Detailed information for compound 511024

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 287.355 | Formula: C15H14FN3S
  • H donors: 2 H acceptors: 0 LogP: 3.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=S)N/N=C(\c1cccc(c1)F)/c1ccc(cc1)C
  • InChi: 1S/C15H14FN3S/c1-10-5-7-11(8-6-10)14(18-19-15(17)20)12-3-2-4-13(16)9-12/h2-9H,1H3,(H3,17,19,20)/b18-14-
  • InChiKey: PWOGTTWZSMQARN-JXAWBTAJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum cysteine proteinase falcipain 1 0.00188629 0.000608178 0.0284483
Brugia malayi SWIRM domain containing protein 0.0473441 0.0489485 0.0488547
Onchocerca volvulus 0.00874116 0.00789772 0.159984
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0139739 0.0134623 0.0356255
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0154752 0.0150588 0.0238866
Echinococcus granulosus serine protease inhibitor 0.00258354 0.00134964 0.00182432
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.00433311 0.00321015 0.173701
Echinococcus granulosus caspase 2 0.00177662 0.000491557 0.000664438
Onchocerca volvulus Fatty acid synthase homolog 0.00702745 0.00607534 0.122693
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.00384215 0.00268806 0.00413457
Plasmodium vivax subtilisin-like serine protease, putative 0.0182523 0.018012 1
Loa Loa (eye worm) integrin alpha pat-2 0.279454 0.295777 0.295707
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.019002 0.0188092 0.227496
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0786843 0.082276 1
Loa Loa (eye worm) angiogenesis inhibito 0.00384215 0.00268806 0.00258974
Schistosoma mansoni protein kinase 0.0144343 0.0139519 0.0221192
Echinococcus granulosus glutamate receptor 2 0.00207718 0.000811167 0.00109646
Onchocerca volvulus 0.00142615 0.000118862 0.000806262
Loa Loa (eye worm) fatty acid synthase 0.00400386 0.00286002 0.00276172
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0154752 0.0150588 0.0202244
Onchocerca volvulus 0.00374463 0.00258435 0.0512572
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.00341712 0.00223607 0.119324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Loa Loa (eye worm) apoptosis regulator protein 0.0059722 0.00495318 0.00485508
Entamoeba histolytica cysteine protease, putative 0.00188629 0.000608178 0.000891347
Trypanosoma cruzi cysteine proteinase, putative 0.00188629 0.000608178 0.00595585
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Plasmodium vivax subtilisin-like protease 1 0.0182523 0.018012 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.00177662 0.000491557 0.0138251
Echinococcus multilocularis cathepsin L cysteine protease 0.00319348 0.00199826 0.00256815
Mycobacterium ulcerans dehydrogenase 0.0069418 0.00598426 0.298875
Echinococcus granulosus lysine specific histone demethylase 1A 0.0069418 0.00598426 0.00808893
Trichomonas vaginalis conserved hypothetical protein 0.00409881 0.00296099 0.00763075
Plasmodium vivax metacaspase 1, putative 0.00177662 0.000491557 0.0219381
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.354156 0.375215 0.507113
Brugia malayi Glutamate receptor 2 precursor 0.0032974 0.00210877 0.00201039
Schistosoma mansoni hypothetical protein 0.0059722 0.00495318 0.00775123
Toxoplasma gondii subtilisin SUB5 0.0182523 0.018012 0.630188
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Onchocerca volvulus 0.00258354 0.00134964 0.0259916
Echinococcus multilocularis protein kinase c epsilon type 0.00892194 0.00808997 0.0108034
Schistosoma mansoni atypical protein kinase C 0.00161665 0.000321438 0.000355844
Plasmodium vivax vivapain-2 0.00319348 0.00199826 0.106048
Echinococcus multilocularis serine protease inhibitor 0.00258354 0.00134964 0.0016913
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0069418 0.00598426 0.00939753
Echinococcus granulosus plasminogen activator inhibitor 2 0.00258354 0.00134964 0.00182432
Toxoplasma gondii histone lysine-specific demethylase 0.0069418 0.00598426 0.207057
Echinococcus multilocularis cathepsin l cysteine peptidase 0.00319348 0.00199826 0.00256815
Plasmodium vivax subtilisin-like protease 2, putative 0.0182523 0.018012 1
Echinococcus multilocularis integrin alpha ps 0.0444598 0.0458813 0.0618928
Loa Loa (eye worm) hypothetical protein 0.00428669 0.00316079 0.00306252
Schistosoma mansoni glutamate receptor AMPA 0.0032974 0.00210877 0.00320963
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0182523 0.018012 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.00181778 0.000535318 0.024381
Schistosoma mansoni septate junction protein 0.00181956 0.000537215 0.000700371
Schistosoma mansoni serine protease inhibitors serpins 0.00258354 0.00134964 0.00199756
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0139739 0.0134623 0.746018
Loa Loa (eye worm) serpin 0.00258354 0.00134964 0.0012512
Brugia malayi Cathepsin L-like precursor 0.00230221 0.00105048 0.000951997
Echinococcus granulosus c-Jun N-terminal kinases 0.0245958 0.0247577 0.033465
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.00338131 0.00219799 0.0781636
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0154752 0.0150588 0.020355
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0182523 0.018012 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Echinococcus granulosus cathepsin L 0.00188629 0.000608178 0.000822074
Entamoeba histolytica hypothetical protein, conserved 0.0139739 0.0134623 0.158146
Toxoplasma gondii hypothetical protein 0.0281376 0.0285241 1
Echinococcus multilocularis glutamate receptor 2 0.0032974 0.00210877 0.00271754
Loa Loa (eye worm) hypothetical protein 0.0401538 0.0413023 0.0412078
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.00627088 0.00527079 0.288735
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.00311688 0.0019168 0.00259093
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00188629 0.000608178 0.000813674
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.00199826 0.0184228
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Trichomonas vaginalis conserved hypothetical protein 0.0182523 0.018012 0.0477542
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Trichomonas vaginalis conserved hypothetical protein 0.116486 0.122474 0.326234
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0281376 0.0285241 0.0757778
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.00199826 0.0184228
Brugia malayi EGF-like domain containing protein 0.0281376 0.0285241 0.0284283
Brugia malayi hypothetical protein 0.0069418 0.00598426 0.00588627
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Echinococcus multilocularis cathepsin b 0.0130955 0.0125282 0.0168034
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0245958 0.0247577 0.0333362
Echinococcus granulosus glutamate receptor 2 0.0032974 0.00210877 0.00285042
Echinococcus multilocularis cysteine protease 0.00319348 0.00199826 0.00256815
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0605638 0.0630065 0.0851659
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.00260709 0.00137468 0.0712376
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.00866835 0.00782029 0.0205848
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0019175 0.000641363 0.0190952
Trypanosoma cruzi metacaspase, putative 0.00177662 0.000491557 0.00453637
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.134738 0.141884 0.377977
Trichomonas vaginalis conserved hypothetical protein 0.00177662 0.000491557 0.00104763
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0139739 0.0134623 0.0180661
Loa Loa (eye worm) hypothetical protein 0.00258354 0.00134964 0.0012512
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.00411942 0.00298291 0.00288462
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0107887 0.0100751 0.350972
Trypanosoma brucei oligopeptidase b 0.00273318 0.00150877 0.0124377
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.00273318 0.00150877 0.0169176
Echinococcus granulosus discoidin domain containing receptor 2 0.00140707 0.0000985722 0.00013324
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0334198 0.0341413 0.0460217
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0139739 0.0134623 0.0356255
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.00140707 0.0000985722 0.00013324
