012 0.6117
Plasmodium falciparum flap endonuclease 1 0.0026 0.0812 0.0623
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0079 0.3451 0.3798
Trypanosoma brucei Metacaspase-4 0.0026 0.0837 0.0513
Mycobacterium ulcerans DNA polymerase IV 0.0079 0.3451 0.4111
Brugia malayi Common central domain of tyrosinase family protein 0.0111 0.5012 0.6117
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.4179 0.5
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0723 0.0395
Giardia lamblia Kinase, PLK 0.0094 0.4179 0.5073
Leishmania major DNA polymerase eta, putative 0.0042 0.1595 0.1298
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0812 0.0623
Trypanosoma brucei unspecified product 0.0037 0.1332 0.1026
Schistosoma mansoni phosphoglycerate kinase 0.017 0.7906 1
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0111 0.5012 0.6117
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0837 0.0655
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0062 0.2605 0.2344
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1782 0.1784
Onchocerca volvulus 0.0111 0.5012 1
Echinococcus granulosus caspase 8 0.0026 0.0837 0.0516
Trichomonas vaginalis DNA polymerase eta, putative 0.0079 0.3451 0.3798
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0837 0.0159
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4179 0.4812
Echinococcus granulosus caspase 2 0.0026 0.0837 0.0516
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0837 0.0159
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0837 0.0159
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.1491 0.152
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0736 0.0522
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4179 0.4812
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0837 0.0513
Trypanosoma cruzi metacaspase, putative 0.0026 0.0837 0.0513
Mycobacterium ulcerans phosphoglycerate kinase 0.017 0.7906 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.017 0.7906 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0812 0.0488
Loa Loa (eye worm) tyrosinase 1 0.0111 0.5012 0.6117
Trypanosoma brucei unspecified product 0.0037 0.1332 0.1026
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0837 0.0159
Schistosoma mansoni phosphoglycerate kinase 0.017 0.7906 1
Giardia lamblia DINP protein human, muc B family 0.006 0.2467 0.281
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0837 0.0159
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1656 0.1362
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.3451 0.322
Echinococcus multilocularis caspase 2 0.0026 0.0837 0.0516
Brugia malayi Phosphoglycerate kinase 0.017 0.7906 1
Trypanosoma brucei phosphoglycerate kinase, putative 0.0062 0.2605 0.2344
Echinococcus granulosus dna polymerase eta 0.0078 0.3396 0.395
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0812 0.0124
Trypanosoma brucei hypothetical protein, conserved 0.0212 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4179 0.4812
Plasmodium falciparum metacaspase 1 0.0026 0.0837 0.0655
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.2605 0.2344
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0837 0.1058
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0452 0.0571
Loa Loa (eye worm) RecQ helicase 0.0045 0.1762 0.1758
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0812 0.1027
Trypanosoma cruzi phosphoglycerate kinase, putative 0.017 0.7906 0.7832
Mycobacterium ulcerans hypothetical protein 0.0024 0.0736 0.0522
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.165 0.1355
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0837 0.0159
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.2605 0.2344
Trypanosoma cruzi hypothetical protein, conserved 0.0212 1 1
Trypanosoma cruzi metacaspase, putative 0.0026 0.0837 0.0513
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.3126 0.2884
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0452 0.0571
Schistosoma mansoni terminal deoxycytidyl transferase 0.0053 0.2142 0.2381
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.4179 0.5073
Trypanosoma cruzi hypothetical protein, conserved 0.0212 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.2142 0.2268
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0837 0.0159
Loa Loa (eye worm) hypothetical protein 0.0078 0.3396 0.395
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0736 0.0522
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1782 0.1904
Brugia malayi Bloom's syndrome protein homolog 0.0045 0.1762 0.1758
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1782 0.1784
Mycobacterium ulcerans hypothetical protein 0.0024 0.0736 0.0522
Plasmodium vivax metacaspase 1, putative 0.0026 0.0837 0.0655
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.3451 0.322
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0837 0.0513
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.4179 0.3974
Onchocerca volvulus 0.0111 0.5012 1
Leishmania major DNA polymerase eta, putative 0.0078 0.3396 0.3163