Loa Loa (eye worm) hypothetical protein 0.00177662 0.000491557 0.000393024
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.00181778 0.000535318 0.000436789
Loa Loa (eye worm) glutamate receptor 1 0.0032974 0.00210877 0.00201039
Echinococcus granulosus cathepsin l1 0.00319348 0.00199826 0.00270105
Brugia malayi Guanylate kinase family protein 0.00342603 0.00224555 0.00214719
Trypanosoma cruzi prolyl endopeptidase 0.00818388 0.0073051 0.0874694
Schistosoma mansoni caspase-7 (C14 family) 0.00177662 0.000491557 0.000627469
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.116486 0.122474 0.326234
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0182523 0.018012 1
Echinococcus granulosus integrin beta 2 0.697008 0.739808 1
Loa Loa (eye worm) hypothetical protein 0.143431 0.151128 0.151045
Schistosoma mansoni hypothetical protein 0.00311688 0.0019168 0.00290311
Entamoeba histolytica cysteine protease, putative 0.00188629 0.000608178 0.000891347
Toxoplasma gondii histone deacetylase SIR2-like 0.0139739 0.0134623 0.470131
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0126165 0.0120188 0.0119214
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0162054 0.0158353 0.0157383
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.134738 0.141884 0.377977
Loa Loa (eye worm) transcriptional regulator 0.0139739 0.0134623 0.013365
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.116486 0.122474 0.326234
Giardia lamblia Transcriptional regulator, Sir2 family 0.0139739 0.0134623 0.0525304
Loa Loa (eye worm) hypothetical protein 0.0537416 0.0557516 0.0556585
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Schistosoma mansoni hypothetical protein 0.00142615 0.000118862 0.0000323964
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0059722 0.00495318 0.00775123
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0107887 0.0100751 0.556932
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.00181778 0.000535318 0.000590429
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Brugia malayi prolyl oligopeptidase family protein 0.00818388 0.0073051 0.00720723
Leishmania major cathepsin L-like protease 0.00319348 0.00199826 0.0228756
Brugia malayi AMP-binding enzyme family protein 0.00374463 0.00258435 0.00248602
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.00177662 0.000491557 0.00104763
Entamoeba histolytica hypothetical protein 0.00409881 0.00296099 0.0296752
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0032974 0.00210877 0.00285042
Onchocerca volvulus 0.00319348 0.00199826 0.039264
Echinococcus multilocularis cysteine protease 0.00319348 0.00199826 0.00256815
Loa Loa (eye worm) hypothetical protein 0.00576322 0.00473095 0.00463283
Loa Loa (eye worm) hypothetical protein 0.0473441 0.0489485 0.0488547
Schistosoma mansoni apoptosis regulator bax 0.0059722 0.00495318 0.00775123
Toxoplasma gondii SWIRM domain-containing protein 0.00409881 0.00296099 0.100699
Loa Loa (eye worm) hypothetical protein 0.00409881 0.00296099 0.0028627
Loa Loa (eye worm) WD40 repeat protein 0.00874116 0.00789772 0.00779991
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.00181778 0.000535318 0.00072359
Schistosoma mansoni SWI/SNF complex-related 0.00409881 0.00296099 0.00457036
Echinococcus granulosus Estrogen regulated protein EP45 0.00258354 0.00134964 0.00182432
Schistosoma mansoni hypothetical protein 0.0444598 0.0458813 0.0731001
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0182523 0.018012 1
Schistosoma mansoni amine oxidase 0.0069418 0.00598426 0.00939753
Entamoeba histolytica SWIRM domain protein 0.00409881 0.00296099 0.0296752
Trypanosoma brucei cysteine peptidase C (CPC) 0.00597015 0.004951 0.0545267
Brugia malayi Will die slowly protein 0.00874116 0.00789772 0.00779991
Brugia malayi celfurPC protein 0.473877 0.502528 0.502479
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.00177662 0.000491557 0.000664438
Echinococcus granulosus integrin alpha ps 0.102034 0.107106 0.144776
Echinococcus granulosus cathepsin L cysteine protease 0.00188629 0.000608178 0.000822074
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0032974 0.00210877 0.00271754
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Brugia malayi Papain family cysteine protease containing protein 0.00188629 0.000608178 0.000509656
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Schistosoma mansoni glutamate receptor kainate 0.0032974 0.00210877 0.00320963
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.00312876 0.00192944 0.102206
Echinococcus multilocularis GPCR, family 2 0.00311688 0.0019168 0.00245802
Brugia malayi serpin 0.00258354 0.00134964 0.0012512
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0139739 0.0134623 0.0356255
Echinococcus multilocularis cathepsin L cysteine protease 0.00319348 0.00199826 0.00256815
Schistosoma mansoni hypothetical protein 0.0059722 0.00495318 0.00775123
Echinococcus multilocularis cathepsin L 0.00188629 0.000608178 0.000688926
Onchocerca volvulus Cathepsin L homolog 0.00319348 0.00199826 0.039264
Echinococcus multilocularis adam 0.0478995 0.0495391 0.0668377
Echinococcus multilocularis growth factor receptor bound protein 2 0.0162054 0.0158353 0.0212742
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.00158999 0.000293086 0.0108586
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.00199826 0.0184228
Onchocerca volvulus Cathepsin F homolog 0.00319348 0.00199826 0.039264
Loa Loa (eye worm) hypothetical protein 0.00928178 0.00847262 0.00837487
Toxoplasma gondii prolyl endopeptidase 0.00818388 0.0073051 0.253523
Echinococcus granulosus serine protease inhibitor 0.00258354 0.00134964 0.00182432
Echinococcus granulosus furin 0.590363 0.6264 0.846706
Loa Loa (eye worm) hypothetical protein 0.00258354 0.00134964 0.0012512
Toxoplasma gondii kringle domain-containing protein 0.00142615 0.000118862 0.000713793
Brugia malayi serpin precursor 0.00258354 0.00134964 0.0012512
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.00311688 0.0019168 0.00245802
Toxoplasma gondii subtilisin SUB9 0.0182523 0.018012 0.630188
Trypanosoma brucei subtilisin peptidase 0.0182523 0.018012 0.214227
Brugia malayi transcriptional regulator, Sir2 family protein 0.0786843 0.082276 0.0821855
Schistosoma mansoni glutamate receptor NMDA 0.0032974 0.00210877 0.00320963
Loa Loa (eye worm) sirtuin 4 0.0139739 0.0134623 0.013365
Echinococcus granulosus caspase 8 0.00177662 0.000491557 0.000664438
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.00335146 0.00216625 0.00330141
Schistosoma mansoni serine protease inhibitors serpins 0.00258354 0.00134964 0.00199756
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.00199826 0.0184228
Schistosoma mansoni serine protease inhibitors serpins 0.00258354 0.00134964 0.00199756
Trichomonas vaginalis hypothetical protein 0.116486 0.122474 0.326234
Trypanosoma cruzi metacaspase 5, putative 0.00177662 0.000491557 0.00453637
Brugia malayi hypothetical protein 0.00258354 0.00134964 0.0012512
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Schistosoma mansoni dihydroceramide desaturase 0.00576322 0.00473095 0.0073964
Echinococcus multilocularis Estrogen regulated protein EP45 0.00258354 0.00134964 0.0016913
Giardia lamblia Tenascin-37 0.0281376 0.0285241 0.117851
Brugia malayi cathepsin L-like precursor 0.00230221 0.00105048 0.000951997
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0432453 0.0445898 0.0601469
Schistosoma mansoni hypothetical protein 0.00311688 0.0019168 0.00290311
Schistosoma mansoni serine/threonine protein kinase 0.0245958 0.0247577 0.0393726
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0107887 0.0100751 0.0134871
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.00177662 0.000491557 0.00104763
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.00338131 0.00219799 0.0781636
Echinococcus granulosus discoidin domain containing receptor 2 0.00140707 0.0000985722 0.00013324
Trichomonas vaginalis conserved hypothetical protein 0.116486 0.122474 0.326234
Trichomonas vaginalis conserved hypothetical protein 0.116486 0.122474 0.326234
Loa Loa (eye worm) serpin 0.00258354 0.00134964 0.0012512
Toxoplasma gondii subtilisin SUB10 0.0182523 0.018012 0.630188
Plasmodium vivax vivapain-3 0.00188629 0.000608178 0.0284483
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0069418 0.00598426 0.328564
Brugia malayi serpin 0.00258354 0.00134964 0.0012512
Echinococcus granulosus GPCR family 2 0.00311688 0.0019168 0.00259093
Giardia lamblia Tenascin-X 0.0281376 0.0285241 0.117851
Echinococcus granulosus protein kinase c iota type 0.00161665 0.000321438 0.000434488
Echinococcus multilocularis integrin alpha ps 0.0927523 0.0972361 0.131318
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.00411942 0.00298291 0.161016
Trypanosoma cruzi cysteine peptidase, putative 0.00319348 0.00199826 0.0228756
Mycobacterium ulcerans Type I modular polyketide synthase 0.00411942 0.00298291 0.123918
Brugia malayi hypothetical protein 0.0197619 0.0196173 0.0195206
Trypanosoma cruzi metacaspase, putative 0.00177662 0.000491557 0.00453637
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0139739 0.0134623 0.162413
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0139739 0.0134623 0.0356255
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.00244504 0.00120236 0.0388308
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00188629 0.000608178 0.000813674
Entamoeba histolytica cysteine protease, putative 0.00188629 0.000608178 0.000891347
Brugia malayi Integrin alpha pat-2 precursor 0.200823 0.21216 0.212082
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0139739 0.0134623 0.0356255
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Loa Loa (eye worm) glutamate receptor 2 0.0032974 0.00210877 0.00201039
Entamoeba histolytica cysteine protease, putative 0.00188629 0.000608178 0.000891347
Entamoeba histolytica serine protease inhibitor, putative 0.00258354 0.00134964 0.00996232
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.00273318 0.00150877 0.0787228
Echinococcus granulosus Protein kinase C brain isozyme 0.00167553 0.000384051 0.000519122
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0786843 0.082276 1
Onchocerca volvulus Cell death protein 3 homolog 0.00177662 0.000491557 0.00843266
Schistosoma mansoni tyrosine kinase 0.018675 0.0184615 0.0293196
Schistosoma mansoni cathepsin F (C01 family) 0.00319348 0.00199826 0.00303318
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.00433311 0.00321015 0.173701
Trypanosoma cruzi metacaspase, putative 0.00177662 0.000491557 0.00453637
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0139739 0.0134623 0.0525304
Trypanosoma cruzi oligopeptidase b 0.00273318 0.00150877 0.0169176
Entamoeba histolytica PH domain containing protein kinase, putative 0.00734999 0.00641833 0.0719717
Schistosoma mansoni serine protease inhibitors serpins 0.00258354 0.00134964 0.00199756
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0786843 0.082276 1
Plasmodium falciparum subtilisin-like protease 2 0.0182523 0.018012 1
Loa Loa (eye worm) hypothetical protein 0.00252626 0.00128872 0.00119027
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0139739 0.0134623 0.158146
Loa Loa (eye worm) hypothetical protein 0.00673399 0.00576327 0.00566526
Brugia malayi Serpin protein 6 0.00258354 0.00134964 0.0012512
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.00409881 0.00296099 0.00386965
Plasmodium falciparum cysteine repeat modular protein 1 0.00142615 0.000118862 0.00113267
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.019002 0.0188092 0.227496
Onchocerca volvulus 0.00319348 0.00199826 0.039264
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0107887 0.0100751 0.121185
Brugia malayi Integrin alpha cytoplasmic region family protein 0.132373 0.139369 0.139284
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.00411942 0.00298291 0.161016
Trichomonas vaginalis conserved hypothetical protein 0.116486 0.122474 0.326234
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0182523 0.018012 0.0286019
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.00181778 0.000535318 0.000590429
Giardia lamblia Sirtuin type 2 0.0139739 0.0134623 0.0525304
Mycobacterium ulcerans Type I modular polyketide synthase 0.00411942 0.00298291 0.123918
Onchocerca volvulus 0.00140707 0.0000985722 0.000391073
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.00212038 0.000857107 0.0423445
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0182523 0.018012 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.00181778 0.000535318 0.00072359
Trypanosoma cruzi oligopeptidase b 0.00273318 0.00150877 0.0169176
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0139739 0.0134623 0.0356255
Loa Loa (eye worm) ctsf protein 0.00319348 0.00199826 0.00189987
Plasmodium vivax plasmepsin V, putative 0.016644 0.0163017 0.904526
Brugia malayi hypothetical protein 0.00258354 0.00134964 0.0012512
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0130955 0.0125282 0.0198461
Trypanosoma brucei prolyl endopeptidase 0.00818388 0.0073051 0.083311
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0069418 0.00598426 0.298875
Leishmania major cathepsin L-like protease 0.00319348 0.00199826 0.0228756
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.00181778 0.000535318 0.0153646
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0032974 0.00210877 0.00271754
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.00576322 0.00473095 0.00639483
Loa Loa (eye worm) hypothetical protein 0.0059722 0.00495318 0.00485508
Loa Loa (eye worm) TK/ROR protein kinase 0.00142615 0.000118862 0.0000202919
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.00199826 0.0184228
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.00866835 0.00782029 0.431058
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.00818388 0.0073051 0.0115065
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0245958 0.0247577 0.0246616
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Schistosoma mansoni integrin beta subunit 0.553577 0.587282 0.937541
Onchocerca volvulus 0.00230221 0.00105048 0.0198697
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.00177662 0.000491557 0.00104763
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.00433311 0.00321015 0.173701
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.00181778 0.000535318 0.0153646
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.00818388 0.0073051 0.0115065
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.00181778 0.000535318 0.0153646
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.134738 0.141884 0.377977
Onchocerca volvulus 0.00319348 0.00199826 0.039264
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0107887 0.0100751 0.121185
Plasmodium vivax vivapain-2 0.00319348 0.00199826 0.106048
Brugia malayi BmSERPIN, truncated 0.00258354 0.00134964 0.0012512
Loa Loa (eye worm) hypothetical protein 0.00818388 0.0073051 0.00720723
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0139739 0.0134623 0.158597
Schistosoma mansoni site-1 peptidase (S08 family) 0.0182523 0.018012 0.0286019
Echinococcus granulosus membrane bound transcription factor site 1 0.0182523 0.018012 0.0243468
Entamoeba histolytica cysteine protease, putative 0.00188629 0.000608178 0.000891347
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0069418 0.00598426 0.328564
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0107887 0.0100751 0.0136186
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.00273318 0.00150877 0.0787228
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Plasmodium falciparum subtilisin-like protease 3 0.0182523 0.018012 1
Echinococcus multilocularis fibrillin 1 0.0281854 0.0285749 0.0384966
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.00199826 0.0184228
Brugia malayi Cathepsin L-like precursor 0.00319348 0.00199826 0.00189987
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.00172603 0.000437751 0.0189344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Trichomonas vaginalis conserved hypothetical protein 0.00177662 0.000491557 0.00104763
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0197619 0.0196173 0.0311651
Schistosoma mansoni caspase-3 (C14 family) 0.00177662 0.000491557 0.000627469
Echinococcus multilocularis membrane bound transcription factor site 1 0.0182523 0.018012 0.0242168
Trichomonas vaginalis conserved hypothetical protein 0.00409881 0.00296099 0.00763075