Leishmania major phosphoglycerate kinase B, cytosolic 0.017 0.7906 0.7832
Giardia lamblia Phosphoglycerate kinase 0.017 0.7906 1
Leishmania major DNA polymerase kappa, putative 0.006 0.2467 0.2201
Trichomonas vaginalis phosphoglycerate kinase, putative 0.017 0.7906 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0812 0.0488
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1782 0.1784
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0837 0.0159
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1656 0.1362
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.4179 0.3974
Echinococcus granulosus flap endonuclease 1 0.0026 0.0812 0.0483
Trypanosoma brucei metacaspase 0.0026 0.0837 0.0513
Schistosoma mansoni flap endonuclease-1 0.0023 0.0689 0.046
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0053 0.2142 0.2268
Echinococcus multilocularis caspase 0.0026 0.0837 0.0516
Plasmodium vivax phosphoglycerate kinase, putative 0.017 0.7906 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0452 0.0146
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0053 0.2142 0.2268
Onchocerca volvulus 0.0111 0.5012 1
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0723 0.0914
Schistosoma mansoni kinase 0.0048 0.1893 0.2051
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.4179 0.5
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0723 0.0395
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.3451 0.322
Echinococcus granulosus phosphoglycerate kinase 1 0.017 0.7906 1
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0736 0.0019
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0837 0.0655
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.3451 0.322
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.1762 0.1447
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.4179 0.5286
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0016 0.0341 0.0431
Brugia malayi ShTK domain containing protein 0.0111 0.5012 0.6117
Trypanosoma brucei metacaspase 5, putative 0.0026 0.0837 0.0513
Brugia malayi Flap endonuclease-1 0.0026 0.0812 0.0483
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.0666 0.0842
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0812 0.1027
Schistosoma mansoni caspase-3 (C14 family) 0.0026 0.0837 0.0655
Schistosoma mansoni tyrosinase precursor 0.0111 0.5012 0.6174
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0026 0.0837 0.0516
Trypanosoma brucei unspecified product 0.0073 0.3126 0.2884
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0837 0.0159
Schistosoma mansoni DNA helicase recq5 0.0019 0.0452 0.0146
Echinococcus multilocularis bloom syndrome protein 0.0045 0.1762 0.1758
Schistosoma mansoni blooms syndrome DNA helicase 0.0036 0.1292 0.1258
Trypanosoma brucei phosphoglycerate kinase 0.017 0.7906 0.7832
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0026 0.0837 0.0655
Loa Loa (eye worm) hypothetical protein 0.0026 0.0837 0.0516
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4179 0.4812
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.3451 0.322
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.3451 0.322
Entamoeba histolytica deoxycytidyl transferase, putative 0.0053 0.2142 0.271
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.2467 0.2414
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.3451 0.322
Trypanosoma cruzi metacaspase, putative 0.0026 0.0837 0.0513
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0812 0.0488
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1782 0.1784
Onchocerca volvulus 0.0111 0.5012 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.3451 0.322
Mycobacterium tuberculosis Conserved hypothetical protein 0.0053 0.2142 0.1961
Echinococcus multilocularis dna polymerase kappa 0.0079 0.3451 0.4023
Brugia malayi ImpB/MucB/SamB family protein 0.0078 0.3396 0.395
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0111 0.5012 0.6117
Trichomonas vaginalis phosphoglycerate kinase, putative 0.017 0.7906 1
Echinococcus granulosus dna polymerase kappa 0.0079 0.3451 0.4023
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0837 0.1058
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0837 0.0159
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0736 0.0409
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0837 0.0159
Leishmania major phosphoglycerate kinase C, glycosomal 0.017 0.7906 0.7832

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Cytotoxicity against mouse B16 cells at 100 uM ChEMBL. 18501598
IC50 (binding) = 2.7 uM Inhibition of mushroom tyrosinase ChEMBL. 18501598
IC50 (binding) = 2.7 uM Inhibition of mushroom tyrosinase ChEMBL. 18501598
Inhibition (functional) = 75.5 % Inhibition of melanin production in mouse B16 cells at 100 uM ChEMBL. 18501598
Inhibition (functional) = 75.5 % Inhibition of melanin production in mouse B16 cells at 100 uM ChEMBL. 18501598

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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