Loa Loa (eye worm) hypothetical protein 0.00258354 0.00134964 0.0012512
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0139739 0.0134623 0.746018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.354156 0.375215 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Brugia malayi amine oxidase, flavin-containing family protein 0.0110406 0.010343 0.0102454
Echinococcus granulosus disks large 3 0.00270552 0.00147936 0.00199965
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.00597015 0.004951 0.0588158
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0182523 0.018012 0.0179152
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.00892194 0.00808997 0.00799218
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0144343 0.0139519 0.0188588
Schistosoma mansoni site-1 peptidase (S08 family) 0.0182523 0.018012 0.0286019
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.00866835 0.00782029 0.405901
Trichomonas vaginalis conserved hypothetical protein 0.0182523 0.018012 0.0477542
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.00319348 0.00199826 0.00189987
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0139739 0.0134623 0.018197
Trichomonas vaginalis hypothetical protein 0.0281376 0.0285241 0.0757778
Mycobacterium tuberculosis Polyketide synthase Pks13 0.00627088 0.00527079 0.288735
Leishmania major cathepsin L-like protease 0.00319348 0.00199826 0.0228756
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Schistosoma mansoni hypothetical protein 0.00874116 0.00789772 0.0124527
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00597015 0.004951 0.00774774
Brugia malayi Kelch motif family protein 0.144181 0.151926 0.151842
Brugia malayi Subtilase family protein 0.0182523 0.018012 0.0179152
Brugia malayi Papain family cysteine protease containing protein 0.00188629 0.000608178 0.000509656
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Brugia malayi Cathepsin L-like precursor 0.00230221 0.00105048 0.000951997
Echinococcus multilocularis serine protease inhibitor 0.00258354 0.00134964 0.0016913
Brugia malayi metalloprotease 0.00384215 0.00268806 0.00258974
Entamoeba histolytica cysteine proteinase, putative 0.00319348 0.00199826 0.0178973
Toxoplasma gondii subtilisin SUB2 0.0182523 0.018012 0.630188
Plasmodium vivax hypothetical protein, conserved 0.0139739 0.0134623 0.746018
Onchocerca volvulus Cathepsin L homolog 0.00319348 0.00199826 0.039264
Mycobacterium tuberculosis Polyketide synthase Pks12 0.00433311 0.00321015 0.173701
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Brugia malayi Latrophilin receptor protein 2 0.00311688 0.0019168 0.0018184
Loa Loa (eye worm) hypothetical protein 0.00258354 0.00134964 0.0012512
Echinococcus multilocularis integrin alpha 3 0.152531 0.160805 0.217256
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.00177662 0.000491557 0.00104763
Brugia malayi Cam kinase protein 1 0.00181778 0.000535318 0.000436789
Echinococcus multilocularis caspase 8 0.00177662 0.000491557 0.000531269
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0182523 0.018012 0.0242168
Echinococcus granulosus integrin alpha ps 0.0444598 0.0458813 0.0620178
Echinococcus granulosus adam 17 protease 0.00576322 0.00473095 0.00639483
Echinococcus granulosus protein will die slowly 0.00874116 0.00789772 0.0106754
Entamoeba histolytica cysteine protease, putative 0.00188629 0.000608178 0.000891347
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0059722 0.00495318 0.00485508
Schistosoma mansoni serpin 0.00258354 0.00134964 0.00199756
Brugia malayi serpin 0.00258354 0.00134964 0.0012512
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.00177662 0.000491557 0.00104763
Loa Loa (eye worm) hypothetical protein 0.0281376 0.0285241 0.0284283
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.00285376 0.001637 0.0454619
Loa Loa (eye worm) cathepsin B 0.00597015 0.004951 0.0048529
Echinococcus granulosus discoidin domain containing receptor 2 0.00140707 0.0000985722 0.00013324
Schistosoma mansoni cathepsin F (C01 family) 0.00230221 0.00105048 0.00151988
Loa Loa (eye worm) hypothetical protein 0.0432453 0.0445898 0.0444956
Trypanosoma brucei prolyl oligopeptidase, putative 0.00273318 0.00150877 0.0124377
Plasmodium falciparum metacaspase 1 0.00177662 0.000491557 0.0219381
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0069418 0.00598426 0.328564
Plasmodium falciparum calcium-dependent protein kinase 3 0.00181778 0.000535318 0.024381
Loa Loa (eye worm) hypothetical protein 0.00258354 0.00134964 0.0012512
Leishmania major oligopeptidase b 0.00273318 0.00150877 0.0169176
Brugia malayi ADAMTS-like protease 0.00812884 0.00724657 0.0071487
Leishmania major UDP-galactopyranose mutase 0.0069418 0.00598426 0.0713925
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0107887 0.0100751 0.556932
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0069418 0.00598426 0.328564
Entamoeba histolytica cysteine protease, putative 0.00188629 0.000608178 0.000891347
Loa Loa (eye worm) hypothetical protein 0.00319348 0.00199826 0.00189987
Echinococcus granulosus tissue type plasminogen activator 0.00142615 0.000118862 0.000160666
Mycobacterium ulcerans NAD-dependent deacetylase 0.0139739 0.0134623 0.734788
Trichomonas vaginalis conserved hypothetical protein 0.116486 0.122474 0.326234
Loa Loa (eye worm) pigment dispersing factor receptor c 0.00985087 0.00907779 0.0089801
Brugia malayi SWIRM domain containing protein 0.00409881 0.00296099 0.0028627
Schistosoma mansoni amine oxidase 0.0069418 0.00598426 0.00939753
Mycobacterium ulcerans polyketide synthase Pks13 0.00627088 0.00527079 0.257285
Loa Loa (eye worm) hypothetical protein 0.00230221 0.00105048 0.000951997
Plasmodium vivax hypothetical protein, conserved 0.00177662 0.000491557 0.0219381
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0130955 0.0125282 0.151044
Loa Loa (eye worm) hypothetical protein 0.0130955 0.0125282 0.0124308
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0154752 0.0150588 0.0238866
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0130955 0.0125282 0.0198461
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0786843 0.082276 0.111094
Loa Loa (eye worm) AMP-binding enzyme family protein 0.00374463 0.00258435 0.00248602
Giardia lamblia Tenascin precursor 0.0281376 0.0285241 0.117851
Plasmodium falciparum calcium-dependent protein kinase 4 0.00181778 0.000535318 0.024381
Echinococcus granulosus fibrillin 2 0.0281376 0.0285241 0.038556
Echinococcus granulosus growth factor receptor bound protein 2 0.0162054 0.0158353 0.0214046
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0432453 0.0445898 0.071038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.134738 0.141884 0.377977
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.00199826 0.0184228
Loa Loa (eye worm) hypothetical protein 0.00258354 0.00134964 0.0012512
Loa Loa (eye worm) hypothetical protein 0.00258354 0.00134964 0.0012512
Loa Loa (eye worm) transcriptional regulator 0.0786843 0.082276 0.0821855
Onchocerca volvulus 0.00681375 0.00584809 0.118043
Brugia malayi EGF-like domain containing protein 0.0281376 0.0285241 0.0284283
Trichomonas vaginalis conserved hypothetical protein 0.116486 0.122474 0.326234
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.134738 0.141884 0.226385
Brugia malayi transcriptional regulator, Sir2 family protein 0.0139739 0.0134623 0.013365
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.00374463 0.00258435 0.138766
Echinococcus multilocularis disks large 3 0.00270552 0.00147936 0.00186666
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00188629 0.000608178 0.00142595
Giardia lamblia hypothetical protein 0.00409881 0.00296099 0.00698813
Toxoplasma gondii subtilisin SUB1 0.0182523 0.018012 0.630188
Brugia malayi protein kinase C II. 0.00892194 0.00808997 0.00799218
Loa Loa (eye worm) subtilase 0.0182523 0.018012 0.0179152
Echinococcus multilocularis disintegrin and metalloproteinase 0.00576322 0.00473095 0.00626242
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0144343 0.0139519 0.018728
Trypanosoma cruzi cysteine peptidase, putative 0.00188629 0.000608178 0.00595585
Toxoplasma gondii subtilisin SUB8 0.0182523 0.018012 0.630188
Schistosoma mansoni hypothetical protein 0.00673399 0.00576327 0.00904469
Onchocerca volvulus 0.0037798 0.00262176 0.0520226
Brugia malayi Disintegrin family protein 0.00576322 0.00473095 0.00463283
Entamoeba histolytica cysteine protease, putative 0.00319348 0.00199826 0.0178973
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.00433311 0.00321015 0.137165
Onchocerca volvulus Prolyl endopeptidase homolog 0.00818388 0.0073051 0.147857
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0139739 0.0134623 0.0180661
Giardia lamblia Cathepsin B precursor 0.00597015 0.004951 0.0156184
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0139739 0.0134623 0.746018
Loa Loa (eye worm) hypothetical protein 0.00258354 0.00134964 0.0012512
Brugia malayi Cell death protein 3 precursor 0.00177662 0.000491557 0.000393024
Echinococcus granulosus cathepsin l cysteine peptidase 0.00319348 0.00199826 0.00270105
Loa Loa (eye worm) hypothetical protein 0.0069418 0.00598426 0.00588627
Echinococcus multilocularis cathepsin b 0.0130955 0.0125282 0.0168034
Leishmania major metacaspase, putative 0.00177662 0.000491557 0.00453637
Echinococcus granulosus calcium dependent protein kinase 0.0017142 0.000425178 0.000574714
Plasmodium vivax vivapain-1 0.00188629 0.000608178 0.0284483
Echinococcus multilocularis glutamate receptor 2 0.0032974 0.00210877 0.00271754
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Loa Loa (eye worm) hypothetical protein 0.0110406 0.010343 0.0102454
Echinococcus multilocularis Estrogen regulated protein EP45 0.00258354 0.00134964 0.0016913
Loa Loa (eye worm) hypothetical protein 0.0182523 0.018012 0.0179152
Loa Loa (eye worm) hypothetical protein 0.00181778 0.000535318 0.000436789
Mycobacterium ulcerans Sir2-like regulatory protein 0.0139739 0.0134623 0.734788
Entamoeba histolytica protein kinase, putative 0.00187666 0.000597931 0.000765991
Loa Loa (eye worm) hypothetical protein 0.108071 0.113526 0.113438
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.134738 0.141884 0.377977
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0786843 0.082276 1
Trichomonas vaginalis CAMK family protein kinase 0.00181778 0.000535318 0.0011643
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Toxoplasma gondii subtilisin SUB12 0.0182523 0.018012 0.630188
Giardia lamblia hypothetical protein 0.0281376 0.0285241 0.117851
Brugia malayi Kringle domain containing protein 0.00142615 0.000118862 0.0000202919
Schistosoma mansoni protein kinase 0.0144343 0.0139519 0.0221192
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.00409881 0.00296099 0.00400238
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.00775023 0.00684395 0.00674604
Plasmodium vivax hypothetical protein, conserved 0.0069418 0.00598426 0.328564
Brugia malayi Stress-activated protein kinase jnk-1 0.0245958 0.0247577 0.0246616
Echinococcus multilocularis Furin 1 0.134738 0.141884 0.191677
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0334198 0.0341413 0.0461488
Trichomonas vaginalis WD repeat domain, putative 0.00874116 0.00789772 0.0207913
Loa Loa (eye worm) papain family cysteine protease containing protein 0.00319348 0.00199826 0.00189987
Brugia malayi serpin 0.00258354 0.00134964 0.0012512
Giardia lamblia High cysteine protein 0.0281376 0.0285241 0.117851
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.00181778 0.000535318 0.024381
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0032974 0.00210877 0.00271754
Loa Loa (eye worm) hypothetical protein 0.0139739 0.0134623 0.013365
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Toxoplasma gondii subtilisin SUB6 0.0182523 0.018012 0.630188
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.134738 0.141884 0.377977
Loa Loa (eye worm) reprolysin 0.0154752 0.0150588 0.0149617
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0130955 0.0125282 0.0198461
Brugia malayi Protein kinase domain containing protein 0.00142615 0.000118862 0.0000202919
Leishmania major cathepsin L-like protease 0.00319348 0.00199826 0.0228756
Schistosoma mansoni chromatin regulatory protein sir2 0.0786843 0.082276 0.131211
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Echinococcus granulosus discoidin domain receptor 0.00140707 0.0000985722 0.00013324
Mycobacterium ulcerans Type I modular polyketide synthase 0.00411942 0.00298291 0.123918
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0605638 0.0630065 0.085044
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.354156 0.375215 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.00167553 0.000384051 0.000385933
Loa Loa (eye worm) endoprotease bli-4 0.590363 0.6264 0.626363
Onchocerca volvulus 0.0473441 0.0489485 1
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.00261233 0.00138026 0.00128181
Schistosoma mansoni growth factor receptor-bound protein 0.0162054 0.0158353 0.0251264
Entamoeba histolytica cysteine protease, putative 0.00188629 0.000608178 0.000891347
Echinococcus multilocularis 0.0069418 0.00598426 0.00795675
Loa Loa (eye worm) TK/EGFR protein kinase 0.018675 0.0184615 0.0183647
Plasmodium vivax hypothetical protein, conserved 0.0069418 0.00598426 0.328564
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0107887 0.0100751 0.5
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.00181778 0.000535318 0.024381
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0139739 0.0134623 0.018197
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.00181778 0.000535318 0.000436789
Brugia malayi NAD-dependent deacetylase SIRT1 0.0139739 0.0134623 0.013365
Giardia lamblia Tenascin-like 0.0281376 0.0285241 0.117851
Giardia lamblia High cysteine membrane protein Group 2 0.219417 0.231933 1
Mycobacterium ulcerans thioesterase TesA 0.00341712 0.00223607 0.0803834
Schistosoma mansoni cathepsin F (C01 family) 0.00319348 0.00199826 0.00303318
Trypanosoma cruzi metacaspase, putative 0.00177662 0.000491557 0.00453637
Echinococcus granulosus serine:threonine protein kinase N2 0.00734999 0.00641833 0.00867567
Giardia lamblia Furin precursor putative serine protease 0.116486 0.122474 0.525297
Schistosoma mansoni hypothetical protein 0.00311688 0.0019168 0.00290311
Plasmodium falciparum cysteine proteinase falcipain 3 0.00319348 0.00199826 0.106048
Loa Loa (eye worm) integrin beta-2 0.941685 1 1
Loa Loa (eye worm) fibroinase 0.00319348 0.00199826 0.00189987
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0069418 0.00598426 0.207057
Entamoeba histolytica cysteine protease, putative 0.00188629 0.000608178 0.000891347
Loa Loa (eye worm) serpin 0.00258354 0.00134964 0.0012512
Schistosoma mansoni hypothetical protein 0.0059722 0.00495318 0.00775123
Trichomonas vaginalis conserved hypothetical protein 0.0182523 0.018012 0.0477542
Schistosoma mansoni ATP-binding cassette transporter 0.00367897 0.00251454 0.00385751
Echinococcus granulosus chromatin regulatory protein sir2 0.0786843 0.082276 0.111213
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.00181778 0.000535318 0.000590429
Leishmania major protein kinase, putative 0.00181778 0.000535318 0.00506902
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0107887 0.0100751 0.00997753
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.00273318 0.00150877 0.0169176
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.00273318 0.00150877 0.0169176
Echinococcus granulosus integrin alpha 3 0.152531 0.160805 0.21736
Brugia malayi Glutamate receptor 1 precursor 0.0032974 0.00210877 0.00201039
Entamoeba histolytica cysteine proteinase, putative 0.00188629 0.000608178 0.000891347
Echinococcus multilocularis caspase 2 0.00177662 0.000491557 0.000531269
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0182523 0.018012 0.217791
Loa Loa (eye worm) hypothetical protein 0.590363 0.6264 0.626363
Onchocerca volvulus 0.00319348 0.00199826 0.039264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00230221 0.00105048 0.00253762
Schistosoma mansoni chromatin regulatory protein sir2 0.0139739 0.0134623 0.0213375
Schistosoma mansoni protein kinase 0.0144343 0.0139519 0.0221192
Mycobacterium leprae conserved hypothetical protein 0.00212038 0.000857107 0.0423445
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0139739 0.0134623 0.162413
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Schistosoma mansoni glutamate receptor NMDA 0.0032974 0.00210877 0.00320963
Onchocerca volvulus 0.00258354 0.00134964 0.0259916
Loa Loa (eye worm) hypothetical protein 0.0281376 0.0285241 0.0284283
Trypanosoma cruzi metacaspase 5, putative 0.00177662 0.000491557 0.00453637
Mycobacterium ulcerans polyketide synthase 0.00411942 0.00298291 0.123918
Echinococcus multilocularis tissue type plasminogen activator 0.00142615 0.000118862 0.0000274296
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0182523 0.018012 1
Trypanosoma cruzi cysteine peptidase, putative 0.00319348 0.00199826 0.0228756
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.00230221 0.00105048 0.0113394
Plasmodium falciparum protoporphyrinogen oxidase 0.0069418 0.00598426 0.328564
Plasmodium vivax NAD-dependent deacetylase, putative 0.0139739 0.0134623 0.746018
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0139739 0.0134623 0.0356255
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.00866835 0.00782029 0.431058
Onchocerca volvulus 0.00258354 0.00134964 0.0259916
Loa Loa (eye worm) hypothetical protein 0.00812884 0.00724657 0.0071487
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00188629 0.000608178 0.00142595
Echinococcus multilocularis caspase 0.00177662 0.000491557 0.000531269
Trypanosoma cruzi UDP-galactopyranose mutase 0.0069418 0.00598426 0.0713925
Leishmania major cathepsin L-like protease 0.00319348 0.00199826 0.0228756
Mycobacterium ulcerans oxidoreductase 0.0069418 0.00598426 0.298875
Schistosoma mansoni serine/threonine protein kinase 0.00167553 0.000384051 0.000455816
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0139739 0.0134623 0.0356255
Echinococcus granulosus caspase 0.00177662 0.000491557 0.000664438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Brugia malayi Cathepsin L-like precursor 0.00319348 0.00199826 0.00189987
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0182523 0.018012 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0182523 0.018012 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.00142615 0.000118862 0.00113267
Onchocerca volvulus 0.00319348 0.00199826 0.039264
Plasmodium falciparum cysteine proteinase falcipain 2b 0.00319348 0.00199826 0.106048
Brugia malayi serpin (BmSERPIN) 0.00258354 0.00134964 0.0012512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Onchocerca volvulus 0.00319348 0.00199826 0.039264
Entamoeba histolytica cysteine proteinase, putative 0.00188629 0.000608178 0.000891347
Brugia malayi Cathepsin L-like precursor 0.00319348 0.00199826 0.00189987
Entamoeba histolytica cysteine protease, putative 0.00188629 0.000608178 0.000891347
Mycobacterium tuberculosis Possible oxidoreductase 0.0069418 0.00598426 0.328564
Echinococcus multilocularis integrin alpha ps 0.102034 0.107106 0.144662
Brugia malayi Cathepsin L-like precursor 0.00319348 0.00199826 0.00189987
Plasmodium falciparum metacaspase-like protein 0.00177662 0.000491557 0.0219381
Echinococcus granulosus cathepsin L cysteine proteinase 0.00319348 0.00199826 0.00270105
Plasmodium falciparum calcium-dependent protein kinase 2 0.00181778 0.000535318 0.024381
Toxoplasma gondii cathepsin CPL 0.00319348 0.00199826 0.0668303
Chlamydia trachomatis protoporphyrinogen oxidase 0.0069418 0.00598426 0.556211
Echinococcus granulosus Estrogen regulated protein EP45 0.00258354 0.00134964 0.00182432
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.00285376 0.001637 0.0858813
Trypanosoma cruzi UDP-galactopyranose mutase 0.0069418 0.00598426 0.0713925
Loa Loa (eye worm) hypothetical protein 0.132373 0.139369 0.139284
Leishmania major cathepsin L-like protease 0.00319348 0.00199826 0.0228756
Echinococcus granulosus protein kinase c epsilon type 0.00892194 0.00808997 0.0109352
Toxoplasma gondii cathepsin B 0.00597015 0.004951 0.170707
Brugia malayi hypothetical protein 0.143431 0.151128 0.151045
Mycobacterium tuberculosis Probable thioesterase TesA 0.00341712 0.00223607 0.119324
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.00338131 0.00219799 0.117198
Onchocerca volvulus 0.0182523 0.018012 0.36695
Schistosoma mansoni hypothetical protein 0.00311688 0.0019168 0.00290311
Echinococcus multilocularis fibrillin 2 0.0281376 0.0285241 0.0384279
Echinococcus granulosus adam 0.0478995 0.0495391 0.066962
Giardia lamblia Neurogenic locus notch-like protein 0.0281376 0.0285241 0.117851
Plasmodium vivax calcium-dependent protein kinase, putative 0.00181778 0.000535318 0.024381
Loa Loa (eye worm) hypothetical protein 0.0575743 0.0598274 0.0597347
Brugia malayi Sex muscle abnormal protein 5 0.0162054 0.0158353 0.0157383
Brugia malayi neuroendocrine convertase 1 precursor 0.370945 0.393069 0.393009
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.00818388 0.0073051 0.0874694
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0182523 0.018012 0.0286019
Mycobacterium leprae Possible secreted protease 0.0182523 0.018012 1
Loa Loa (eye worm) serpin protein 6 0.00258354 0.00134964 0.0012512
Brugia malayi Cathepsin L-like precursor 0.00319348 0.00199826 0.00189987
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0130955 0.0125282 0.0198461
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.00597015 0.004951 0.0588158
Brugia malayi serpin 0.00258354 0.00134964 0.0012512
Toxoplasma gondii serpin (serine proteinase inhibitor) superfamily protein 0.00258354 0.00134964 0.0440124
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0059722 0.00495318 0.00669522
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.00181778 0.000535318 0.00072359
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.00177662 0.000491557 0.00104763
Brugia malayi Integrin beta pat-3 precursor 0.941685 1 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0069418 0.00598426 0.298875
Toxoplasma gondii type I fatty acid synthase, putative 0.00265852 0.00142938 0.0468174
Trichomonas vaginalis conserved hypothetical protein 0.116486 0.122474 0.326234
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.00597015 0.004951 0.0129358
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.00347806 0.00230088 0.122942
Loa Loa (eye worm) latrophilin receptor protein 2 0.00311688 0.0019168 0.0018184
Schistosoma mansoni chromatin regulatory protein sir2 0.0786843 0.082276 0.131211
Toxoplasma gondii histone deacetylase SIR2 0.0139739 0.0134623 0.470131
Schistosoma mansoni chromatin regulatory protein sir2 0.0139739 0.0134623 0.0213375
Loa Loa (eye worm) hypothetical protein 0.0069418 0.00598426 0.00588627
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.00866835 0.00782029 0.5
Loa Loa (eye worm) hypothetical protein 0.00215681 0.000895849 0.000797356
Loa Loa (eye worm) cysteine protease 0.00319348 0.00199826 0.00189987
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0139739 0.0134623 0.162413
Brugia malayi Reprolysin 0.009712 0.00893012 0.00883242
Loa Loa (eye worm) hypothetical protein 0.0432453 0.0445898 0.0444956
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.00177662 0.000491557 0.00104763
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.00199826 0.0184228
Giardia lamblia Neurogenic locus Notch protein precursor 0.0281376 0.0285241 0.117851
Leishmania major sir2-family protein-like protein 0.0139739 0.0134623 0.162413
Trichomonas vaginalis conserved hypothetical protein 0.116486 0.122474 0.326234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00230221 0.00105048 0.00253762
Entamoeba histolytica cysteine proteinase 1, putative 0.00188629 0.000608178 0.000891347
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.00411942 0.00298291 0.161016
Echinococcus granulosus glutamate NMDA receptor subunit 0.0032974 0.00210877 0.00285042
Brugia malayi proprotein convertase 2 0.370945 0.393069 0.393009
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.00361033 0.00244154 0.130794
Schistosoma mansoni chromatin regulatory protein sir2 0.0139739 0.0134623 0.0213375
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.354156 0.375215 0.507179
Echinococcus granulosus fibrillin 1 0.0281854 0.0285749 0.0386247
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.00177662 0.000491557 0.000393024
Loa Loa (eye worm) acyl carrier protein 0.00165549 0.000362742 0.000264196
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0032974 0.00210877 0.00271754
Mycobacterium leprae Polyketide synthase Pks13 0.00627088 0.00527079 0.288735
Trichomonas vaginalis conserved hypothetical protein 0.00177662 0.000491557 0.00104763
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.00311688 0.0019168 0.0018184
Mycobacterium tuberculosis Probable peptidase 0.00273318 0.00150877 0.0787228
Loa Loa (eye worm) hypothetical protein 0.156363 0.164881 0.164798
Entamoeba histolytica cysteine proteinase, putative 0.00230221 0.00105048 0.00630234
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0786843 0.082276 0.219072
Loa Loa (eye worm) hypothetical protein 0.00177662 0.000491557 0.000393024
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0139739 0.0134623 0.0356255
Brugia malayi transcriptional regulator, Sir2 family protein 0.0139739 0.0134623 0.013365
Loa Loa (eye worm) guanylate kinase 0.0029542 0.00174381 0.0016454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.00199826 0.0184228
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0032974 0.00210877 0.00271754
Plasmodium falciparum subtilisin-like protease 1 0.0182523 0.018012 1
Echinococcus granulosus cysteine protease 0.00188629 0.000608178 0.000822074
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0032974 0.00210877 0.00285042
Echinococcus multilocularis neuroendocrine convertase 2 0.370945 0.393069 0.53125
Brugia malayi BmSERPIN 0.00258354 0.00134964 0.0012512
Schistosoma mansoni serine protease inhibitors serpins 0.00258354 0.00134964 0.00199756
Schistosoma mansoni serine/threonine protein kinase 0.00181778 0.000535318 0.000697342
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.00213098 0.000868385 0.0429741
Schistosoma mansoni integrin alpha-ps 0.0575743 0.0598274 0.0953675
Entamoeba histolytica SWIRM domain protein 0.00409881 0.00296099 0.0296752
Giardia lamblia Cathepsin B precursor 0.00597015 0.004951 0.0156184
Mycobacterium ulcerans monoamine oxidase 0.0069418 0.00598426 0.298875
Trichomonas vaginalis conserved hypothetical protein 0.0182523 0.018012 0.0477542
Leishmania major subtilisin-like serine peptidase 0.0182523 0.018012 0.217791
Echinococcus multilocularis protein will die slowly 0.00874116 0.00789772 0.0105435
Mycobacterium ulcerans thioesterase 0.00341712 0.00223607 0.0803834
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0182523 0.018012 0.0179152
Trichomonas vaginalis conserved hypothetical protein 0.00177662 0.000491557 0.00104763
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.00177662 0.000491557 0.0138251
Echinococcus granulosus cathepsin l1 0.00230221 0.00105048 0.00141993
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Brugia malayi Furin-like cysteine rich region family protein 0.018675 0.0184615 0.0183647
Plasmodium falciparum plasmepsin V 0.016644 0.0163017 0.904526
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.00188629 0.000608178 0.00595585
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.00273318 0.00150877 0.0379868
Mycobacterium ulcerans polyketide synthase 0.00433311 0.00321015 0.137165
Trypanosoma cruzi cruzipain precursor, putative 0.00319348 0.00199826 0.0228756
Loa Loa (eye worm) metalloprotease 0.00384215 0.00268806 0.00258974
Schistosoma mansoni serine protease inhibitors serpins 0.00258354 0.00134964 0.00199756
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.00199826 0.0184228
Loa Loa (eye worm) kelch domain-containing protein family protein 0.144181 0.151926 0.151842
Trypanosoma brucei SIR2-like protein 4, putative 0.0139739 0.0134623 0.158597
Echinococcus multilocularis protoporphyrinogen oxidase 0.0069418 0.00598426 0.00795675
Entamoeba histolytica cysteine protease, putative 0.00188629 0.000608178 0.000891347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00188629 0.000608178 0.00135853
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.116486 0.122474 0.326234
Entamoeba histolytica cysteine proteinase 2 0.00188629 0.000608178 0.000891347
Brugia malayi ADAM-TS Spacer 1 family protein 0.00812884 0.00724657 0.0071487
Schistosoma mansoni serine/threonine protein kinase 0.00892194 0.00808997 0.0127597
Giardia lamblia High cysteine protein 0.0281376 0.0285241 0.117851
Trichomonas vaginalis conserved hypothetical protein 0.116486 0.122474 0.326234
Mycobacterium ulcerans polyketide synthase Pks9 0.00285376 0.001637 0.0454619
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00188629 0.000608178 0.000813674
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.00576322 0.00473095 0.00626242
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0032974 0.00210877 0.00285042
Loa Loa (eye worm) hypothetical protein 0.00230221 0.00105048 0.000951997
Echinococcus granulosus disintegrin and metalloproteinase 0.00576322 0.00473095 0.00639483
Echinococcus granulosus Furin 1 0.134738 0.141884 0.191785
Schistosoma mansoni serpin 0.00258354 0.00134964 0.00199756
Giardia lamblia Cathepsin B precursor 0.00597015 0.004951 0.0156184
Onchocerca volvulus 0.00258354 0.00134964 0.0259916
Echinococcus multilocularis calcium dependent protein kinase 0.0017142 0.000425178 0.000441532
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.00177662 0.000491557 0.000531269
Leishmania major cathepsin L-like protease 0.00319348 0.00199826 0.0228756
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.590363 0.6264 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.00361033 0.00244154 0.130794
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.00411942 0.00298291 0.161016
Schistosoma mansoni serine/threonine protein kinase 0.00167553 0.000384051 0.000455816
Echinococcus multilocularis integrin beta 2 0.697008 0.739808 1
Trypanosoma cruzi subtilisin peptidase 0.0182523 0.018012 0.217791
Loa Loa (eye worm) hypothetical protein 0.00230221 0.00105048 0.000951997
Brugia malayi EGF-like domain containing protein 0.0281376 0.0285241 0.0284283
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0107887 0.0100751 0.00997753
Mycobacterium leprae Probable polyketide synthase Pks1 0.00433311 0.00321015 0.173701
Echinococcus multilocularis cathepsin l cysteine peptidase 0.00319348 0.00199826 0.00256815
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.00181778 0.000535318 0.00053508
Leishmania major cysteine peptidase A (CPA) 0.00319348 0.00199826 0.0228756
Loa Loa (eye worm) hypothetical protein 0.00142615 0.000118862 0.0000202919
Brugia malayi angiogenesis inhibito 0.00812884 0.00724657 0.0071487
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Echinococcus granulosus prolyl endopeptidase 0.00818388 0.0073051 0.00987431
Loa Loa (eye worm) transcriptional regulator 0.0139739 0.0134623 0.013365
Schistosoma mansoni furin-1 (S08 family) 0.25446 0.269197 0.429663
Loa Loa (eye worm) hypothetical protein 0.0281376 0.0285241 0.0284283
Schistosoma mansoni integrin alpha-ps 0.0927523 0.0972361 0.155097
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.00411942 0.00298291 0.161016
Schistosoma mansoni integrin alpha 0.200823 0.21216 0.338593
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Trypanosoma cruzi cysteine peptidase, putative 0.00319348 0.00199826 0.0228756
Onchocerca volvulus 0.00258354 0.00134964 0.0259916
Loa Loa (eye worm) hypothetical protein 0.00812884 0.00724657 0.0071487
Schistosoma mansoni glutamate receptor kainate 0.0032974 0.00210877 0.00320963
Schistosoma mansoni hypothetical protein 0.116486 0.122474 0.195394
Mycobacterium tuberculosis Conserved hypothetical protein 0.0069418 0.00598426 0.328564
Echinococcus granulosus lysine specific histone demethylase 1A 0.0432453 0.0445898 0.0602721
Brugia malayi cathepsin B-like cysteine proteinase 0.0130955 0.0125282 0.0124308
Echinococcus granulosus neuroendocrine convertase 2 0.370945 0.393069 0.531312
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.00265214 0.00142259 0.0158687
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.019002 0.0188092 0.223975
Plasmodium falciparum calcium-dependent protein kinase 5 0.00181778 0.000535318 0.024381
Schistosoma mansoni glutamate receptor AMPA 0.0032974 0.00210877 0.00320963
Echinococcus multilocularis glutamate receptor 2 0.00207718 0.000811167 0.000963343
Plasmodium falciparum cysteine proteinase falcipain 2a 0.00319348 0.00199826 0.106048
Brugia malayi Cathepsin L-like precursor 0.00319348 0.00199826 0.00189987
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.00177662 0.000491557 0.0138251
Echinococcus multilocularis protein kinase c iota type 0.00161665 0.000321438 0.000301288
Brugia malayi serpin (BmSERPIN) 0.00258354 0.00134964 0.0012512
Trypanosoma cruzi cysteine proteinase, putative 0.00188629 0.000608178 0.00595585
Brugia malayi serpin 0.00258354 0.00134964 0.0012512
Trypanosoma cruzi cysteine peptidase, putative 0.00319348 0.00199826 0.0228756
Loa Loa (eye worm) hypothetical protein 0.00384215 0.00268806 0.00258974
Onchocerca volvulus 0.00140707 0.0000985722 0.000391073
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0139739 0.0134623 0.0180661
Brugia malayi endoprotease bli-4 precursor 0.590363 0.6264 0.626363
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.00433311 0.00321015 0.137165
Echinococcus multilocularis chromatin regulatory protein sir2 0.0786843 0.082276 0.111094
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.00433311 0.00321015 0.173701
Entamoeba histolytica cysteine proteinase, putative 0.00319348 0.00199826 0.0178973
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0069418 0.00598426 0.298875
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.00177662 0.000491557 0.00104763
Brugia malayi latrophilin 2 splice variant baaae 0.00673399 0.00576327 0.00566526
Schistosoma mansoni growth factor receptor-bound protein 0.0162054 0.0158353 0.0251264
Entamoeba histolytica cysteine protease, putative 0.00188629 0.000608178 0.000891347
Toxoplasma gondii protease inhibitor PI1 0.00258354 0.00134964 0.0440124
Toxoplasma gondii subtilisin SUB4 0.0182523 0.018012 0.630188
Schistosoma mansoni glutamate receptor kainate 0.0032974 0.00210877 0.00320963
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0069418 0.00598426 0.328564
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Loa Loa (eye worm) serpin 0.00258354 0.00134964 0.0012512
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0059722 0.00495318 0.00656285
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0069894 0.00603487 0.331389
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.00177662 0.000491557 0.000627469
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0032974 0.00210877 0.00285042
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0107887 0.0100751 0.0159293
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0182523 0.018012 0.0243468
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.00177662 0.000491557 0.00104763
Trichomonas vaginalis conserved hypothetical protein 0.116486 0.122474 0.326234
Echinococcus multilocularis epidermal growth factor receptor 0.018675 0.0184615 0.0248245
Trichomonas vaginalis conserved hypothetical protein 0.00177662 0.000491557 0.00104763
Trichomonas vaginalis conserved hypothetical protein 0.116486 0.122474 0.326234
Leishmania major cathepsin L-like protease 0.00319348 0.00199826 0.0228756
Toxoplasma gondii subtilisin SUB11 0.0182523 0.018012 0.630188
Brugia malayi Papain family cysteine protease containing protein 0.00319348 0.00199826 0.00189987
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.00411942 0.00298291 0.123918
Toxoplasma gondii type I fatty acid synthase, putative 0.00433311 0.00321015 0.109464
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Echinococcus granulosus epidermal growth factor receptor 0.018675 0.0184615 0.0249544
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0786843 0.082276 1
Echinococcus granulosus serine protease inhibitor 0.00258354 0.00134964 0.00182432
Echinococcus granulosus cathepsin b 0.0130955 0.0125282 0.0169344
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.00181778 0.000535318 0.000436789
Schistosoma mansoni chromatin regulatory protein sir2 0.0139739 0.0134623 0.0213375
Echinococcus multilocularis protein jagged 2 0.0281376 0.0285241 0.0384279
Brugia malayi Calcitonin receptor-like protein seb-1 0.00985087 0.00907779 0.0089801
Loa Loa (eye worm) hypothetical protein 0.00694979 0.00599275 0.00589476
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0182523 0.018012 1
Loa Loa (eye worm) hypothetical protein 0.0281376 0.0285241 0.0284283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00188629 0.000608178 0.00135853
Schistosoma mansoni chromatin regulatory protein sir2 0.0786843 0.082276 0.131211
Loa Loa (eye worm) proprotein convertase 2 0.134738 0.141884 0.141799
Plasmodium vivax unspecified product 0.00188629 0.000608178 0.0284483
Loa Loa (eye worm) hypothetical protein 0.236207 0.249787 0.249713
Giardia lamblia Hypothetical protein 0.0786843 0.082276 0.350963
Schistosoma mansoni caspase-7 (C14 family) 0.00177662 0.000491557 0.000627469
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0126165 0.0120188 0.0119214
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0786843 0.082276 0.219072
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0786843 0.082276 0.111213
Entamoeba histolytica cysteine protease, putative 0.00188629 0.000608178 0.000891347
Trichomonas vaginalis conserved hypothetical protein 0.00177662 0.000491557 0.00104763
Echinococcus multilocularis prolyl endopeptidase 0.00818388 0.0073051 0.00974237
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0139739 0.0134623 0.018197
Echinococcus multilocularis serine:threonine protein kinase N2 0.00822834 0.00735238 0.00980629
Echinococcus multilocularis 0.473877 0.502528 0.679225
Loa Loa (eye worm) hypothetical protein 0.00311688 0.0019168 0.0018184
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0139739 0.0134623 0.158146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.00199826 0.00506425
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0401538 0.0413023 0.0412078
Brugia malayi Cathepsin L-like cysteine proteinase 0.00230221 0.00105048 0.000951997
Entamoeba histolytica cysteine proteinase, putative 0.00188629 0.000608178 0.000891347
Leishmania major silent information regulator 2, putative 0.0786843 0.082276 1
Toxoplasma gondii subtilisin SUB7 0.0182523 0.018012 0.630188
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.00273318 0.00150877 0.0124377
Loa Loa (eye worm) hypothetical protein 0.00258354 0.00134964 0.0012512
Trypanosoma cruzi cysteine protease, putative 0.00188629 0.000608178 0.00595585
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0107887 0.0100751 1
Onchocerca volvulus 0.0281376 0.0285241 0.582057
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.00181778 0.000535318 0.024381
Onchocerca volvulus 0.00258354 0.00134964 0.0259916
Brugia malayi EGF-like domain containing protein 0.0281376 0.0285241 0.0284283
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0107887 0.0100751 0.117181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.00199826 0.0184228
Toxoplasma gondii aspartyl protease ASP5 0.0155043 0.0150897 0.527383
Schistosoma mansoni cell polarity protein 0.00270552 0.00147936 0.00220467
Loa Loa (eye worm) hypothetical protein 0.0154752 0.0150588 0.0149617
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Echinococcus granulosus cathepsin b 0.0130955 0.0125282 0.0169344
Trichomonas vaginalis conserved hypothetical protein 0.0182523 0.018012 0.0477542
Onchocerca volvulus 0.00319348 0.00199826 0.039264
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182523 0.018012 0.0477542
Entamoeba histolytica cysteine proteinase, putative 0.00188629 0.000608178 0.000891347

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 10 uM Antitrypanosomal activity against Trypanosoma brucei ChEMBL. 18420405
EC50 (functional) > 10 uM Antitrypanosomal activity against Trypanosoma brucei ChEMBL. 18420405
IC50 (binding) = 0.044 uM Inhibition of human cathepsin L ChEMBL. 18420405
IC50 (binding) = 0.044 uM Inhibition of human cathepsin L ChEMBL. 18420405
IC50 (binding) = 0.089 uM Inhibition of Trypanosoma brucei rhodesain ChEMBL. 18420405
IC50 (binding) = 4.5 uM Inhibition of human cathepsin B ChEMBL. 18420405
IC50 (binding) = 4.5 uM Inhibition of human cathepsin B ChEMBL. 18420405
IC50 (binding) > 25 uM Inhibition of Trypanosoma brucei cathepsin B ChEMBL. 18420405

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense 18420405
Trypanosoma brucei ChEMBL23 18420405

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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